{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:02:10Z","timestamp":1789970530868,"version":"4.0.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470670, 82270675"],"award-info":[{"award-number":["82470670, 82270675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early prediction of acute pancreatitis (AP) severity is essential for timely intervention and improved outcomes. The C-reactive protein\u2013triglyceride\u2013glucose index (CTI) is a simple, routine laboratory-derived biomarker. It integrates signals of inflammation and insulin resistance (IR) and has demonstrated predictive value in cardiovascular and metabolic diseases. However, its association with AP severity remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study included AP patients admitted between January 2019 and January 2026. CTI was calculated as 0.412 \u00d7 ln (CRP, mg\/L) + ln [triglycerides (mg\/dL) \u00d7 fasting glucose (mg\/dL)\/2]. We assessed the association between CTI and AP severity using Spearman\u2019s correlation, logistic regression, and receiver operating characteristic (ROC) curve analysis. Severity was graded according to both the revised Atlanta criteria (RAC) and the modified computed tomography severity index (MCTSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 567 patients with AP were included in this study. The high CTI group had significantly more severe AP than the low CTI group under both the RAC and MCTSI grading systems (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Spearman\u2019s rank correlation confirmed a positive monotonic association (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). In multivariate models, CTI independently predicted severity under the RAC (odds ratio [OR] 1.180, 95% confidence interval [CI] 1.027\u20131.357,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019) and MCTSI (OR 1.436, 95% CI 1.237\u20131.667,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). For MCTSI \u2265 8, the area under the ROC curve (AUC) reached 0.763 (95% CI 0.681\u20130.845,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). The combined model of CTI + white blood cell (WBC) + lactate dehydrogenase (LDH) yielded the highest AUCs across all endpoints (range 0.697\u20130.795).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CTI independently predicts AP severity with moderate discriminative accuracy. Its routine availability and low cost support its potential as an adjunct for early risk stratification. Adding WBC and LDH further improved predictive performance, though the incremental benefit was modest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1964371","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:35:48Z","timestamp":1789968948000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["C-reactive protein\u2013triglyceride\u2013glucose index predicts acute pancreatitis severity: a retrospective cross-sectional study"],"prefix":"10.3389","volume":"17","author":[{"given":"Tiantian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, Sun 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