{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:35Z","timestamp":1791355775118,"version":"4.3.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Fungal Biol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Grifola frondosa<\/jats:italic>\n                      (maitake) is an edible and medicinal mushroom known for its diverse bioactive compounds, particularly polysaccharides, including biologically active \u03b2-glucans, which have been associated with immunomodulatory, antioxidant, antitumor, antimicrobial, and metabolic effects. However, a comprehensive assessment of the intellectual structure and global development of this research area has not yet been conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a scientometric analysis of 605 English-language journal articles indexed in Scopus from 1980 to 2025. Bibliometric data were analyzed using Bibliometrix\/Biblioshiny and VOSviewer to assess publication and citation trends, leading authors, institutions, countries, collaboration networks, keyword co-occurrence, thematic evolution, conceptual structure, and emerging research frontiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Publication output rose significantly after 2024, peaking in 2025, reflecting sustained global interest in\n                      <jats:italic>G. frondosa<\/jats:italic>\n                      bioactivity. Logistic growth modeling shows the field is nearing maturity. China and Japan showed the highest publication output and substantial representation in institutional and international collaboration networks, indicating a pronounced concentration of the analyzed literature in East Asia. Keyword and thematic analyses highlight \u03b2-glucans, polysaccharides, immunomodulation, antioxidant activity, and antitumor mechanisms as core research themes. Recent studies increasingly address structural characterization, gut microbiota modulation, fermentation technologies, oxidative stress, hypoglycemic activity, and functional food applications, indicating a shift toward mechanistic and translational research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Research on\n                      <jats:italic>G. frondosa<\/jats:italic>\n                      bioactivity has evolved into a multidisciplinary field characterized by expanding international collaboration and heightened focus on translational research. The identified trends, knowledge structure, and emerging themes offer a framework for future mechanistic, preclinical, and clinical studies exploring the therapeutic, nutraceutical, and functional food applications of\n                      <jats:italic>G. frondosa<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/ffunb.2026.1940029","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:55Z","timestamp":1791352255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactivity research in Grifola frondosa: a global scientometric analysis of emerging bioactivities and translational applications"],"prefix":"10.3389","volume":"7","author":[{"given":"Christian Joseph N.","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, De La Salle University","place":["Manila, Philippines"]},{"name":"Department of Biology, College of Arts and Sciences, Manila Central University","place":["Caloocan, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil Allen G.","family":"Fortaleza","sequence":"additional","affiliation":[{"name":"National University","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Smith P.","family":"Cabuhat","sequence":"additional","affiliation":[{"name":"Research Fellow, Bulacan State University","place":["Malolos, Bulacan, Philippines"]},{"name":"Basic Education Department, La Consolacion University Philippines","place":["Malolos, Bulacan, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glocielle F.","family":"Molabola","sequence":"additional","affiliation":[{"name":"Molecular Science Unit Laboratory, Center for Natural Sciences and Environmental Research, De La Salle University","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnalie N.","family":"Cabalbag","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, De La Salle University","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Jurel M.","family":"Nuevo","sequence":"additional","affiliation":[{"name":"College of Medical Laboratory Sciences, Our Lady of Fatima University","place":["Valenzuela, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jowi Tsidkenu Pili","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, De La Salle University","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza C.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, De La Salle University","place":["Manila, Philippines"]},{"name":"Molecular Science Unit Laboratory, Center for Natural Sciences and Environmental Research, De La Salle University","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1248\/bpb.17.1554","article-title":"Enhancement of cytokine production by macrophages stimulated with (1\u21923)-\u03b2-D-glucan, grifolan (GRN), isolated from Grifola frondosa","volume":"17","author":"Adachi","year":"1994","journal-title":"Biol. 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