{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:11:07Z","timestamp":1791875467634,"version":"4.3.4"},"reference-count":198,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.00826","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T05:05:15Z","timestamp":1596603915000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms"],"prefix":"10.3389","volume":"11","author":[{"given":"Vincenzo","family":"Dattilo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Perrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Gennarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jpsychores.2015.04.008","article-title":"Tumour necrosis factor-\u03b1 inhibitor therapy in chronic physical illness: a systematic review and meta-analysis of the effect on depression and anxiety.","volume":"79","author":"Abbott","year":"2015","journal-title":"J. Psychosom. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"110743","DOI":"10.18632\/oncotarget.22500","article-title":"The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.","volume":"8","author":"Abbruzzese","year":"2017","journal-title":"Oncotarget"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-4","article-title":"Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas.","volume":"31","author":"Abbruzzese","year":"2012","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"22529","DOI":"10.1002\/jcp.28816","article-title":"The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells.","volume":"234","author":"Abbruzzese","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.lfs.2014.02.014","article-title":"The role of mTOR in depression and antidepressant responses.","volume":"101","author":"Abelaira","year":"2014","journal-title":"Life Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00109-009-0525-5","article-title":"Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.","volume":"87","author":"Amato","year":"2009","journal-title":"J. Mol. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00109-007-0205-2","article-title":"IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells.","volume":"85","author":"Amato","year":"2007","journal-title":"J. Mol. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.1038\/onc.2012.470","article-title":"Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.","volume":"32","author":"Amato","year":"2013","journal-title":"Oncogene"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00141","article-title":"Alterations of the innate immune system in susceptibility and resilience after social defeat stress.","volume":"12","author":"Ambr\u00e9e","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/npp.2012.253","article-title":"Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.","volume":"38","author":"Anacker","year":"","journal-title":"Neuropsychopharmacology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"8708","DOI":"10.1073\/pnas.1300886110","article-title":"Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.","volume":"110","author":"Anacker","year":"","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1001\/jamapsychiatry.2013.1111","article-title":"Autoimmune diseases and severe infections as risk factors for mood disorders a nationwide study.","volume":"70","author":"Benros","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbi.2017.08.001","article-title":"Th17 cells in depression.","volume":"69","author":"Beurel","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S0889-1591(02)00021-1","article-title":"Stress and the inflammatory response: a review of neurogenic inflammation.","volume":"16","author":"Black","year":"2002","journal-title":"Brain. Behav. Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ajp.2014.09.001","article-title":"Emerging antidepressants to treat major depressive disorder.","volume":"12","author":"Block","year":"2014","journal-title":"Asian J. Psychiatr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/15592294.2015.1017199","article-title":"Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress.","volume":"10","author":"Bockm\u00fchl","year":"2015","journal-title":"Epigenetics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s00424-008-0483-8","article-title":"Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB\/SGK-resistant GSK3.","volume":"456","author":"Boini","year":"2008","journal-title":"Pflugers. Arch."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6439","DOI":"10.1016\/j.febslet.2005.10.040","article-title":"RFX-1, a putative alpha Adducin interacting protein in a human kidney library.","volume":"579","author":"Boito","year":"2005","journal-title":"FEBS Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1038\/npp.2009.75","article-title":"Antidepressants increase neural progenitor cells in the human hippocampus.","volume":"34","author":"Boldrini","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.60","article-title":"Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations.","volume":"1","author":"Bose","year":"2010","journal-title":"Cell Death Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/mp.2010.38","article-title":"Poor replication of candidate genes for major depressive disorder using genome-wide association data.","volume":"16","author":"Bosker","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5189","article-title":"Clinical efficacy of ketamine for treatment-resistant depression.","volume":"11","author":"Bratsos","year":"2019","journal-title":"Cureus"},{"key":"B24","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3109\/08977194.2010.518616","article-title":"Second AKT: the rise of SGK in cancer signalling.","volume":"28","author":"Bruhn","year":"2010","journal-title":"Growth Factors"},{"key":"B25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nature14659","article-title":"Sparse whole-genome sequencing identifies two loci for major depressive disorder.","volume":"523","author":"Cai","year":"2015","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12264-014-1486-4","article-title":"New hypothesis and treatment targets of depression: an integrated view of key findings.","volume":"31","author":"Cai","year":"2015","journal-title":"Neurosci. Bull."},{"key":"B27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/01.yco.0000194371.47685.f2","article-title":"An update on regional brain volume differences associated with mood disorders.","volume":"19","author":"Campbell","year":"2006","journal-title":"Curr. Opin. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s00018-013-1283-7","article-title":"VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration.","volume":"70","author":"Carmeliet","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/dneu.20758","article-title":"The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity.","volume":"70","author":"Castr\u00e9n","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111675","article-title":"Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition.","volume":"183","author":"Catalogna","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000480328","article-title":"The SGK1 Kinase Inhibitor SI113 sensitizes theranostic effects of the 64CuCl2 in human glioblastoma multiforme cells.","volume":"43","author":"Catalogna","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.2174\/1381612823666170111141915","article-title":"BDNF\/NF-\u03baB signaling in the neurobiology of depression.","volume":"23","author":"Caviedes","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0295-x","article-title":"Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells.","volume":"10","author":"Chen","year":"2017","journal-title":"Mol. Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1073\/pnas.96.5.2514","article-title":"Epithelial sodium channel regulated by aldosterone-induced protein sgk.","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/mp.2014.136","article-title":"Neurotrophic factor-\u03b11 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.","volume":"20","author":"Cheng","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/wps.20128","article-title":"Risks of all-cause and suicide mortality in mental disorders: a meta-review.","volume":"13","author":"Chesney","year":"2014","journal-title":"World Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.3390\/molecules15042814","article-title":"Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease.","volume":"15","author":"Choi","year":"2010","journal-title":"Molecules"},{"key":"B38","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1159\/000358636","article-title":"PPAR\u03b3-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells is serum and insulin dependent.","volume":"33","author":"Chra\u00efbi","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.biopsych.2019.10.015","article-title":"The genetics of the mood disorder spectrum: genome-wide association analyses of more THAN 185,000 cases and 439,000 controls.","volume":"88","author":"Coleman","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.tranon.2019.05.008","article-title":"In preclinical model of ovarian cancer, the SGK1 Inhibitor SI113 counteracts the development of paclitaxel resistance and restores drug sensitivity.","volume":"12","author":"D\u2019Antona","year":"2019","journal-title":"Transl. Oncol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183396","article-title":"Effects of the ethanol extract of dipterocarpus alatus leaf on the unpredictable chronic mild stress-induced depression in ICR Mice and Its Possible mechanism of action.","volume":"24","author":"Daodee","year":"2019","journal-title":"Molecules"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/srep45361","article-title":"SGK1 affects RAN\/RANBP1\/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation.","volume":"7","author":"Dattilo","year":"2017","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1210\/edrv.19.3.0331","article-title":"Brain corticosteroid receptor balance in health and disease 1.","volume":"19","author":"de Kloet","year":"1998","journal-title":"Endocr. Rev."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaj1549","article-title":"Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression.","volume":"10","author":"Descalzi","year":"2017","journal-title":"Sci. Signal."},{"key":"B45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biopsych.2018.12.014","article-title":"Neurotrophic and antidepressant actions of brain-derived neurotrophic factor require vascular endothelial growth factor.","volume":"86","author":"Deyama","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.05.011","article-title":"Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice.","volume":"149","author":"Dong","year":"2019","journal-title":"Steroids"},{"key":"B47","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression.","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1098\/rstb.2011.0357","article-title":"A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists.","volume":"367","author":"Duman","year":"2012","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders.","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neulet.2010.02.063","article-title":"Differential brain, but not serum VEGF levels in a genetic rat model of depression.","volume":"474","author":"Elfving","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue.","volume":"81","author":"Enache","year":"2019","journal-title":"Brain. Behav. Immun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"C494","DOI":"10.1152\/ajpcell.00408.2001","article-title":"sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport.","volume":"282","author":"Faletti","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2713-3","article-title":"Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.","volume":"17","author":"Ficek","year":"2016","journal-title":"BMC Genomics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nrn4023","article-title":"A new mechanism of nervous system plasticity: activity-dependent myelination.","volume":"16","author":"Fields","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.neuron.2014.01.027","article-title":"The genetics of major depression.","volume":"81","author":"Flint","year":"2014","journal-title":"Neuron"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.1093\/emboj\/cdf551","article-title":"A phosphoserine\/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.","volume":"21","author":"Fr\u00f6din","year":"2002","journal-title":"EMBO J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1042\/BJ20081668","article-title":"mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).","volume":"416","author":"Garc\u00eda-Mart\u00ednez","year":"2008","journal-title":"Biochem. J."