{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:29:50Z","timestamp":1787909390741,"version":"build-2784847793"},"reference-count":181,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2018.00575","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T08:17:32Z","timestamp":1543306652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa"],"prefix":"10.3389","volume":"9","author":[{"given":"Saikou Y.","family":"Bah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins Misita","family":"Morang\u2019a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas A.","family":"Kengne-Ouafo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Amenga\u2013Etego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Awandare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.1115030","article-title":"Long-term transmission of defective RNA viruses in humans and aedes mosquitoes.","volume":"311","author":"Aaskov","year":"2006","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000741","article-title":"Global elimination of lymphatic filariasis: addressing the public health problem.","volume":"4","author":"Addiss","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-9-10","article-title":"H3Africa: a tipping point for a revolution in bioinformatics, genomics and health research in Africa.","volume":"9","author":"Adoga","year":"2014","journal-title":"Source Code Biol. Med. BioMed Central"},{"key":"B4","first-page":"12","article-title":"\u201cPhylogenetic analysis of dengue viruses using bioinformatics techniques,\u201d in","author":"Ahn","year":"2015","journal-title":"Paper Presented at the Bioscience and Medical Research 2015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114401","article-title":"Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.","volume":"9","author":"Almelli","year":"2014","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1179\/136485908X337436","article-title":"The african programme for onchocerciasis control (APOC).","author":"Amazigo","year":"2008","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1056\/NEJMoa1303657","article-title":"Diagnosis of childhood tuberculosis and host RNA expression in Africa.","volume":"370","author":"Anderson","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1089\/omi.2016.0058","article-title":"Transcriptomic analysis of chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum: toward malaria diagnostics and therapeutics for global health.","volume":"20","author":"Antony","year":"2016","journal-title":"OMICS"},{"key":"B9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1074\/mcp.M115.055640","article-title":"Stage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle.","volume":"15","author":"Armstrong","year":"2016","journal-title":"Mol. Cell. Proteom."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032891","article-title":"Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.","volume":"7","author":"Auburn","year":"2012","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004929","article-title":"The effects of ivermectin on Brugia malayi females in vitro: a transcriptomic approach.","volume":"10","author":"Ballesteros","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pt.2017.09.003","article-title":"Mining filarial genomes for diagnostic and therapeutic targets.","volume":"34","author":"Bennuru","year":"2017","journal-title":"Trends Parasitol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1093\/nar\/gki063","article-title":"GenBank.","volume":"33","author":"Benson","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.","volume":"466","author":"Berry","year":"2010","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12038-007-0004-5","article-title":"A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes.","volume":"32","author":"Bhasin","year":"2007","journal-title":"J. Biosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/bib\/bbu022","article-title":"Bioinformatics education-perspectives and challenges out of Africa.","volume":"16","author":"Bishop","year":"2015","journal-title":"Brief. Bioinform."},{"key":"B18","first-page":"1","article-title":"Special report: genotyping for cytochrome P450 polymorphisms to determine drug-metabolizer status.","volume":"19","year":"2004","journal-title":"Technol. Eval. Cent. Assess. Program Exec. Summ."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003293","article-title":"Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.","volume":"9","author":"Bopp","year":"2013","journal-title":"PLoS Genet."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000005","article-title":"The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum.","volume":"1","author":"Bozdech","year":"2003","journal-title":"PLoS Biol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10063","article-title":"Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.","volume":"6","author":"Bradley","year":"2015","journal-title":"Nat. Commun."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005673","article-title":"Flavivirus and filovirus evoprinters: new alignment tools for the comparative analysis of viral evolution.","volume":"11","author":"Brody","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-11-r128","article-title":"Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum.","volume":"14","author":"Bunnik","year":"2013","journal-title":"Genome Biol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04106","article-title":"Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages.","volume":"3","author":"Caro","year":"2014","journal-title":"eLife"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1204-4","article-title":"Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance.","volume":"18","author":"Cerqueira","year":"2017","journal-title":"Genome Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/infdis\/jiw212","article-title":"Familial aggregation and heritability of Wuchereria bancrofti infection.","volume":"214","author":"Chesnais","year":"2016","journal-title":"J. