{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:48:10Z","timestamp":1790484490488,"version":"4.1.0"},"reference-count":131,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.01092","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T10:56:41Z","timestamp":1573124201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders"],"prefix":"10.3389","volume":"10","author":[{"given":"Huntington","family":"Potter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J.","family":"Chial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julbert","family":"Caneus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihret","family":"Elos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiy","family":"Borysov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoneta","family":"Granic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14645","DOI":"10.1523\/JNEUROSCI.1327-13.2013","article-title":"MiR-26b, upregulated in Alzheimer\u2019s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons","volume":"33","author":"Absalon","year":"2013","journal-title":"J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1093\/hmg\/ddh335","article-title":"Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway","volume":"13","author":"Alderton","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cancergencyto.2003.07.004","article-title":"Molecular cytogenetic parameters in fibroblasts from patients and carriers of xeroderma pigmentosum","volume":"149","author":"Amiel","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mad.2016.03.007","article-title":"Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain","volume":"161","author":"Andriani","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1083\/jcb.147.2.277","article-title":"Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons","volume":"147","author":"Annaert","year":"1999","journal-title":"J. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12035-012-8262-0","article-title":"Cell cycle activation and aneuploid neurons in Alzheimer\u2019s disease","volume":"46","author":"Arendt","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2353\/ajpath.2010.090955","article-title":"Selective cell death of hyperploid neurons in Alzheimer\u2019s disease","volume":"177","author":"Arendt","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.3390\/ijms10041609","article-title":"Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons","volume":"10","author":"Arendt","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/s0140-6736(96)91346-x","article-title":"Apolipoprotein E allele distribution in parents of Down\u2019s syndrome children","volume":"347","author":"Avramopoulos","year":"1996","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/(SICI)1097-0169(1998)39:4<286::AID-CM4>3.0.CO;2-1","article-title":"Depletion of a Drosophila homolog of yeast Sup35p disrupts spindle assembly, chromosome segregation, and cytokinesis during male meiosis","volume":"39","author":"Basu","year":"1998","journal-title":"Cell Motil. Cytoskeleton"},{"key":"B11","doi-asserted-by":"publisher","first-page":"12564","DOI":"10.1073\/pnas.0605177103","article-title":"Neocortical neurogenesis in humans is restricted to development","volume":"103","author":"Bhardwaj","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1590\/1678-4685-GMB-2016-0138","article-title":"Combined association of Presenilin-1 and Apolipoprotein E polymorphisms with maternal meiosis II error in Down syndrome births","volume":"40","author":"Bhaumik","year":"2017","journal-title":"Genet. Mol. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.neurobiolaging.2006.10.027","article-title":"Alzheimer\u2019s presenilin 1 causes chromosome missegregation and aneuploidy","volume":"29","author":"Boeras","year":"2008","journal-title":"Neurobiol Aging"},{"key":"B15","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","article-title":"Human Hippocampal Neurogenesis Persists throughout Aging","volume":"22","author":"Boldrini","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s002940050529","article-title":"Recessive mutations in SUP35 and SUP45 genes coding for translation release factors affect chromosome stability in Saccharomyces cerevisiae","volume":"37","author":"Borchsenius","year":"2000","journal-title":"Curr. Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.4161\/cc.10.9.15478","article-title":"Alzheimer Abeta disrupts the mitotic spindle and directly inhibits mitotic microtubule motors","volume":"10","author":"Borysov","year":"2011","journal-title":"Cell Cycle"},{"key":"B18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/dmm.022558","article-title":"Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death","volume":"9","author":"Bouge","year":"2016","journal-title":"Dis. Model Mech."},{"key":"B19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.semcdb.2013.02.003","article-title":"The genomically mosaic brain: aneuploidy and more in neural diversity and disease","volume":"24","author":"Bushman","year":"2013","journal-title":"Semin Cell Dev. Biol."