{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:56:30Z","timestamp":1790636190939,"version":"4.1.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.00006","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T05:04:10Z","timestamp":1580447050000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Assessing the Relationship Between Gut Microbiota and Bone Mineral Density"],"prefix":"10.3389","volume":"11","author":[{"given":"Shiqiang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chujun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om Prakash","family":"Kafle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/ar2936","article-title":"Interleukin-17A upregulates receptor activator of NF-\u03baB on osteoclast precursors","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1101\/166298","article-title":"Genome-wide genetic data on ~500,000 UK Biobank participants","volume":"166298","author":"Bycroft","year":"2017","journal-title":"bioRxiv"},{"key":"B4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/s41588-018-0248-z","article-title":"An atlas of genetic associations in UK Biobank","volume":"50","author":"Canela-Xandri","year":"2018","journal-title":"Nat. Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"B7","doi-asserted-by":"publisher","first-page":"l1855","DOI":"10.1136\/bmj.l1855","article-title":"Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study","volume":"365","author":"Carter","year":"2019","journal-title":"BMJ"},{"key":"B8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.cell.2014.05.052","article-title":"Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences","volume":"158","author":"Cox","year":"2014","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003348","article-title":"Power and predictive accuracy of polygenic risk scores","volume":"9","author":"Dudbridge","year":"2013","journal-title":"PloS Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1002\/jbmr.350","article-title":"Interferon-\u03b3 plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice","volume":"26","author":"Duque","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat. Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1093\/bioinformatics\/btu848","article-title":"PRSice: Polygenic Risk Score software","volume":"31","author":"Euesden","year":"2014","journal-title":"Bioinformatics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/00002281-199505000-00014","article-title":"Genetic aspects of osteoporosis","volume":"7","author":"Garabedian","year":"1995","journal-title":"Curr. Opin. Rheumatol."},{"key":"B15","first-page":"1","article-title":"The effect of probiotic bacteria on transepithelial calcium transport and calcium uptake in human intestinal-like Caco-2 cells","volume":"7","author":"Gilman","year":"2006","journal-title":"Curr. Issues Intest. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.chom.2016.04.017","article-title":"Genetic determinants of the gut microbiome in UK Twins","volume":"19","author":"Goodrich","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1007\/s00198-013-2508-1","article-title":"Osteoporosis epidemiology in UK Biobank: a unique opportunity for international researchers","volume":"24","author":"Harvey","year":"2013","journal-title":"Osteoporos. Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.1093\/hmg\/ddw289","article-title":"Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study","volume":"25","author":"Hsu","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1192\/bjp.bp.113.130419","article-title":"Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study","volume":"205","author":"Hung","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00198-005-0014-9","article-title":"The use of multiple sites for the diagnosis of osteoporosis","volume":"17","author":"Kanis","year":"2006","journal-title":"Osteoporos. Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/cen.13356","article-title":"A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes","volume":"87","author":"Kawai","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jbmr.5650080102","article-title":"Heritable and life-style determinants of bone mineral density","volume":"8","author":"Krall","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1172\/JCI86062","article-title":"Sex steroid deficiency\u2013associated bone loss is microbiota dependent and prevented by probiotics","volume":"126","author":"Li","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","article-title":"Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice","volume":"228","author":"McCabe","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s11914-015-0292-x","article-title":"Prebiotic and probiotic regulation of bone health: role of the intestine and its microbiome","volume":"13","author":"McCabe","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jamacardio.2019.2202","article-title":"Systolic blood pressure and risk of valvular heart disease: a Mendelian randomization study","volume":"4","author":"Nazarzadeh","year":"2019","journal-title":"JAMA Cardiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"l2327","DOI":"10.1136\/bmj.l2327","article-title":"Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study","volume":"365","author":"Richmond","year":"2019","journal-title":"BMJ"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/jbmr.1588","article-title":"The gut microbiota regulates bone mass in mice","volume":"27","author":"Sj\u00f6gren","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PloS Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/ng.3693","article-title":"Association of host genome with intestinal microbial composition in a large healthy cohort","volume":"48","author":"Turpin","year":"2016","journal-title":"Nat. Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1359\/jbmr.070606","article-title":"Heritability of BMD of femoral neck and lumbar spine: a multivariate twin study of finnish men","volume":"22","author":"Videman","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s11657-014-0182-3","article-title":"Estimating prevalence of osteoporosis: Examples from industrialized countries","volume":"9","author":"Wade","year":"2014","journal-title":"Arch. Osteoporos."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e3450","DOI":"10.7717\/peerj.3450","article-title":"Diversity analysis of gut microbiota in osteoporosis and osteopenia patients","volume":"5","author":"Wang","year":"2017","journal-title":"PeerJ"},{"key":"B40","doi-asserted-by":"publisher","first-page":"201607235","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","volume":"113","author":"Yan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ng.2310","article-title":"Genome-wide efficient mixed-model analysis for association studies","volume":"44","author":"Zhou","year":"2012","journal-title":"Nat. Genet."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.00006\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T05:04:13Z","timestamp":1580447053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.00006\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,31]]},"references-count":42,"alternative-id":["10.3389\/fgene.2020.00006"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.00006","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,31]]},"article-number":"6"}}