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252304","article-title":"Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.","volume":"344","author":"Gibson","year":"2014","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.biopsych.2017.09.023","article-title":"Transcriptome alterations in posttraumatic stress disorder.","volume":"83","author":"Girgenti","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.psyneuen.2015.06.015","article-title":"Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats.","volume":"60","author":"G\u0142ombik","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder.","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain. Behav. Immun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2014.10.002","article-title":"Integrating the monoamine, neurotrophin and cytokine hypotheses of depression - A central role for the serotonin transporter?","volume":"147","author":"Haase","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00921","article-title":"Association of SGK1 polymorphisms with susceptibility to coronary heart disease in Chinese han patients with comorbid depression.","volume":"10","author":"Han","year":"2019","journal-title":"Front. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/j.1460-9568.2005.03951.x","article-title":"Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression.","volume":"21","author":"Heine","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1172\/JCI81151","article-title":"Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.","volume":"125","author":"Hernandez","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175075","article-title":"Dynamic glucocorticoid-dependent regulation of Sgk1 expression in oligodendrocytes of adult male rat brain by acute stress and time of day.","volume":"12","author":"Hinds","year":"2017","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nn.4113","article-title":"Neuroimmune mechanisms of depression.","volume":"18","author":"Hodes","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.molcel.2008.04.027","article-title":"mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.","volume":"30","author":"Hong","year":"2008","journal-title":"Mol. Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.","volume":"22","author":"Howard","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020198","article-title":"Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex.","volume":"6","author":"Howell","year":"2011","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118530","article-title":"PARVA promotes metastasis by modulating ILK Signalling pathway in lung adenocarcinoma.","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/ng.3623","article-title":"Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.","volume":"48","author":"Hyde","year":"2016","journal-title":"Nat. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2016.07.094","article-title":"Serum- and glucocorticoid-inducible kinases in microglia.","volume":"478","author":"Inoue","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/B978-0-12-813333-0.00006-8","article-title":"The neurotrophic hypothesis of depression revisited: new insights and therapeutic implications","author":"Jaggar","year":"2019","journal-title":"Neurobiology of Depression"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and Injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017.","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/mp.2015.57","article-title":"Gene expression in major depressive disorder.","volume":"21","author":"Jansen","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.celrep.2016.06.101","article-title":"miR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety, and depression.","volume":"16","author":"Jin","year":"2016","journal-title":"Cell Rep."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00515","article-title":"The role of BDNF in the neuroimmune axis regulation of mood disorders.","volume":"10","author":"Jin","year":"2019","journal-title":"Front. Neurol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1080\/15548627.2019.1630222","article-title":"Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.","volume":"16","author":"Jung","year":"2019","journal-title":"Autophagy"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.2741\/e195","article-title":"Contribution of central SGK-1 to the acute phase responses of mice to social isolation.","volume":"2","author":"Kaji","year":"2010","journal-title":"Front. Biosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.pnpbp.2007.09.008","article-title":"Comparison between intraperitoneal and subcutaneous phencyclidine administration in sprague-dawley rats: a locomotor activity and gene induction study.","volume":"32","author":"Kalinichev","year":"2008","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B83","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.molbrainres.2004.12.020","article-title":"Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs.","volume":"136","author":"Karege","year":"2005","journal-title":"Mol. Brain Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.","volume":"22","author":"Keller","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4614-6434-1_174-1","article-title":"Neuroimmune signaling: cytokines and the CNS","author":"Kennedy","year":"2016","journal-title":"Neuroscience in the 21st Century"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2014.1332","article-title":"Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life a population-based longitudinal study.","volume":"71","author":"Khandaker","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00230","article-title":"Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: implications to mood disorders.","volume":"6","author":"Kino","year":"2015","journal-title":"Front. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1042\/0264-6021:3440189","article-title":"Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.","volume":"344","author":"Kobayashi","year":"1999","journal-title":"Biochem. J."