{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:57:44Z","timestamp":1790686664798,"version":"4.1.0"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.00570","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T09:32:53Z","timestamp":1560504773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":156,"title":["Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis"],"prefix":"10.3389","volume":"10","author":[{"given":"Marina V.","family":"Nemtsova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry V.","family":"Zaletaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina V.","family":"Bure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry S.","family":"Mikhaylenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina B.","family":"Kuznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Alekseeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina I.","family":"Beloukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei A.","family":"Deviatkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Lukashev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Andrey A.","family":"Zamyatnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/09674845.2017.1343545","article-title":"Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis.","volume":"74","author":"Abdul-Maksoud","year":"2017","journal-title":"Br. J. Biomed. Sci."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04310-9","article-title":"Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.","volume":"9","author":"Ai","year":"2018","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1002\/art.39123","article-title":"DNA methylome signature in synoviocytes from patients with early rheumatoid arthritis compared to synoviocytes from patients with longstanding rheumatoid arthritis.","volume":"67","author":"Ai","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1136\/annrheumdis-2014-205635","article-title":"Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression.","volume":"75","author":"Angiolilli","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1136\/annrheumdis-2015-209064","article-title":"Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.","volume":"76","author":"Angiolilli","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/6290682","article-title":"The mechanisms underlying chronic inflammation in rheumatoid arthritis from the perspective of the epigenetic landscape.","volume":"2016","author":"Araki","year":"2016","journal-title":"J. Immunol. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/art.39563","article-title":"Histone methylation and STAT3 differentially regulate IL-6-induced MMP gene activation in rheumatoid arthritis synovial fibroblasts.","volume":"68","author":"Araki","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11010-018-3351-7","article-title":"Possible use of miRNAs-146a and -499 expression and their polymorphisms as diagnostic markers for rheumatoid arthritis.","volume":"449","author":"Ayeldeen","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"B9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.32607\/20758251-2016-8-1-21-33","article-title":"MicroRNAs: the role in autoimmune inflammation.","volume":"8","author":"Baulina","year":"2016","journal-title":"Acta Naturae"},{"key":"B10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00005-016-0443-5","article-title":"Significance of polymorphism and expression ofmiR-146a and NFkB1 genetic variants in patients with rheumatoid arthritis.","volume":"64","author":"Bogunia-Kubik","year":"2016","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"B11","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.gene.2015.10.037","article-title":"Identification of differentially methylated regions in new genes associated with knee osteoarthritis.","volume":"576","author":"Bonin","year":"2016","journal-title":"Gene"},{"key":"B12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12016-011-8290-y","article-title":"Autoimmune diseases and polyamines.","volume":"42","author":"Brooks","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0555-z","article-title":"Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNF\u03b1.","volume":"17","author":"Castro-Villegas","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/aps.2011.98","article-title":"Hypomethylation of proximal CpG motif of interleukin-10 promoter regulates its expression in human rheumatoid arthritis.","volume":"32","author":"Chen","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.autrev.2016.09.003","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases.","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060900","article-title":"Rheumatoid arthritis: the stride from research to clinical practice.","volume":"17","author":"Chung","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/eci.12776","article-title":"The role of microRNA-5196 in the pathogenesis of systemic sclerosis.","volume":"47","author":"Ciechomska","year":"2017","journal-title":"Eur. J. Clin. Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1177\/1759720X15598307","article-title":"Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.","volume":"7","author":"Cribbs","year":"2015","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/art.39031","article-title":"Methotrexate restores regulatory T cell function through demethylation of the FoxP3 upstream enhancer in patients with rheumatoid arthritis.","volume":"67","author":"Cribbs","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1002\/art.38715","article-title":"Treg cell function in rheumatoid arthritis is compromised by CTLA-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.","volume":"66","author":"Cribbs","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0748-5","article-title":"Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate.","volume":"17","author":"de Andres","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jaut.2012.12.005","article-title":"Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression.","volume":"41","author":"de la Rica","year":"2013","journal-title":"J. Autoimmun."