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4122","DOI":"10.1128\/AAC.01833-10","article-title":"The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.","volume":"55","author":"Chigutsa","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001409","article-title":"A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi.","volume":"5","author":"Choi","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.207","article-title":"Genomic diversity in Onchocerca volvulus and its Wolbachia endosymbiont.","volume":"2","author":"Choi","year":"2016","journal-title":"Nat. Microbiol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1093\/bioinformatics\/bts544","article-title":"SpolPred: rapid and accurate prediction of Mycobacterium tuberculosis spoligotypes from short genomic sequences.","volume":"28","author":"Coll","year":"2012","journal-title":"Bioinformatics"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0164-0","article-title":"Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences.","volume":"7","author":"Coll","year":"2015","journal-title":"Genome Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41588-017-0029-0","article-title":"Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.","volume":"50","author":"Coll","year":"2018","journal-title":"Nat. Genet."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.216","article-title":"The genome of Onchocerca volvulus, agent of river blindness.","volume":"2","author":"Cotton","year":"2016","journal-title":"Nat. Microbiol."},{"key":"B35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4269\/ajtmh.2004.70.180","article-title":"A family study of lymphedema of the leg in a lymphatic filariasis-endemic area.","volume":"70","author":"Cuenco","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/371707a0","article-title":"Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans.","volume":"371","author":"Cully","year":"1994","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/ng.3248","article-title":"Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.","volume":"47","author":"Curtis","year":"2015","journal-title":"Nat. Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/jac\/dkr173","article-title":"Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs.","volume":"66","author":"da Silva","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"B39","first-page":"193","article-title":"Genotyping for cytochrome P450 polymorphisms.","volume":"320","author":"Daly","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5863\/1551-6776-19.4.325","article-title":"Severe malaria complicated by G6PD deficiency in a pediatric tanzanian immigrant.","volume":"19","author":"Damhoff","year":"2014","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-15-58","article-title":"A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1in Thai patients with dengue shock syndrome.","volume":"15","author":"Dang","year":"2014","journal-title":"BMC Med. Genet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1586\/14787210.2016.1141676","article-title":"Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis.","volume":"14","author":"Dapat","year":"2016","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.trstmh.2007.08.013","article-title":"Podoconiosis: non-infectious geochemical elephantiasis.","volume":"101","author":"Davey","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"B44","doi-asserted-by":"publisher","first-page":"7496","DOI":"10.1016\/j.vaccine.2015.09.059","article-title":"Large screen approaches to identify novel malaria vaccine candidates.","volume":"33","author":"Davies","year":"2015","journal-title":"Vaccine"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.1128\/JVI.02677-14","article-title":"Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication.","volume":"89","author":"de Borba","year":"2015","journal-title":"J. Virol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.meegid.2017.11.009","article-title":"Host genetics and dengue fever.","volume":"56","author":"de Carvalho","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.coph.2008.08.002","article-title":"Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates.","volume":"8","author":"De Groot","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans.","volume":"45","author":"Desjardins","year":"2013","journal-title":"Nat. Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.ijpara.2014.07.010","article-title":"Genome-based vaccine design: the promise for malaria and other infectious diseases.","volume":"44","author":"Doolan","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005816","article-title":"Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.","volume":"11","author":"Doyle","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1746-3","article-title":"Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.","volume":"16","author":"Duffy","year":"2015","journal-title":"BMC Genomics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1111\/mec.14066","article-title":"Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.","volume":"26","author":"Duffy","year":"2017","journal-title":"Mol. Ecol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15152-8","article-title":"Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil.","volume":"7","author":"Faria","year":"2017","journal-title":"Sci. Rep."