{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:01:08Z","timestamp":1791216068998,"version":"4.1.0"},"reference-count":100,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2014.00317","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T13:59:10Z","timestamp":1410357550000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Epigenetic control of gene function in schistosomes: a source of therapeutic targets?"],"prefix":"10.3389","volume":"5","author":[{"given":"Alejandro","family":"Cabezas-Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lancelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Caby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.molbiopara.2012.03.001","article-title":"Schistosoma mansoni histones: from transcription to chromatin regulation; an in silico analysis","volume":"183","author":"Anderson","year":"2012","journal-title":"Mol. Biochem. Parasitol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nrd3674","article-title":"Epigenetic protein families: a new frontier for drug discovery","volume":"11","author":"Arrowsmith","year":"2012","journal-title":"Nat. Rev. Drug Discov"},{"key":"B3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.exppara.2008.11.010","article-title":"Schistosoma mansoni: developmental arrest of miracidia treated with histone deacetylase inhibitors","volume":"121","author":"Azzi","year":"2009","journal-title":"Exp. Parasitol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrm3545","article-title":"Emerging roles for chromatin as a signal integration and storage platform","volume":"14","author":"Badeaux","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nbt.1759","article-title":"Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes","volume":"29","author":"Bantscheff","year":"2011","journal-title":"Nat. Biotechnol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.gde.2013.11.015","article-title":"Genomic patterns and context-specific interpretation of DNA methylation","volume":"25","author":"Baubec","year":"2014","journal-title":"Genet. Dev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The Genome of the blood fluke Schistosoma mansoni","volume":"462","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.molbiopara.2005.12.006","article-title":"Schistosoma mansoni CBP\/P300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1","volume":"146","author":"Bertin","year":"2006","journal-title":"Mol. Biochem. Parasitol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.chembiol.2010.03.006","article-title":"Virtual ligand screening of the p300\/CBP histone acetyltransferase: identification of a selective small molecule inhibitor","volume":"17","author":"Bowers","year":"2010","journal-title":"Chem. Biol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0166-6851(03)00078-1","article-title":"Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts","volume":"128","author":"Boyle","year":"2003","journal-title":"Mol. Biochem. Parasitol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e1256","DOI":"10.1371\/journal.pntd.0001256","article-title":"Profiles of small non-coding RNAs in Schistosoma japonicum during development","volume":"5","author":"Cai","year":"2011","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1004116","DOI":"10.1371\/journal.ppat.1004116","article-title":"Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis","volume":"8","author":"Carneiro","year":"2014","journal-title":"PLoS Pathog"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1021\/jm200108t","article-title":"Discovery and characterization of small molecule inhibitors of the BET family bromodomains","volume":"54","author":"Chung","year":"2011","journal-title":"J. Med. Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e2596","DOI":"10.1371\/journal.pntd.0002596","article-title":"Praziquantel Treatment Decreases Schistosoma mansoni genetic diversity in experimental infections","volume":"7","author":"Coeli","year":"2013","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/SD140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1073\/pnas.0602266103","article-title":"Pre-B cell proliferation and lymphoblastic leukemia \/high grade lymphoma in E\u03bc-miR155 transgenic mice","volume":"103","author":"Costinean","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1182\/blood-2013-04-497644","article-title":"Potent inhibition of DOT1L as treatment for MLL-fusion leukemia","volume":"122","author":"Daigle","year":"2013","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0169-4758(92)90070-I","article-title":"Praziquantel: the enigmatic antiparasitic","volume":"8","author":"Day","year":"1992","journal-title":"Parasitol. Today"},{"key":"B19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nature11316","article-title":"HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle","volume":"489","author":"Deardorff","year":"2012","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2008.03.022","article-title":"Protein acetylation sites mediated by Schistosoma mansoni GCN5","volume":"370","author":"de Moraes Maciel","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.pt.2010.09.001","article-title":"Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?","volume":"27","author":"Dissous","year":"2010","journal-title":"Trends Parasitol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"Doenhoff","year":"2008","journal-title":"Curr. Opin. Infect. Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/j.bmcl.2010.02.069","article-title":"Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases","volume":"20","author":"Dowden","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"B24","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.06.001","article-title":"Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene expression in Schistosoma mansoni","volume":"168","author":"Dubois","year":"2009","journal-title":"Mol. Biochem. Parasitol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrd4336","article-title":"The discovery of first-in-class drugs: origins and evolution","volume":"13","author":"Eder","year":"2014","journal-title":"Nat. Rev. Drug Discov"},{"key":"B27","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.cell.2010.01.007","article-title":"miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts","volume":"140","author":"Elring","year":"2010","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"23858","DOI":"10.1074\/jbc.M113.480517","article-title":"Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1","volume":"288","author":"Fagan","year":"2013","journal-title":"J. Biol. Chem"},{"key":"B29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific","volume":"51","author":"Fallon","year":"1994","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.ijpara.2008.02.003","article-title":"Cloning of SmNCoA-62, a novel nuclear receptor co-activator from Schistosoma mansoni: assembly of a complex with a SmRXR1\/SmNR1 heterodimer, SmGCN5 and SmCBP1","volume":"38","author":"Fantappi\u00e9","year":"2008","journal-title":"Int. J. Parasitol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1006\/expr.2001.4630","article-title":"Lack of DNA methylation in Schistosoma mansoni","volume":"98","author":"Fantappi\u00e9","year":"2001","journal-title":"Exp. Parasitol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"42419","DOI":"10.1074\/jbc.R112.378877","article-title":"Sirtuin catalysis and regulation","volume":"287","author":"Feldman","year":"2012","journal-title":"J. Biol. Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1017\/S0031182009990400","article-title":"The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008","volume":"136","author":"Fenwick","year":"2009","journal-title":"Parasitology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrd4286","article-title":"Targeting bromodomains: epigenetic readers of lysine acetylation","volume":"13","author":"Filippakopoulos","year":"2014","journal-title":"Nat. Rev. Drug. Discov"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2011","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1093\/molbev\/mst155","article-title":"Substantial loss of conserved and gain of novel microRNA families in flatworms","volume":"30","author":"Fromm","year":"2013","journal-title":"Mol. Biol. Evol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1016\/j.bmc.2011.01.063","article-title":"Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors","volume":"19","author":"Furdas","year":"2011","journal-title":"Bioorg. Med. Chem"},{"key":"B38","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/1471-2164-14-462","article-title":"Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes","volume":"14","author":"Geyer","year":"2013","journal-title":"BMC Genomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ncomms1433","article-title":"Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni","volume":"2","author":"Geyer","year":"2011","journal-title":"Nat. Commun"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1016\/j.ejmech.2009.07.025","article-title":"Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of PCAF histone acetyltransferase","volume":"44","author":"Ghizzoni","year":"2009","journal-title":"Eur. J. Med. Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1126\/science.1120976","article-title":"Methylation of tRNA Asp by the DNA methyltransferase homolog Dnmt2","volume":"311","author":"Goll","year":"2006","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jmb.2004.02.006","article-title":"Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis","volume":"338","author":"Gregoretti","year":"2004","journal-title":"J. Mol. Biol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10059-009-0169-x","article-title":"Sirtuin\/Sir2 phylogeny, evolutionary considerations and structural conservation","volume":"28","author":"Greiss","year":"2009","journal-title":"Mol. Cells"},{"key":"B44","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2006.06.057","article-title":"SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells","volume":"126","author":"Haigis","year":"2006","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1471-2164-11-55","article-title":"Identification and characterization of microRNAs and endogenous siRNAs in Schistosoma japonicum","volume":"11","author":"Hao","year":"2010","journal-title":"BMC Genomics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature12751","article-title":"Chromatin proteins and modifications as drug targets","volume":"502","author":"Helin","year":"2013","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"31717","DOI":"10.1074\/jbc.M30544820","article-title":"The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity","volume":"278","author":"Hermann","year":"2003","journal-title":"J. Biol. Chem"},{"key":"B48","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.1021\/jm300915b","article-title":"Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions","volume":"55","author":"Hewings","year":"2012","journal-title":"J. Med. Chem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd4154","article-title":"Histone lysine demethylases as targets for anticancer therapy","volume":"12","author":"Hojfeldt","year":"2013","journal-title":"Nat. Rev. Drug. Discov"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1073\/pnas.0308738101","article-title":"The Nash equilibrium: a