},{"key":"B20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-1-4939-7280-7_16","article-title":"Using Fluorescence In Situ Hybridization (FISH) Analysis to Measure Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative Diseases","volume-title":"Genomic Mosaicism in Neurons and Other Cell Types.","author":"Caneus","year":"2017"},{"key":"B21","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1091\/mbc.E17-01-0031","article-title":"Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations","volume":"29","author":"Caneus","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1086\/422701","article-title":"Chromosomal instability at common fragile sites in Seckel syndrome","volume":"75","author":"Casper","year":"2004","journal-title":"Am. J. Hum Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e827","DOI":"10.1016\/j.celrep.2018.12.107","article-title":"Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex","author":"Chronister","year":"2019","journal-title":"Cell Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.molcel.2008.10.014","article-title":"FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex","volume":"32","author":"Collis","year":"2008","journal-title":"Mol. Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3233\/JAD-160836","article-title":"Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer\u2019s Disease: The Role of APP","volume":"56","author":"Doran","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1002\/glia.22837","article-title":"Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury","volume":"63","author":"Duan","year":"2015","journal-title":"Glia"},{"key":"B27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ajmg.1320370706","article-title":"The consequences of chromosome imbalance","volume":"7","author":"Epstein","year":"1990","journal-title":"Am. J. Med. Genet. Suppl."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.cell.2014.01.044","article-title":"Neurogenesis in the striatum of the adult human brain","volume":"156","author":"Ernst","year":"2014","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"451","DOI":"10.17265\/2328-2150\/2019.08.001","article-title":"Chromosomal Alterations in Patients with Alzheimer Disease in Manaus, Amazonas, Brazil","volume":"7","author":"Fantin","year":"2019","journal-title":"J. Pharmacy Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1474-9726.2012.00826.x","article-title":"Changes in neuronal DNA content variation in the human brain during aging","volume":"11","author":"Fischer","year":"2012","journal-title":"Aging Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1006\/nbdi.1999.0236","article-title":"Chromosome missegregation and trisomy 21 mosaicism in Alzheimer\u2019s disease","volume":"6","author":"Geller","year":"1999","journal-title":"Neurobiol Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/0006-291x(84)91209-9","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome: sharing of a unique cerebrovascular amyloid fibril protein","volume":"122","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1471-4159.2011.07575.x","article-title":"Twenty years of Alzheimer\u2019s disease-causing mutations","volume":"120","author":"Goate","year":"2012","journal-title":"J. Neurochem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1091\/mbc.E09-10-0850","article-title":"Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP","volume":"21","author":"Granic","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e60718","DOI":"10.1371\/journal.pone.0060718","article-title":"Mitotic spindle defects and chromosome mis-segregation induced by LDL\/cholesterol-implications for Niemann-Pick C1, Alzheimer\u2019s disease, and atherosclerosis","volume":"8","author":"Granic","year":"2013","journal-title":"PloS One"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1172\/JCI20098","article-title":"Neurogenesis and brain injury: managing a renewable resource for repair","volume":"112","author":"Hallbergson","year":"2003","journal-title":"J. Clin. Invest"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/febs.14004","article-title":"The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the \u201camyloid cascade hypothesis\u201d","volume":"284","author":"Hardy","year":"2017","journal-title":"FEBS J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jalz.2014.10.007","article-title":"Down syndrome and Alzheimer\u2019s disease: Common pathways, common goals","volume":"11","author":"Hartley","year":"2015","journal-title":"Alzheimers Dement."},{"key":"B40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1001\/jamaneurol.2018.3616","article-title":"Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years","volume":"76","author":"Hithersay","year":"2019","journal-title":"JAMA Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0168-0102(00)00106-1","article-title":"Familial Alzheimer\u2019s disease-associated mutations block translocation of full-length presenilin 1 to the nuclear envelope","volume":"37","author":"Honda","year":"2000","journal-title":"Neurosci. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/cbf.1840","article-title":"NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity","volume":"30","author":"Hou","year":"2012","journal-title":"Cell Biochem. Funct."