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003516","article-title":"Computational biology and bioinformatics in nigeria.","volume":"10","author":"Fatumo","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1128\/JCM.00025-15","article-title":"PhyResSE: a web tool delineating Mycobacterium tuberculosis antibiotic resistance and lineage from whole-genome sequencing data.","volume":"53","author":"Feuerriegel","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00278","article-title":"The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design.","volume":"8","author":"Fleri","year":"2017","journal-title":"Front. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/ng.2656","article-title":"Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.","volume":"45","author":"Ford","year":"2013","journal-title":"Nat. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.virol.2011.10.025","article-title":"Composition of the sequence downstream of the dengue virus 5\u2032 cyclization sequence (dCS) affects viral RNA replication.","volume":"422","author":"Friebe","year":"2012","journal-title":"Virology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.3390\/v3091739","article-title":"Functional RNA elements in the dengue virus genome.","volume":"3","author":"Gebhard","year":"2011","journal-title":"Viruses"},{"key":"B60","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3855\/jidc.4696","article-title":"Low rifampicin concentrations in tuberculosis patients with HIV infection.","volume":"8","author":"Gengiah","year":"2014","journal-title":"J. Infect. Dev. Ctries."},{"key":"B61","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(08)60238-X","article-title":"Pathogenic flaviviruses.","volume":"371","author":"Gould","year":"2008","journal-title":"Lancet"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1016\/j.vaccine.2013.06.046","article-title":"Proteins as T cell antigens: methods for high-throughput identification.","volume":"31","author":"Grubaugh","year":"2013","journal-title":"Vaccine"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05166","article-title":"Large-scale whole genome sequencing of M. tuberculosis provides insights into transmission in a high prevalence area.","volume":"4","author":"Guerra-Assun\u00e7\u00e3o","year":"2015","journal-title":"eLife"},{"key":"B64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molbiopara.2004.03.015","article-title":"A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling.","volume":"136","author":"Guiliano","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005715","article-title":"Designing a course model for distance-based online bioinformatics training in Africa: the H3ABioNet experience.","volume":"13","author":"Gurwitz","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-med-091014-090848","article-title":"Vaccination against dengue: challenges and current developments.","volume":"67","author":"Guy","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"B67","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.1251546","article-title":"Research capacity. Enabling the genomic revolution in Africa.","volume":"344","author":"Rotimi","year":"2014","journal-title":"Science"},{"key":"B68","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJMp1006304","article-title":"The path to personalized medicine.","volume":"363","author":"Hamburg","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B69","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The Gene Ontology (GO) database and informatics resource.","volume":"32","author":"Harris","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B70","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ddr.21049","article-title":"Omics-based systems vaccinology for vaccine target identification.","volume":"73","author":"He","year":"2012","journal-title":"Drug Dev. Res."},{"key":"B71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/v9050097","article-title":"Historical perspectives on flavivirus research.","volume":"9","author":"Holbrook","year":"2017","journal-title":"Viruses"},{"key":"B72","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s41588-018-0117-9","article-title":"Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.","volume":"50","author":"Holt","year":"2018","journal-title":"Nat. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ebiom.2016.04.011","article-title":"Integrated analysis of the Plasmodium species transcriptome.","volume":"7","author":"Hoo","year":"2016","journal-title":"EBioMedicine"},{"key":"B74","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-007-0157-6","article-title":"Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis.","volume":"85","author":"Jacobsen","year":"2007","journal-title":"J. Mol. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1128\/JCM.01726-14","article-title":"Whole-genome sequencing of the Mycobacterium tuberculosis manila Sublineage results in less clustering and better resolution than Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and Spoligotyping.","volume":"52","author":"Jamieson","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes.","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00436-010-1932-9","article-title":"Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis.","volume":"107","author":"Junpee","year":"2010","journal-title":"Parasitol. Res."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001538","article-title":"Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.","volume":"10","author":"Kaforou","year":"2013","journal-title":"PLoS Med."