{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:02Z","timestamp":1791352202811,"version":"4.3.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between type 2 diabetes mellitus (T2DM) and mortality in patients with liver cirrhosis remains controversial. This study aimed to evaluate whether a history of T2DM influences short-term all-cause mortality in hospitalized patients with decompensated liver cirrhosis (DLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of hospitalized patients with DLC at three medical centers in China between November 2019 and June 2024. The study endpoint was the 6-month mortality. The association between T2DM and mortality was assessed using multivariable logistic regression, and stabilized inverse probability of treatment weighting (sIPTW) analysis was applied for sensitivity analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 984 eligible patients, 239 (24.3%) had a history of T2DM. Patients with T2DM were older and had a higher prevalence of hypertension and coronary artery disease; however, no significant difference in 6-month mortality was observed between patients with and without T2DM. Multivariable logistic regression showed no independent association between a history of T2DM and mortality (OR\u00a0=\u00a00.80, 95% CI: 0.51\u20131.23), this result remained consistent using sIPTW analysis (OR\u00a0=\u00a00.78, 95% CI: 0.51\u20131.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A history of T2DM may not be independently associated with short-term mortality in patients with DLC. These findings suggest that T2DM status may not be prioritized over liver-specific prognostic factors when assessing the short-term mortality risk in patients with DLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2026.1971737","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:52:44Z","timestamp":1791348764000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of a history of type 2 diabetes with short-term mortality in patients with decompensated cirrhosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Honglei","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Maanshan People\u2019s Hospital","place":["Maanshan, Anhui, China"]},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Wannan Medical University","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Wuhu","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]},{"name":"Department of Gastroenterology, Affiliated Hospital of West Anhui Health Vocational College","place":["Lu\u2019an, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, 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