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1001\/jamapsychiatry.2014.1611","article-title":"Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects a systematic review and meta-analysis of randomized clinical trials.","volume":"71","author":"K\u00f6hler","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127643","article-title":"Blood BDNF level is gender specific in severe depression.","volume":"10","author":"Kreinin","year":"2015","journal-title":"PLoS One"},{"key":"B92","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/14656566.2019.1683161","article-title":"Efficacy and safety of intranasal esketamine for the treatment of major depressive disorder.","volume":"21","author":"Kryst","year":"2020","journal-title":"Expert Opin. Pharmacother."},{"key":"B93","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.kjms.2018.02.004","article-title":"IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K\/Akt\/FoxO3a pathway.","volume":"34","author":"Kuang","year":"2018","journal-title":"Kaohsiung J. Med. Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1016\/j.febslet.2011.09.010","article-title":"Glucocorticoid suppresses BDNF-stimulated MAPK\/ERK pathway via inhibiting interaction of Shp2 with TrkB.","volume":"585","author":"Kumamaru","year":"2011","journal-title":"FEBS Lett."},{"key":"B95","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/MNH.0b013e32832f125e","article-title":"The physiological impact of the serum and glucocorticoid-inducible kinase SGK1.","volume":"18","author":"Lang","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1152\/physrev.00050.2005","article-title":"(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.","volume":"86","author":"Lang","year":"2006","journal-title":"Physiol. Rev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1517\/13543770903365209","article-title":"Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448.","volume":"20","author":"Lang","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"B98","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1096\/fj.12-218230","article-title":"Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.","volume":"27","author":"Lang","year":"2013","journal-title":"FASEB J."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1113\/jphysiol.2010.190926","article-title":"Significance of SGK1 in the regulation of neuronal function.","volume":"588","author":"Lang","year":"2010","journal-title":"J. Physiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1517\/13543784.2013.778971","article-title":"Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.","volume":"22","author":"Lang","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B101","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1055\/s-0031-1273425","article-title":"Cell volume, the serum and glucocorticoid inducible kinase 1 and the liver.","volume":"49","author":"Lang","year":"2011","journal-title":"Z. Gastroenterol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00213-018-4950-4","article-title":"Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression.","volume":"235","author":"Levy","year":"2018","journal-title":"Psychopharmacology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1017\/S0033291715002743","article-title":"Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions.","volume":"46","author":"Li","year":"2016","journal-title":"Psychol. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuroscience.2015.10.023","article-title":"Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone.","volume":"311","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002282","article-title":"Decreased SGK1 expression and function contributes to behavioral deficits induced by traumatic stress.","volume":"13","author":"Licznerski","year":"2015","journal-title":"PLoS Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1016\/j.fct.2010.06.020","article-title":"Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice.","volume":"48","author":"Liou","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00305","article-title":"From serotonin to neuroplasticity: evolvement of theories for major depressive disorder.","volume":"11","author":"Liu","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6871089","article-title":"The role of neural plasticity in depression: from hippocampus to prefrontal cortex.","volume":"2017","author":"Liu","year":"2017","journal-title":"Neural Plast."},{"key":"B109","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.pbb.2006.11.005","article-title":"Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats.","volume":"86","author":"Liu","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1475-7","article-title":"Role of inflammation in depression relapse.","volume":"16","author":"Liu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146392","article-title":"Acute stress imposed during adolescence yields heightened anxiety in sprague dawley rats that persists into adulthood: sex differences and potential involvement of the medial amygdala.","volume":"1723","author":"Lovelock","year":"2019","journal-title":"Brain Res."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000489","article-title":"Adaptive variation regulates the expression of the human SGK1 gene in response to stress.","volume":"5","author":"Luca","year":"2009","journal-title":"PLoS Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00401-013-1223-5","article-title":"Neuropathology of stress.","volume":"127","author":"Lucassen","year":"2014","journal-title":"Acta Neuropathol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.neuropharm.2010.01.012","article-title":"Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients.","volume":"58","author":"Lucassen","year":"2010","journal-title":"Neuropharmacology"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08154-1","article-title":"Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.","volume":"10","author":"Ma","year":"2019","journal-title":"Nat. Commun."