{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:14:48Z","timestamp":1790032488539,"version":"4.0.1"},"reference-count":50,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2014.00250","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T14:37:23Z","timestamp":1407249443000},"source":"Crossref","is-referenced-by-count":63,"title":["Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index"],"prefix":"10.3389","volume":"5","author":[{"given":"Robert M.","family":"Cronin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Bradford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bastarache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd L.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hebbring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia A.","family":"Hindorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Crane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Pendergrass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylyn D.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotishman","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette J.","family":"Bielinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Carrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Crosslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Ledbetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P.","family":"Jarvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy L.","family":"Peissig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray H.","family":"Brilliant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Chute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar J.","family":"Kullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Bottinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex","family":"Chisholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Abecasis","year":"2010","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0140-6736(12)60681-3","article-title":"Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study","volume":"380","author":"Zeggini","year":"2012","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1158\/1055-9965.EPI-05-0525","article-title":"Early life factors and incidence of proliferative benign breast disease","volume":"14","author":"Baer","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev"},{"key":"B4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Statist. Soc. B Methodol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3171\/2010.9.SPINE10151","article-title":"Comparison of ICD-9-based, retrospective, and prospective assessments of perioperative complications: assessment of accuracy in reporting","volume":"14","author":"Campbell","year":"2011","journal-title":"J. Neurosurg. Spine"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu197","article-title":"R PheWAS: data analysis and plotting tools for phenome wide association studies in the R environment","author":"Carroll","year":"2014","journal-title":"Bioinformatics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e52344","DOI":"10.1371\/journal.pone.0052344","article-title":"Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption","volume":"7","author":"Corella","year":"2012","journal-title":"PLoS ONE"},{"key":"B8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05707.x","article-title":"The origins and evolution of genetic disease risk in modern humans","volume":"1206","author":"Crespi","year":"2010","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/hmg\/ddt010","article-title":"Genetic variation associated with circulating monocyte count in the eMERGE Network","volume":"22","author":"Crosslin","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"Denny","year":"2013","journal-title":"Nat. Biotechnol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ajhg.2011.09.008","article-title":"Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies","volume":"89","author":"Denny","year":"2011","journal-title":"Am. J. Hum. Genet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/bioinformatics\/btq126","article-title":"PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations","volume":"26","author":"Denny","year":"2010a","journal-title":"Bioinformatics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.110.948828","article-title":"Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science","volume":"122","author":"Denny","year":"2010b","journal-title":"Circulation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1534\/g3.113.006452","article-title":"Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study","volume":"3","author":"Ding","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/ije\/29.4.637","article-title":"Risk factors for benign proliferative breast disease","volume":"29","author":"Friedenreich","year":"2000","journal-title":"Int. J. Epidemiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/gepi.20430","article-title":"Avoiding the high Bonferroni penalty in genome-wide association studies","volume":"34","author":"Gao","year":"2010","journal-title":"Genet. Epidemiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ajhg.2013.08.012","article-title":"Fine Mapping and Identification of BMI Loci in African Americans","volume":"93","author":"Gong","year":"2013","journal-title":"Am. J. Hum. Genet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/gim.2013.72","article-title":"The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future","volume":"15","author":"Gottesman","year":"2013","journal-title":"Genet. Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.2337\/db09-0205","article-title":"Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue","volume":"58","author":"Grunnet","year":"2009","journal-title":"Diabetes"},{"key":"B21","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/gene.2013.2","article-title":"A PheWAS approach in studying HLA-DRB1*1501","volume":"14","author":"Hebbring","year":"2013","journal-title":"Genes Immun"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.2337\/db10-1340","article-title":"FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies","volume":"60","author":"Hertel","year":"2011","journal-title":"Diabetes"},{"key":"B23","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/jhg.2011.74","article-title":"Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population","volume":"56","author":"Hotta","year":"2011","journal-title":"J. Hum. Genet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1038\/oby.2008.421","article-title":"The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study","volume":"16","author":"Hubacek","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"B25","volume-title":"Meta-Analysis","author":"Hunter","year":"1982"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1467-789X.2012.01025.x","article-title":"The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO","volume":"13","author":"Jacobsson","year":"2012","journal-title":"Obes. Rev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/JAD-2010-101068","article-title":"The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study","volume":"23","author":"Keller","year":"2011","journal-title":"J. Alzheimers Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/j.1475-6773.2005.00482.x","article-title":"Failure of ICD-9-CM codes to identify patients with comorbid chronic kidney disease in diabetes","volume":"41","author":"Kern","year":"2006","journal-title":"Health Serv. Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00125-008-0928-9","article-title":"Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans","volume":"51","author":"Kl\u00c3\u00b6ting","year":"2008","journal-title":"Diabetologia"},{"key":"B30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ajhg.2011.05.019","article-title":"Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate","volume":"89","author":"Kullo","year":"2011","journal-title":"Am. J. Hum. Genet"},{"key":"B31","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s00125-011-2370-7","article-title":"Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians","volume":"55","author":"Li","year":"2012","journal-title":"Diabetologia"},{"key":"B32","doi-asserted-by":"publisher","first-page":"264","DOI":"10.2337\/db07-1130","article-title":"Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population","volume":"57","author":"Li","year":"2008","journal-title":"Diabetes"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.1073\/pnas.130028697","article-title":"Regulation of the homeodomain CCAAT displacement\/cut protein function by histone acetyltransferases p300\/CREB-binding protein (CBP)-associated factor and CBP","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/ijc.20964","article-title":"Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case-control study in Shanghai, China","volume":"115","author":"Li","year":"2005","journal-title":"Int. J. Cancer"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/oby.2009.469","article-title":"Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population","volume":"18","author":"Liu","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e16756","DOI":"10.1371\/journal.pone.0016756","article-title":"The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women","volume":"6","author":"Lurie","year":"2011","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"Marchini","year":"2007","journal-title":"Nat. Genet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1755-8794-4-13","article-title":"The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies","volume":"4","author":"McCarty","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1467-789X.2010.00734.x","article-title":"Genetic studies of common types of obesity: a critique of the current use of phenotypes","volume":"11","author":"M\u00c3\u00bcller","year":"2010","journal-title":"Obes. Rev"},{"key":"B41","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/HJH.0b013e3282f624b7","article-title":"Comparison of body mass index with waist circumference, waist-to-hip ratio, and waist-to-stature ratio as a predictor of hypertension incidence in Mauritius","volume":"26","author":"Nyamdorj","year":"2008","journal-title":"J. Hypertens"},{"key":"B40","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/oby.2008.503","article-title":"BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius","volume":"17","author":"Nyamdorj","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1093\/aje\/kwt028","article-title":"Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial\/ethnic populations: the PAGE study","volume":"178","author":"Park","year":"2013","journal-title":"Am. J. Epidemiol"},{"key":"B43","first-page":"699","article-title":"Mining the human phenome using semantic web technologies: a case study for Type 2 Diabetes","volume":"2012","author":"Pathak","year":"2012","journal-title":"AMIA Annu. Symp. Proc"},{"key":"B44","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1136\/amiajnl-2010-000061","article-title":"Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network experience","volume":"18","author":"Pathak","year":"2011","journal-title":"J. Am. Med. Inform. Assoc"},{"key":"B45","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.tree.2012.01.016","article-title":"A model of developmental evolution: selection, pleiotropy and compensation","volume":"27","author":"Pavlicev","year":"2012","journal-title":"Trends Ecol. Evol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1003087","DOI":"10.1371\/journal.pgen.1003087","article-title":"Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network","volume":"9","author":"Pendergrass","year":"2013","journal-title":"PLoS Genet"},{"key":"B47","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/gepi.20589","article-title":"The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery","volume":"35","author":"Pendergrass","year":"2011","journal-title":"Genet. Epidemiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet"},{"key":"B49","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","article-title":"Inference of population structure using multilocus genotype data","volume":"155","author":"Pritchard","year":"2000","journal-title":"Genetics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet"}],"container-title":["Frontiers in Genetics"],"original-title":[],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T22:35:59Z","timestamp":1717194959000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2014.00250\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":50,"URL":"https:\/\/doi.org\/10.3389\/fgene.2014.00250","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}