{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:51:54Z","timestamp":1771660314662,"version":"3.50.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.01132","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T04:25:04Z","timestamp":1574396704000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Copy Number Variation of Satellite III (1q12) in Patients With Schizophrenia"],"prefix":"10.3389","volume":"10","author":[{"given":"Elizaveta S.","family":"Ershova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana N.","family":"Agafonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Zakharova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia V.","family":"Bravve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizaveta M.","family":"Jestkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera E.","family":"Golimbet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana V.","family":"Lezheiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Y.","family":"Morozova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V.","family":"Martynov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman V.","family":"Veiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel E.","family":"Umriukhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgiy P.","family":"Kostyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey I.","family":"Kutsev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia N.","family":"Veiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana V.","family":"Kostyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030651","article-title":"Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk","volume":"18","author":"Barron","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1176\/appi.ajp.2009.09071016","article-title":"Copy number variations in schizophrenia: critical review and new perspectives on conceptsof genetics and disease","volume":"167","author":"Bassett","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ejogrb.2003.09.041","article-title":"Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship","volume":"114","author":"Boog","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"B4","first-page":"90","article-title":"Separation of leukocytes from blood and bone marrow","volume":"21","author":"Boyum","year":"1968","journal-title":"Scandinavian J. Clin. Lab. Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.psychres.2016.05.014","article-title":"Are obstetrical complications really involved in the etiology and course of schizophrenia and mood disorders","volume":"241","author":"Buoli","year":"2016","journal-title":"Psychiatry Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1001\/archpsyc.56.2.162","article-title":"Heritability estimates for psychotic disorders: the Maudsley twin psychosis series","volume":"56","author":"Cardno","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/B978-0-12-387718-5.00005-5","article-title":"Converging evidence of blood-based biomarkers for schizophrenia: an update","volume":"101","author":"Chan","year":"2011","journal-title":"Int. Rev. Neurobiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.schres.2018.01.001","article-title":"Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients","volume":"197","author":"Chestkov","year":"2018","journal-title":"Schizophr. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1093\/nar\/6.10.3177","article-title":"Cloning of human satellite III DNA: different components are on different chromosomes","volume":"6","author":"Cooke","year":"1979","journal-title":"Nucleic Acids Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/YCO.0000000000000054","article-title":"Oxidative stress and schizophrenia: recent breakthroughs from an old story","volume":"27","author":"Emiliani","year":"2014","journal-title":"Curr. Opin. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000106440","article-title":"Human chromosome 1 satellite 3 DNA is decondensed, demethylated and transcribed in senescent cells and in A431 epithelial carcinoma cells","volume":"118","author":"Enukashvily","year":"2007","journal-title":"Cytogenet. Genome Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.mrfmmm.2009.06.005","article-title":"Oxidative stress as a significant factor for development of an adaptive response in irradiated and nonirradiated human lymphocytes after inducing the bystander effect by low-dose X-radiation","volume":"669","author":"Ermakov","year":"2009","journal-title":"Mutat. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"8390585","DOI":"10.1155\/2019\/8390585","article-title":"Accumulation of circulating cell-free CpG-enriched ribosomal DNA fragments on the background of high endonuclease activity of blood plasma in schizophrenic patients","volume":"2019","author":"Ershova","year":"2019","journal-title":"Int. J. Genomics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3389\/fgene.2019.00704","article-title":"Copy number variation of human satellite III (1q12) with Aging","volume":"10","author":"Ershova","year":"2019","journal-title":"Front. Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/schbul\/sbs098","article-title":"Genetic risk for schizophrenia, obstetric complications, and adolescent school outcome: evidence for gene-environment interaction","volume":"39","author":"Forsyth","year":"2013","journal-title":"Schizophr. Bull."},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s42000-018-0007-7","article-title":"Perinatal hypoxia as a risk factor for psychopathology later in life: the role of dopamine and neurotrophins","volume":"17","author":"Giannopoulou","year":"2018","journal-title":"Hormones (Athens)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrn.2015.19","article-title":"Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis","volume":"17","author":"Hardingham","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/S0140-6736(13)62036-X","article-title":"Schizophrenia: an integrated sociodevelopmental-cognitive model","volume":"383","author":"Howes","year":"2014","journal-title":"Lancet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"5508","DOI":"10.1093\/nar\/gkl711","article-title":"Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells","volume":"34","author":"Jolly","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1083\/jcb.200306104","article-title":"Stress-induced transcription of satellite III repeats","volume":"164","author":"Jolly","year":"2004","journal-title":"J. Cell. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"B22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1192\/bjp.2018.301","article-title":"Cognitive performance and functional outcomes of carriers of pathogenic cop number variants: analysis of the UK Biobank","volume":"214","author":"Kendall","year":"2019","journal-title":"Br. J. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/schbul\/sbn183","article-title":"Schizophrenia as a systemic disease","volume":"35","author":"Kirkpatrick","year":"2009","journal-title":"Schizophr. Bull."