{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:45:56Z","timestamp":1790682356965,"version":"4.1.0"},"reference-count":197,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.01104","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T04:48:48Z","timestamp":1573620528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Epigenetic Regulation in the Pathogenesis of Sj\u00f6gren Syndrome and Rheumatoid Arthritis"],"prefix":"10.3389","volume":"10","author":[{"given":"Jos\u00e9 Santiago","family":"Ib\u00e1\u00f1ez-Cabellos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Seco-Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Osca-Verdegal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico V.","family":"Pallard\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Garc\u00eda-Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.berh.2015.04.010","article-title":"Role of autoantibody testing","volume":"28","author":"Aggarwal","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"B2","first-page":"1332","article-title":"Early undifferentiated connective tissue disease. I. Early clinical manifestation in a large cohort of patients with undifferentiated connective tissue diseases compared with cohorts of well established connective tissue disease","volume":"18","author":"Alarc\u00f3n","year":"1991","journal-title":"J. Rheumatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.autrev.2010.05.009","article-title":"MicroRNAs in Sj\u00f6gren\u2019s syndrome as a prototypic autoimmune disease","volume":"9","author":"Alevizos","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/art.38264","article-title":"Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary sj\u00f6gren\u2019s syndrome","volume":"66","author":"Altorok","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.rdc.2016.03.005","article-title":"Polyautoimmunity in Sj\u00f6gren Syndrome","volume":"42","author":"Anaya","year":"2016","journal-title":"Rheum. Dis. Clin. North Am"},{"key":"B6","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1136\/annrheumdis-2014-205635","article-title":"Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression","volume":"75","author":"Angiolilli","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13075-018-1638-4","article-title":"Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation","volume":"20","author":"Angiolilli","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1136\/annrheumdis-2015-209064","article-title":"Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes","volume":"76","author":"Angiolilli","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1136\/ard.2010.138966","article-title":"Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome","volume":"70","author":"Appel","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S1040-8428(02)00003-3","article-title":"The role of a Runt domain transcription factor AML1\/RUNX1 in leukemogenesis and its clinical implications","volume":"45","author":"Asou","year":"2003","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3892\/br.2017.855","article-title":"Association between interleukin-1 receptor associated kinase 1 rs3027898 A\/C gene polymorphism and rheumatoid arthritis","volume":"6","author":"Atabaki","year":"2017","journal-title":"Biomed. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrm.2016.76","article-title":"Epigenetic control of adult stem cell function","volume":"17","author":"Avgustinova","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/ar2751","article-title":"Rheumatoid arthritis and smoking: putting the pieces together","volume":"11","author":"Baka","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/eji.200939381","article-title":"Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells","volume":"40","author":"Banerjee","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"32415","DOI":"10.1074\/jbc.M112.351569","article-title":"The Histone Chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation","volume":"287","author":"Begum","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.envres.2015.12.021","article-title":"Fine particulate air pollution and systemic autoimmune rheumatic disease in two Canadian provinces","volume":"146","author":"Bernatsky","year":"2016","journal-title":"Environ. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1084\/jem.20111386","article-title":"miR-150 regulates the development of NK and iNKT cells","volume":"208","author":"Bezman","year":"2011","journal-title":"J. Exp. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3324\/haematol.2011.051730","article-title":"MicroRNAs are shaping the hematopoietic landscape","volume":"97","author":"Bissels","year":"2012","journal-title":"Haematologica"},{"key":"B20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.molcel.2012.06.019","article-title":"DNA methylation dynamics during in vivo differentiation of blood and skin stem cells","volume":"47","author":"Bock","year":"2012","journal-title":"Mol. Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1084\/jem.20101823","article-title":"miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice","volume":"208","author":"Boldin","year":"2011","journal-title":"J. Exp. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nature14590","article-title":"Single-cell chromatin accessibility reveals principles of regulatory variation","volume":"523","author":"Buenrostro","year":"2015","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.autrev.2014.02.002","article-title":"Genome-wide association studies in Sj\u00f6gren\u2019s syndrome: What do the genes tell us about disease pathogenesis","volume":"13","author":"Burbelo","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.stem.2014.07.005","article-title":"Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome Analysis","volume":"15","author":"Cabezas-Wallscheid","year":"2014","journal-title":"Cell Stem Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/rheumatology\/kev022","article-title":"Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis","volume":"54","author":"Cantley","year":"2015","journal-title":"Rheumatology (Oxford)."},{"key":"B26","doi-asserted-by":"publisher","first-page":"22279","DOI":"10.3390\/ijms151222279","article-title":"Smoking and rheumatoid arthritis","volume":"15","author":"Chang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00296-009-0870-2","article-title":"The expression of PADI4 in synovium of rheumatoid arthritis","volume":"29","author":"Chang","year":"2009","journal-title":"Rheumatol. Int."},{"key":"B28","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jbspin.2010.05.013","article-title":"A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility","volume":"77","author":"Chatzikyriakidou","year":"2010","journal-title":"Joint. Bone. Spine"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0170-4","article-title":"Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-\u03b2 production by mediating H3K79me2\/3 methylation in macrophages","author":"Chen","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.cell.2018.03.079","article-title":"Single-cell chromatin modification profiling reveals increased epigenetic variations with aging","volume":"173","author":"Cheung","year":"2018","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"15872","DOI":"10.1073\/pnas.0808462105","article-title":"Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus","volume":"105","author":"Chowdhury","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/9607946","article-title":"Epigenetic modulation as a therapeutic prospect for treatment of autoimmune rheumatic diseases","volume":"2016","author":"Ciechomska","year":"2016","journal-title":"Mediators Inflamm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1084\/jem.20061692","article-title":"A role for Dicer in immune regulation","volume":"203","author":"Cobb","year":"2006","journal-title":"J. Exp. Med."},{"key":"B34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/B978-0-12-803604-4.00010-1","article-title":"Sj\u00f6gren\u2019s Syndrome and Environmental Factors","volume-title":"Sj\u00f6gren\u2019s Syndrome","author":"Colafrancesco","year":"2016"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1002\/art.39792","article-title":"Epigenetic Signatures of Salivary Gland Inflammation in Sj\u00f6gren\u2019s Syndrome","volume":"68","author":"Cole","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169956","article-title":"Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis","volume":"12","author":"Conigliaro","year":"2017","journal-title":"PloS One"},{"key":"B37","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.autrev.2009.11.017","article-title":"Profiling of rheumatoid arthritis associated autoantibodies","volume":"9","author":"Conrad","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0378-4347(91)80265-E","article-title":"5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases","volume":"566","author":"Corvetta","year":"1991","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/art.39031","article-title":"Methotrexate restores regulatory T Cell function through demethylation of the FoxP3 upstream enhancer in patients with rheumatoid arthritis","volume":"67","author":"Cribbs","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1002\/art.38715","article-title":"Treg cell function in rheumatoid arthritis is compromised by CTLA-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway","volume":"66","author":"Cribbs","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.aab1601","article-title":"Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing","volume":"348","author":"Cusanovich","year":"2015","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/art.22458","article-title":"Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"56","author":"Daridon","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B43","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s13075-015-0748-5","article-title":"Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate","volume":"17","author":"de Andres","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jaut.2012.12.005","article-title":"Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression","volume":"41","author":"de la Rica","year":"2013","journal-title":"J. Autoimmun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/ni.3799","article-title":"Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues","volume":"18","author":"Delacher","year":"2017","journal-title":"Nat. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"15306","DOI":"10.1073\/pnas.1112520108","article-title":"Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells","volume":"108","author":"Denton","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/art.22536","article-title":"Improvement of Sj\u00f6gren\u2019s syndrome after two infusions of rituximab (anti-CD20)","volume":"57","author":"Devauchelle-Pensec","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1083\/jcb.201808028","article-title":"Polycomb complexes in normal and malignant hematopoiesis","volume":"218","author":"Di Carlo","year":"2018","journal-title":"J. Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1111\/jcmm.12353","article-title":"Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis","volume":"18","author":"Dong","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/imr.12049","article-title":"MicroRNA regulation of T-cell development","volume":"253","author":"Dooley","year":"2013","journal-title":"Immunol. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1101\/gad.233791.113","article-title":"miR-99a\/100\u223c125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF\u03b2 and Wnt signaling","volume":"28","author":"Emmrich","year":"2014","journal-title":"Genes Dev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.celrep.2015.02.001","article-title":"Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics","volume":"10","author":"Farlik","year":"2015","journal-title":"Cell Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.cell.2005.09.023","article-title":"A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C\/EBPalpha regulates human granulopoiesis","volume":"123","author":"Fazi","year":"2005","journal-title":"Cell"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1084\/jem.170.6.2081","article-title":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones","volume":"170","author":"Fiorentino","year":"1989","journal-title":"J. Exp. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.autrev.2009.01.012","article-title":"Interleukin-6 as a key player in systemic inflammation and joint destruction","volume":"8","author":"Fonseca","year":"2009","journal-title":"Autoimmun. Rev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/aps.2011.98","article-title":"Hypomethylation of proximal CpG motif of interleukin-10 promoter regulates its expression in human rheumatoid arthritis","volume":"32","author":"Fu","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and Inflamm-aging as two sides of the same coin: friends or foes","volume":"8","author":"Fulop","year":"2018","journal-title":"Front. Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.4049\/jimmunol.0802960","article-title":"Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation","volume":"183","author":"Gamper","year":"2009","journal-title":"J. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1002\/art.20371","article-title":"Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sj\u00f6gren\u2019s syndrome patients by use of a transfected cell line assay","volume":"50","author":"Gao","year":"2004","journal-title":"Arthritis Rheum."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1073\/pnas.0610983104","article-title":"CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control","volume":"104","author":"Georgantas","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1182\/blood-2011-02-335141","article-title":"Macrophage development from HSCs requires PU.1-coordinated microRNA expression","volume":"118","author":"Ghani","year":"2011","journal-title":"Blood"},{"key":"B63","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1182\/blood-2010-12-326629","article-title":"Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150","volume":"117","author":"Ghisi","year":"2011","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2217\/epi.15.103","article-title":"Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes","volume":"8","author":"Glossop","year":"2016","journal-title":"Epigenomics"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.4161\/epi.29718","article-title":"Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations","volume":"9","author":"Glossop","year":"2014","journal-title":"Epigenetics"},{"key":"B66","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.semcancer.2012.02.009","article-title":"Tumor metabolism as modulator of immune response and tumor progression","volume":"22","author":"Gottfried","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.cell.2009.04.046","article-title":"Ars2 links the nuclear cap-binding complex to rna interference and cell proliferation","volume":"138","author":"Gruber","year":"2009","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1093\/brain\/awr262","article-title":"Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity","volume":"134","author":"Arellano","year":"2011","journal-title":"Brain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"14229","DOI":"10.1073\/pnas.0913574107","article-title":"MicroRNA miR-125a controls hematopoietic stem cell number","volume":"107","author":"Guo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B70","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.humimm.2010.12.013","article-title":"Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells","volume":"72","author":"Hamaguchi","year":"2011","journal-title":"Hum. Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5367","DOI":"10.1093\/hmg\/ddv258","article-title":"Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis","volume":"24","author":"Hawtree","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1093\/rheumatology\/kes374","article-title":"Characteristics of Sjogren's syndrome in rheumatoid arthritis","volume":"52","author":"He","year":"2013","journal-title":"Rheumatology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2217\/imt.13.101","article-title":"Histone methyltransferase and histone methylation in inflammatory T-cell responses","volume":"5","author":"He","year":"2013","journal-title":"Immunotherapy"},{"key":"B74","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cyto.2017.02.022","article-title":"Aberrant expression of interleukin-10 in rheumatoid arthritis: relationship with IL10 haplotypes and autoantibodies","volume":"95","author":"Hern\u00e1ndez-Bello","year":"2017","journal-title":"Cytokine"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.3899\/jrheum.081115","article-title":"Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts","volume":"36","author":"Horiuchi","year":"2009","journal-title":"J. Rheumatol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/0896-8411(89)90189-3","article-title":"Autoantibody synthesis in salivary glands of Sj\u00f6gren\u2019s syndrome patients","volume":"2","author":"Horsfall","year":"1989","journal-title":"J. Autoimmun"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e1166","DOI":"10.1038\/cddis.2014.133","article-title":"Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009","volume":"5","author":"Hsieh","year":"2014","journal-title":"Cell Death Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/art.22512","article-title":"Histone deacetylase\/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients","volume":"56","author":"Huber","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1136\/annrheumdis-2015-208659","article-title":"Genome-wide DNA methylation analysis in multiple tissues in primary Sj\u00f6gren\u2019s syndrome reveals regulatory effects at interferon-induced genes","volume":"75","author":"Imgenberg-Kreuz","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1161\/01.ATV.0000247247.89787.e7","article-title":"Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression","volume":"26","author":"Inoue","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1902\/jop.2011.110356","article-title":"Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis","volume":"83","author":"Ishida","year":"2012","journal-title":"J. Periodontol."},{"key":"B83","first-page":"246","article-title":"Expression of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis","volume":"28","author":"Ishino","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1101\/gr.100289.109","article-title":"Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus","volume":"20","author":"Javierre","year":"2010","journal-title":"Genome Res."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070721","article-title":"Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations","volume":"8","author":"Jensen","year":"2013","journal-title":"PloS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1182\/blood-2011-05-355644","article-title":"Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation","volume":"118","author":"Jiang","year":"2011","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-020711-075058","article-title":"Transcriptional and epigenetic control of t helper cell specification: molecular mechanisms underlying commitment and plasticity","volume":"30","author":"Kanno","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"B88","first-page":"293","article-title":"Autoantibodies in Sj\u00f6gren\u2019s Syndrome and Laboratory Markers","author":"Kapsogeorgou","year":"2016"},{"key":"B89","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jaut.2011.05.003","article-title":"Cellular microRNAs (miRNAs) and Sj\u00f6gren\u2019s syndrome: Candidate regulators of autoimmune response and autoantigen expression","volume":"37","author":"Kapsogeorgou","year":"2011","journal-title":"J. Autoimmun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/art.34340","article-title":"Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts","volume":"64","author":"Karouzakis","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B91","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1002\/art.25018","article-title":"DNA hypomethylation in rheumatoid arthritis synovial fibroblasts","volume":"60","author":"Karouzakis","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B92","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/gene.2011.45","article-title":"DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts","volume":"12","author":"Karouzakis","year":"2011","journal-title":"Genes Immun."},{"key":"B93","doi-asserted-by":"publisher","first-page":"R133","DOI":"10.1186\/ar3071","article-title":"Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis","volume":"12","author":"Kawabata","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s13287-018-0948-4","article-title":"Epigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients","volume":"9","author":"Kim","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"B95","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/ar2333","article-title":"Cells of the synovium in rheumatoid arthritis. Macrophages","volume":"9","author":"Kinne","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.smim.2011.01.014","article-title":"Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis","volume":"23","author":"Klareskog","year":"2011","journal-title":"Semin. Immunol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/ncprheum0249","article-title":"Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis","volume":"2","author":"Klareskog","year":"2006","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/BOR.0000000000000128","article-title":"Epigenetics in rheumatoid arthritis","volume":"27","author":"Klein","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"B99","article-title":"Epigenetic modifications in salivary glands from patients with Sj\u00f6gren\u2019s syndrome affect cytokeratin 19 expression","volume":"53","author":"Konsta","year":"2016","journal-title":"Bull. Group. Int. Rech. Sci. Stomatol. Odontol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3389\/fimmu.2015.00437","article-title":"An in silico approach reveals associations between genetic and epigenetic factors within regulatory elements in B cells from primary sj\u00f6gren\u2019s syndrome patients","volume":"6","author":"Konsta","year":"2015","journal-title":"Front. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jaut.2015.12.002","article-title":"Defective DNA methylation in salivary gland epithelial acini from patients with Sj\u00f6gren\u2019s syndrome is associated with SSB gene expression, anti-SSB\/LA detection, and lymphocyte infiltration","volume":"68","author":"Konsta","year":"2016","journal-title":"J. Autoimmun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fgene.2014.00071","article-title":"The contribution of epigenetics in Sj\u00f6gren\u2019s Syndrome","volume":"5","author":"Konsta","year":"2014","journal-title":"Front. Genet."},{"key":"B103","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1080\/08830185.2017.1284212","article-title":"Role of MicroRNAs in the development and function of innate immune cells","volume":"36","author":"Kumar Kingsley","year":"2017","journal-title":"Int. Rev. Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1182\/blood-2005-04-1447","article-title":"Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma","volume":"106","author":"Kundu","year":"2005","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1101\/gr.155473.113","article-title":"DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation","volume":"23","author":"Lai","year":"2013","journal-title":"Genome Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4049\/jimmunol.182.1.259","article-title":"Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation","volume":"182","author":"Lal","year":"2009","journal-title":"J. Immunol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/path.1533","article-title":"Expression of BAFF(BLyS) in T cells infiltrating labial salivary glands from patients with Sj\u00f6gren\u2019s syndrome","volume":"202","author":"Lavie","year":"2004","journal-title":"J. Pathol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.2174\/138920112802273326","article-title":"Epigenetics and Sj\u00f6gren\u2019s syndrome","volume":"13","author":"Le Dantec","year":"2012","journal-title":"Curr. Pharm. Biotechnol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/s1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sj\u00f6gren\u2019s syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat. Genet."},{"key":"B111","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/crj.12389","article-title":"Particulate matter-induced epigenetic changes and lung cancer","volume":"11","author":"Li","year":"2017","journal-title":"Clin. Respir. J."},{"key":"B112","doi-asserted-by":"publisher","first-page":"R81","DOI":"10.1186\/ar3006","article-title":"Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis","volume":"12","author":"Li","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B113","doi-asserted-by":"publisher","first-page":"23910","DOI":"10.3390\/ijms141223910","article-title":"Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-\u03b1 and IL-1\u03b2 in PBMCs","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jaut.2017.02.007","article-title":"Demethylase Kdm6a epigenetically promotes IL-6 and IFN-\u03b2 production in macrophages","volume":"80","author":"Li","year":"2017","journal-title":"J. Autoimmun."},{"key":"B115","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.imlet.2010.10.003","article-title":"Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis","volume":"135","author":"Liu","year":"2011","journal-title":"Immunol. Lett."},{"key":"B116","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nbt.2487","article-title":"Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis","volume":"31","author":"Liu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"6422","DOI":"10.4049\/jimmunol.0901969","article-title":"Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem\/Progenitor Cell Pool","volume":"183","author":"Loizou","year":"2009","journal-title":"J. Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/ar3318","article-title":"Aspects of innate immunity in Sj\u00f6gren\u2019s syndrome","volume":"13","author":"Low","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"B119","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"B120","doi-asserted-by":"publisher","first-page":"5423","DOI":"10.4049\/jimmunol.175.8.5423","article-title":"Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin e 2 through enhancement of nf-\u03bab activity in lipopolysaccharide-activated human primary monocytes","volume":"175","author":"Lu","year":"2005","journal-title":"J. Immunol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B","article-title":"Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins","volume":"43","author":"MacGregor","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J. Exp. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1136\/ard.62.2.168","article-title":"The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome","volume":"62","author":"Mariette","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"B124","doi-asserted-by":"publisher","first-page":"7","DOI":"10.18632\/oncotarget.3057","article-title":"MicroRNAs in B-cells: from normal differentiation to treatment of malignancies","volume":"6","author":"Marques","year":"2015","journal-title":"Oncotarget"},{"key":"B125","doi-asserted-by":"publisher","first-page":"18704","DOI":"10.1073\/pnas.0905063106","article-title":"Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease","volume":"106","author":"Mattes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B126","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nri.2016.40","article-title":"MicroRNAs as regulatory elements in immune system logic","volume":"16","author":"Mehta","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1038\/cdd.2013.125","article-title":"The miR-17\/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease","volume":"20","author":"Mogilyansky","year":"2013","journal-title":"Cell Death Differ."