{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:46:26Z","timestamp":1791978386194,"version":"4.4.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671284"],"award-info":[{"award-number":["31671284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31123004"],"award-info":[{"award-number":["31123004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971568"],"award-info":[{"award-number":["30971568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2017.00234","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T04:39:01Z","timestamp":1517373541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["ZIP13: A Study of Drosophila Offers an Alternative Explanation for the Corresponding Human Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Guiran","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","article-title":"The genome sequence of Drosophila melanogaster","volume":"287","author":"Adams","year":"2000","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1021\/bi201553p","article-title":"The human ZIP4 transporter has two distinct binding affinities and mediates transport of multiple transition metals","volume":"51","author":"Antala","year":"2012","journal-title":"Biochemistry"},{"key":"B3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O","article-title":"Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK)","volume":"77","author":"Beighton","year":"1998","journal-title":"Am. J. Med. Genet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1242\/jeb.051664","article-title":"Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase","volume":"214","author":"Bettedi","year":"2011","journal-title":"J. Exp. Biol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"40255","DOI":"10.1074\/jbc.M111.256784","article-title":"Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome","volume":"286","author":"Bin","year":"2011","journal-title":"J. Biol. Chem"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.15252\/emmm.201303809","article-title":"Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins","volume":"6","author":"Bin","year":"2014","journal-title":"EMBO Mol. Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/ajmg.c.31548","article-title":"Ehlers-Danlos syndrome, classical type","volume":"175","author":"Bowen","year":"2017","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/ajmg.c.31550","article-title":"The Ehlers-Danlos syndromes, rare types","volume":"175","author":"Brady","year":"2017","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"E1456","DOI":"10.3390\/ijms18071456","article-title":"Drosophila melanogaster models of metal-related human diseases and metal toxicity","volume":"18","author":"Calap-Quintana","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"C169","DOI":"10.1152\/ajpcell.00116.2016","article-title":"The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human beta-cells","volume":"312","author":"Coffey","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"22789","DOI":"10.1074\/jbc.M200577200","article-title":"A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane","volume":"277","author":"Cragg","year":"2002","journal-title":"J. Biol. Chem"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1073\/pnas.0406085102","article-title":"Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis","volume":"102","author":"Dalton","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/sj.emboj.7601735","article-title":"Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin","volume":"26","author":"De Domenico","year":"2007","journal-title":"EMBO J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/B978-0-12-394390-3.00009-4","article-title":"The cation selectivity of the ZIP transporters","volume":"69","author":"Dempski","year":"2012","journal-title":"Curr. Top. Membr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1089\/104454999314791","article-title":"Organization of the ferritin genes in Drosophila melanogaster","volume":"18","author":"Dunkov","year":"1999","journal-title":"DNA Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ibmb.2006.01.007","article-title":"Insect iron binding proteins: insights from the genomes","volume":"36","author":"Dunkov","year":"2006","journal-title":"Insect Biochem. Mol. Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1007\/s00424-003-1074-3","article-title":"The SLC39 family of metal ion transporters","volume":"447","author":"Eide","year":"2004","journal-title":"Pflugers Arch"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1242\/jeb.02193","article-title":"Immunolocalisation of the D. melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous","volume":"209","author":"Folwell","year":"2006","journal-title":"J. Exp. Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e3642","DOI":"10.1371\/journal.pone.0003642","article-title":"The zinc transporter SLC39A13\/ZIP13 is required for connective tissue development; its involvement in BMP\/TGF-beta signaling pathways","volume":"3","author":"Fukada","year":"2008","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1039\/c1mt00011j","article-title":"Molecular and genetic features of zinc transporters in physiology and pathogenesis","volume":"3","author":"Fukada","year":"2011","journal-title":"Metallomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"21462","DOI":"10.1074\/jbc.M803150200","article-title":"The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells","volume":"283","author":"Gao","year":"2008","journal-title":"J. Biol. Chem"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1124\/mol.107.043588","article-title":"Slc39a14 gene encodes ZIP14, a metal\/bicarbonate symporter: similarities to the ZIP8 transporter","volume":"73","author":"Girijashanker","year":"2008","journal-title":"Mol. Pharmacol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.ajhg.2008.05.001","article-title":"Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome\u2013an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13","volume":"82","author":"Giunta","year":"2008","journal-title":"Am. J. Hum. Genet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1007\/s11033-010-0304-y","article-title":"Over-expression of Zip-13 mRNA in kidney and lung during dietary zinc deficiency in Wistar