{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T23:00:50Z","timestamp":1771801250530,"version":"3.50.1"},"reference-count":57,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2017.00070","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:04:00Z","timestamp":1496016240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma"],"prefix":"10.3389","volume":"8","author":[{"given":"Jelena","family":"Kresoja-Rakic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Sulemani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela B.","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Ronner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Schwaller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Weder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf A.","family":"Stahel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Felley-Bosco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs.","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"B2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0014-5793(03)00576-3","article-title":"Heme oxygenase-1 induction by endogenous nitric oxide: influence of intracellular glutathione.","volume":"546","author":"Andre","year":"2003","journal-title":"FEBS Lett."},{"key":"B3","doi-asserted-by":"publisher","first-page":"7138","DOI":"10.1093\/nar\/gki1012","article-title":"AU-rich elements and associated factors: Are there unifying principles?","volume":"33","author":"Barreau","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"D149","DOI":"10.1093\/nar\/gkm995","article-title":"The microRNA.org resource: targets and expression.","volume":"36","author":"Betel","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.cell.2006.04.031","article-title":"Relief of microRNA-mediated translational repression in human cells subjected to stress.","volume":"125","author":"Bhattacharyya","year":"2006","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.stemcr.2017.02.005","article-title":"Stem cell factor-based identification and functional properties of in vitro-selected subpopulations of malignant mesothelioma cells.","volume":"8","author":"Blum","year":"2017","journal-title":"Stem Cell Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1002\/ijc.28218","article-title":"Calretinin is essential for mesothelioma cell growth\/survival in vitro: a potential new target for malignant mesothelioma therapy?","volume":"133","author":"Blum","year":"2013","journal-title":"Int. J. Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/PL00000854","article-title":"HuR and mRNA stability.","volume":"58","author":"Brennan","year":"2001","journal-title":"Cell Mol. Life Sci."},{"key":"B9","year":"2016","journal-title":"Clustering of miRseq Mature Expression: Consensus NMF. Broad Institute of MIT and Harvard"},{"key":"B10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1165\/rcmb.2009-0060OC","article-title":"MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications.","volume":"42","author":"Busacca","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0529-z","article-title":"KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma.","volume":"15","author":"Cheng","year":"2016","journal-title":"Mol. Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"D90","DOI":"10.1093\/nar\/gkv1238","article-title":"AREsite2: an enhanced database for the comprehensive investigation of AU\/GU\/U-rich elements.","volume":"44","author":"Fallmann","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005857","article-title":"Chromatoid body protein TDRD6 supports long 3\u2032 UTR triggered nonsense mediated mRNA decay.","volume":"12","author":"Fanourgakis","year":"2016","journal-title":"PLoS Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/S0002-9440(10)62492-3","article-title":"Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.","volume":"166","author":"Gordon","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA websuite.","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1202s26","article-title":"RNA secondary structure analysis using the Vienna RNA package.","author":"Hofacker","year":"2009","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"8713","DOI":"10.1093\/nar\/gkv871","article-title":"A legion of potential regulatory sRNAs exists beyond the typical microRNAs microcosm.","volume":"43","author":"Jha","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.cell.2004.12.038","article-title":"Involvement of microRNA in AU-rich element-mediated mRNA instability.","volume":"120","author":"Jing","year":"2005","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1097\/JTO.0b013e31822a3740","article-title":"Low calretinin expression and high neutrophil-to-lymphocyte ratio are poor prognostic factors in patients with malignant mesothelioma undergoing extrapleural pneumonectomy.","volume":"6","author":"Kao","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ncb2105","article-title":"A Pumilio-induced RNA structure switch in p27-3\u2032 UTR controls miR-221 and miR-222 accessibility.","volume":"12","author":"Kedde","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1007\/s00018-010-0383-x","article-title":"Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.","volume":"67","author":"Khabar","year":"2010","journal-title":"Cell Mol. Life Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.molonc.2014.11.007","article-title":"MiR-score: a novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma.","volume":"9","author":"Kirschner","year":"2015","journal-title":"Mol. Oncol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions.","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"21272","DOI":"10.18632\/oncotarget.7114","article-title":"Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells.","volume":"7","author":"Kresoja-Rakic","year":"2016","journal-title":"Oncotarget"},{"key":"B26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay.","volume":"11","author":"Krol","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1038\/bjc.2014.478","article-title":"Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales.","volume":"111","author":"Linton","year":"2014","journal-title":"Br. J. Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers.","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1074\/jbc.271.14.8144","article-title":"Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein.","volume":"271","author":"Ma","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ijc.2910470219","article-title":"Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.","volume":"47","author":"Manning","year":"1991","journal-title":"Int. J. Cancer"},{"key":"B32","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.tcb.2015.10.012","article-title":"Evolution and biological roles of alternative 3\u2032UTRs.","volume":"26","author":"Mayr","year":"2016","journal-title":"Trends Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1002\/ijc.29512","article-title":"microRNA regulation in cancer: One arm or two arms?","volume":"137","author":"Mitra","year":"2015","journal-title":"Int. J. Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/PAI.0b013e31829b6fbd","article-title":"Value of calretinin immunostaining in diagnostic pathology: a review and update.","volume":"22","author":"Ord\u00f3\u00f1ez","year":"2014","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1038\/bjc.2014.117","article-title":"CD74: a new prognostic factor for patients with malignant pleural mesothelioma.","volume":"110","author":"Otterstrom","year":"2014","journal-title":"Br. J. Cancer"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing.","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"S397","DOI":"10.3978\/j.issn.2072-1439.2013.08.08","article-title":"Malignant pleural mesothelioma: current and future perspectives.","author":"Porpodis","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3978\/j.issn.2072-1439.2015.04.56","article-title":"MicroRNAs in mesothelioma: from tumour suppressors and biomarkers to therapeutic targets.","volume":"7","author":"Reid","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-399","article-title":"Alternative splicing is frequent during early embryonic development in mouse.","volume":"11","author":"Revil","year":"2010","journal-title":"BMC Genomics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/ijc.2910510220","article-title":"Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: interleukin-6 production as a common feature.","volume":"51","author":"Schmitter","year":"1992","journal-title":"Int. J. Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1432-1033.1995.0424h.x","article-title":"Alternative splicing of calretinin mRNA leads to different forms of calretinin.","volume":"230","author":"Schwaller","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6628","DOI":"10.1074\/jbc.275.9.6628","article-title":"Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.","volume":"275","author":"Sheng","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1158\/1078-0432.CCR-12-0599","article-title":"Role of hedgehog signaling in malignant pleural mesothelioma.","volume":"18","author":"Shi","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ejca.2010.09.044","article-title":"Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: an exploratory analysis.","volume":"47","author":"Sidi","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2174\/138920312801619394","article-title":"Functional interplay between RNA-binding protein HuR and microRNAs.","volume":"13","author":"Srikantan","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1002\/cncr.23904","article-title":"Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis.","volume":"113","author":"Stoppoloni","year":"2008","journal-title":"Cancer"},{"key":"B48","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nn.4216","article-title":"Adult mouse cortical cell taxonomy revealed by single cell transcriptomics.","volume":"19","author":"Tasic","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition.","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.lungcan.2008.08.014","article-title":"Functional inactivation of NF2\/merlin in human mesothelioma.","volume":"64","author":"Thurneysen","year":"2009","journal-title":"Lung Cancer"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002977","article-title":"The p38\/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.","volume":"8","author":"Tiedje","year":"2012","journal-title":"PLoS Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1349-7006.2006.00184.x","article-title":"Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.","volume":"97","author":"Usami","year":"2006","journal-title":"Cancer Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nrc3107","article-title":"MicroRNA regulation by RNA-binding proteins and its implications for cancer.","volume":"11","author":"van Kouwenhove","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"B54","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4331\/wjbc.v5.i1.40","article-title":"Role of 3\u2032-untranslated region translational control in cancer development, diagnostics and treatment.","volume":"5","author":"Vislovukh","year":"2014","journal-title":"World J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets.","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B56","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/wrna.55","article-title":"Turnover of AU-rich-containing mRNAs during stress: a matter of survival.","volume":"2","author":"von Roretz","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"B57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200712054","article-title":"Decoding ARE-mediated decay: is microRNA part of the equation?","volume":"181","author":"von Roretz","year":"2008","journal-title":"J. Cell Biol"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2017.00070\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:04:06Z","timestamp":1496016246000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2017.00070\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,29]]},"references-count":57,"alternative-id":["10.3389\/fgene.2017.00070"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2017.00070","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,29]]},"article-number":"70"}}