{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:24:39Z","timestamp":1791300279729,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2014.00224","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T10:53:23Z","timestamp":1407408803000},"source":"Crossref","is-referenced-by-count":23,"title":["Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD"],"prefix":"10.3389","volume":"5","author":[{"given":"Susan M.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Berres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Flentke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10476","DOI":"10.1073\/pnas.162356199","article-title":"Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure.","volume":"99","author":"Ahlgren","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.alcohol.2010.04.002","article-title":"Alcohol-induced facial dysmorphology in C57BL\/6 mouse models of fetal alcohol spectrum disorder.","volume":"44","author":"Anthony","year":"2010","journal-title":"Alcohol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/bdra.20447","article-title":"Fetal ethanol exposure activates protein kinase A and impairs shh expression in prechordal plate mesoderm cells in the pathogenesis of holoprosencephaly.","volume":"82","author":"Aoto","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1006\/dbio.1998.8995","article-title":"Ethanol impairs migration of the prechordal plate in the zebrafish embryo.","volume":"201","author":"Blader","year":"1998","journal-title":"Dev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0741-8329(97)87950-5","article-title":"Ethanol teratogenesis in the C57BL\/6J, DBA\/2J, and A\/J inbred mouse strains.","volume":"14","author":"Boehm","year":"1997","journal-title":"Alcohol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1111\/acer.12417","article-title":"Apoptosis of alcohol-exposed human placental cytotrophoblast cells is downstream of intracellular calcium signaling.","volume":"38","author":"Bolnick","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the \u00ce\u00b2-catenin gene by Wnt-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"B8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0899-9007(99)00090-8","article-title":"Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease.","volume":"15","author":"Bunout","year":"1999","journal-title":"Nutrition"},{"key":"B9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/alcalc\/33.5.457","article-title":"Teratogenicity of ethanol in different chicken strains.","volume":"33","author":"Bupp Becker","year":"1998","journal-title":"Alcohol Alcohol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1111\/j.1530-0277.1995.tb01007.x","article-title":"Stage dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome.","volume":"19","author":"Cartwright","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1530-0277.1998.tb03630.x","article-title":"Ethanol-induced neural crest apoptosis is coincident with their endogenous death but is mechanistically distinct.","volume":"22","author":"Cartwright","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.ntt.2004.06.016","article-title":"Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis.","volume":"26","author":"Carvan","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1530-0277.2000.tb04559.x","article-title":"Genetic and developmental modulation of cardiac deficits in prenatal alcohol exposure.","volume":"24","author":"Cavieres","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0741-8329(99)00058-0","article-title":"Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity.","volume":"20","author":"Chen","year":"2000","journal-title":"Alcohol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.reprotox.2013.08.003","article-title":"Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response.","volume":"42","author":"Chen","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1530-0277.2000.tb04612.x","article-title":"Avian genetic background modulates the neural crest apoptosis induced by ethanol exposure.","volume":"24","author":"Debelak","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/01.ALC.0000056615.34253.A8","article-title":"Ethanol-induced cephalic apoptosis requires phospholipase C-dependent intracellular calcium signaling.","volume":"27","author":"Debelak-Kragtorp","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1111\/j.1530-0277.2009.00949.x","article-title":"Ethanol teratogenesis in five inbred strains of mice.","volume":"33","author":"Downing","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1111\/j.1530-0277.2012.01754.x","article-title":"Quantitative trait locus mapping for ethanol teratogenesis in BXD recombinant inbred mice.","volume":"36","author":"Downing","year":"2012a","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1111\/j.1530-0277.2012.01757.x","article-title":"Gene expression following changes in C57BL\/6J and DBA\/2J mice following prenatal alcohol exposure.","volume":"36","author":"Downing","year":"2012b","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"8","key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-8","article-title":"Holoprosencephaly.","volume":"2","author":"Dubourg","year":"2007","journal-title":"Orphanet. J. Rare Dis."},{"key":"B22","first-page":"1340","article-title":"Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications for alcohol-related birth defects and neurodevelopmental disorder.","volume":"36","author":"Dunty","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrgastro.2013.86","article-title":"Genetics and alcoholism.","volume":"10","author":"Edenberg","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1006\/dbio.2002.0815","article-title":"Apoptosis of premigratory neural crest cells in rhombomeres 3 and 5: consequences for patterning of the branchial region.","volume":"251","author":"Ellies","year":"2002","journal-title":"Dev. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/bdra.20833","article-title":"Calcium-mediated repression of \u00ce\u00b2-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome.","volume":"91","author":"Flentke","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/jnc.12464","article-title":"CaMKII represses transcriptionally-active \u00ce\u00b2-catenin to mediate acute ethanol neurodegeneration and can phosphorylate \u00ce\u00b2-catenin.","volume":"128","author":"Flentke","year":"2014a","journal-title":"J. Neurochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1111\/acer.12360","article-title":"An evolutionarily-conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of FASD.","volume":"38","author":"Flentke","year":"2014b","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1053\/j.seminhematol.2011.02.004","article-title":"The role of p53 in ribosomopathies.","volume":"48","author":"Fumagalli","year":"2011","journal-title":"Sem. Hematol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1111\/acer.12457","article-title":"High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders.","volume":"38","author":"Garic","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/j.1471-4159.2011.07273.x","article-title":"CaMKII activation is a novel effector of alcohol\u00e2\u20ac\u2122s neurotoxicity in neural crest stem\/progenitor cells.","volume":"118","author":"Garic","year":"2011","journal-title":"J. Neurochem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1097\/01.ALC.0000172460.05756.D9","article-title":"Ethanol triggers neural crest apoptosis through the selective activation of a pertussis toxin-sensitive G protein and a phospholipase C\u00ce\u00b2-dependent Ca2+ transient.","volume":"29","author":"Garic-Stankovic","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1111\/j.1530-0277.2005.00061.x","article-title":"Structural constraints for alcohol-stimulated Ca2+ release in neural crest, and dual agonist\/antagonist properties of n-octanol.","volume":"30","author":"Garic-Stankovic","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0741-8329(95)02010-1","article-title":"Dose-related growth deficits in LS but not SS mice prenatally exposed to alcohol.","volume":"13","author":"Gilliam","year":"1996","journal-title":"Alcohol"},{"key":"B34","first-page":"321","article-title":"Genetic influences on brain growth restriction induced by developmental exposure to alcohol.","volume":"10","author":"Goodlett","year":"1989","journal-title":"Neurotoxicity"},{"key":"B35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.yexcr.2004.03.016","article-title":"Ribosome biogenesis: of knobs and RNA processing.","volume":"296","author":"Granneman","year":"2004","journal-title":"Exp. Cell Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/dvdy.21048","article-title":"Reprogramming of genetic networks during initiation of the fetal alcohol syndrome.","volume":"236","author":"Green","year":"2007","journal-title":"Dev. Dyn."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1097\/01.ALC.0000148117.17707.B4","article-title":"Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis.","volume":"28","author":"Gutala","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B38","first-page":"129","article-title":"Effects of ethanol on the cytoskeleton of migrating and differentiating neural crest cells: possible role in teratogenesis.","volume":"(Suppl. 2)","author":"Hassler","year":"1986","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"issue":"e1002999","key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002999","article-title":"Codon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice.","volume":"8","author":"Hong","year":"2012","journal-title":"PLoS Genet."},{"key":"B40","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1530-0277.2011.01502.x","article-title":"Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.","volume":"35","author":"Howard","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"e89448","key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089448","article-title":"The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse.","volume":"9","author":"Kietzman","year":"2014","journal-title":"PLoS ONE"},{"key":"B42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1530-0277.2006.00008.x","article-title":"Rapid induction of apoptosis in gastrulating mouse embryos by ethanol and its prevention by HB-EGF.","volume":"30","author":"Kilburn","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.alcohol.2009.10.016","article-title":"Prenatal alcohol exposure alters the patterns of facial asymmetry.","volume":"44","author":"Klingenberg","year":"2010","journal-title":"Alcohol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ceca.2005.06.022","article-title":"Wnt and calcium signaling: \u00ce\u00b2-catenin-independent pathways.","volume":"38","author":"Kohn","year":"2005","journal-title":"Cell Calcium"},{"key":"B45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/jnc.12076","article-title":"Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons.","volume":"124","author":"Kouzoukas","year":"2013","journal-title":"J. Neurochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1016\/j.cell.2009.04.050","article-title":"Modes of p53 regulation.","volume":"137","author":"Kruse","year":"2009","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/labinvest.3700516","article-title":"Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling.","volume":"87","author":"Li","year":"2007","journal-title":"Lab. Invest."