},{"key":"B116","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1101\/lm.179206","article-title":"SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons.","volume":"13","author":"Ma","year":"2006","journal-title":"Learn. Mem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1017\/S1092852915000449","article-title":"Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways.","volume":"21","author":"Martin-Subero","year":"2016","journal-title":"CNS Spectr"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1212-1","article-title":"The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.","volume":"38","author":"Matteoni","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/WNR.0000000000001180","article-title":"Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR\/SGK1 signaling pathway in cultured PC12 cells.","volume":"30","author":"Meng","year":"2019","journal-title":"Neuroreport"},{"key":"B120","doi-asserted-by":"publisher","first-page":"C148","DOI":"10.1152\/ajpcell.00284.2004","article-title":"Serum and glucocorticoid-regulated kinase Sgk1 inhibits insulin-dependent activation of phosphomannomutase 2 in transfected COS-7 cells.","volume":"288","author":"Menniti","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019859","article-title":"Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum.","volume":"6","author":"Miyata","year":"2011","journal-title":"PLoS One"},{"key":"B122","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbrc.2015.05.109","article-title":"Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.","volume":"464","author":"Miyata","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/mp.2010.98","article-title":"Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment.","volume":"16","author":"Molendijk","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"B124","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0165-0327(02)00353-1","article-title":"Remission in major depression with two antidepressant mechanisms: results from a naturalistic study.","volume":"79","author":"Montes","year":"2004","journal-title":"J. Affect. Disord."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092197","article-title":"Resveratrol and depression in animal models: a systematic review of the biological mechanisms.","volume":"23","author":"Moore","year":"2018","journal-title":"Molecules"},{"key":"B126","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.semcdb.2003.12.022","article-title":"PDK1, the master regulator of AGC kinase signal transduction.","volume":"15","author":"Mora","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s00213-016-4357-z","article-title":"Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus.","volume":"233","author":"Mu","year":"2016","journal-title":"Psychopharmacology"},{"key":"B128","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11011-008-9114-5","article-title":"Neuropsychiatric disorders related to interferon and interleukins treatment.","volume":"24","author":"Myint","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"B129","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00702-017-1709-8","article-title":"Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis.","volume":"125","author":"Naoi","year":"2018","journal-title":"J. Neural Transm."},{"key":"B130","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/iub.209","article-title":"Relative resistance of SGK1 knockout mice against chemical carcinogenesis.","volume":"61","author":"Nasir","year":"2009","journal-title":"IUBMB Life"},{"key":"B131","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1192\/bjp.bp.115.180752","article-title":"Childhood maltreatment and characteristics of adult depression: meta-analysis.","volume":"210","author":"Nelson","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"B132","doi-asserted-by":"publisher","first-page":"530","DOI":"10.2174\/157015911798376262","article-title":"Neurotrophins role in depression neurobiology: a review of basic and clinical evidence.","volume":"9","author":"Neto","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.bbrc.2006.03.196","article-title":"Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice.","volume":"344","author":"Nonogaki","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B134","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.neuroscience.2012.09.073","article-title":"Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system.","volume":"239","author":"Numakawa","year":"2013","journal-title":"Neuroscience"},{"key":"B135","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1073\/pnas.0800888106","article-title":"Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-\u03b3 signaling for glutamate release via a glutamate transporter.","volume":"106","author":"Numakawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00136","article-title":"The role of brain-derived neurotrophic factor (BDNF) in comorbid depression: possible linkage with steroid hormones, cytokines, and nutrition.","volume":"5","author":"Numakawa","year":"2014","journal-title":"Front. Psychiatry"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.4103\/1673-5374.211174","article-title":"Impact of glucocorticoid on neurogenesis.","volume":"12","author":"Odaka","year":"2017","journal-title":"Neural Regen. Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.3552","article-title":"Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.","volume":"48","author":"Okbay","year":"2016","journal-title":"Nat. Genet."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder.","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B140","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.pbb.2007.04.009","article-title":"Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats.","volume":"87","author":"Pan","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B141","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.psyneuen.2009.06.020","article-title":"Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.","volume":"35","author":"Pan","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"B142","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1248\/bpb.29.2399","article-title":"Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed sprague-dawley rats.","volume":"29","author":"Pan","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"B143","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jpsychires.2014.01.021","article-title":"Toll-like receptors in the depressed and suicide brain.","volume":"53","author":"Pandey","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B144","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1503\/jpn.170192","article-title":"Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide.","volume":"43","author":"Pandey","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation.","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1176\/appi.focus.20180030","article-title":"Ketamine for treatment-resistant mood