{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:27:06Z","timestamp":1793154426212,"version":"4.5.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Fungal Biol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The rapid global expansion of aquaculture has intensified the demand for sustainable and alternative lipid sources for fish feed formulations, driving interest in microbial platforms with specialized metabolic capabilities. Among these, oleaginous yeasts have emerged as promising candidates due to their ability to accumulate substantial intracellular lipid reserves and to modulate fatty acid composition in response to environmental and nutritional cues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, the lipid production potential and physiological responses of two native yeast strains isolated from volcanic soils of southern Chile were investigated. The strains were identified by ITS sequencing as\n                      <jats:italic>Solicoccozyma gelidoterrea<\/jats:italic>\n                      (7C) and\n                      <jats:italic>Rhodotorula mucilaginosa<\/jats:italic>\n                      (Rho 6S). Growth kinetics, substrate utilization, and lipid accumulation were systematically evaluated under different carbon sources, carbon-to-nitrogen (C\/N) ratios, and temperature regimes (7\u201325 \u00b0C). Response surface methodology was applied to determine the combined effects of nutritional and thermal factors on biomass production and lipid yield, while fatty acid composition was analyzed to elucidate lipid remodeling strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>R. mucilaginosa<\/jats:italic>\n                      exhibited pronounced metabolic versatility, characterized by higher maximum specific growth rates on alternative carbon sources such as xylose, sucrose, and raffinose. Under optimal conditions (25 \u00b0C and C\/N 20), this strain achieved a lipid content of 30% and a biomass concentration of 2.54 g\/L. In contrast,\n                      <jats:italic>S. gelidoterrea<\/jats:italic>\n                      displayed a distinct physiological profile associated with cold adaptation, reaching optimal lipid accumulation at 7 \u00b0C and C\/N 20, with 26.6% lipid content and 2.11 g\/L biomass. Increasing the C\/N ratio to 90 significantly constrained lipid accumulation in both strains, highlighting the central role of nitrogen availability in regulating yeast lipid metabolism. Fatty acid profiling revealed clear species-specific lipid remodeling patterns:\n                      <jats:italic>R. mucilaginosa<\/jats:italic>\n                      produced a nutritionally favorable lipid profile enriched in mono and polyunsaturated fatty acids, reflected by high MUFA\/SAFA and PUFA\/SAFA ratios. In contrast,\n                      <jats:italic>S. gelidoterrea<\/jats:italic>\n                      exhibited a distinctive lipid profile dominated by monounsaturated fatty acids, particularly oleic acid, under nitrogen limited and low temperature conditions, and demonstrated the capacity to synthesize long chain polyunsaturated fatty acids under stress conditions, suggesting the activation of adaptive and stress responsive lipid metabolic pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study provides the first evidence of lipid accumulation and fatty acid composition in\n                      <jats:italic>S. gelidoterrea<\/jats:italic>\n                      and puts into evidence contrasting lipid metabolic strategies among native oleaginous yeasts. Collectively, these findings contribute to a deeper understanding of fungal lipid physiology and environmental adaptation and support the potential of native yeast strains as sustainable lipid sources for functional foods and aquaculture nutrition.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/ffunb.2026.1664434","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:47:13Z","timestamp":1770706033000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Native oleaginous yeasts Rhodotorula mucilaginosa and Solicoccozyma gelidoterrea: a sustainable biotechnological alternative for lipid production with potential application in diets for farmed fish"],"prefix":"10.3389","volume":"7","author":[{"given":"Paola","family":"D\u00edaz-Navarrete","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Veterinarias y Salud P\u00fablica, Facultad de Recursos Naturales, Universidad Cat\u00f3lica de Temuco","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Marileo","sequence":"additional","affiliation":[{"name":"Escuela de Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tom\u00e1s","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Madrid","sequence":"additional","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor","place":["Temuco, Chile"]},{"name":"Centro para la Resilencia, Adaptaci\u00f3n y Mitigaci\u00f3n (CReAM), Universidad Mayor","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wladimir","family":"Mardones","sequence":"additional","affiliation":[{"name":"Instituto Milenio de Biolog\u00eda Integrativa","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Correa Galeote","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Facultad de Farmacia, Universidad de Granada","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle","family":"Parra","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Veterinarias y Salud P\u00fablica, Facultad de Recursos Naturales, Universidad Cat\u00f3lica de Temuco","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Dehnhardt-Amengual","sequence":"additional","affiliation":[{"name":"Instituto Milenio de Biolog\u00eda Integrativa","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Dantagnan","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Agropecuarias y Acu\u00edcolas, Facultad de Recursos Naturales, Universidad Cat\u00f3lica de Temuco","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-024-00755-7","article-title":"Enhancing the biosynthesis of polyunsaturated fatty acids by Rhodotorula mucilaginosa and Lodderomyces elongisporus. 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