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00022","article-title":"Systematic identification of anti-fungal drug targets by a metabolic network approach.","volume":"3","author":"Kaltdorf","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004308","article-title":"Bioinformatics in africa: the rise of ghana?","volume":"11","author":"Karikari","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"B81","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.atg.2015.10.002","article-title":"Developing expertise in bioinformatics for biomedical research in Africa.","volume":"6","author":"Karikari","year":"2015","journal-title":"Appl. Transl. Genomics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/ng.960","article-title":"Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.","volume":"43","author":"Khor","year":"2011","journal-title":"Nat. Genet."},{"key":"B83","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1056\/NEJMc1215305","article-title":"Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis.","volume":"369","author":"K\u00f6ser","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001189","article-title":"Mining predicted essential genes of Brugia malayi for nematode drug targets.","volume":"2","author":"Kumar","year":"2007","journal-title":"PLoS One"},{"key":"B85","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1093\/inthealth\/ihv007","article-title":"Malaria genomics: tracking a diverse and evolving parasite population.","volume":"7","author":"Kwiatkowski","year":"2015","journal-title":"Int. Health"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar3619","article-title":"Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.","volume":"10","author":"Lee","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153079","article-title":"The host response to a clinical MDR mycobacterial strain cultured in a detergent-free environment: a global transcriptomics approach.","volume":"11","author":"Leisching","year":"2016","journal-title":"PLoS One"},{"key":"B88","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.tube.2011.07.002","article-title":"Transcriptional responses of host peripheral blood cells to tuberculosis infection.","volume":"91","author":"Lesho","year":"2011","journal-title":"Tuberculosis"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-267","article-title":"Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3.","volume":"10","author":"Li","year":"2009","journal-title":"BMC Genomics"},{"key":"B90","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.virol.2014.08.013","article-title":"Sub-genomic RNA of defective interfering (D.I.) dengue viral particles is replicated in the same manner as full length genomes.","author":"Li","year":"2014","journal-title":"Virology"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019447","article-title":"Defective interfering viral particles in acute dengue infections.","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"B92","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/nar\/gkj517","article-title":"Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains.","volume":"34","author":"Llin\u00e1s","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1093\/infdis\/jiw423","article-title":"Current status of dengue therapeutics research and development.","author":"Low","year":"2017","journal-title":"J. Infect. Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ijpddr.2012.07.002","article-title":"In silico prediction of antimalarial drug target candidates.","author":"Ludin","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"B95","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molbiopara.2004.08.003","article-title":"RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting.","volume":"138","author":"Lustigman","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"B96","first-page":"4517","article-title":"\u201cGlucose 6-phosphate dehydrogenase deficiency,\u201d in","author":"Luzatto","year":"2001","journal-title":"The Metabolic and Molecular Bases of Inherited Disease"},{"key":"B97","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/bjh.12665","article-title":"G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications.","volume":"164","author":"Luzzatto","year":"2014","journal-title":"Br. J. Haematol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"86","DOI":"10.15252\/emmm.201505790","article-title":"Concise gene signature for point-of-care classification of tuberculosis.","volume":"8","author":"Maertzdorf","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026938","article-title":"Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis.","volume":"6","author":"Maertzdorf","year":"2011","journal-title":"PLoS One"},{"key":"B100","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature15390","article-title":"A novel locus of resistance to severe malaria in a region of ancient balancing selection.","volume":"526","year":"2015","journal-title":"Nature"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08714","article-title":"Genomic epidemiology of artemisinin resistant malaria.","volume":"5","year":"2016","journal-title":"eLife"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-37","article-title":"Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from Kerala.","volume":"10","author":"Manakkadan","year":"2013","journal-title":"Virol. J."},{"key":"B103","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nature11174","article-title":"Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.","volume":"487","author":"Manske","year":"2012","journal-title":"Nature"},{"key":"B104","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1517\/14712598.2.8.895","article-title":"Reverse vaccinology: a genome-based approach for vaccine development.","volume":"2","author":"Masignani","year":"2002","journal-title":"Expert Opin. Biol. Ther."