{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:33:08Z","timestamp":1776954788286,"version":"3.51.4"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005329","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700169"],"award-info":[{"award-number":["81700169"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["201842920480710623"],"award-info":[{"award-number":["201842920480710623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2018.00218","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T04:33:10Z","timestamp":1528950790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations Between XPD Lys751Gln Polymorphism and Leukemia: A Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Min","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldad","family":"Zacksenhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaacov","family":"Ben-David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3872","DOI":"10.1182\/blood-2004-06-2161","article-title":"Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.","volume":"104","author":"Allan","year":"2004","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9357","DOI":"10.1007\/s13277-016-4815-6","article-title":"Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.","volume":"37","author":"Banescu","year":"2016","journal-title":"Tumour Biol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/213790","article-title":"Polymorphism of XRCC1 XRCC3 and XPD genes and risk of chronic myeloid leukemia.","volume":"2014","author":"Banescu","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.leukres.2008.11.005","article-title":"DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia","volume":"33","author":"Batar","year":"2009","journal-title":"Leuk. Res."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2015.539","article-title":"Genetic susceptibility in childhood acute leukaemias: a systematic review.","volume":"9","author":"Brisson","year":"2015","journal-title":"Ecancermedicalscience"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.3109\/10428194.2011.559672","article-title":"Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia.","volume":"52","author":"Canalle","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1093\/nar\/gkw102","article-title":"Mechanism of DNA loading by the DNA repair helicase XPD.","volume":"44","author":"Constantinescu-Aruxandei","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/1099-1069(200009)18:3<99::AID-HON662>3.0.CO;2-Z","article-title":"DNA repair mechanisms and acute myeloblastic leukemia.","volume":"18","author":"Das-Gupta","year":"2000","journal-title":"Hematol. Oncol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/MPH.0000000000000133","article-title":"DNA repair gene polymorphisms and their relation with dna damage, dna repair, and total antioxidant capacity in childhood acute lymphoblastic leukemia survivors.","volume":"37","author":"Dincer","year":"2015","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.3109\/10428194.2014.974045","article-title":"Polymorphisms in XPC, XPD and XPG DNA repair genes and leukemia risk in a Tunisian population.","volume":"56","author":"Douzi","year":"2015","journal-title":"Leuk. Lymphoma"},{"key":"B12","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s00412-014-0482-9","article-title":"DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance.","volume":"123","author":"Esposito","year":"2014","journal-title":"Chromosoma"},{"key":"B13","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.cell.2008.04.030","article-title":"XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.","volume":"133","author":"Fan","year":"2008","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"E125","DOI":"10.1002\/ajh.23744","article-title":"The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies.","volume":"89","author":"Fircanis","year":"2014","journal-title":"Am. J. Hematol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/gcc.20680","article-title":"DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia.","volume":"48","author":"Ganster","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"84872","DOI":"10.18632\/oncotarget.12744","article-title":"Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population.","volume":"7","author":"He","year":"2016","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer.","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3617-6","article-title":"Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia.","volume":"18","author":"Huang","year":"2017","journal-title":"BMC Genomics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096822","article-title":"The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.","volume":"9","author":"Jiang","year":"2014","journal-title":"PLoS One"},{"key":"B20","first-page":"346","article-title":"Study on the relationship between genetic polymorphism and susceptibility for adult acute leukemi.","volume":"25","author":"Juan","year":"2005","journal-title":"Tumor"},{"key":"B21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/ng.3557","article-title":"Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.","volume":"48","author":"Kim","year":"2016","journal-title":"Nat. Genet."},{"key":"B22","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/emboj.2011.374","article-title":"Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation.","volume":"31","author":"Kuper","year":"2012","journal-title":"EMBO J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/ijc.23176","article-title":"Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies.","volume":"122","author":"Larsson","year":"2008","journal-title":"Int. J. Cancer"},{"key":"B24","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/nm.4125","article-title":"Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.","volume":"22","author":"Li","year":"2016","journal-title":"Nat. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.gene.2014.01.049","article-title":"The effect of XPD\/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis.","volume":"538","author":"Liu","year":"2014","journal-title":"Gene"},{"key":"B26","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.cell.2008.04.029","article-title":"Structure of the DNA repair helicase XPD.","volume":"133","author":"Liu","year":"2008","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/carcin\/21.4.551","article-title":"XPD polymorphisms: effects on DNA repair proficiency.","volume":"21","author":"Lunn","year":"2000","journal-title":"Carcinogenesis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.ijheh.2016.09.015","article-title":"Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.","volume":"219","author":"Malagoli","year":"2016","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"B29","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/carcin\/bgi280","article-title":"DNA repair polymorphisms and cancer risk in non-smokers in a cohort study.","volume":"27","author":"Matullo","year":"2006","journal-title":"Carcinogenesis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1182\/blood-2005-06-2305","article-title":"XPD Lys751Gln polymorphism in the etiology and outcome of childhood acute myeloid leukemia: a Children\u2019s Oncology Group report.","volume":"107","author":"Mehta","year":"2006","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4103\/1477-3163.54918","article-title":"Conformational effects of a common codon 751 polymorphism on the C-terminal domain of the xeroderma pigmentosum D protein.","volume":"8","author":"Monaco","year":"2009","journal-title":"J. Carcinog."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/srep04112","article-title":"Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population.","volume":"4","author":"Ni","year":"2014","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1002\/ijc.30264","article-title":"Background radiation and childhood leukemia: a nationwide register-based case-control study.","volume":"139","author":"Nikkila","year":"2016","journal-title":"Int. J. Cancer"},{"key":"B35","doi-asserted-by":"publisher","first-page":"8860","DOI":"10.5897\/AJB10.1839","article-title":"Polymorphisms of the DNA repair gene XPD (751) and XRCC1 (399) correlates with risk of hematological malignancies in Turkish population.","volume":"10","author":"Ozcan","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.leukres.2011.10.012","article-title":"DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma.","volume":"36","author":"Ozdemir","year":"2012","journal-title":"Leuk. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/pbc.20742","article-title":"Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia.","volume":"48","author":"Pakakasama","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/ijc.28123","article-title":"Xeroderma pigmentosum genes and melanoma risk.","volume":"133","author":"Paszkowska-Szczur","year":"2013","journal-title":"Int. J. Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012609","article-title":"Nucleotide excision repair in eukaryotes.","volume":"5","author":"Scharer","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1182\/blood-2002-04-1152","article-title":"The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia.","volume":"100","author":"Seedhouse","year":"2002","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ijc.25318","article-title":"Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.","volume":"128","author":"Shi","year":"2011","journal-title":"Int. J. Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1089\/gtmb.2012.0278","article-title":"The genotype distribution of the XRCC1 XRCC3 and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia.","volume":"17","author":"Sorour","year":"2013","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1002\/cncr.25063","article-title":"Polymorphisms in ERCC2 MSH2 and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India.","volume":"116","author":"Srivastava","year":"2010","journal-title":"Cancer"},{"key":"B44","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"11243","DOI":"10.1007\/s13277-014-2379-x","article-title":"Association between the XPD\/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case-control studies.","volume":"35","author":"Wu","year":"2014","journal-title":"Tumour Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"50124","DOI":"10.18632\/oncotarget.15394","article-title":"Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00218\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T09:37:00Z","timestamp":1532684220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00218\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,14]]},"references-count":46,"alternative-id":["10.3389\/fgene.2018.00218"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2018.00218","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,14]]},"article-number":"218"}}