{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:36:18Z","timestamp":1790336178400,"version":"4.1.0"},"reference-count":44,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2015.00360","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T06:31:55Z","timestamp":1452493915000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["Milk Bottom-Up Proteomics: Method Optimization"],"prefix":"10.3389","volume":"6","author":[{"given":"Delphine","family":"Vincent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilnis","family":"Ezernieks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Elkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Moate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin G.","family":"Cocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Rochfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF03195649","article-title":"Genetic variability of milk fatty acids","volume":"50","author":"Arnould","year":"2009","journal-title":"J. Appl. Genet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jprot.2010.11.005","article-title":"Farm animal proteomics\u2013a review","volume":"74","author":"Bendixen","year":"2011","journal-title":"J. Proteomics"},{"key":"B3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4206","DOI":"10.3168\/jds.2008-1297","article-title":"Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis","volume":"91","author":"Boehmer","year":"2008","journal-title":"J. Dairy Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1126\/science.1169588","article-title":"The genome sequence of taurine cattle: a window to ruminant biology and evolution","volume":"324","author":"Bovine Genome Sequencing Analysis Consortium","year":"2009","journal-title":"Science"},{"key":"B6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/B978-0-12-374407-4.00432-5","article-title":"Milk proteins: \u03b1-Lactalbumin","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Brew","year":"2011"},{"key":"B7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3168\/jds.2011-4360","article-title":"A comparison of the environmental impact of Jersey compared with Holstein milk for cheese production","volume":"95","author":"Capper","year":"2012","journal-title":"J. Dairy Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.chroma.2005.09.060","article-title":"Liquid chromatography\/tandem mass spectrometric confirmatory method for determining aflatoxin M1 in cow milk: comparison between electrospray and atmospheric pressure photoionization sources","volume":"1101","author":"Cavaliere","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1002\/pmic.200900771","article-title":"Quantitative milk proteomics\u2013host responses to lipopolysaccharide-mediated inflammation of bovine mammary gland","volume":"10","author":"Danielsen","year":"2010","journal-title":"Proteomics"},{"key":"B10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/B978-0-12-374407-4.00157-6","article-title":"Enzymes indigenous to milk: Lipases and Esterases","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Deeth","year":"2011"},{"key":"B11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/B978-0-12-374407-4.00162-X","article-title":"Enzymes indigenous to milk: other enzymes","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Farkye","year":"2011"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.3168\/jds.2012-6122","article-title":"Milk fat globule membrane isolated from buttermilk or whey cream and their lipid components inhibit infectivity of rotavirus in vitro","volume":"96","author":"Fuller","year":"2013","journal-title":"J. Dairy Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.3168\/jds.2013-7312","article-title":"Effects of breed and casein genetic variants on protein profile in milk from Swedish Red, Danish Holstein, and Danish Jersey cows","volume":"97","author":"Gustavsson","year":"2014","journal-title":"J. Dairy Sci."},{"key":"B14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/B978-0-12-374407-4.00161-8","article-title":"Enzymes Indigenous to Milk: Xanthine Oxidoreductase","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Harrison","year":"2011"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e19433","DOI":"10.1371\/journal.pone.0019433","article-title":"The host defense proteome of human and bovine milk","volume":"6","author":"Hettinga","year":"2011","journal-title":"PLoS ONE"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1002\/pmic.200300723","article-title":"Differential protein composition of bovine whey: a comparison of whey from healthy animals and from those with clinical mastitis","volume":"4","author":"Hogarth","year":"2004","journal-title":"Proteomics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"827","DOI":"10.2174\/156652412801318755","article-title":"Alpha 1 anti-trypsin: one protein, many functions","volume":"12","author":"Hunt","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.3168\/jds.2012-5346","article-title":"Milk protein genetic variants and isoforms identified in bovine milk representing extremes in coagulation properties","volume":"95","author":"Jensen","year":"2012a","journal-title":"J. Dairy Sci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"6905","DOI":"10.3168\/jds.2012-5675","article-title":"Distinct composition of bovine milk from Jersey and Holstein-Friesian cows with good, poor, or noncoagulation properties as reflected in protein genetic variants and isoforms","volume":"95","author":"Jensen","year":"2012b","journal-title":"J. Dairy Sci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/14356007.a16_589.pub2","article-title":"Milk and Dairy Products","author":"Jost","year":"2005","journal-title":"Ullmann's Encyclopedia of Industrial Chemistry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1746-6148-7-51","article-title":"Changes in Holstein cow milk and serum proteins during intramammary infection with three different strains of Staphylococcus aureus","volume":"7","author":"Kim","year":"2011","journal-title":"BMC Vet. Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1021\/pr100884z","article-title":"Exploration of bovine milk proteome in colostral and mature whey using an ion-exchange approach","volume":"10","author":"Le","year":"2011","journal-title":"J. Proteome Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"B24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/B978-0-12-374407-4.00436-2","article-title":"Milk Proteins: Immunoglobulins","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Marnila","year":"2011"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1002\/pmic.201200231","article-title":"In-depth analysis of low abundant proteins in bovine colostrum using different fractionation techniques","volume":"12","author":"Nissen","year":"2012","journal-title":"Proteomics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"7854","DOI":"10.3168\/jds.2013-7106","article-title":"Expanding the bovine milk proteome through extensive fractionation","volume":"96","author":"Nissen","year":"2013","journal-title":"J. Dairy Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/glycob\/cwt162","article-title":"Structural and functional characteristics of bovine milk protein glycosylation","volume":"24","author":"O'Riordan","year":"2014","journal-title":"Glycobiology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4830","DOI":"10.3168\/jds.2012-6422","article-title":"The occurrence of noncoagulating milk and the association of bovine milk coagulation properties with genetic variants of the caseins in 3 Scandinavian dairy breeds","volume":"96","author":"Poulsen","year":"2013","journal-title":"J. Dairy Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jprot.2013.02.013","article-title":"Bovine milk proteome: quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis","volume":"26","author":"Reinhardt","year":"2013","journal-title":"J. Proteomics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1016\/j.jprot.2012.05.028","article-title":"Farm animal milk proteomics","volume":"75","author":"Roncada","year":"2012","journal-title":"J. Proteomics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/j.1740-0929.2011.00886.x","article-title":"Changes in the bovine whey proteome during the early lactation period","volume":"82","author":"Senda","year":"2011","journal-title":"Anim. Sci. J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.aquaculture.2006.08.024","article-title":"Fatty acid composition of New Zealand green-lipped mussels, Perna canaliculus: Implications for harvesting for n-3 extracts","volume":"261","author":"Taylor","year":"2006","journal-title":"Aquaculture"},{"key":"B34","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/BF01024961","article-title":"Solubility and reactivity of caseins and beta-lactoglobulin in protic solvents","volume":"11","author":"Touati","year":"1992","journal-title":"J. Protein Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"216","DOI":"10.5584\/jiomics.v1i2.59","article-title":"Development of an in-house protocol for the OFFGEL fractionation of plant proteins","volume":"1","author":"Vincent","year":"2011","journal-title":"JIOMICS"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1002\/elps.200900415","article-title":"Hunting down fungal secretomes using liquid-phase IEF prior to high resolution 2-DE","volume":"30","author":"Vincent","year":"2009","journal-title":"Electrophoresis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1364-3703.2011.00763.x","article-title":"A functional genomics approach to dissect the mode of action of the Stagonospora nodorum effector protein SnToxA in wheat","volume":"13","author":"Vincent","year":"2012a","journal-title":"Mol. Plant Pathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1093\/jxb\/erm012","article-title":"Proteomic analysis reveals differences between Vitis vinifera L. cv. Chardonnay and cv. Cabernet Sauvignon and their responses to water deficit and salinity","volume":"58","author":"Vincent","year":"2007","journal-title":"J. Exp. Bot."},{"key":"B39","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1021\/pr200895f","article-title":"Secretome of the free-living mycelium from the ectomycorrhizal basidiomycete Laccaria bicolor","volume":"11","author":"Vincent","year":"2012b","journal-title":"J. Proteome Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1104\/pp.104.050815","article-title":"Water deficits affect caffeate O-methyltransferase, lignification, and related enzymes in maize leaves. A proteomic investigation","volume":"137","author":"Vincent","year":"2005","journal-title":"Plant Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1002\/elps.200500698","article-title":"Optimization of protein extraction and solubilization for mature grape berry clusters","volume":"27","author":"Vincent","year":"2006","journal-title":"Electrophoresis"},{"key":"B42","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination","volume":"30","author":"Vizca\u00edno","year":"2014","journal-title":"Nat. Biotechnol"},{"key":"B43","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/B978-0-12-374407-4.00434-9","article-title":"Milk proteins: minor proteins, bovine serum albumin, vitamin-binding proteins","volume-title":"The Encyclopedia of Dairy Sciences, 2nd Edn.","author":"Wynn","year":"2011"},{"key":"B44","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1017\/S175173111200153X","article-title":"Effects of duodenal infusion of free \u03b1-linolenic acid on the plasma and milk proteome of lactating dairy cows","volume":"7","author":"Yang","year":"2013","journal-title":"Animal"}],"container-title":["Frontiers in Genetics"],"original-title":[],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T03:25:03Z","timestamp":1498274703000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fgene.2015.00360\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3389\/fgene.2015.00360","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}