},{"key":"B128","doi-asserted-by":"publisher","first-page":"R71","DOI":"10.1186\/gb-2005-6-8-r71","article-title":"MicroRNA profiling of the murine hematopoietic system","volume":"6","author":"Monticelli","year":"2005","journal-title":"Genome Biol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2018.08.001","article-title":"DNA methylation as a transcriptional regulator of the immune system","volume":"204","author":"Morales-Nebreda","year":"2019","journal-title":"Transl. Res."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag0192","article-title":"Epigenomics of human CD8 T cell differentiation and aging","volume":"2","author":"Moskowitz","year":"2017","journal-title":"Sci. Immunol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1093\/rheumatology\/kem025","article-title":"MHC class II expression on myeloid cells inversely correlates with disease progression in early rheumatoid arthritis","volume":"46","author":"Mueller","year":"2007","journal-title":"Rheumatology"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069118","article-title":"Comprehensive microRNA Analysis Identifies miR-24 and miR-125a-5p as Plasma Biomarkers for Rheumatoid Arthritis","volume":"8","author":"Murata","year":"2013","journal-title":"PloS One"},{"key":"B133","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/annrheumdis-2012-201526","article-title":"DNA methylome signature in rheumatoid arthritis","volume":"72","author":"Nakano","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"B134","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/1471-2474-11-209","article-title":"MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients","volume":"11","author":"Niimoto","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"key":"B135","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/ncprheum0173","article-title":"Mechanisms of Disease: primary Sj\u00f6gren\u2019s syndrome and the type I interferon system","volume":"2","author":"Nordmark","year":"2006","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O\u2019Connell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B137","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13075-017-1357-2","article-title":"Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro","volume":"19","author":"Oh","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"B138","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/ar3323","article-title":"Regulation of bone by the adaptive immune system in arthritis","volume":"13","author":"Okamoto","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"B139","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/BF02982057","article-title":"RUNX1\/AML1: a central player in hematopoiesis","volume":"74","author":"Okuda","year":"2001","journal-title":"Int. J. Hematol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fgene.2013.00121","article-title":"Circulating inflamma-miRs in aging and age-related diseases","volume":"4","author":"Olivieri","year":"2013","journal-title":"Front. Genet"},{"key":"B141","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/10715762.2012.748904","article-title":"Sj\u00f8gren\u2019s syndrome-associated oxidative stress and mitochondrial dysfunction: Prospects for chemoprevention trials","volume":"47","author":"Pagano","year":"2013","journal-title":"Free Radic. Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s10059-013-2302-0","article-title":"Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis","volume":"35","author":"Park","year":"2013","journal-title":"Mol. Cells"},{"key":"B143","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrg3502","article-title":"Genetic insights into common pathways and complex relationships among immune-mediated diseases","volume":"14","author":"Parkes","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/eji.201040757","article-title":"Altered miR-146a expression in Sj\u00f6gren\u2019s syndrome and its functional role in innate immunity","volume":"41","author":"Pauley","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.3899\/jrheum.131154","article-title":"MicroRNA Profiling in Chinese Patients with Primary Sj\u00f6gren Syndrome Reveals Elevated miRNA-181a in Peripheral Blood Mononuclear Cells","volume":"41","author":"Peng","year":"2014","journal-title":"J. Rheumatol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/sji.12139","article-title":"Peripheral and site-specific CD4(+) CD28(null) T cells from rheumatoid arthritis patients show distinct characteristics","volume":"79","author":"Pieper","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.semarthrit.2006.08.007","article-title":"The Overlap of Sj\u00f6gren\u2019s Syndrome with Other Systemic Autoimmune Diseases","volume":"36","author":"Ramos-Casals","year":"2007","journal-title":"Semin. Arthritis Rheum."