perspective","volume":"101","author":"Holt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e8206","DOI":"10.1371\/journal.pone.0008206","article-title":"Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach","volume":"4","author":"Huang","year":"2009","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule Sirt1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol. Sci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"B53a","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature12038","article-title":"Sirt6 regulates TNF- secretion through hydrolysis of long-chain fatty acyl lysine","volume":"496","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"36873","DOI":"10.1074\/jbc.C100273200","article-title":"Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel","volume":"276","author":"Kohn","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B56","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","article-title":"HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor","volume":"18","author":"Kovacs","year":"2005","journal-title":"Mol. Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-387685-0.00003-2","article-title":"DNA methylation in Drosophila \u2013 a critical evaluation","volume":"101","author":"Kraus","year":"2011","journal-title":"Prog. Mol. Biol. Transf. Sci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nature11262","article-title":"A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response","volume":"488","author":"Kruidenier","year":"2012","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1056\/NEJMe1301348","article-title":"Micromanaging hepatitis C virus","volume":"368","author":"Lieberman","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e2428","DOI":"10.1371\/journal.pntd.0002428","article-title":"Schistosoma mansoni sirtuins: characterization and potential as chemotherapeutic targets","volume":"7","author":"Lancelot","year":"2013","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrd4359","article-title":"Therapeutic targeting of microRNAs: current status and future challenges","volume":"13","author":"Li","year":"2014","journal-title":"Nat. Rev. Drug Discov"},{"key":"B62","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nrd4140","article-title":"MicroRNAs and other non-coding RNAs as targets for anticancer drug development","volume":"12","author":"Ling","year":"2013","journal-title":"Nat. Rev. Drug. Discov"},{"key":"B63","doi-asserted-by":"crossref","first-page":"e13543","DOI":"10.1200\/jco.2013.31.15_suppl.e13543","article-title":"Preclinical characterization of a potent and selective inhibitor of the histone demethylase KDM1A for MLL leukemia","volume":"31","author":"Maes","year":"2013","journal-title":"J. Clin. Oncol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e1003645","DOI":"10.1371\/journal.ppat.1003645","article-title":"Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni","volume":"9","author":"Marek","year":"2013","journal-title":"PLoS Pathog"},{"key":"B65","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature11606","article-title":"EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations","volume":"492","author":"McCabe","year":"2012","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e504","DOI":"10.1371\/journal.pntd.0000504","article-title":"Reduced susceptibility to praziquantel among naturally occurring Kenya isolates of Schistosoma mansoni","volume":"3","author":"Melman","year":"2009","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B67","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.molbiopara.2009.04.007","article-title":"Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility","volume":"167","author":"Messerli","year":"2009","journal-title":"Mol. Biochem. Parasitol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature04020","article-title":"LSD1 demethylates repressive histone marks to promote androgen-receptor dependent transcription","volume":"437","author":"Metzger","year":"2005","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3892\/or.18.4.769","article-title":"Expression profile of class I histone deacetylases in human cancer tissues","volume":"18","author":"Nakagawa","year":"2007","journal-title":"Oncol. Rep"},{"key":"B70","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1073\/pnas.36.1.48","article-title":"Equilibrium points in N-person games","volume":"36","author":"Nash","year":"1950","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature09589","article-title":"Suppression of inflammation by a synthetic histone mimic","volume":"468","author":"Nicodeme","year":"2010","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"951","DOI":"10.4269\/ajtmh.2010.10-0283","article-title":"Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania","volume":"83","author":"Norton","year":"2010","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100273200","article-title":"Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia","author":"Ntziachristos","year":"2014","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.bbrc.2008","article-title":"The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni","volume":"377","author":"Oger","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B75","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1590\/S0001-37652011000200026","article-title":"Non-coding RNAs in schistosomes: an unexplored world","volume":"83","author":"Oliveira","year":"2011","journal-title":"An. Acad. Bras. Cienc"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e1003571","DOI":"10.1371\/journal.ppat.1003571","article-title":"Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host","volume":"9","author":"Perrin","year":"2013","journal-title":"PLoS Pathog"},{"key":"B78","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s11030-010-9299-5","article-title":"Chemical