rats","volume":"38","author":"Guo","year":"2011","journal-title":"Mol. Biol. Rep"},{"key":"B25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1124\/mol.106.024521","article-title":"ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties","volume":"70","author":"He","year":"2006","journal-title":"Mol. Pharmacol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of Mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"15456","DOI":"10.1074\/jbc.M412188200","article-title":"The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus","volume":"280","author":"Huang","year":"2005","journal-title":"J. Biol. Chem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"E3530","DOI":"10.1073\/pnas.1211775110","article-title":"Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome","volume":"109","author":"Jeong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B29","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.mam.2012.05.011","article-title":"The SLC39 family of zinc transporters","volume":"34","author":"Jeong","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1007\/s00018-014-1617-0","article-title":"Current understanding of ZIP and ZnT zinc transporters in human health and diseases","volume":"71","author":"Kambe","year":"2014","journal-title":"Cell. Mol. Life Sci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"22566","DOI":"10.1074\/jbc.M604730200","article-title":"YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae","volume":"281","author":"Kum\u00e1novics","year":"2006","journal-title":"J. Biol. Chem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/ng913","article-title":"Identification of SLC39A4, a gene involved in acrodermatitis enteropathica","volume":"31","author":"K\u00fcry","year":"2002","journal-title":"Nat. Genet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"13337","DOI":"10.1073\/pnas.1208703109","article-title":"Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster","volume":"109","author":"Lang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1126\/science.1215759","article-title":"Structural insight into the ion-exchange mechanism of the sodium\/calcium exchanger","volume":"335","author":"Liao","year":"2012","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev-nutr-033009-083312","article-title":"Mammalian zinc transporters: nutritional and physiologic regulation","volume":"29","author":"Lichten","year":"2009","journal-title":"Annu. Rev. Nutr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.bbrc.2007.11.067","article-title":"Cd2+ versus Zn2+ uptake by the ZIP8 HCO3-dependent symporter: kinetics, electrogenicity and trafficking","volume":"365","author":"Liu","year":"2008","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B37","doi-asserted-by":"publisher","first-page":"13612","DOI":"10.1073\/pnas.0606424103","article-title":"Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells","volume":"103","author":"Liuzzi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1242\/jeb.069260","article-title":"Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster","volume":"215","author":"Lye","year":"2012","journal-title":"J. Exp. Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.3390\/nu5051622","article-title":"Iron absorption in Drosophila melanogaster","volume":"5","author":"Mandilaras","year":"2013","journal-title":"Nutrients"},{"key":"B40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4067\/S0716-97602002000100004","article-title":"Glucose transporters: expression, regulation and cancer","volume":"35","author":"Medina","year":"2002","journal-title":"Biol. Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1534\/genetics.107.075150","article-title":"Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin","volume":"177","author":"Missirlis","year":"2007","journal-title":"Genetics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3109\/03008208509152396","article-title":"Serum stimulation of lysyl hydroxylase activity in cultured human skin fibroblasts","volume":"13","author":"Murad","year":"1985","journal-title":"Connect Tissue Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1080\/07853890801986594","article-title":"Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets","volume":"40","author":"Myllyharju","year":"2008","journal-title":"Ann. Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tig.2003.11.004","article-title":"Collagens, modifying enzymes and their mutations in humans, flies and worms","volume":"20","author":"Myllyharju","year":"2004","journal-title":"Trends Genet"},{"key":"B45","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1432-1033.1977.tb11889.x","article-title":"Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence","volume":"80","author":"Myllyl\u00e4","year":"1977","journal-title":"Eur. J. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1021\/ic200270p","article-title":"Metal binding ability of cysteine-rich peptide domain of ZIP13 Zn2+ ions transporter","volume":"50","author":"Potocki","year":"2011","journal-title":"Inorg Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0005-2744(80)90041-8","article-title":"Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism","volume":"611","author":"Puistola","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"B48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1741-7007-11-101","article-title":"Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation","volume":"11","author":"Qin","year":"2013","journal-title":"BMC Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.abb.2016.07.015","article-title":"A fly's eye view of zinc homeostasis: novel insights into the genetic control of zinc metabolism from Drosophila","volume":"611","author":"Richards","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"B50","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/j.1460-2075.1995.tb07303.x","article-title":"malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour","volume":"14","author":"Rodrigues","year":"1995","journal-title":"EMBO J"},{"key":"B51","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1242\/jeb.014159","article-title":"Malvolio is a copper transporter in Drosophila melanogaster","volume":"211","author":"Southon","year":"2008","journal-title":"J Exp Biol."