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112928","article-title":"Marked microevolution of a unique Mycobacterium tuberculosis strain in 17 years of ongoing transmission in a high risk population.","volume":"9","author":"Mehaffy","year":"2014","journal-title":"PLoS One"},{"key":"B106","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/ng.3195","article-title":"Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.","volume":"47","author":"Merker","year":"2015","journal-title":"Nat. Genet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1101\/gr.203711.115","article-title":"Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum.","volume":"26","author":"Miles","year":"2016","journal-title":"Genome Res."},{"key":"B108","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1086\/510397","article-title":"Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.","volume":"195","author":"Mistry","year":"2007","journal-title":"J. Infect. Dis."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1093\/molbev\/msu106","article-title":"genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in west african populations of differing infection endemicity.","volume":"31","author":"Mobegi","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1017\/S0031182011002435","article-title":"Serine protease inhibitors of parasitic helminths.","volume":"139","author":"Molehin","year":"2012","journal-title":"Parasitology"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117849","article-title":"New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences.","volume":"10","author":"Moureau","year":"2015","journal-title":"PLoS One"},{"key":"B112","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.gheart.2017.01.005","article-title":"Development of bioinformatics infrastructure for genomics research.","volume":"12","author":"Mulder","year":"2017","journal-title":"Glob. Heart"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004395","article-title":"The development of computational biology in south africa: successes achieved and lessons learnt.","volume":"12","author":"Mulder","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02724-x","article-title":"High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology.","volume":"7","author":"Nag","year":"2017","journal-title":"Sci. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.molbiopara.2012.05.005","article-title":"Single nucleotide polymorphisms in beta-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: possible indication of resistance selection.","volume":"185","author":"Nana-Djeunga","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002824","article-title":"Reproductive status of Onchocerca volvulus after ivermectin treatment in an ivermectin-na\u00efve and a frequently treated population from cameroon.","volume":"8","author":"Nana-Djeunga","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006144","article-title":"Cloud computing applications for biomedical science: a perspective.","volume":"14","author":"Navale","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ijpddr.2016.09.005","article-title":"Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq.","volume":"6","author":"O\u2019Neill","year":"","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004698","article-title":"An in vitro\/in vivo model to analyze the effects of flubendazole exposure on adult female Brugia malayi.","volume":"10","author":"O\u2019Neill","year":"","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ijpddr.2015.06.002","article-title":"In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi.","volume":"5","author":"O\u2019Neill","year":"2015","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"B121","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ijpddr.2012.01.005","article-title":"Genotypic analysis of beta-tubulin in Onchocerca volvulus from communities and individuals showing poor parasitological response to ivermectin treatment.","volume":"2","author":"Osei-Atweneboana","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045839","article-title":"Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.","volume":"7","author":"Ottenhoff","year":"2012","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1365-2958.2009.07026.x","article-title":"New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.","volume":"76","author":"Otto","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/infdis\/jir258","article-title":"Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease.","volume":"204","author":"Panda","year":"2011","journal-title":"J. Infect. Dis."},{"key":"B125","doi-asserted-by":"publisher","first-page":"8546","DOI":"10.1128\/JVI.00736-12","article-title":"Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity.","volume":"86","author":"Parameswaran","year":"2012","journal-title":"J. Virol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ijpddr.2017.10.006","article-title":"P-glycoproteins play a role in ivermectin resistance in cyathostomins.","volume":"7","author":"Peachey","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"B127","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0035-9203(76)90078-X","article-title":"The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks.","volume":"70","author":"Price","year":"1976","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00741","article-title":"The case for a rational genome-based vaccine against malaria.","volume":"5","author":"Proietti","year":"2015","journal-title":"Front. Microbiol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"15066","DOI":"10.1073\/pnas.1206598109","article-title":"Unifying the spatial epidemiology and molecular evolution of emerging epidemics.","volume":"109","author":"Pybus","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B130","doi-asserted-by":"publisher","first-page":"4752","DOI":"10.1093\/hmg\/ddx365","article-title":"Discovery of susceptibility loci associated with tuberculosis in Han Chinese.","volume":"26","author":"Qi","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B131","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1039\/C6MB00115G","article-title":"Next generation sequencing: implications in personalized medicine and pharmacogenomics.","volume":"12","author":"Rabbani","year":"2016","journal-title":"Mol. Biosyst."