{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:34:36Z","timestamp":1787726076889,"version":"build-2784847793"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.00563","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:06:41Z","timestamp":1560319601000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["MiR-30e-5p and MiR-15a-5p Expressions in Plasma and Urine of Type 1 Diabetic Patients With Diabetic Kidney Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Cristine","family":"Dieter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00eds Silveira","family":"Assmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Rodrigues","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Henrique","family":"Canani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Marmontel","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Carla","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Crispim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018.","volume":"41","year":"2018","journal-title":"Diabetes Care"},{"key":"B2","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/ki.2013.243","article-title":"Comments on KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease\u2019.","volume":"84","author":"Andrassy","year":"2013","journal-title":"Kidney Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1530\/EJE-13-0963","article-title":"Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus.","volume":"170","author":"Assmann","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00592-018-1216-x","article-title":"Circulating miRNAs in diabetic kidney disease: case-control study and in silico analyses.","volume":"56","author":"Assmann","year":"","journal-title":"Acta Diabetol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.mce.2018.06.005","article-title":"MicroRNAs and diabetic kidney disease: systematic review and bioinformatic analysis.","volume":"477","author":"Assmann","year":"","journal-title":"Mol. Cell. Endocrinol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1530\/EC-17-0248","article-title":"MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis.","volume":"6","author":"Assmann","year":"2017","journal-title":"Endocr. Connect."},{"key":"B7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cmet.2005.06.002","article-title":"Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.","volume":"2","author":"Brand","year":"2005","journal-title":"Cell Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3390\/genes4040596","article-title":"The genetics of diabetic nephropathy.","volume":"4","author":"Brennan","year":"2013","journal-title":"Genes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism.","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1373\/clinchem.2017.274175","article-title":"Identification, confirmation, and replication of novel urinary microrna biomarkers in lupus nephritis and diabetic nephropathy.","volume":"63","author":"Cardenas-Gonzalez","year":"2017","journal-title":"Clin. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1681\/ASN.2013010060","article-title":"Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury.","volume":"24","author":"Chai","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3109\/0886022X.2014.930650","article-title":"Downregulation of uncoupling protein-2 by genipin exacerbates diabetes-induced kidney proximal tubular cells apoptosis.","volume":"36","author":"Chen","year":"2014","journal-title":"Ren. Fail."},{"key":"B14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.kint.2016.02.043","article-title":"Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease.","volume":"90","author":"Coughlan","year":"2016","journal-title":"Kidney Int."},{"key":"B15","doi-asserted-by":"publisher","first-page":"26268","DOI":"10.1074\/jbc.M202535200","article-title":"No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.","volume":"277","author":"Couplan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1365-2265.2009.03684.x","article-title":"Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus.","volume":"72","author":"Crispim","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132938","article-title":"Polymorphisms of the UCP2 gene are associated with glomerular filtration rate in type 2 diabetic patients and with decreased UCP2 gene expression in human kidney.","volume":"10","author":"de Souza","year":"2015","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150154","article-title":"Urinary exosomal miRNA signature in Type II diabetic nephropathy patients.","volume":"11","author":"Delic","year":"2016","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1161\/HYPERTENSIONAHA.111.00101","article-title":"Differential modulation of uncoupling protein 2 in kidneys of stroke-prone spontaneously hypertensive rats under high-salt\/low-potassium diet.","volume":"61","author":"Di Castro","year":"2013","journal-title":"Hypertension"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1172\/JCI66218","article-title":"AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.","volume":"123","author":"Dugan","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/cdd.2014.226","article-title":"TSPYL2 is an essential component of the REST\/NRSF transcriptional complex for TGFbeta signaling activation.","volume":"22","author":"Epping","year":"2015","journal-title":"Cell Death Differ."},{"key":"B22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jmb.2010.07.051","article-title":"The miR-15\/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.","volume":"402","author":"Finnerty","year":"2010","journal-title":"J. Mol. Biol."},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1186\/1743-7075-3-38","article-title":"Uncoupling proteins, dietary fat and the metabolic syndrome.","volume":"3","author":"Fisler","year":"2006","journal-title":"Nutr. Metab."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-015-0047-y","article-title":"Circulating micrornas associated with glycemic impairment and progression in Asian Indians.","volume":"3","author":"Flowers","year":"2015","journal-title":"Biomark Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications.","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"B26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment.","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"B27","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1006\/bbrc.2002.6475","article-title":"MUC17, a novel membrane-tethered mucin.","volume":"291","author":"Gum","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"F589","DOI":"10.1152\/ajprenal.00486.2016","article-title":"MicroRNA-30e targets BNIP3L to protect against aldosterone-induced podocyte apoptosis and mitochondrial dysfunction.","volume":"312","author":"Guo","year":"2017","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/ki.2013.80","article-title":"A microRNA-30e\/mitochondrial uncoupling protein 2 axis mediates TGF-beta1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis.","volume":"84","author":"Jiang","year":"2013","journal-title":"Kidney Int."