},{"key":"B43","doi-asserted-by":"publisher","first-page":"21793","DOI":"10.1038\/srep21793","article-title":"Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus","volume":"6","author":"Ibrahim","year":"2016","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1093\/hmg\/ddp207","article-title":"Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain","volume":"18","author":"Iourov","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.nbd.2009.01.003","article-title":"Aneuploidy in the normal, Alzheimer\u2019s disease and ataxia-telangiectasia brain: differential expression and pathological meaning","volume":"34","author":"Iourov","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.mehy.2006.09.021","article-title":"Ataxia telangiectasia paradox can be explained by chromosome instability at the subtissue level","volume":"68","author":"Iourov","year":"2007","journal-title":"Med. Hypotheses"},{"key":"B47","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000315398","article-title":"Genomic landscape of the Alzheimer\u2019s disease brain: chromosome instability\u2013aneuploidy, but not tetraploidy\u2013mediates neurodegeneration","volume":"8","author":"Iourov","year":"2011","journal-title":"Neurodegener. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000347053","article-title":"Somatic cell genomics of brain disorders: a new opportunity to clarify genetic-environmental interactions","volume":"139","author":"Iourov","year":"2013","journal-title":"Cytogenet Genome Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.mehy.2007.05.037","article-title":"Mosaic X chromosome aneuploidy can help to explain the male-to-female ratio in autism","volume":"70","author":"Iourov","year":"2008","journal-title":"Med. Hypotheses"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1096\/fj.99-1068com","article-title":"Subcellular localization of presenilins during mouse preimplantation development","volume":"14","author":"Jeong","year":"2000","journal-title":"FASEB J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1750-1326-6-80","article-title":"Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes","volume":"6","author":"Judge","year":"2011","journal-title":"Mol. Neurodegener"},{"key":"B52","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1126\/science.aan6490","article-title":"A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation","volume":"359","author":"Kabeche","year":"2018","journal-title":"Science"},{"key":"B53","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/cr.2008.305","article-title":"Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance","volume":"19","author":"Kai","year":"2009","journal-title":"Cell Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/s0006-8993(01)03146-8","article-title":"Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain","volume":"922","author":"Kimura","year":"2001","journal-title":"Brain Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1007\/s00018-006-6169-5","article-title":"Aneuploidy in the normal and diseased brain","volume":"63","author":"Kingsbury","year":"2006","journal-title":"Cell Mol. Life Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"13409","DOI":"10.1073\/pnas.1415287111","article-title":"Single cell sequencing reveals low levels of aneuploidy across mammalian tissues","volume":"111","author":"Knouse","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.1242\/dev.139022","article-title":"ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation","volume":"143","author":"Lang","year":"2016","journal-title":"Development"},{"key":"B58","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/s0092-8674(00)80356-6","article-title":"Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation","volume":"90","author":"Li","year":"1997","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3233\/JAD-2009-0993","article-title":"Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology","volume":"16","author":"Lopes","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.346.6206.237","article-title":"A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse","volume":"346","author":"Magnusson","year":"2014","journal-title":"Science"},{"key":"B61","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.brainres.2008.04.050","article-title":"Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle","volume":"1218","author":"Majd","year":"2008","journal-title":"Brain Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"40764","DOI":"10.1038\/srep40764","article-title":"Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models","volume":"7","author":"Malmanche","year":"2017","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"8090","DOI":"10.1523\/JNEUROSCI.2263-04.2004","article-title":"Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex","volume":"24","author":"McConnell","year":"2004","journal-title":"J. Neurosci."},{"key":"B64","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer\u2019s disease","volume":"150","author":"McShea","year":"1997","journal-title":"Am. J. Pathol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.neurobiolaging.2005.03.025","article-title":"Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age","volume":"27","author":"Migliore","year":"2006","journal-title":"Neurobiol Aging"},{"key":"B66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000015389","article-title":"Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients","volume":"87","author":"Migliore","year":"1999","journal-title":"Cytogenet Cell Genet."