},{"key":"B24","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.biopsych.2013.07.022","article-title":"The penetrance of copy number variations for schizophrenia and developmental delay","volume":"75","author":"Kirov","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.schres.2015.06.022","article-title":"Implications for reactive oxygen species in schizophrenia pathogenesis","volume":"176","author":"Koga","year":"2016","journal-title":"Schizophr. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mrfmmm.2016.09.001","article-title":"Human circulating ribosomal DNA content significantly increases while circulating satellite III (1q12) content decreases under chronic occupational exposure to low-dose gamma- neutron and tritium beta-radiation","author":"Korzeneva","year":"2016","journal-title":"Mutat. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1016\/j.celrep.2018.08.022","article-title":"Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights","volume":"24","author":"Kushima","year":"2018","journal-title":"Cell Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"102","DOI":"10.5498\/wjp.v6.i1.102","article-title":"Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics","volume":"6","author":"Lai","year":"2016","journal-title":"World J. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuron.2006.09.027","article-title":"Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron."},{"key":"B30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/cyto.990160405","article-title":"Interactive computer- assisted analysis of chromosome 1 colocalization with nucleoli","volume":"16","author":"L\u00e9ger","year":"1994","journal-title":"Cytometry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1171","DOI":"10.1038\/tp.2017.138","article-title":"Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia","volume":"7","author":"Maas","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ng.3725","article-title":"Contribution of copy number variants to schizophreni from a genome-wide study of 41,321 subjects","volume":"49","author":"Marshall","year":"2017","journal-title":"Nat. Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1093\/schbul\/sbn080","article-title":"Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications","volume":"34","author":"Mittal","year":"2008","journal-title":"Schizophr. Bull."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1001376","DOI":"10.1371\/journal.pgen.1001376","article-title":"Ribosomal DNA deletions modulate genome-wide gene expression: \u201crDNA-sensitive\u201d genes and natural variation","volume":"7","author":"Paredes","year":"2011","journal-title":"PloS Genet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"17829","DOI":"10.1073\/pnas.0906811106","article-title":"Ribosomal DNA contributes to global chromatin regulation","volume":"106","author":"Paredes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neubiorev.2017.08.025","article-title":"Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches","volume":"83","author":"Patel","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.3390\/ijms18040733","article-title":"Theranostic Biomarkers for Schizophrenia","volume":"18","author":"Perkovic","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/humu.20815","article-title":"Somatic mosaicism for copy number variation in differentiated human tissues","volume":"29","author":"Piotrowski","year":"2008","journal-title":"Hum. Mutat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1091\/mbc.e03-07-0487","article-title":"Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock","volume":"15","author":"Rizzi","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1080\/14789450.2016.1252262","article-title":"Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays","volume":"13","author":"Sabherwal","year":"2016","journal-title":"Expert. Rev. Proteomics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbrc.2009.02.137","article-title":"Satellite III non-coding RNAs show distinct and stress-specific patterns of induction","volume":"382","author":"Sengupta","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.psychres.2015.07.036","article-title":"Increased oxidative stress and oxidative DNA damage in non-remission schizophrenia patients","volume":"229","author":"Sertan Copoglu","year":"2015","journal-title":"Psychiatry Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.pharep.2014.12.015","article-title":"Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism","volume":"67","author":"Smaga","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/s0531-5565(02)00061-x","article-title":"Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts","volume":"37","author":"Suzuki","year":"2002","journal-title":"Exp. Gerontol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/nar\/gkm1056","article-title":"Transcription of Satellite III non-coding RNAs is a general stress response in human cells","volume":"36","author":"Valgardsdottir","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1091\/mbc.e04-12-1078","article-title":"Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells","volume":"16","author":"Valgardsdottir","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1093\/hmg\/ddq259","article-title":"Penetrance for copy number variants associated with schizophrenia","volume":"19","author":"Vassos","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0355-y","article-title":"Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank","author":"Warland","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"S186","DOI":"10.1016\/s0387-7604(01)00363-1","article-title":"Multicolor fluorescent in situ hybridization on post-mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases","volume":"23","author":"Yurov","year":"2001","journal-title":"Brain Dev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.schres.2007.07.035","article-title":"The schizophrenia brain exhibits low- level aneuploidy involving chromosome 1","volume":"98","author":"Yurov","year":"2008","journal-title":"Schizophr. Res."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000558","article-title":"Aneuploidy and confined chromosomal mosaicism in the developing human brain","volume":"2","author":"Yurov","year":"2007","journal-title":"PloS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2174\/1389202918666170717154340","article-title":"Mosaic Brain Aneuploidy in Mental Illnesses: An Association of Low-level Post-zygotic Aneuploidy with Schizophrenia and Comorbid Psychiatric Disorders","volume":"19","author":"Yurov","year":"2018","journal-title":"Curr. Genomics"},{"key":"B53","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnmol.2017.00204","article-title":"Potential Value of Genomic Copy Number Variations in Schizophrenia","volume":"10","author":"Zhuo","year":"2017","journal-title":"Front. Mol. Neurosci."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01132\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T05:12:48Z","timestamp":1575349968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01132\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":53,"alternative-id":["10.3389\/fgene.2019.01132"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.01132","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]},"article-number":"1132"}}