{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:02:19Z","timestamp":1783465339615,"version":"3.55.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2019.01376","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:46:22Z","timestamp":1579826782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach"],"prefix":"10.3389","volume":"10","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/infdis\/jiu410","article-title":"A multiplex panel of plasma markers of immunity and inflammation in classical kaposi sarcoma","volume":"211","author":"Aka","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1101\/gr.4527806","article-title":"Large-scale identification of protein-protein interaction of Escherichia coli K-12","volume":"16","author":"Arifuzzaman","year":"2006","journal-title":"Genome Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1126\/science.6189183","article-title":"Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Barr\u00e9-Sinoussi","year":"1983","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0140-6736(90)90001-l","article-title":"Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection","volume":"335","author":"Beral","year":"1990","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1053\/j.seminoncol.2014.12.027","article-title":"Kaposi sarcoma-associated herpesvirus-associated malignancies: epidemiology, pathogenesis, and advances in treatment","volume":"42","author":"Bhutani","year":"2015","journal-title":"Semin. Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1023\/A:1008131810233","article-title":"The herpesvirus alkaline exonuclease belongs to the restriction endonuclease PD-(D\/E)XK superfamily: insight from molecular modeling and phylogenetic analysis","volume":"22","author":"Bujnicki","year":"2001","journal-title":"Virus Genes"},{"key":"B7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-1-61779-477-3_10","article-title":"Analysis of stable and transient protein-protein interactions","volume":"833","author":"Byrum","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026104","article-title":"The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression","volume":"6","author":"Chen","year":"2016","journal-title":"Cold Spring HarbPerspect Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5614","DOI":"10.1128\/JVI.75.12.5614-5626.2001","article-title":"Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures","volume":"75","author":"Ciufo","year":"2001","journal-title":"J. Virol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1365-2133.2004.06060.x","article-title":"Susceptibility to human herpesvirus-8 infection in a healthy population from Sardinia is not directly correlated with the expression of HLA-DR alleles","volume":"151","author":"Cottoni","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"10696","DOI":"10.1073\/pnas.1004882107","article-title":"Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells","volume":"107","author":"Delgado","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1520","DOI":"10.1371\/journal.pone.0001520","article-title":"Peripheral blood endothelial progenitors as potential reservoirs of Kaposi's sarcoma-associated herpesvirus","volume":"3","author":"Della Bella","year":"2008","journal-title":"PloS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.0959-9673.2004.00407.x","article-title":"Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes","volume":"85","author":"Direkze","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-030-03502-0_3","article-title":"Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update","volume-title":"HIV\/AIDS-Associated Viral Oncogenesis","author":"Dittmer","year":"2019"},{"key":"B16","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/jmv.20361","article-title":"HLA-B, -DRB1\/3\/4\/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma","volume":"76","author":"Dorak","year":"2005","journal-title":"J. Med. Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4074","DOI":"10.1128\/jvi.78.8.4074-4084.2004","article-title":"Wild-type Kaposi's sarcoma-associated herpesvirus isolated from the oropharynx of immune-competent individuals has tropism for cultured oral epithelial cells","volume":"78","author":"Duus","year":"2004","journal-title":"J. Virol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top11","article-title":"Identification of protein-protein interactions with glutathione-S-Transferase (GST) fusion proteins","volume":"2007","author":"Einarson","year":"2007","journal-title":"CSH Protoc."},{"key":"B19","article-title":"Detection of Protein-Protein Interactions Using the GST Q21 Fusion Protein Pulldown Technique","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Einarson","year":"2001"},{"key":"B20","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1084\/jem.193.5.637","article-title":"Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue","volume":"193","author":"Ensser","year":"2001","journal-title":"J. Exp. Med."