disorders.","volume":"17","author":"Park","year":"2019","journal-title":"Focus"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00399","article-title":"How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?","volume":"12","author":"Pepper","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00423","article-title":"Glucocorticoid resistance: is it a requisite for increased cytokine production in depression? a systematic review and meta-analysis.","volume":"10","author":"Perrin","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","first-page":"9406","DOI":"10.1074\/jbc.M007052200","article-title":"Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin.","volume":"276","author":"Perrotti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B150","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s11033-019-05129-3","article-title":"The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression.","volume":"47","author":"Pitsillou","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.jad.2014.11.044","article-title":"BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis.","volume":"174","author":"Polyakova","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B152","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/400_2007_032","article-title":"Regulation of excitability by potassium channels.","volume":"44","author":"Pongs","year":"2007","journal-title":"Results Probl. Cell Differ."},{"key":"B153","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/cercor\/bht203","article-title":"Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders.","volume":"25","author":"Qi","year":"2015","journal-title":"Cereb. Cortex"},{"key":"B154","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3892\/etm.2019.7633","article-title":"Investigation of the underling mechanism of ketamine for antidepressant effects in treatment-refractory affective disorders via molecular profile analysis.","volume":"18","author":"Qiao","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1159\/000374013","article-title":"Genistein inhibits human colorectal cancer growth and suppresses miR-95. Akt and SGK1.","volume":"35","author":"Qin","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"B156","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuropharm.2016.03.022","article-title":"Glucocorticoids alter neuronal differentiation of human neuroepithelial-like cells by inducing long-lasting changes in the reactive oxygen species balance.","volume":"107","author":"Raciti","year":"2016","journal-title":"Neuropharmacology"},{"key":"B157","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/sj.mp.4001791","article-title":"Neural stem cell proliferation is decreased in schizophrenia, but not in depression.","volume":"11","author":"Reif","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"B158","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1177\/0269881107081521","article-title":"Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study.","volume":"22","author":"Robbins","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"16657","DOI":"10.1073\/pnas.1102821108","article-title":"Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation.","volume":"108","author":"Samarasinghe","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1210\/en.2009-1119","article-title":"Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain.","volume":"151","author":"Sarabdjitsingh","year":"2010","journal-title":"Endocrinology"},{"key":"B161","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/j.1471-4159.2008.05489.x","article-title":"Large-scale analysis of glucocorticoid target genes in rat hypothalamus.","volume":"106","author":"Sato","year":"2008","journal-title":"J. Neurochem."},{"key":"B162","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.phymed.2012.03.012","article-title":"Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract\u2013stimulation of anti-oxidative enzyme expression.","volume":"19","author":"Schild","year":"2012","journal-title":"Phytomedicine"},{"key":"B163","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1159\/000366311","article-title":"Serum- and glucocorticoid-inducible kinase 1 sensitive NF-\u03baB signaling in dendritic cells.","volume":"34","author":"Schmid","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B164","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/FBP.0b013e3282ee2aa8","article-title":"The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior.","volume":"18","author":"Schmidt","year":"2007","journal-title":"Behav. Pharmacol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1038\/npp.2011.151","article-title":"Functional biomarkers of depression: diagnosis, treatment, and pathophysiology.","volume":"36","author":"Schmidt","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B166","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000113757","article-title":"Association of SGK1 gene polymorphisms with type 2 diabetes.","volume":"21","author":"Schwab","year":"2008","journal-title":"Cell. Physiol. Biochem."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00334","article-title":"Genetics factors in major depression disease.","volume":"9","author":"Shadrina","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1401790","article-title":"Baicalin attenuates subarachnoid hemorrhagic brain injury by modulating blood-brain barrier disruption, inflammation, and oxidative damage in mice.","volume":"2017","author":"Shi","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B169","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.4049\/jimmunol.0803017","article-title":"Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1.","volume":"183","author":"Sobiesiak","year":"2009","journal-title":"J. Immunol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1042\/BJ20130342","article-title":"Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.","volume":"452","author":"Sommer","year":"2013","journal-title":"Biochem. J."