{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:30Z","timestamp":1790622090517,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["P-13-00555"],"award-info":[{"award-number":["P-13-00555"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2018.00277","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T04:24:37Z","timestamp":1533529477000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population"],"prefix":"10.3389","volume":"9","author":[{"given":"Nontaya","family":"Nakkam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinya","family":"Konyoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirimas","family":"Kanjanawart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niwat","family":"Saksit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thachanan","family":"Kongpan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanyarat","family":"Khaeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usanee","family":"Khunarkornsiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areerat","family":"Dornsena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wongwiwat","family":"Tassaneeyakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichittra","family":"Tassaneeyakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.2165\/00002018-200528100-00003","article-title":"Clarification of terminology in drug safety","volume":"28","author":"Aronson","year":"2005","journal-title":"Drug Saf."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1093\/cid\/cit021","article-title":"Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population","volume":"56","author":"Carr","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1365-4632.2010.04745.x","article-title":"Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population","volume":"50","author":"Chang","year":"2011","journal-title":"Int. J. Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/FPC.0b013e32831d0faf","article-title":"HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients","volume":"19","author":"Chantarangsu","year":"2009","journal-title":"Pharmacogenet. Genom."},{"key":"B5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1212\/WNL.0000000000003453","article-title":"Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians","volume":"88","author":"Chen","year":"2017","journal-title":"Neurology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e16635","DOI":"10.1371\/journal.pone.0016635","article-title":"Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association alleles","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/cpt.309","article-title":"HLA-B*38:02:01 predicts carbimazole\/methimazole-induced agranulocytosis","volume":"99","author":"Cheung","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/epi.12217","article-title":"HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese","volume":"54","author":"Cheung","year":"2013","journal-title":"Epilepsia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1001\/jama.2014.7859","article-title":"Genetic variants associated with phenytoin-related severe cutaneous adverse reactions","volume":"312","author":"Chung","year":"2014","journal-title":"JAMA"},{"key":"B10","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/1346-8138.13430","article-title":"Severe cutaneous adverse drug reactions","volume":"43","author":"Chung","year":"2016","journal-title":"J. Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1212\/WNL.0b013e31826aac73","article-title":"Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore","volume":"79","author":"Dong","year":"2012","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/tpj.2013.40","article-title":"HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis","volume":"14","author":"Genin","year":"2014","journal-title":"Pharmacogenom. J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1399-0039.2007.00982.x","article-title":"HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in the Kinh population in Vietnam","volume":"71","author":"Hoa","year":"2008","journal-title":"Tissue Antigens"},{"key":"B15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","article-title":"Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions","volume":"16","author":"Hung","year":"2006","journal-title":"Pharmacogenet. Genom."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1073\/pnas.0409500102","article-title":"HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol","volume":"102","author":"Hung","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1111\/j.1528-1167.2010.02766.x","article-title":"HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients","volume":"51","author":"Kaniwa","year":"2010","journal-title":"Epilepsia"},{"key":"B18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.eplepsyres.2011.08.010","article-title":"Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans","volume":"97","author":"Kim","year":"2011","journal-title":"Epilepsy Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/tan.12637","article-title":"HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand","volume":"86","author":"Kongmaroeng","year":"2015","journal-title":"Tissue Antigens"},{"key":"B20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1097\/FPC.0000000000000153","article-title":"Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions","volume":"25","author":"Kongpan","year":"2015","journal-title":"Pharmacogenet. Genom."},{"key":"B21","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/j.1399-0039.2010.01450.x","article-title":"HLA-A, -B, -DR haplotype frequencies in the Thai Stem Cell Donor Registry","volume":"75","author":"Kupatawintu","year":"2010","journal-title":"Tissue Antigens"},{"key":"B22","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/clpt.2013.103","article-title":"Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and carbamazepine dosing","volume":"94","author":"Leckband","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1399-0039.2005.00386.x","article-title":"Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population","volume":"65","author":"Lee","year":"2005","journal-title":"Tissue Antigens"},{"key":"B24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/FPC.0b013e3282f3ef9c","article-title":"A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs","volume":"18","author":"Lonjou","year":"2008","journal-title":"Pharmacogenet. Genom."