},{"key":"B67","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s004390050632","article-title":"Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer\u2019s disease","volume":"101","author":"Migliore","year":"1997","journal-title":"Hum. Genet."},{"key":"B68","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2174\/138920210793176047","article-title":"The human genome puzzle - the role of copy number variation in somatic mosaicism","volume":"11","author":"Mkrtchyan","year":"2010","journal-title":"Curr. Genomics"},{"key":"B69","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/humu.22245","article-title":"Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations","volume":"34","author":"Mokrani-Benhelli","year":"2013","journal-title":"Hum Mutat"},{"key":"B70","doi-asserted-by":"publisher","first-page":"6859","DOI":"10.1523\/JNEUROSCI.0379-07.2007","article-title":"Aneuploidy and DNA replication in the normal human brain and Alzheimer\u2019s disease","volume":"27","author":"Mosch","year":"2007","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer\u2019s disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener"},{"key":"B72","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/ng.420","article-title":"A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging","volume":"41","author":"Murga","year":"2009","journal-title":"Nat. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1172\/JCI67364","article-title":"Fanconi anemia signaling network regulates the spindle assembly checkpoint","volume":"123","author":"Nalepa","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B74","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.bbrc.2012.07.153","article-title":"Prion protein impairs kinesin-driven transport","volume":"425","author":"Nieznanska","year":"2012","journal-title":"Biochem. Biophys Res. Commun."},{"key":"B75","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1196\/annals.1397.091","article-title":"Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells","volume":"1096","author":"Nizzari","year":"2007","journal-title":"Ann N Y Acad. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"13833","DOI":"10.1074\/jbc.M610146200","article-title":"Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling","volume":"282","author":"Nizzari","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"7668","DOI":"10.1038\/ncomms8668","article-title":"Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells","volume":"6","author":"Ohashi","year":"2015","journal-title":"Nat. Commun."},{"key":"B78","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1242\/dmm.013391","article-title":"Aneuploidy: implications for protein homeostasis and disease","volume":"7","author":"Oromendia","year":"2014","journal-title":"Dis. Model Mech."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1101\/gad.207407.112","article-title":"Aneuploidy causes proteotoxic stress in yeast","volume":"26","author":"Oromendia","year":"2012","journal-title":"Genes Dev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/1096-8628(20000828)93:5<366::aid-ajmg5>3.0.co;2-g","article-title":"Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome","volume":"93","author":"Petersen","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"B81","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00415-018-8940-6","article-title":"Multiple clinical features of Huntington\u2019s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration","volume":"266","author":"Podvin","year":"2019","journal-title":"J. Neurol."},{"key":"B82","first-page":"1192","article-title":"Review and hypothesis: Alzheimer disease and Down syndrome\u2013chromosome 21 nondisjunction may underlie both disorders","volume":"48","author":"Potter","year":"1991","journal-title":"Am. J. Hum. Genet."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2174\/156720501301151207100616","article-title":"Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer\u2019s Disease","volume":"13","author":"Potter","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B84","first-page":"643","article-title":"Beyond \u03b2-protein: New steps in the pathogenic pathway to Alzheimer\u2019s disease","volume-title":"Research Advances in Alzheimer\u2019s Disease and Related Disorders","author":"Potter","year":"1995"},{"key":"B85","doi-asserted-by":"publisher","first-page":"489428","DOI":"10.1155\/2012\/489428","article-title":"Apolipoprotein e: essential catalyst of the Alzheimer amyloid cascade","volume":"2012","author":"Potter","year":"2012","journal-title":"Int. J. Alzheimers Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/ana.410430316","article-title":"Molecular mapping of Alzheimer-type dementia in Down\u2019s syndrome","volume":"43","author":"Prasher","year":"1998","journal-title":"Ann Neurol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/hmg\/ddw371","article-title":"A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype","volume":"26","author":"Quek","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B88","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrneurol.2012.117","article-title":"Advances in understanding the molecular basis of frontotemporal dementia","volume":"8","author":"Rademakers","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1002\/dneu.20656","article-title":"Apoptotic