{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:55:13Z","timestamp":1753890913439,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RL1AG032115","R01 HD036071","R01 AG18442","R01 AG048252"],"award-info":[{"award-number":["RL1AG032115","R01 HD036071","R01 AG18442","R01 AG048252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2018.00327","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T10:01:02Z","timestamp":1537264862000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cognitive Deficits and Associated ERP N400 Abnormalities in FXTAS With Parkinsonism"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiao-Hong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Soohoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devyn","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuja","family":"Yaqub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Doty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qiong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Olichney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1212\/01.wnl.0000338632.00552.cb","article-title":"Cognitive impairment in incident, untreated Parkinson disease The Norwegian ParkWest Study.","volume":"72","author":"Aarsland","year":"2009","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1136\/jnnp-2014-309460","article-title":"Concomitant fragile X-associated tremor ataxia syndrome and Parkinson\u2019s disease: a clinicopathological report of two cases.","volume":"86","author":"De Pablo-Fernandez","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"journal-title":"California Verbal Learning Test.","year":"1987","author":"Delis","key":"B3"},{"key":"B4","first-page":"162","article-title":"Cognitive assessment in closed head-injury - stability, validity and parallel forms for 2 neuropsychological measures of recovery.","volume":"9","author":"Desrosiers","year":"1987","journal-title":"Int. J. Clin. Neuropsychol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B6","article-title":"The birth of the MMS. This Week\u2019s Citation Classic","volume":"2","author":"Folstein","year":"1990"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1093\/brain\/awf184","article-title":"Neuronal intranuclear inclusions in a new cerebellar tremor\/ataxia syndrome among fragile X carriers.","volume":"125","author":"Greco","year":"2002","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-6-28","article-title":"The cognitive neuropsychological phenotype of carriers of the FMR1 premutation.","volume":"6","author":"Grigsby","year":"2014","journal-title":"J. Neurodev. Disord."},{"journal-title":"The Behavioral Dyscontrol Scale: Manual","year":"1996","author":"Grigsby","key":"B9"},{"key":"B10","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S1474-4422(13)70125-X","article-title":"Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor\/ataxia syndrome.","volume":"12","author":"Hagerman","year":"2013","journal-title":"Lancet Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrneurol.2016.82","article-title":"Fragile X-associated tremor\/ataxia syndrome - features, mechanisms and management.","volume":"12","author":"Hagerman","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1006\/nimg.2002.1268","article-title":"N400-like magnetoencephalography responses modulated by semantic context, word frequency, and lexical class in sentences.","volume":"17","author":"Halgren","year":"2002","journal-title":"Neuroimage"},{"key":"B14","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.parkreldis.2008.04.037","article-title":"Parkinsonism in FMR1 premutation carriers may be indistinguishable from Parkinson disease.","volume":"15","author":"Hall","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.parkreldis.2014.04.019","article-title":"Accuracy of clinical-diagnosis of idiopathic Parkinsons-disease - a clinicopathological study of 100 cases.","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/brain\/awh650","article-title":"Protein composition of the intranuclear inclusions of FXTAS.","volume":"129","author":"Iwahashi","year":"2006","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1086\/374321","article-title":"Fragile X premutation tremor\/ataxia syndrome: molecular, clinical, and neuroimaging correlates.","volume":"72","author":"Jacquemont","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/GIM.0b013e3182064362","article-title":"Evidence for the toxicity of bidirectional transcripts and mitochondrial dysfunction in blood associated with small CGG expansions in the FMR1 gene in patients with parkinsonism.","volume":"13","author":"Loesch","year":"2011","journal-title":"Genet. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1385\/NMM:4:1-2:95","article-title":"Role for the ubiquitin-proteasome system in Parkinson\u2019s disease and other neurodegenerative brain amyloidoses.","volume":"4","author":"Moore","year":"2003","journal-title":"Neuromol. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1212\/01.wnl.0000180516.69442.95","article-title":"Cognitive profile of patients with newly diagnosed Parkinson disease.","volume":"65","author":"Muslimovic","year":"2005","journal-title":"Neurology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.parkreldis.2014.01.006","article-title":"Parkinsonism in fragile X-associated tremor\/ataxia syndrome (FXTAS): revisited.","volume":"20","author":"Niu","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"B22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/372260a0","article-title":"Word recognition in the human inferior temporal lobe.","volume":"372","author":"Nobre","year":"1994","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/brain\/awq077","article-title":"Abnormal N400 word repetition effects in fragile X-associated tremor\/ataxia syndrome.","volume":"133","author":"Olichney","year":"2010","journal-title":"Brain"},{"journal-title":"A Compendium of Neuropsychological Tests","year":"1998","author":"Spreen","key":"B24"},{"key":"B25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1086\/302720","article-title":"Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.","volume":"66","author":"Tassone","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2353\/jmoldx.2008.070073","article-title":"A rapid polymerase chain reaction-based screening method for identification of all expanded alleles of the fragile x (FMR1) gene in newborn and high-risk populations.","volume":"10","author":"Tassone","year":"2008","journal-title":"J. Mol. Diagn."},{"key":"B27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000356190","article-title":"White matter changes in patients with Parkinson\u2019s disease carrying small CGG expansion FMR1 alleles: a pilot study.","volume":"14","author":"Trost","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00297","article-title":"Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding.","volume":"6","author":"Wang","year":"2012","journal-title":"Front. Hum. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-6-30","article-title":"Associated features in females with an FMR1 premutation.","volume":"6","author":"Wheeler","year":"2014","journal-title":"J. Neurodev. Disord."},{"key":"B30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuropsychologia.2014.08.001","article-title":"ERP abnormalities elicited by word repetition in fragile X-associated tremor\/ataxia syndrome (FXTAS) and amnestic MCI.","volume":"63","author":"Yang","year":"","journal-title":"Neuropsychologia"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1038\/npp.2014.122","article-title":"Memantine effects on verbal memory in Fragile X-associated Tremor\/Ataxia Syndrome (FXTAS): a double-blind brain potential study.","volume":"39","author":"Yang","year":"","journal-title":"Neuropsychopharmacology"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00327\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T10:01:03Z","timestamp":1537264863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00327\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,18]]},"references-count":31,"alternative-id":["10.3389\/fgene.2018.00327"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2018.00327","relation":{},"ISSN":["1664-8021"],"issn-type":[{"type":"electronic","value":"1664-8021"}],"subject":[],"published":{"date-parts":[[2018,9,18]]},"article-number":"327"}}