},{"issue":"e43067","key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043067","article-title":"Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent.","volume":"7","author":"Lipinski","year":"2012","journal-title":"PLoS ONE"},{"key":"B49","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.ntt.2004.06.017","article-title":"Strain-dependent effects of developmental ethanol exposure in zebrafish.","volume":"26","author":"Loucks","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/\u00ce\u00b2-catenin signaling: components, mechanisms, and diseases.","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1242\/dev.094938","article-title":"Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD.","volume":"140","author":"McCarthy","year":"2013","journal-title":"Development"},{"key":"B52","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1182\/blood-2009-10-178129","article-title":"Ribosomopathies: human disorders of ribosome dysfunction.","volume":"115","author":"Narla","year":"2010","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.alcohol.2013.04.001","article-title":"Nuanced but significant: how ethanol perturbs avian cranial neural crest cell actin cytoskeleton, migration and proliferation.","volume":"47","author":"Oyedele","year":"2013","journal-title":"Alcohol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0163-7258(01)00163-2","article-title":"Identification of novel ethanol-sensitive genes by expression profiling.","volume":"92","author":"Rahman","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"B55","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ntt.2006.05.007","article-title":"Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants.","volume":"28","author":"Reimers","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1111\/j.1530-0277.2002.tb02669.x","article-title":"Ethanol induces morphological and dynamic changes on in vivo and in vitro neural crest cells.","volume":"26","author":"Rovasio","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrm2428","article-title":"A gene regulatory network orchestrates neural crest formation.","volume":"9","author":"Sauka-Spengler","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1038\/sj.onc.1202751","article-title":"The role of c-myc in cellular growth control.","volume":"18","author":"Schmidt","year":"1999","journal-title":"Oncogene"},{"key":"B59","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signaling crosstalk.","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B60","doi-asserted-by":"crossref","DOI":"10.1002\/bdrc.21078","article-title":"Neural crest development in fetal alcohol syndrome.","author":"Smith","year":"2014","journal-title":"Birth Defects Res. C"},{"key":"B61","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/ajmg.1320470612","article-title":"Fetal alcohol syndrome in twins of alcoholic mothers: concordance of diagnosis and IQ.","volume":"47","author":"Streissguth","year":"1993","journal-title":"Am. J. Med. Genet."},{"key":"B62","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1530-0277.2001.tb02128.x","article-title":"Genetic influences on craniofacial outcome in an avian model of prenatal alcohol exposure.","volume":"25","author":"Su","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/9780470720868.ch8","article-title":"\u00e2\u20ac\u0153Critical periods for alcohol teratogenesis in mice, with special reference to the gastrulation stage of embryogenesis,\u00e2\u20ac\u009d in","volume":"105","author":"Sulik","year":"1984","journal-title":"Mechanisms of Alcohol Damage in Utero. Ciba Foundation Symposium"},{"key":"B64","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.6795717","article-title":"Fetal alcohol syndrome: embryogenesis in a mouse model.","volume":"214","author":"Sulik","year":"1981","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1111\/acer.12286","article-title":"A screen of zebrafish mutants identifies ethanol-sensitive genetic loci.","volume":"38","author":"Swartz","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1002\/ajmg.a.33454","article-title":"Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.","author":"Trainor","year":"2010","journal-title":"Am. J. Med. Genet. Part A"},{"key":"B67","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/bdra.20125","article-title":"Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders.","volume":"73","author":"Warren","year":"2005","journal-title":"Birth Defects Res. Part A"},{"key":"B68","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/j.1530-0277.2008.00647.x","article-title":"Genetic influences on dysmorphogenesis in embryos from different rat strains exposed to ethanol in vivo and in vitro.","volume":"32","author":"Wentzel","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1006\/dbio.1995.1220","article-title":"Calmodulin-dependent protein kinase II is activated transiently in ethanol-stimulated mouse oocytes.","volume":"170","author":"Winston","year":"1995","journal-title":"Dev. Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.bcp.2010.03.004","article-title":"Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells.","volume":"80","author":"Yan","year":"2010","journal-title":"Biochem. Pharmacol."}],"container-title":["Frontiers in Genetics"],"original-title":[],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:55:58Z","timestamp":1717203358000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2014.00224\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":70,"URL":"https:\/\/doi.org\/10.3389\/fgene.2014.00224","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}