cell death, long-term persistence, and neuronal differentiation of aneuploid cells generated in the adult brain of teleost fish","volume":"68","author":"Rajendran","year":"2008","journal-title":"Dev Neurobiol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1080\/15384101.2018.1515554","article-title":"Critical role of mitosis in spontaneous late-onset Alzheimer\u2019s disease; from a Shugoshin 1 cohesinopathy mouse model","volume":"17","author":"Rao","year":"2018","journal-title":"Cell Cycle"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e12797","DOI":"10.1111\/acel.12797","article-title":"Spontaneous development of Alzheimer\u2019s disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model","volume":"17","author":"Rao","year":"2018","journal-title":"Aging Cell"},{"key":"B92","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.brainres.2007.07.032","article-title":"Association study and meta-analysis of Alzheimer\u2019s disease risk and presenilin-1 intronic polymorphism","volume":"1170","author":"Rodriguez-Manotas","year":"2007","journal-title":"Brain Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/dneu.22626","article-title":"Genomic mosaicism in the developing and adult brain","volume":"78","author":"Rohrback","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10048-013-0380-y","article-title":"Mutations in MAPT give rise to aneuploidy in animal models of tauopathy","volume":"15","author":"Rossi","year":"2014","journal-title":"Neurogenetics"},{"key":"B95","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3233\/JAD-2012-121633","article-title":"Mutations in MAPT gene cause chromosome instability and introduce copy number variations widely in the genome","volume":"33","author":"Rossi","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.4161\/cc.7.12.6012","article-title":"A new function of microtubule-associated protein tau: involvement in chromosome stability","volume":"7","author":"Rossi","year":"2008","journal-title":"Cell Cycle"},{"key":"B97","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/ng1718","article-title":"APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy","volume":"38","author":"Rovelet-Lecrux","year":"2006","journal-title":"Nat. Genet."},{"key":"B98","doi-asserted-by":"publisher","first-page":"5788","DOI":"10.1523\/JNEUROSCI.0674-14.2014","article-title":"Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning","volume":"34","author":"Sakamoto","year":"2014","journal-title":"J. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1126\/science.aar4799","article-title":"A new mitotic activity comes into focus","volume":"359","author":"Saldivar","year":"2018","journal-title":"Science"},{"key":"B100","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1093\/hmg\/10.21.2425","article-title":"Centrosome disorganization in fibroblast cultures derived from R6\/2 Huntington\u2019s disease (HD) transgenic mice and HD patients","volume":"10","author":"Sathasivam","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"B101","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/s0140-6736(94)91398-6","article-title":"Increased risk of Alzheimer\u2019s disease in mothers of adults with Down\u2019s syndrome","volume":"344","author":"Schupf","year":"1994","journal-title":"Lancet"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1242\/jcs.1125880","article-title":"Amyloid-beta signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer\u2019s disease","volume":"126","author":"Seward","year":"2013","journal-title":"J. Cell Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"8747","DOI":"10.1158\/0008-5472.CAN-05-1471","article-title":"ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development","volume":"65","author":"Shen","year":"2005","journal-title":"Cancer Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1111\/j.1349-7006.2010.01702.x","article-title":"Differential role of repair proteins, BRCA1\/NBS1 and Ku70\/DNA-PKcs, in radiation-induced centrosome overduplication","volume":"101","author":"Shimada","year":"2010","journal-title":"Cancer Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1158\/0008-5472.CAN-08-3016","article-title":"Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR\/BRCA1 pathway","volume":"69","author":"Shimada","year":"2009","journal-title":"Cancer Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1093\/brain\/awl203","article-title":"APP duplication is sufficient to cause early onset Alzheimer\u2019s dementia with cerebral amyloid angiopathy","volume":"129","author":"Sleegers","year":"2006","journal-title":"Brain"},{"key":"B107","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nature25975","article-title":"Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults","volume":"555","author":"Sorrells","year":"2018","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"B109","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/ng958","article-title":"Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer","volume":"32","author":"Spring","year":"2002","journal-title":"Nat. Genet."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1093\/hmg\/ddw034","article-title":"ATR promotes cilia signalling: links to developmental impacts","volume":"25","author":"Stiff","year":"2016","journal-title":"Hum Mol. Genet."