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/342524","article-title":"Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis.","volume":"2014","author":"Duroux-Richard","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"B24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0959-437X(05)80052-8","article-title":"Role of DNA methylation in the regulation of transcription.","volume":"4","author":"Eden","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1002\/art.39060","article-title":"The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like synoviocytes.","volume":"67","author":"Ekwall","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00109-015-1332-9","article-title":"Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.","volume":"94","author":"Engler","year":"2016","journal-title":"J. Mol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs.","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.semarthrit.2004.08.003","article-title":"Rheumatoid arthritis in american indians and alaska natives: a review of the literature.","volume":"34","author":"Ferucci","year":"2005","journal-title":"Semin. Arthritis Rheum."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1136\/annrheumdis-2012-202815","article-title":"Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis.","volume":"73","author":"Filkov\u00e1","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/ar3615","article-title":"MiRs in RA: possible biomarkers and therapeutic targets.","volume":"14","author":"Filkova","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/B978-1-4377-1738-9.00124-9","author":"Firenstein","year":"2013","journal-title":"Kelley\u2019s Textbook of Rheumatology"},{"key":"B32","first-page":"1661","article-title":"Levels of urinary polyamines in patients with rheumatoid arthritis.","volume":"20","author":"Furumitsu","year":"1993","journal-title":"J. Rheumatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0889-857X(05)70201-5","article-title":"The epidemiology of rheumatoid arthritis.","volume":"27","author":"Gabriel","year":"2001","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-35","article-title":"Epigenetics in the pathogenesis of rheumatoid arthritis.","volume":"12","author":"Glant","year":"2014","journal-title":"BMC Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2217\/epi.15.103","article-title":"Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes.","volume":"8","author":"Glossop","year":"2016","journal-title":"Epigenomics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"8661","DOI":"10.3390\/ijms12128661","article-title":"A concise review on epigenetic regulation: insight into molecular mechanisms.","volume":"12","author":"Golbabapour","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1002\/art.39746","article-title":"LBH gene transcription regulation by the interplay of an enhancer risk allele and DNA methylation in rheumatoid arthritis.","volume":"68","author":"Hammaker","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/ar4158","article-title":"Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation.","volume":"15","author":"Hardy","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"B39","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2174\/1389201019666180417155140","article-title":"Circulating miR-10a as predictor of therapy response in rheumatoid arthritis patients treated with methotrexate.","volume":"19","author":"Hong","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"692","DOI":"10.4161\/rna.8.4.16029","article-title":"Population differences in microRNA expression and biological implications.","volume":"8","author":"Huang","year":"2011","journal-title":"RNA Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/art.22512","article-title":"Histone deacetylase\/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients.","volume":"56","author":"Huber","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B42","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/jcmm.13312","article-title":"Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation.","volume":"22","author":"Hussain","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1093\/hmg\/ddx177","article-title":"Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells.","volume":"26","author":"Juli\u00e0","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.25716","article-title":"Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers.","volume":"6","author":"Juskaite","year":"2017","journal-title":"eLife"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24240-2","article-title":"Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis.","volume":"8","author":"Karouzakis","year":"2018","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.4049\/jimmunol.1400066","article-title":"Epigenome analysis reveals TBX5 as a novel transcription factor involved in the activation of rheumatoid arthritis synovial fibroblasts.","volume":"193","author":"Karouzakis","year":"2014","journal-title":"J. Immunol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/ar3071","article-title":"Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis.","volume":"12","author":"Kawabata","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"D1093","DOI":"10.1093\/nar\/gkr1177","article-title":"MOPED: model organism protein expression database.","volume":"40","author":"Kolker","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/tpj.2015.30","article-title":"Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis.","volume":"16","author":"Krintel","year":"2016","journal-title":"Pharmacogenomics J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nm.2050","article-title":"Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.","volume":"15","author":"Lef\u00e8vre","year":"2009","journal-title":"Nat. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","article-title":"The alternative role of DNA methylation in splicing regulation.","volume":"31","author":"Lev Maor","year":"2015","journal-title":"Trends Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/art.38142","article-title":"A Novel p53\/microRNA-22\/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis.","volume":"66","author":"Lin","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nbt.2487","article-title":"Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.","volume":"31","author":"Liu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5167\/uzh-62509","article-title":"Upregulated MicroRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis.","volume":"2013","author":"Long","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jaut.2009.12.010","article-title":"Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression.","volume":"35","author":"Maciejewska-Rodrigues","year":"2010","journal-title":"J. Autoimmun."