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1080\/15592294.2017.1403692","article-title":"Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"12","author":"Reynolds","year":"2017","journal-title":"Epigenetics"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1002\/art.1780331109","article-title":"Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis","volume":"33","author":"Richardson","year":"1990","journal-title":"Arthritis Rheum."},{"key":"B150","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Rodriguez","year":"2007","journal-title":"Science"},{"key":"B151","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s12016-007-8003-8","article-title":"Sj\u00f6gren\u2019s syndrome\u2013study of autoantigens and autoantibodies","volume":"32","author":"Routsias","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nm.2106","article-title":"Programmed death-1\u2013induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection","volume":"16","author":"Said","year":"2010","journal-title":"Nat. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/03009740310000076","article-title":"Local production of Ro\/SSA and La\/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sj\u00f6gren\u2019s syndrome","volume":"32","author":"Salomonsson","year":"2003","journal-title":"Scand. J. Rheumatol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1053\/j.seminhematol.2017.04.006","article-title":"RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM)","volume":"54","author":"Schlegelberger","year":"2017","journal-title":"Semin. Hematol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/ni1474","article-title":"Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma","volume":"8","author":"Schoenborn","year":"2007","journal-title":"Nat. Immunol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/ni.3198","article-title":"Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages","volume":"16","author":"Sellars","year":"2015","journal-title":"Nat. Immunol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019827","article-title":"miR-346 Controls Release of TNF-\u03b1 Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization","volume":"6","author":"Semaan","year":"2011","journal-title":"PloS One"},{"key":"B158","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fgene.2013.00008","article-title":"Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance","volume":"4","author":"Sethi","year":"2013","journal-title":"Front. Genet"},{"key":"B159","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1111\/jop.12187","article-title":"miR-146a and miR-155 expression in PBMCs from patients with Sj\u00f6gren\u2019s syndrome","volume":"43","author":"Shi","year":"2014","journal-title":"J. Oral Pathol. Med."},{"key":"B160","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"B161","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF02686079","article-title":"Auto-antibodies and autoreactive T-cells in rheumatoid arthritis","volume":"32","author":"Steiner","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B163","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jaut.2013.02.002","article-title":"Epigenetic dysregulation in salivary glands from patients with primary Sj\u00f6gren\u2019s syndrome may be ascribed to infiltrating B cells","volume":"41","author":"Thabet","year":"2013","journal-title":"J. Autoimmun."},{"key":"B164","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1136\/ard.2005.041186","article-title":"Lymphoma and other malignancies in primary Sj\u00f6gren\u2019s syndrome: a cohort study on cancer incidence and lymphoma predictors","volume":"65","author":"Theander","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"B165","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/art.37834","article-title":"Tumor Necrosis Factor \u03b1-Induced MicroRNA-18a Activates Rheumatoid Arthritis Synovial Fibroblasts Through a Feedback Loop in NF-\u03baB Signaling","volume":"65","author":"Trenkmann","year":"2013","journal-title":"Arthritis Rheum."},{"key":"B166","doi-asserted-by":"publisher","first-page":"13107","DOI":"10.1038\/srep13107","article-title":"Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes","volume":"5","author":"Tserel","year":"2015","journal-title":"Sci. Rep."},{"key":"B167","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13059-015-0863-2","article-title":"IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation","volume":"17","author":"Vento-Tormo","year":"2016","journal-title":"Genome Biol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exphem.2016.12.006","article-title":"Polycomb complexes PRC1 and their function in hematopoiesis","volume":"48","author":"Vidal","year":"2017","journal-title":"Exp. Hematol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/imr.12057","article-title":"miR-155: an ancient regulator of the immune system","volume":"253","author":"Vigorito","year":"2013","journal-title":"Immunol. Rev."},{"key":"B170","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.clim.2017.04.005","article-title":"Sjogren's syndrome: Clinical aspects","volume":"182","author":"Vivino","year":"2017","journal-title":"Clin. Immunol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1002\/art.30238","article-title":"Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis","volume":"63","author":"Vojinovic","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B172","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/ni.1613","article-title":"A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses","volume":"9","author":"Volpe","year":"2008","journal-title":"Nat. Immunol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.bbrc.2014.01.195","article-title":"Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts","volume":"444","author":"Wada","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B174","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3892\/etm.2017.5407","article-title":"Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sj\u00f6gren