biology of histone acetyltransferase natural compounds modulators","volume":"15","author":"Piaz","year":"2011","journal-title":"Mol. Divers"},{"key":"B79","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.2174\/138161212801327248","article-title":"Targeting schistosome histone modifying enzymes for drug development","volume":"18","author":"Pierce","year":"2012","journal-title":"Curr. Pharm. Des"},{"key":"B80","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.1073\/pnas.1306723110","article-title":"Dnmt2-dependent methylomes lack defined DNA methylation patterns","volume":"110","author":"Raddatz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B81","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nm1737","article-title":"Identification of oxadiazoles as new drug leads for the control of schistosomiasis","volume":"14","author":"Sayed","year":"2008","journal-title":"Nat. Med"},{"key":"B82","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00412-009-0240-6","article-title":"Solving the Dnmt2 enigma","volume":"119","author":"Schaefer","year":"2010","journal-title":"Chromosoma"},{"key":"B83","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nm.2661","article-title":"Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic differentiation pathway in acute myeloid leukemia","volume":"18","author":"Schenk","year":"2012","journal-title":"Nature Med"},{"key":"B84","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-2164-12-47","article-title":"Identification of Schistosoma mansoni microRNAs","volume":"12","author":"Simoes","year":"2011","journal-title":"BMC Genomics"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1002\/cmdc.200900301","article-title":"The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors","volume":"4","author":"Spannhoff","year":"2009","journal-title":"CheMedChem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e850","DOI":"10.1371\/journal.pntd.0000850","article-title":"RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening","volume":"4","author":"Stefanic","year":"2010","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.03.007","article-title":"Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen Schistosoma mansoni","author":"Stolfa","year":"2014","journal-title":"J. Mol. Biol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ijc.23607","article-title":"Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine","volume":"123","author":"Streseman","year":"2008","journal-title":"Int. J. Cancer"},{"key":"B90","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/1756-3305-7-177","article-title":"Novel expression profiles of microRNAs suggest that specific miRNAs regulate gene expression for the sexual maturation of female Schistosoma japonicum after pairing","volume":"7","author":"Sun","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B91","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrd3480","article-title":"How were new medicines discovered?","volume":"10","author":"Swinney","year":"2011","journal-title":"Nat. Rev. Drug. Discov"},{"key":"B92","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cmet.2014.03.014","article-title":"Lysine glutarylation is a protein posttranslational modification regulated by Sirt5","volume":"19","author":"Tan","year":"2014","journal-title":"Cell Metab"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e596","DOI":"10.1371\/journal.pntd.0000596","article-title":"An \u226a in-depth \u226b description of the small non-coding RNA population of Schistosoma japonicum schistosomulum","volume":"4","author":"Wang","year":"2010","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B94","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S1046-2023(02)00060-9","article-title":"Identification and resolution of artifacts in bisulfite sequencing","volume":"27","author":"Warnecke","year":"2002","journal-title":"Methods"},{"key":"B95","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1172\/JCI69738","article-title":"New and emerging HDAC inhibitors for cancer treatment","volume":"124","author":"West","year":"2014","journal-title":"J. Clin. Invest"},{"key":"B96","doi-asserted-by":"publisher","first-page":"e4034","DOI":"10.1371\/journal.pone.0004034","article-title":"Identification and characterization of novel microRNAs from Schistosoma japonicum","volume":"3","author":"Xue","year":"2008","journal-title":"PLoS ONE"},{"key":"B97","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrd1930","article-title":"Epigenetic therapy of cancer. Past, present, and future","volume":"5","author":"Yoo","year":"2006","journal-title":"Nat. Rev. Drug Discov"},{"key":"B98","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of Schistosoma haematobium","volume":"44","author":"Young","year":"2012","journal-title":"Nat. Genet"},{"key":"B99","doi-asserted-by":"publisher","first-page":"42428","DOI":"10.1074\/jbc.R112.372300","article-title":"Structural basis for sirtuin activity and inhibition","volume":"287","author":"Yuan","year":"2012","journal-title":"J. Biol. Chem"},{"key":"B100","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature08140","article-title":"The Schistosoma japonicum genome reveals features of host-parasite interplay","volume":"460","author":"Zhou","year":"2009","journal-title":"Nature"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2014.00317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T07:28:57Z","timestamp":1598254137000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2014.00317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,10]]},"references-count":100,"URL":"https:\/\/doi.org\/10.3389\/fgene.2014.00317","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,10]]}}}