{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:49:49Z","timestamp":1783122589689,"version":"3.54.6"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Epidemiol."],"abstract":"<jats:p>\n                    Syphilis, caused by the bacterium\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    , is among the most prevalent STIs globally and represents a significant public health challenge in Brazil. Vertical transmission can occur at any stage of pregnancy, leading to severe consequences such as miscarriage, stillbirth, preterm birth, and low birth weight. In severe cases, congenital syphilis may result, potentially causing deformities, neurological damage, or even neonatal death. Maternal syphilis (MS) occurrence is often influenced by social inequalities, meager income, and educational levels, which present further public health challenges. We evaluated the incidence of maternal syphilis in the Administrative Regions of the Federal District (FD), Brazil, from 2019 to 2023, highlighting the distribution of notified cases regarding the sociodemographic profile of affected pregnant women. We utilized data from the\n                    <jats:italic>Info Sa\u00fade DF<\/jats:italic>\n                    portal (\n                    <jats:ext-link>https:\/\/info.saude.df.gov.br\/sifilissalasit\/<\/jats:ext-link>\n                    ) and the latest report from the most recent District Household Sample Survey. The cumulative incidence of MS was 25.3 cases per 1,000 live births. Simple linear regression analysis was used to assess the association between MS incidence and sociodemographic characteristics. A moderate negative correlation was observed (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.4038), indicating that higher education levels are associated with a lower incidence of MS. Lower-income populations living in the FD, Brazil, face a heightened risk of maternal syphilis, possibly due to a combination of economic and social factors, suggesting that public health policies aimed at controlling the disease should prioritize this population.\n                  <\/jats:p>","DOI":"10.3389\/fepid.2025.1613872","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:29:01Z","timestamp":1763706541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal syphilis in the Federal District, Brazil: a five-year analysis of notified data (2019\u20132023)"],"prefix":"10.3389","volume":"5","author":[{"given":"Paula Beatriz de Medeiros","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda Santiago","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza de Lima","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Santiago","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela Ara\u00fajo","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Nunes de Carvalho","family":"Mariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro Martins","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Nunes","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17073","DOI":"10.1038\/nrdp.2017.73","article-title":"Syphilis","volume":"3","author":"Peeling","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","article-title":"Biological basis for syphilis","volume":"19","author":"Lafond","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1067\/mob.2002.121541","article-title":"Congenital syphilis after maternal treatment for syphilis during pregnancy","volume":"186","author":"Sheffield","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"B4","article-title":"WHO publishes new estimates on congenital syphilis 2019","year":"2019"},{"key":"B5","first-page":"575","article-title":"Trends in primary and secondary syphilis and HIV infections in men who have sex with men\u2013San Francisco and Los Angeles, California, 1998\u20132002","volume":"53","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/01.OLQ.0000123653.84940.59","article-title":"Resurgence in infectious syphilis in Ireland: an epidemiological study","volume":"31","author":"Hopkins","year":"2004","journal-title":"Sex Transm Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/01.olq.0000149848.03733.c1","article-title":"The re-emergence of syphilis in the United Kingdom: the new epidemic phases","volume":"32","author":"Simms","year":"2005","journal-title":"Sex Transm Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1136\/sti.2003.007997","article-title":"Increase of sexually transmitted infections, but not HIV, among young homosexual men in Amsterdam: are STIs still reliable markers for HIV transmission?","volume":"81","author":"van der Bij","year":"2005","journal-title":"Sex Transm Infect"},{"key":"B9","article-title":"Epidemiological report\u2014syphilis","year":"2023"},{"key":"B10","doi-asserted-by":"publisher","first-page":"100564","DOI":"10.1016\/j.lana.2023.100564","article-title":"Estimating the real burden of gestational syphilis in Brazil, 2007\u20132018: a Bayesian modeling study","volume":"25","author":"Lopes de Oliveira","year":"2023","journal-title":"Lancet Reg Health Am"},{"key":"B11","article-title":"Syphilis","year":"2025"},{"key":"B12","article-title":"Portal de informa\u00e7\u00f5es de transpar\u00eancia da sa\u00fade do DF","year":"2024"},{"key":"B13","article-title":"Pesquisa Distrital por Amostra de Domic\u00edlios. PDAD 2021\u2014Resultados por RA","year":"2022"},{"key":"B14","article-title":"Epidemiological Report\u2014HIV\/AIDS","year":"2022"}],"container-title":["Frontiers in Epidemiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fepid.2025.1613872\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:29:04Z","timestamp":1763706544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fepid.2025.1613872\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":14,"alternative-id":["10.3389\/fepid.2025.1613872"],"URL":"https:\/\/doi.org\/10.3389\/fepid.2025.1613872","relation":{},"ISSN":["2674-1199"],"issn-type":[{"value":"2674-1199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"article-number":"1613872"}}