syndrome patients","volume":"15","author":"Wang","year":"2018","journal-title":"Exp. Ther. Med"},{"key":"B175","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1136\/annrheumdis-2017-211417","article-title":"Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sj\u00f6gren\u2019s syndrome","volume":"77","author":"Wang-Renault","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"B176","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","article-title":"Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells","volume":"30","author":"Wei","year":"2009","journal-title":"Immunity"},{"key":"B177","doi-asserted-by":"publisher","first-page":"e000193","DOI":"10.1128\/mBio.00193-13","article-title":"In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms","volume":"4","author":"Whisnant","year":"2013","journal-title":"MBio"},{"key":"B178","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1158\/0008-5472.CAN-08-2361","article-title":"Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue","volume":"69","author":"Wieczorek","year":"2009","journal-title":"Cancer Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13075-016-0987-0","article-title":"Sj\u00f6gren\u2019s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGF\u03b2 signaling","volume":"18","author":"Williams","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"B180","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.gde.2009.08.005","article-title":"Balancing dormant and self-renewing hematopoietic stem cells","volume":"19","author":"Wilson","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"B182","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1038\/emboj.2010.136","article-title":"Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis","volume":"29","author":"Wilting","year":"2010","journal-title":"EMBO J."},{"key":"B183","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/cmi.2017.133","article-title":"Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity","volume":"15","author":"Wu","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001020","article-title":"miRNA profiling of na\u00efve, effector and memory CD8 T cells","volume":"2","author":"Wu","year":"2007","journal-title":"PloS One"},{"key":"B185","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"Xiao","year":"2007","journal-title":"Cell"},{"key":"B186","first-page":"8929","article-title":"Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"6180","DOI":"10.1038\/s41598-018-24279-1","article-title":"Clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sj\u00f6gren\u2019s syndrome","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep"},{"key":"B188","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature07021","article-title":"IL-21 and TGF-beta are required for differentiation of human T(H)17 cells","volume":"454","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"B189","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s10067-016-3203-3","article-title":"Autoantigen-targeting microRNAs in Sj\u00f6gren\u2019s syndrome","volume":"35","author":"Yang","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046082","article-title":"MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1","volume":"7","author":"Yao","year":"2012","journal-title":"PloS One"},{"key":"B191","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jdermsci.2010.06.011","article-title":"Hypomethylation and overexpression of CD70 (TNFSF7) in CD4+ T cells of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"59","author":"Yin","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"B192","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.clim.2013.05.005","article-title":"DNA hypermethylation leads to lower FOXP3 expression in CD4+ T cells of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"148","author":"Yu","year":"2013","journal-title":"Clin. Immunol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1159\/000491532","article-title":"Regulation of Memory CD8+ T Cell Differentiation by MicroRNAs","volume":"47","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B194","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.stem.2014.01.007","article-title":"Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis","volume":"14","author":"Zhao","year":"2014","journal-title":"Cell Stem Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1136\/annrheumdis-2013-204377","article-title":"Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis","volume":"74","author":"Zhou","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-\u03b1","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat. Med."},{"key":"B197","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.imlet.2011.09.006","article-title":"Increased microRNA-146a\/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sj\u00f6gren\u2019s syndrome","volume":"141","author":"Zilahi","year":"2012","journal-title":"Immunol. Lett."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01104\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T04:48:52Z","timestamp":1573620532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01104\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":197,"alternative-id":["10.3389\/fgene.2019.01104"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.01104","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"article-number":"1104"}}