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.5588\/ijtld.15.1007","article-title":"SLCO1B1 gene polymorphisms do not influence plasma rifampicin concentrations in a South Indian population.","volume":"20","author":"Ramesh","year":"2016","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"B133","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/molbev\/mst203","article-title":"Reconciling phylodynamics with epidemiology: the case of dengue virus in southern vietnam.","volume":"31","author":"Rasmussen","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"B134","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00251-004-0709-7","article-title":"Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles.","volume":"56","author":"Reche","year":"2004","journal-title":"Immunogenetics"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33105","article-title":"Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.","volume":"7","author":"Reid","year":"2018","journal-title":"Elife"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023204","article-title":"Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients.","volume":"6","author":"Robinson","year":"2011","journal-title":"PLoS One"},{"key":"B137","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network.","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins"},{"key":"B138","article-title":"\u201cBcePred: prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties,\u201d in","author":"Saha","year":"2004","journal-title":"Proceedings of the 3rd International Conference Artificial Immune Systems, ICARIS 2004"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000121","article-title":"Temperature shift and host cell contact up-regulate sporozoite expression of Plasmodium falciparum genes involved in hepatocyte infection.","volume":"4","author":"Siau","year":"2008","journal-title":"PLoS Pathog."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00210-17","article-title":"Genetic determinants of the pharmacokinetic variability of rifampin in malawian adults with pulmonary tuberculosis.","volume":"61","author":"Sloan","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1111\/mec.13574","article-title":"Population genomics of the filarial nematode parasite Wuchereria bancrofti from mosquitoes.","volume":"25","author":"Small","year":"2016","journal-title":"Mol. Ecol."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4988-z","article-title":"Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data.","volume":"19","author":"Sobkowiak","year":"2018","journal-title":"BMC Genomics"},{"key":"B143","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ajhg.2016.01.015","article-title":"A locus at 5q33.3 confers resistance to tuberculosis in highly susceptible individuals.","volume":"98","author":"Sobota","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B144","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.lungcan.2016.04.026","article-title":"Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients.","volume":"107","author":"Sorber","year":"2017","journal-title":"Lung Cancer"},{"key":"B145","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.jbi.2014.11.003","article-title":"An overview of bioinformatics tools for epitope prediction: implications on vaccine development.","volume":"53","author":"Soria-Guerra","year":"2015","journal-title":"J. Biomed. Inform."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"B147","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates.","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1093\/infdis\/jiu601","article-title":"Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing.","volume":"211","author":"Stucki","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1093\/infdis\/jis601","article-title":"Dynamic population changes in mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.","volume":"206","author":"Sun","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B150","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ng.3498","article-title":"HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.","volume":"48","author":"Sveinbjornsson","year":"2016","journal-title":"Nat. Genet."},{"key":"B151","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1073\/pnas.0710780104","article-title":"A combined transcriptome and proteome survey of malaria parasite liver stages.","volume":"105","author":"Tarun","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B152","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1749-6632.2003.tb07409.x","article-title":"Wolbachia in the inflammatory pathogenesis of human filariasis.","volume":"990","author":"Taylor","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B153","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(10)60586-7","article-title":"Lymphatic filariasis and onchocerciasis.","volume":"376","author":"Taylor","year":"2010","journal-title":"Lancet"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1056\/NEJMoa1108448","article-title":"HLA class II locus and susceptibility to podoconiosis.","volume":"366","author":"Tekola Ayele","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1128\/JVI.05985-11","article-title":"High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections.","volume":"86","author":"Thai","year":"2012","journal-title":"J. Virol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tube.2017.08.004","article-title":"Host blood RNA signatures predict the outcome of tuberculosis treatment.","volume":"107","author":"Thompson","year":"2017","journal-title":"Tuberculosis"},{"key":"B157","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/ng.1080","article-title":"Common variants at 11p13 are associated with susceptibility to tuberculosis.","volume":"44","author":"Thye","year":"2012","journal-title":"Nat. Genet."