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781107415324.004","author":"Melorose","year":"2015","journal-title":"Harrison\u2019s Principles of Internal Medicine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"64","DOI":"10.2174\/2211536611302010007","article-title":"Circulating MicroRNAs as biomarkers for inflammatory diseases.","volume":"2","author":"Mi","year":"2013","journal-title":"MicroRNA"},{"key":"B58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.imlet.2015.05.011","article-title":"MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression.","volume":"166","author":"Miao","year":"","journal-title":"Immunol. Lett."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2015.01.003","article-title":"miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.","volume":"164","author":"Miao","year":"","journal-title":"Immunol. Lett."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00702","article-title":"Long non-coding RNA gaplinc promotes tumor-like biologic behaviors of fibroblast-like synoviocytes as MicroRNA sponging in rheumatoid arthritis patients.","volume":"9","author":"Mo","year":"2018","journal-title":"Front. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jim.2013.10.001","article-title":"High degree of correlation between whole blood and PBMC expression levels of miR-155 and miR-146a in healthy controls and rheumatoid arthritis patients.","author":"Mookherjee","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"B62","doi-asserted-by":"publisher","first-page":"246","DOI":"10.22045\/ibj.2016.01","article-title":"Role of epigenetics in biology and human diseases.","volume":"20","author":"Moosavi","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2474529","article-title":"Rheumatoid arthritis and miRNAs: a critical review through a functional view.","volume":"2018","author":"Moran-Moguel","year":"2018","journal-title":"J. Immunol. Res."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/srep20059","article-title":"A novel NF-\u03baB\/YY1\/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis.","volume":"6","author":"Mu","year":"2016","journal-title":"Sci. Rep."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069118","article-title":"Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis.","volume":"8","author":"Murata","year":"2013","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/ar3013","article-title":"Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis.","volume":"12","author":"Murata","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.4049\/jimmunol.1202572","article-title":"Regulation of DNA methylation in rheumatoid arthritis synoviocytes.","volume":"190","author":"Nakano","year":"","journal-title":"J. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/annrheumdis-2012-201526","article-title":"DNA methylome signature in rheumatoid arthritis.","volume":"72","author":"Nakano","year":"","journal-title":"Ann. Rheum. Dis."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1002\/1529-0131(200012)43:12<2634::aid-anr3>3.0.co;2-1","article-title":"Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression.","volume":"43","author":"Neidhart","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1002\/art.34334","article-title":"Down-regulation of microRNA-34a\u2217 in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance.","volume":"64","author":"Niederer","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1002\/art.23758","article-title":"Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis.","volume":"58","author":"Nile","year":"2008","journal-title":"Arthritis Rheum."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2016.14312","article-title":"Epigenetic biomarkers in rheumatology \u2013 the future?","volume":"146","author":"Ospelt","year":"2016","journal-title":"Swiss Med. Wkly."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1492-9","article-title":"Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis.","volume":"19","author":"Ouboussad","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/annrheumdis-2011-200803","article-title":"Identification of microRNA-221\/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model.","volume":"71","author":"Pandis","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2217\/pme.15.53","article-title":"Integration of genetic and epigenetic markers for risk stratification: opportunities and challenges.","volume":"13","author":"Pashayan","year":"2016","journal-title":"Per. Med."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-7-53","article-title":"Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers.","volume":"7","author":"Rawlings-Goss","year":"2014","journal-title":"BMC Med. Genomics"},{"key":"B77","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat. Genet."},{"key":"B78","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10067-015-2898-x","article-title":"MicroRNAs in rheumatoid arthritis.","volume":"34","author":"Salehi","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.bbadis.2016.11.030","article-title":"Epigenetic dysfunctional diseases and therapy for infection and inflammation.","volume":"1863","author":"Samanta","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"B80","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3109\/s10165-012-0710-1","article-title":"Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation.","volume":"23","author":"Shibuya","year":"2013","journal-title":"Mod. Rheumatol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.autrev.2013.07.003","article-title":"The role of miRNA in inflammation and autoimmunity.","volume":"12","author":"Singh","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.rdc.2014.07.005","article-title":"Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases.","volume":"40","author":"Sparks","year":"2014","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"B83","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/art.30115","article-title":"Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.","volume":"63","author":"Stanczyk","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/art.37872","article-title":"Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.","volume":"65","author":"Stanford","year":"2013","journal-title":"Arthritis Rheum."