},{"key":"B111","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1212\/wnl.47.2.449","article-title":"Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein","volume":"47","author":"Tatzelt","year":"1996","journal-title":"Neurology"},{"key":"B112","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/mutage\/gem044","article-title":"Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer\u2019s disease","volume":"23","author":"Thomas","year":"2008","journal-title":"Mutagenesis"},{"key":"B113","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/mutage\/16.4.323","article-title":"Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer\u2019s disease patients","volume":"16","author":"Trippi","year":"2001","journal-title":"Mutagenesis"},{"key":"B114","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0079-6603(08)60723-0","article-title":"Genetic disorders associated with cancer predisposition and genomic instability","volume":"63","author":"Vessey","year":"1999","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1083\/jcb.132.3.413","article-title":"Aberrant expression of mitotic cdc2\/cyclin B1 kinase in degenerating neurons of Alzheimer\u2019s disease brain","volume":"17","author":"Vincent","year":"1997","journal-title":"J. Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1083\/jcb.132.3.413","article-title":"Mitotic mechanisms in Alzheimer\u2019s disease","volume":"132","author":"Vincent","year":"1996","journal-title":"J. Cell Biol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/ana.410170310","article-title":"Occurrence of neuropathological changes and dementia of Alzheimer\u2019s disease in Down\u2019s syndrome","volume":"17","author":"Wisniewski","year":"1985","journal-title":"Ann. Neurol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"7445","DOI":"10.1073\/pnas.95.13.7445","article-title":"Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control","volume":"95","author":"Wright","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B119","doi-asserted-by":"publisher","first-page":"479","DOI":"10.4161\/cc.11.3.18994","article-title":"Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis","volume":"11","author":"Yamada","year":"2012","journal-title":"Cell Cycle"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer\u2019s disease","volume":"21","author":"Yang","year":"2001","journal-title":"J. Neurosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.neurobiolaging.2014.12.016","article-title":"Aneuploidy in Lewy body diseases","volume":"36","author":"Yang","year":"2015","journal-title":"Neurobiol Aging"},{"key":"B122","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev-genet-121415-121658","article-title":"Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway","volume":"50","author":"Yazinski","year":"2016","journal-title":"Annu. Rev. Genet."},{"key":"B123","doi-asserted-by":"publisher","first-page":"10431","DOI":"10.1523\/JNEUROSCI.1445-10.2010","article-title":"Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development","volume":"30","author":"Young-Pearse","year":"2010","journal-title":"J. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1755-8166-2-23","article-title":"GIN\u2019n\u2019CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny","volume":"2","author":"Yurov","year":"2009","journal-title":"Mol. Cytogenet"},{"key":"B125","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2174\/138920210793175958","article-title":"Ontogenetic variation of the human genome","volume":"11","author":"Yurov","year":"2010","journal-title":"Curr. Genomics"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1100\/2011\/625690","article-title":"The DNA replication stress hypothesis of Alzheimer\u2019s disease","volume":"11","author":"Yurov","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"B127","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/jmg.2007.049312","article-title":"Unexplained autism is frequently associated with low-level mosaic aneuploidy","volume":"44","author":"Yurov","year":"2007","journal-title":"J. Med. Genet."},{"key":"B128","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/jcb.21195","article-title":"Centrosomal localization of DNA damage checkpoint proteins","volume":"101","author":"Zhang","year":"2007","journal-title":"J. Cell Biochem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1089\/neu.2010.1579","article-title":"Neurogenesis in adult human brain after traumatic brain injury","volume":"30","author":"Zheng","year":"2013","journal-title":"J. Neurotrauma"},{"key":"B131","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainres.2004.05.115","article-title":"Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms","volume":"1021","author":"Zhou","year":"2004","journal-title":"Brain Res."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01092\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T10:56:46Z","timestamp":1573124206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01092\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":131,"alternative-id":["10.3389\/fgene.2019.01092"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.01092","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]},"article-number":"1092"}}