},{"key":"B158","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/ng.639","article-title":"Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.","volume":"42","author":"Thye","year":"2010","journal-title":"Nat. Genet."},{"key":"B159","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/gene.2015.21","article-title":"Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment.","volume":"16","author":"Tientcheu","year":"2015","journal-title":"Genes Immun."},{"key":"B160","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature11334","article-title":"Genome-wide association study indicates two novel resistance loci for severe malaria.","volume":"489","author":"Timmann","year":"2012","journal-title":"Nature"},{"key":"B161","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ijbiomac.2016.12.045","article-title":"Genome analysis of Chlamydia trachomatis for functional characterization of hypothetical proteins to discover novel drug targets.","volume":"96","author":"Turab Naqvi","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.03.041","article-title":"Evaluation of whole genome sequencing and software tools for drug susceptibility testing of Mycobacterium tuberculosis.","author":"van Beek","year":"2018","journal-title":"Clin. Microbiol. Infecti."},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-74","article-title":"A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children.","volume":"14","author":"Verhagen","year":"2013","journal-title":"BMC Genomics"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004604","article-title":"Dengue virus RNA structure specialization facilitates host adaptation.","volume":"11","author":"Villordo","year":"2015","journal-title":"PLoS Pathog."},{"key":"B165","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S1473-3099(15)00062-6","article-title":"Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.","volume":"15","author":"Walker","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2326","article-title":"Analysis of genotype diversity and evolution of Dengue virus serotype 2 using complete genomes.","volume":"4","author":"Waman","year":"2016","journal-title":"PeerJ"},{"key":"B167","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.1128\/AAC.00353-10","article-title":"Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.","volume":"54","author":"Weiner","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059067","article-title":"Genetic variants of MICB and PLCE1 and associations with non-severe dengue.","volume":"8","author":"Whitehorn","year":"2013","journal-title":"PLoS One"},{"key":"B169","year":"2017","journal-title":"WHO Dengue and Severe Dengue."},{"key":"B170","year":"","journal-title":"Global Tuberculosis Report 2018."},{"key":"B171","first-page":"1","year":"","journal-title":"World Malaria Day 2018: Ready to Beat Malaria."},{"key":"B172","first-page":"441","article-title":"Global programme to eliminate lymphatic filariasis: progress report, 2015.","volume":"39","year":"2016","journal-title":"Wkly. Epidemiol. Rec."},{"key":"B173","first-page":"1","year":"2018"},{"key":"B174","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2174\/1568026617666161116143440","article-title":"Bioinformatics and drug discovery.","volume":"17","author":"Xia","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1101\/gr.158980.113","article-title":"Interactive transcriptome analysis of malaria patients and infecting Plasmodium falciparum.","volume":"24","author":"Yamagishi","year":"2014","journal-title":"Genome Res."},{"key":"B176","first-page":"3","article-title":"\u2018Omics\u2019 in pharmaceutical research: overview, applications, challenges, and future perspectives.","volume":"13","author":"Yan","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"B177","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molbiopara.2005.05.007","article-title":"The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.","volume":"143","author":"Young","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01519-15","article-title":"Draft genome sequence of Mycobacterium tuberculosis KT-0204 isolated in South Korea.","volume":"4","author":"Yun","year":"2016","journal-title":"Genome Announc."},{"key":"B179","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study.","volume":"387","author":"Zak","year":"2016","journal-title":"Lancet"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ng.2735","article-title":"Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.","volume":"45","author":"Zhang","year":"2013","journal-title":"Nat. Genet."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/srep20498","article-title":"New insights into the Plasmodium vivax transcriptome using RNA-Seq.","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00575\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T08:17:38Z","timestamp":1543306658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2018.00575\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":181,"alternative-id":["10.3389\/fgene.2018.00575"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2018.00575","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"article-number":"575"}}