},{"key":"B30","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","article-title":"A glimpse of various pathogenetic mechanisms of diabetic nephropathy.","volume":"6","author":"Kanwar","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/nyas.12758","article-title":"MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets.","volume":"1353","author":"Kato","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1261\/rna.058834.116","article-title":"Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease.","volume":"23","author":"Khurana","year":"2017","journal-title":"RNA"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082160","article-title":"CyTargetLinker: a cytoscape app to integrate regulatory interactions in network analysis.","volume":"8","author":"Kutmon","year":"2013","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.biocel.2010.03.001","article-title":"Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis.","volume":"42","author":"Luu","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks.","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"B37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1113\/eph8802502","article-title":"The \u2018novel\u2019 \u2018uncoupling\u2019 proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.","volume":"88","author":"Nedergaard","year":"2003","journal-title":"Exp. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1101\/gr.154872.113","article-title":"Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.","volume":"23","author":"Neyret-Kahn","year":"2013","journal-title":"Genome Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00125-009-1555-9","article-title":"Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-beta in a murine diabetic model of atherosclerosis.","volume":"53","author":"Pham","year":"2010","journal-title":"Diabetologia"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041391","article-title":"Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice.","volume":"7","author":"Qiu","year":"2012","journal-title":"PLoS One"},{"key":"B41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1159\/000324939","article-title":"Clinical manifestation and natural history of diabetic nephropathy.","volume":"170","author":"Ritz","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2337\/diacare.29.1.89","article-title":"Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes.","volume":"29","author":"Rudofsky","year":"2006","journal-title":"Diabetes Care"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks.","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"663","DOI":"10.2337\/db14-0874","article-title":"Mitochondrial hormesis and diabetic complications.","volume":"64","author":"Sharma","year":"2015","journal-title":"Diabetes"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075572","article-title":"Smad2-dependent downregulation of miR-30 is required for TGF-beta-induced apoptosis in podocytes.","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1590\/s0004-27302011000400001","article-title":"The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications.","volume":"55","author":"Souza","year":"2011","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.diabres.2010.11.006","article-title":"MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression.","volume":"91","author":"Sun","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1080\/09168451.2014.936345","article-title":"Down-regulated miR-15a mediates the epithelial-mesenchymal transition in renal tubular epithelial cells promoted by high glucose.","volume":"78","author":"Sun","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021602","article-title":"TSPYL2 is important for G1 checkpoint maintenance upon DNA damage.","volume":"6","author":"Tao","year":"2011","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.18","article-title":"Diabetic kidney disease.","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B51","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jdiacomp.2007.10.003","article-title":"Oxidative stress pathway genes and chronic renal insufficiency in asian indians with type 2 diabetes.","volume":"23","author":"Tiwari","year":"2009","journal-title":"J. Diabetes Complications"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"12","author":"von Elm","year":"2014","journal-title":"Int. J. Surg."},{"key":"B53","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00441-017-2588-x","article-title":"Epigenetics of kidney disease.","volume":"369","author":"Wanner","year":"2017","journal-title":"Cell Tissue Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1681\/ASN.2012111101","article-title":"Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids.","volume":"25","author":"Wu","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1172\/JCI81061","article-title":"MicroRNA-30 family members regulate calcium\/calcineurin signaling in podocytes.","volume":"125","author":"Wu","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6978984","article-title":"Urinary exosomal MicroRNA profiling in incipient type 2 diabetic kidney disease.","volume":"2017","author":"Xie","year":"2017","journal-title":"J. Diabetes Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.3892\/ijmm.2018.3852","article-title":"Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.","volume":"42","author":"Yamada","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"516","DOI":"10.2337\/diacare.20.4.516","article-title":"The receiver operating characteristics curve in the evaluation of a random urine specimen as a screening test for diabetic nephropathy.","volume":"20","author":"Zelmanovitz","year":"1997","journal-title":"Diabetes Care"},{"key":"B59","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1530\/jme-17-0083","article-title":"miR-30e targets GLIPR-2 to modulate diabetic nephropathy: in vitro and in vivo experiments.","volume":"59","author":"Zhao","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00109-017-1547-z","article-title":"Angiotensin II induces calcium\/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members.","volume":"95","author":"Zhao","year":"2017","journal-title":"J. Mol. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1253\/circj.CJ-16-0751","article-title":"Effect of MicroRNA-30e on the behavior of vascular smooth muscle cells via targeting ubiquitin-conjugating enzyme E2I.","volume":"81","author":"Zong","year":"2017","journal-title":"Circ. J."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.00563\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:06:46Z","timestamp":1560319606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.00563\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":61,"alternative-id":["10.3389\/fgene.2019.00563"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.00563","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"article-number":"563"}}