{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:59:54Z","timestamp":1790830794875,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride-glucose body roundness index (TyG-BRI) has emerged as a promising biomarker correlated with elevated risks of adverse cardiovascular events. Notably, the potential linkage between TyG-BRI and carotid atherosclerosis (CAS) has not been formally evaluated in individuals with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional observational study consecutively enrolled 1060 adults with type 2 diabetes mellitus in Fujian, China. Anthropometric measurements and fasting venous blood biochemical data were collected to calculate TyG-BRI. CAS was ascertained using high-resolution B-mode ultrasound. Spearman correlation analysis was performed to examine the correlations between TyG-BRI and metabolic indicators. Following stepwise adjustment for confounding variables, hierarchical binary logistic regression and restricted cubic spline curves were applied to evaluate the association of TyG-BRI with CAS risk as well as potential effect modifiers. Finally, receiver operating characteristic (ROC) curve analysis was conducted to evaluate the identification capability of TyG-BRI for CAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with CAS had significantly higher TyG-BRI levels than non-CAS controls. TyG-BRI was positively correlated with carotid intima-media thickness, glycated hemoglobin (HbA1c), blood pressure, total cholesterol, low-density lipoprotein cholesterol, and uric acid. In fully adjusted models, elevated TyG-BRI was non-linearly associated with higher CAS risk (P for overall association &amp;lt; 0.001, P for non-linearity &amp;lt; 0.01). Per 1-standard-deviation increment in TyG-BRI, the ORs were 1.503 (95% CI 1.281\u20131.763, P &amp;lt; 0.001) for carotid intima-media thickening, 1.453 (95% CI 1.236\u20131.709, P &amp;lt; 0.001) for carotid plaque, and 2.247 (95% CI 1.820\u20132.773, P &amp;lt; 0.001) for CAS. Associations remained consistent across subgroups stratified by age, sex, body mass index (BMI), HbA1c and hypertension, with a stronger effect in participants with BMI &amp;lt; 24 kg\/m\u00b2 (OR 4.838, 95% CI 3.007\u20137.784, P &amp;lt; 0.001). ROC analysis showed TyG-BRI significantly identified CAS (AUC\u00a0=\u00a00.698, 95% CI 0.664\u20130.731, P &amp;lt; 0.001), outperforming TyG and TyG-BMI while matching the performance of the composite indices of TyG combined with waist circumference or waist-to-height ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TyG-BRI demonstrated an independent, non-linear dose-response association with CAS risk in type 2 diabetes. Its integration into cardiovascular risk stratification holds promise for enabling earlier identification of CAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1952432","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:42:42Z","timestamp":1790829762000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of triglyceride-glucose body roundness index with carotid atherosclerosis in type 2 diabetes: a cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Cuihua","family":"Huang","sequence":"first","affiliation":[{"name":"Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tong","sequence":"additional","affiliation":[{"name":"Longyan First Affiliated Hospital of Fujian Medical 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