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1093\/ibd\/izy158","article-title":"Deregulation of SGK1 in ulcerative colitis: a paradoxical relationship between immune cells and colonic epithelial cells.","volume":"24","author":"Spagnuolo","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"B172","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ygyno.2015.06.033","article-title":"Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.","volume":"138","author":"Stringer-Reasor","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1074\/jbc.M805055200","article-title":"SGK1 phosphorylation of I\u03baB kinase \u03b1 and p300 up-regulates NF-\u03baB activity and increases N-methyl-D-aspartate receptorNR2A and NR2B expression.","volume":"284","author":"Tai","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B174","doi-asserted-by":"publisher","first-page":"37511","DOI":"10.18632\/oncotarget.5527","article-title":"Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.","volume":"6","author":"Talarico","year":"2015","journal-title":"Oncotarget"},{"key":"B175","doi-asserted-by":"publisher","first-page":"15868","DOI":"10.18632\/oncotarget.7520","article-title":"SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.","volume":"7","author":"Talarico","year":"","journal-title":"Oncotarget"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1159\/000447885","article-title":"SGK1, the new player in the game of resistance: chemo-radio molecular target and strategy for inhibition.","volume":"39","author":"Talarico","year":"","journal-title":"Cell. Physiol. Biochem."},{"key":"B177","year":"2020","journal-title":"Efficacy of Resveratrol in Depression - Full Text View - <ext-link ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\">ClinicalTrials.gov<\/ext-link>."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.4172\/2167-1044.1000150","article-title":"The Genetics of MDD \u2013 A review of challenges and opportunities.","volume":"3","author":"Verbeek","year":"2014","journal-title":"Depress Anxiety"},{"key":"B179","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1159\/000430380","article-title":"SGK1-sensitive regulation of cyclin-dependent kinase inhibitor 1B (p27) in cardiomyocyte hypertrophy.","volume":"37","author":"Voelkl","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01393","article-title":"Kv1.3 channel as a key therapeutic target for neuroinflammatory diseases: state of the art and beyond.","volume":"13","author":"Wang","year":"2020","journal-title":"Front. Neurosci."},{"key":"B181","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3892\/ijmm.2016.2591","article-title":"Icariin alters the expression of glucocorticoid receptor, FKBP5 and SGK1 in rat brains following exposure to chronic mild stress.","volume":"38","author":"Wei","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B182","year":"","journal-title":"Depression."},{"key":"B183","year":"","journal-title":"Suicide."},{"key":"B184","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.","volume":"50","author":"Wray","year":"2018","journal-title":"Nat. Genet."},{"key":"B185","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature11984","article-title":"Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.","volume":"496","author":"Wu","year":"2013","journal-title":"Nature"},{"key":"B186","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuint.2012.09.016","article-title":"Ginsenoside Rg1 facilitates neural differentiation of mouse embryonic stem cells via GR-dependent signaling pathway.","volume":"62","author":"Wu","year":"2013","journal-title":"Neurochem. Int."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1172\/JCI15696","article-title":"Impaired renal Na(+) retention in the sgk1-knockout mouse.","volume":"110","author":"Wulff","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B188","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.gene.2015.10.072","article-title":"Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells.","volume":"576","author":"Xiaobo","year":"2016","journal-title":"Gene"},{"key":"B189","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1248\/bpb.34.253","article-title":"Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade.","volume":"34","author":"Xiong","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"B190","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1177\/0269881118758304","article-title":"miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice.","volume":"32","author":"Yi","year":"2018","journal-title":"J. Psychopharmacol."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080268","article-title":"Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction.","volume":"8","author":"Zarrinpashneh","year":"2013","journal-title":"PLoS One"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1038\/srep30951","article-title":"Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety\/depression.","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"B193","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1159\/000363000","article-title":"Protective effect of SGK1 in rat hippocampal neurons subjected to ischemia reperfusion.","volume":"34","author":"Zhang","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B194","first-page":"20","article-title":"Role of brain-derived neurotrophic factor in the molecular neurobiology of major depressive disorder.","volume":"4","author":"Zhang","year":"2017","journal-title":"Transl. Perioper. Pain Med."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.lfs.2004.04.014","article-title":"Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders.","volume":"75","author":"Zhang","year":"2004","journal-title":"Life Sci."},{"key":"B196","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.mehy.2015.10.012","article-title":"Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder.","volume":"85","author":"Zhou","year":"","journal-title":"Med. Hypotheses"},{"key":"B197","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1126\/science.aaa5619","article-title":"SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.","volume":"349","author":"Zhou","year":"","journal-title":"Science"},{"key":"B198","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.pnpbp.2010.04.011","article-title":"Glucocorticoids, cytokines and brain abnormalities in depression.","volume":"35","author":"Zunszain","year":"2011","journal-title":"Prog. Neuro -Psychopharmacol. Biol. Psychiatry"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.00826\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T05:05:19Z","timestamp":1596603919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.00826\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":198,"alternative-id":["10.3389\/fgene.2020.00826"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.00826","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]},"article-number":"826"}}