},{"key":"B25","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"Mallal","year":"2002","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1056\/NEJMoa0706135","article-title":"HLA-B*5701 screening for hypersensitivity to abacavir","volume":"358","author":"Mallal","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"579","DOI":"10.4103\/0378-6323.57718","article-title":"Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians","volume":"75","author":"Mehta","year":"2009","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1093\/ndt\/gfn450","article-title":"The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309","volume":"24","author":"Praditpornsilpa","year":"2009","journal-title":"Nephrol. Dial. Transplant"},{"key":"B29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fgene.2014.00478","article-title":"HLA-B allele and haplotype diversity among Thai patients identified by PCR-SSOP: evidence for high risk of drug-induced hypersensitivity","volume":"5","author":"Puangpetch","year":"2014","journal-title":"Front. Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1111\/epi.12325","article-title":"Economic evaluation of HLA-B*15:02 screening for carbamazepine-induced severe adverse drug reactions in Thailand","volume":"54","author":"Rattanavipapong","year":"2013","journal-title":"Epilepsia"},{"key":"B31","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/j.1399-0039.2010.01448.x","article-title":"HLA class I and II alleles and haplotypes in ethnic Northeast Thais","volume":"75","author":"Romphruk","year":"2010","journal-title":"Tissue Antigens"},{"key":"B32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.tox.2004.12.022","article-title":"Clinical heterogeneity of drug hypersensitivity","volume":"209","author":"Roujeau","year":"2005","journal-title":"Toxicology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1034\/j.1399-0039.2000.560606.x","article-title":"Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population","volume":"56","author":"Saito","year":"2000","journal-title":"Tissue Antigens"},{"key":"B34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/cpt.161","article-title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for human leukocyte antigen B (HLA-B) genotype and allopurinol dosing: 2015 update","volume":"99","author":"Saito","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e94294","DOI":"10.1371\/journal.pone.0094294","article-title":"Cost-Effectiveness Analysis of HLA-B*5801 Testing in Preventing Allopurinol-Induced SJS\/TEN in Thai Population","volume":"9","author":"Saokaew","year":"2014","journal-title":"PLoS ONE"},{"key":"B36","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.humimm.2016.06.022","article-title":"HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia","volume":"77","author":"Tan","year":"2016","journal-title":"Hum. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1097\/FPC.0b013e328330a3b8","article-title":"Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population","volume":"19","author":"Tassaneeyakul","year":"2009","journal-title":"Pharmacogenet. Genom."},{"key":"B38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/FPC.0000000000000211","article-title":"Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population","volume":"26","author":"Tassaneeyakul","year":"2016","journal-title":"Pharmacogenet. Genom."},{"key":"B39","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/j.1528-1167.2010.02533.x","article-title":"Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population","volume":"51","author":"Tassaneeyakul","year":"2010","journal-title":"Epilepsia"},{"key":"B40","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/FPC.0000000000000306","article-title":"Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population","volume":"27","author":"Tempark","year":"2017","journal-title":"Pharmacogenet. Genom."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1038\/srep04862","article-title":"Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement","volume":"4","author":"Ueta","year":"2014","journal-title":"Sci. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1182\/blood-2010-01-266775","article-title":"Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology","volume":"115","author":"Wang","year":"2010","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/tpj.2015.25","article-title":"HLA-B*59:01: a marker for Stevens-Johnson syndrome\/toxic epidermal necrolysis caused by methazolamide in Han Chinese","volume":"16","author":"Yang","year":"2016","journal-title":"Pharmacogenom. J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1399-0039.2008.01178.x","article-title":"Polymorphisms of HLA genes in Western Javanese (Indonesia): close affinities to Southeast Asian populations","volume":"73","author":"Yuliwulandari","year":"2009","journal-title":"Tissue Antigens"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1056\/NEJMoa1213096","article-title":"HLA-B*13:01 and the dapsone hypersensitivity syndrome","volume":"369","author":"Zhang","year":"2013","journal-title":"N. Engl. J. Med."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00277\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T04:24:44Z","timestamp":1533529484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00277\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":45,"alternative-id":["10.3389\/fgene.2018.00277"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2018.00277","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]},"article-number":"277"}}