},{"key":"B52","first-page":"1505","article-title":"Urinary pyridinoline cross-links in Ehlers-Danlos syndrome type VI","volume":"57","author":"Steinmann","year":"1995","journal-title":"Am. J. Hum. Genet"},{"key":"B53","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/iub.1211","article-title":"Iron homeostasis in insects: Insights from Drosophila studies","volume":"65","author":"Tang","year":"","journal-title":"IUBMB Life"},{"key":"B54","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1096\/fj.12-213595","article-title":"Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster","volume":"27","author":"Tang","year":"","journal-title":"FASEB J"},{"key":"B55","doi-asserted-by":"publisher","first-page":"396","DOI":"10.2119\/2007-00040.Taylor","article-title":"The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer","volume":"13","author":"Taylor","year":"2007","journal-title":"Mol. Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S0005-2736(03)00048-8","article-title":"The LZT proteins; the LIV-1 subfamily of zinc transporters","volume":"1611","author":"Taylor","year":"2003","journal-title":"Biochim. Biophys Acta"},{"key":"B57","doi-asserted-by":"publisher","first-page":"E141","DOI":"10.1152\/ajpendo.00712.2009","article-title":"Glucose transporters in the 21st century","volume":"298","author":"Thorens","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/ncb2111","article-title":"Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila","volume":"12","author":"Tiklov\u00e1","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1017\/S0007114515001592","article-title":"The influence of dietary zinc source and coccidial vaccine exposure on intracellular zinc homeostasis and immune status in broiler chickens","volume":"114","author":"Troche","year":"2015","journal-title":"Br. J. Nutr"},{"key":"B60","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1432-1033.1977.tb11888.x","article-title":"Mechanism of the prolyl hydroxylase reaction. 1. Role of co-substrates","volume":"80","author":"Tuderman","year":"1977","journal-title":"Eur. J. Biochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"14389","DOI":"10.1074\/jbc.M701752200","article-title":"ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells","volume":"282","author":"Valentine","year":"2007","journal-title":"J. Biol. Chem"},{"key":"B62","doi-asserted-by":"publisher","first-page":"pR38","DOI":"10.1186\/gb-2003-4-6-r38","article-title":"A phylogenetic study of cytochrome b561 proteins","volume":"4","author":"Verelst","year":"2003","journal-title":"Genome Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1074\/jbc.M112.367284","article-title":"ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1086\/341125","article-title":"A novel member of a zinc transporter family is defective in acrodermatitis enteropathica","volume":"71","author":"Wang","year":"2002","journal-title":"Am. J. Hum. Genet"},{"key":"B65","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ibmb.2006.01.006","article-title":"Iron metabolism in insect disease vectors: mining the Anopheles gambiae translated protein database","volume":"36","author":"Winzerling","year":"2006","journal-title":"Insect Biochem. Mol. Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"14995","DOI":"10.1073\/pnas.1308535110","article-title":"Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding","volume":"110","author":"Xiao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e03191","DOI":"10.7554\/eLife.03191","article-title":"The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster","volume":"3","author":"Xiao","year":"2014","journal-title":"Elife"},{"key":"B68","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.abb.2016.04.016","article-title":"What can flies tell us about zinc homeostasis?","volume":"611","author":"Xiao","year":"2016","journal-title":"Arch. Biochem. Biophys"},{"key":"B69","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/1098-1004(200007)16:1<90::AID-HUMU19>3.0.CO;2-U","article-title":"Mutational analysis of the lysyl hydroxylase 1 gene (PLOD) in six unrelated patients with Ehlers-Danlos syndrome type VI: prenatal exclusion of this disorder in one family","volume":"16","author":"Yeowell","year":"2000","journal-title":"Hum Mutat."},{"key":"B70","first-page":"229","article-title":"The Ehlers-Danlos syndromes","volume":"12","author":"Yeowell","year":"1993","journal-title":"Semin. Dermatol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1006\/mgme.2000.3076","article-title":"Mutations in the lysyl hydroxylase 1 gene that result in enzyme deficiency and the clinical phenotype of Ehlers-Danlos syndrome type VI","volume":"71","author":"Yeowell","year":"2000","journal-title":"Mol. Genet. Metab"},{"key":"B72","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1046\/j.1432-1327.1999.00173.x","article-title":"Drosophila melanogaster transferrin. Cloning, deduced protein sequence, expression during the life cycle, gene localization and up-regulation on bacterial infection","volume":"260","author":"Yoshiga","year":"1999","journal-title":"Eur. J. Biochem"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e1700344","DOI":"10.1126\/sciadv.1700344","article-title":"Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway","volume":"3","author":"Zhang","year":"2017","journal-title":"Sci Adv"},{"key":"B74","doi-asserted-by":"publisher","first-page":"11979","DOI":"10.1038\/ncomms11979","article-title":"Structural insights of ZIP4 extracellular domain critical for optimal zinc transport","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat. Commun"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1073\/pnas.93.6.2454","article-title":"The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation","volume":"93","author":"Zhao","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B76","doi-asserted-by":"publisher","first-page":"32141","DOI":"10.1074\/jbc.M110.143248","article-title":"ZRT\/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin","volume":"285","author":"Zhao","year":"2010","journal-title":"J. Biol. Chem"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2017.00234\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:43:20Z","timestamp":1570668200000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fgene.2017.00234\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":76,"alternative-id":["10.3389\/fgene.2017.00234"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2017.00234","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]},"article-number":"234"}}