},{"key":"B85","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/jcb.26205","article-title":"Altered expression of MicroRNAs in rheumatoid arthritis.","volume":"119","author":"Tavasolian","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrm3890","article-title":"Histone core modifications regulating nucleosome structure and dynamics.","volume":"15","author":"Tessarz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070939","article-title":"Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.","volume":"8","author":"Toussirot","year":"2013","journal-title":"PLoS One"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1136\/ard.2010.143040","article-title":"Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis.","volume":"70","author":"Trenkmann","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1093\/rheumatology\/keu380","article-title":"Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study.","volume":"53","author":"van Steenbergen","year":"2014","journal-title":"Rheumatology"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-12","article-title":"Sex differences in rheumatoid arthritis: more than meets the eye.","volume":"7","author":"van Vollenhoven","year":"2009","journal-title":"BMC Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrrheum.2012.237","article-title":"Genetics and epigenetics of rheumatoid arthritis.","volume":"9","author":"Viatte","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrrheum.2015.162","article-title":"Deregulation and therapeutic potential of microRNAs in arthritic diseases.","volume":"12","author":"Vicente","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.bbrc.2014.01.195","article-title":"Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts.","volume":"444","author":"Wada","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s10067-016-3247-4","article-title":"Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF\/TOF.","volume":"35","author":"Wang","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.trsl.2012.04.002","article-title":"Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus.","volume":"160","author":"Wang","year":"2012","journal-title":"Transl. Res."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0575-9","article-title":"Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.","volume":"10","author":"Webster","year":"2018","journal-title":"Genome Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"25533","DOI":"10.1074\/jbc.M709962200","article-title":"Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.","volume":"283","author":"Weinbaum","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124254","article-title":"Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.","volume":"10","author":"Whitaker","year":"2015","journal-title":"PLoS One"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1186\/gm444","article-title":"An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype.","volume":"5","author":"Whitaker","year":"2013","journal-title":"Genome Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.86580","article-title":"Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.","volume":"1","author":"Whitaker","year":"2016","journal-title":"JCI Insight"},{"key":"B101","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0378-5122(00)00118-3","article-title":"Menopause, oestrogens and arthritis.","volume":"35","author":"Wluka","year":"2000","journal-title":"Maturitas"},{"key":"B102","doi-asserted-by":"publisher","first-page":"495","DOI":"10.11817\/j.issn.1672-7347.2015.05.006","article-title":"Single nucleotide polymorphism of miR-149 and susceptibility of rheumatoid arthritis.","volume":"40","author":"Xiao","year":"2015","journal-title":"Zhong Nan Da Xue Xue Bao. Yi Xue Ban"},{"key":"B103","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.3892\/mmr.2015.3642","article-title":"Downregulation of microRNA-221 decreases migration and invasion in fibroblast-like synoviocytes in rheumatoid arthritis.","volume":"12","author":"Yang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/rheumatology\/keu323","article-title":"The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA.","volume":"55","author":"Yarwood","year":"2016","journal-title":"Rheumatology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s13577-017-0179-5","article-title":"LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis.","volume":"31","author":"Ye","year":"2018","journal-title":"Hum. Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.biopha.2017.07.042","article-title":"Elevated microRNA-125b promotes inflammation in rheumatoid arthritis by activation of NF-\u03baB pathway.","volume":"93","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B107","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.intimp.2017.06.021","article-title":"LncRNA HOTAIR alleviates rheumatoid arthritis by targeting miR-138 and inactivating NF-\u03baB pathway.","volume":"50","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"8029","DOI":"10.3892\/mmr.2017.7638","article-title":"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology.","volume":"16","author":"Zheng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1136\/annrheumdis-2013-204377","article-title":"Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis.","volume":"74","author":"Zhou","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164207","article-title":"Demethylation of MicroRNA-124a genes attenuated proliferation of rheumatoid arthritis derived fibroblast-like synoviocytes and synthesis of tumor necrosis Factor-\u03b1.","volume":"11","author":"Zhou","year":"2016","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1136\/annrheumdis-2018-213970","article-title":"Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells.","volume":"78","author":"Zhu","year":"2019","journal-title":"Ann. Rheum. Dis."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.00570\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T23:33:02Z","timestamp":1574983982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.00570\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":111,"alternative-id":["10.3389\/fgene.2019.00570"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.00570","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]},"article-number":"570"}}