{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:10:02Z","timestamp":1778479802506,"version":"3.51.4"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Fungal Biol."],"abstract":"<jats:p>\n                    <jats:italic>Scedosporium apiospermum<\/jats:italic>\n                    is an emerging opportunistic fungal pathogen, primarily affecting immunocompromised individuals. Notably, it ranks second among filamentous fungi infecting cystic fibrosis (CF) patients. Infections caused by\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    can range from localized infections to pulmonary colonization and invasive disseminated infections, often resulting in high mortality rates. This is largely attributed to the patient\u2019s clinical condition, limited diagnostic tools, and resistance to current antifungal therapies. Therefore, ongoing research is crucial to better understand the pathophysiology of these deep-seated fungal infections and to develop new strategies for early diagnosis and more effective antifungal treatments. In the present study, the\n                    <jats:italic>\u0394sch9<\/jats:italic>\n                    gene, which encodes a major effector of the TOR pathway in fungi, was characterized. The deletion of\n                    <jats:italic>sch9<\/jats:italic>\n                    significantly impaired\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    fitness under standard growth conditions and reduced hyphal development. Additionally, the\n                    <jats:italic>\u0394sch9<\/jats:italic>\n                    mutant strain displayed increased sensitivity to oxidative stress and cell wall stress-inducing agents. The mutant strain showed an increase in germ tube formation during the early hours of growth, particularly under hypoxic and hypercapnic conditions. Furthermore, under standard growth conditions, the\n                    <jats:italic>\u0394sch9<\/jats:italic>\n                    mutant strain exhibited a decrease in germ tube cell wall thickness compared to the\n                    <jats:italic>\u0394ku70<\/jats:italic>\n                    parent strain. Finally, disruption of\n                    <jats:italic>\u0394sch9<\/jats:italic>\n                    affected the\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    ability to resist ingestion and killing by macrophages. Taken together, these findings suggest that Sch9 plays a crucial role in stress tolerance, morphogenesis, and host-pathogen interactions in\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    . Further studies are needed to explore Sch9 as a potential therapeutic target in the treatment of\n                    <jats:italic>S. apiospermum<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.3389\/ffunb.2026.1820509","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:30:55Z","timestamp":1778477455000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the role of the Sch9 serine\/threonine kinase in Scedosporium apiospermum"],"prefix":"10.3389","volume":"7","author":[{"given":"Samar","family":"Kabbara","sequence":"first","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar","family":"Yaakoub","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Bidon","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Godon","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bienvenue","family":"Razafimandimby","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Delneste","sequence":"additional","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, Inserm, CNRS, CRCI2NA, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Pignon","sequence":"additional","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, Inserm, CNRS, CRCI2NA, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Bouchara","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monzer","family":"Hamze","sequence":"additional","affiliation":[{"name":"Laboratoire Microbiologie Sant\u00e9 et Environnement (LMSE), Ecole Doctorale des Sciences et de Technologie, Facult\u00e9 de Sant\u00e9 Publique, Universit\u00e9 Libanaise","place":["Tripoli, Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Papon","sequence":"additional","affiliation":[{"name":"Univ Angers, Univ Brest, IRF, SFR ICAT","place":["Angers, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/mmi.13484","article-title":"The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence","volume":"102","author":"Alves de Castro","year":"2016","journal-title":"Mol. 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