},{"key":"B21","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1128\/JVI.70.9.6012-6019.1996","article-title":"Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes","volume":"70","author":"Fickenscher","year":"1996","journal-title":"J. Virol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/29093","article-title":"Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus","volume":"394","author":"Flore","year":"1998","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"D808","DOI":"10.1093\/nar\/gks1094","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"Franceschini","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1365-2559.2005.02098.x","article-title":"Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours","volume":"46","author":"Fukunaga","year":"2005","journal-title":"Histopathology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1126\/science.282.5395.1837","article-title":"The enigmas of Kaposi's sarcoma","volume":"282","author":"Gallo","year":"1998","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00705-018-4060-y","article-title":"Kaposi sarcoma-associated herpes virus (KSHV) latent protein LANA modulates cellular genes associated with epithelial-to-mesenchymal transition","volume":"164","author":"Gaur","year":"2019","journal-title":"Arch. Virol."},{"key":"B27","first-page":"1311","article-title":"The interleukin-6-174 promoter polymorphism is associated with a risk of development of Kaposi's sarcoma in renal transplant recipients","volume":"24","author":"Gazouli","year":"2004","journal-title":"Anticancer Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1126\/science.6601822","article-title":"Proviral DNA of a retrovirus, human T-cell leukemia virus, in two patients with AIDS","volume":"220","author":"Gelmann","year":"1983","journal-title":"Science"},{"key":"B29","doi-asserted-by":"publisher","first-page":"11919","DOI":"10.1128\/jvi.74.24.11919-11927.2000","article-title":"Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity","volume":"74","author":"Glykofrydes","year":"2000","journal-title":"J. Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1126\/science.1199478","article-title":"Discovery of a viral NLR homolog that inhibits the inflammasome","volume":"331","author":"Gregory","year":"2011","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1089\/rej.2016.1909","article-title":"Comprehensive analysis of interaction networks of telomerase reverse transcriptase with multiple bioinformatic approaches: deep mining the potential functions of telomere and telomerase","volume":"20","author":"Hou","year":"2017","journal-title":"Rejuvenation Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.1073\/pnas.062525799","article-title":"Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus","volume":"99","author":"Huang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B33","volume-title":"Vascular tumors","author":"Hunt","year":"2004"},{"key":"B34","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/bioinformatics\/btu744","article-title":"DISOPRED3: precise disordered region predictions with annotated protein-binding activity","volume":"31","author":"Jones","year":"2015","journal-title":"Bioinformatics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices","volume":"292","author":"Jones","year":"1999","journal-title":"J. Mol. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"15836","DOI":"10.1073\/pnas.2536558100","article-title":"Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin","volume":"100","author":"Kanashiro","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/BF01830024","article-title":"Idiopathisches multiples Pigmentsarkom der Haut","volume":"4","year":"1872","journal-title":"Arch. f. Dermat."},{"key":"B38","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.tibs.2011.06.006","article-title":"The death-fold superfamily of homotypic interaction motifs","volume":"36","author":"Kersse","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"B39","first-page":"2354","article-title":"Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era","volume":"17","author":"La Ferla","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.14440\/jbm.2017.161","article-title":"A guide to simple, direct, and quantitative in vitro binding assays","volume":"4","author":"Lapetina","year":"2017","journal-title":"J. Biol. Methods"},{"key":"B41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.semcancer.2008.09.003","article-title":"Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis","volume":"18","author":"Liang","year":"2008","journal-title":"Semin. Cancer Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1128\/JVI.03721-14","article-title":"Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization","volume":"89","author":"Majerciak","year":"2015","journal-title":"J. Virol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1056\/NEJM199804023381403","article-title":"Sexual transmission and the natural history of human herpesvirus 8 infection","volume":"338","author":"Martin","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nrc2888","article-title":"Kaposi's sarcoma and its associated herpesvirus","volume":"10","author":"Mesri","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"B45","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1128\/JVI.73.8.6892-6902.1999","article-title":"Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8","volume":"73","author":"Moses","year":"1999","journal-title":"J. Virol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/QAD.0b013e3282ff6275","article-title":"Persistent Kaposi sarcoma in the era of HAART: characterizing the predictors of clinical response","volume":"22","author":"Nguyen","year":"2008","journal-title":"AIDS"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"B48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.neo.7900101","article-title":"Cell cycle and apoptosis","volume":"2","author":"Pucci","year":"2000","journal-title":"Neoplasia"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/80459","article-title":"The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells","volume":"6","author":"Radkov","year":"2000","journal-title":"Nat. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coisb.2018.08.006","article-title":"Protein interactome mapping in Caenorhabditiselegans","volume":"13","author":"Remmelzwaal","year":"2019","journal-title":"Curr. Opin. Syst. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000149269","article-title":"Herpesviridae. definition, provisional nomenclature, and taxonomy. The Herpesvirus study group, the international committee on taxonomy of viruses","volume":"16","author":"Roizman","year":"1981","journal-title":"Intervirology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"14862","DOI":"10.1073\/pnas.93.25.14862","article-title":"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)","volume":"93","author":"Russo","year":"1996","journal-title":"PNAS"},{"key":"B53","doi-asserted-by":"publisher","first-page":"5911","DOI":"10.1128\/jvi.77.10.5911-5925.2003","article-title":"The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication","volume":"77","author":"Sch\u00e4fer","year":"2003","journal-title":"J. Virol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/jac\/45.suppl_4.15","article-title":"Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis","author":"Schulz","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.1128\/jvi.78.8.4207-4223.2004","article-title":"Kaposi's sarcoma-associated herpesvirus\/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangements","volume":"78","author":"Sharma-Walia","year":"2004","journal-title":"J. Virol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/jmbi.2001.4762","article-title":"FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties","volume":"310","author":"Shi","year":"2001","journal-title":"J. Mol. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/pbc.20917","article-title":"Spectrum and presentation of pediatric malignancies in the HIV era: experience from Blantyre, Malawi, 1998-2003","volume":"48","author":"Sinfield","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/36606","article-title":"Herpes viral cyclin\/Cdk6 complexes evade inhibition by CDK inhibitor proteins","volume":"390","author":"Swanton","year":"1997","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"W441","DOI":"10.1093\/nar\/gkt428","article-title":"PlantLoc: an accurate web server for predicting plant protein subcellular localization by substantiality motif","volume":"41","author":"Tang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/386517a0","article-title":"Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors","volume":"386","author":"Thome","year":"1997","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10070213","article-title":"Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers","volume":"10","author":"Tornesello","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1073\/pnas.0808624106","article-title":"Functional organization of the yeast proteome by a yeast interactome map","volume":"106","author":"Valente","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1385\/1-59259-762-9:175","article-title":"Glutathione-S-transferase-fusion based assays for studying protein-protein interactions","volume":"261","author":"Vikis","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"W469","DOI":"10.1093\/nar\/gkq406","article-title":"3DLigandSite: predicting ligand-binding sites using similar structures","volume":"38","author":"Wass","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"B65","volume-title":"Vascular tumor In Skin Pathology","author":"Weeden","year":"2002"},{"key":"B66","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1086\/432103","article-title":"Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins","volume":"192","author":"Woodberry","year":"2005","journal-title":"J. Infect. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e55832","DOI":"10.1371\/journal.pone.0055832","article-title":"Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi's sarcoma-associated herpesvirus lytic replication by targeting RTA","volume":"8","author":"Yan","year":"2013","journal-title":"PloS One"},{"key":"B68","article-title":"117 - HIV-associated malignancies","volume-title":"DeVita, Hellman, and Rosenberg\"s Cancer: Principles and Practice of Oncology","author":"Yarchoan","year":"2015"},{"key":"B69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2174\/1389557517666170717125821","article-title":"Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment","volume":"18","author":"Yee-Lin","year":"2018","journal-title":"Mini Rev Med Chem"},{"key":"B70","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1128\/JVI.79.2.800-811.2005","article-title":"Virion proteins of Kaposi's sarcoma-associated herpesvirus","volume":"79","author":"Zhu","year":"2005","journal-title":"J. Virol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"7820","DOI":"10.1038\/sj.onc.1204958","article-title":"Oncogenic DNA viruses","volume":"20","author":"zur Hausen","year":"2001","journal-title":"Oncogene"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01376\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:46:27Z","timestamp":1579826787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2019.01376\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":71,"alternative-id":["10.3389\/fgene.2019.01376"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2019.01376","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"article-number":"1376"}}