{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:54:12Z","timestamp":1789062852110,"version":"build-2803163510"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770545"],"award-info":[{"award-number":["81770545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701746"],"award-info":[{"award-number":["81701746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.572194","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T07:01:07Z","timestamp":1605078067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Identification of Common Differentially Expressed Genes and Potential Therapeutic Targets in Ulcerative Colitis and Rheumatoid Arthritis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yueying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1097\/MIB.0b013e318298118e","article-title":"Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis.","volume":"19","author":"Asano","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1080\/14397595.2016.1211229","article-title":"Association of inflammatory bowel disease with ankylosing spondylitis and rheumatoid arthritis: a nationwide population-based study.","volume":"27","author":"Bae","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429x-14-83","article-title":"MultiContrast Delayed Enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: a clinical validation study.","volume":"14","author":"Bandettini","year":"2012","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1084\/jem.20181657","article-title":"Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.","volume":"216","author":"Bersellini Farinotti","year":"2019","journal-title":"J. Exp. Med."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00805","article-title":"IgG and Fcgamma receptors in intestinal immunity and inflammation.","volume":"10","author":"Castro-Dopico","year":"2019","journal-title":"Front. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.clim.2007.09.001","article-title":"Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population.","volume":"126","author":"Chen","year":"2008","journal-title":"Clin. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1182\/blood-2011-12-401133","article-title":"Endocytosis of soluble immune complexes leads to their clearance by FcgammaRIIIB but induces neutrophil extracellular traps via FcgammaRIIA in vivo.","volume":"120","author":"Chen","year":"2012","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-s4-s11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome.","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-540","article-title":"Response of the goat mammary gland to infection with Staphylococcus aureus revealed by gene expression profiling in milk somatic and white blood cells.","volume":"13","author":"Cremonesi","year":"2012","journal-title":"BMC Genomics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/s1471-4906(01)02014-2","article-title":"Inflammation in autoimmunity: receptors for IgG revisited.","volume":"22","author":"Dijstelbloem","year":"2001","journal-title":"Trends Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.4049\/jimmunol.179.1.647","article-title":"Phosphorylation of pleckstrin increases proinflammatory cytokine secretion by mononuclear phagocytes in diabetes mellitus.","volume":"179","author":"Ding","year":"2007","journal-title":"J. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGENucleic.","volume":"31","author":"Farre","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0603-4","article-title":"A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?","volume":"6","author":"Forbes","year":"2018","journal-title":"Microbiome"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1038\/onc.2016.404","article-title":"Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.","volume":"36","author":"Guo","year":"2017","journal-title":"Oncogene"},{"key":"B15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s40259-019-00333-w","article-title":"Selective JAKinibs: prospects in inflammatory and autoimmune diseases.","volume":"33","author":"Virtanen","year":"2019","journal-title":"BioDrugs"},{"key":"B16","doi-asserted-by":"publisher","first-page":"6137","DOI":"10.3748\/wjg.v23.i33.6137","article-title":"Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.","volume":"23","author":"Halling","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1515\/hsz-2015-0277","article-title":"Endocytosis of pro-inflammatory cytokine receptors and its relevance for signal transduction.","volume":"397","author":"Hermanns","year":"2016","journal-title":"Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1136\/gutjnl-2016-312135","article-title":"Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.","volume":"67","author":"Imhann","year":"2018","journal-title":"Gut"},{"key":"B19","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","article-title":"Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.","volume":"10","author":"Jess","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1136\/ard.2007.083675","article-title":"The effectiveness and medication costs of three anti-tumour necrosis factor alpha agents in the treatment of rheumatoid arthritis from prospective clinical practice data.","volume":"67","author":"Kievit","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1136\/ard.51.8.1009","article-title":"Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroiliitis.","volume":"51","author":"Klausen","year":"1992","journal-title":"Ann. Rheum. Dis."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00327","article-title":"Serglycin: at the crossroad of inflammation and malignancy.","volume":"3","author":"Korpetinou","year":"2014","journal-title":"Front. Oncol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078157","article-title":"Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.","volume":"8","author":"Korpetinou","year":"2013","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.3892\/or.2017.5946","article-title":"Screening and identification of key biomarkers in hepatocellular carcinoma: evidence from bioinformatic analysis.","volume":"38","author":"Li","year":"2017","journal-title":"Oncol. Rep."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1158\/0008-5472.Can-10-3557","article-title":"Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.","volume":"71","author":"Li","year":"2011","journal-title":"Cancer Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1182\/blood.2019000435","article-title":"Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.","volume":"134","author":"Lindstrom","year":"2019","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00284-013-0338-1","article-title":"Analysis of fecal Lactobacillus community structure in patients with early rheumatoid arthritis.","volume":"67","author":"Liu","year":"2013","journal-title":"Curr. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/ar1926","article-title":"Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells.","volume":"8","author":"Mathsson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.4049\/jimmunol.1701187","article-title":"Novel anti-inflammatory peptides based on chemokine-glycosaminoglycan interactions reduce leukocyte migration and disease severity in a model of rheumatoid arthritis.","volume":"200","author":"McNaughton","year":"2018","journal-title":"J. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/ahg.12293","article-title":"Expression patterns common and unique to ulcerative colitis and celiac disease.","volume":"83","author":"Medrano","year":"2019","journal-title":"Ann. Hum. Genet."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00201","article-title":"Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) regulate the activities of inflammation and cancer.","volume":"6","author":"Misra","year":"2015","journal-title":"Front. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"46.e42","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review.","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.12.1155","article-title":"Rheumatoid arthritis associated with ulcerative colitis.","volume":"60","author":"Mosquera-Martinez","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.mayocp.2019.01.002","article-title":"Trends in prevalence of functional disability in rheumatoid arthritis compared with the general population.","volume":"94","author":"Myasoedova","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/s0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.","volume":"390","author":"Ng","year":"2018","journal-title":"Lancet"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146276","article-title":"Different gene expression signatures in children and adults with celiac disease.","volume":"11","author":"Pascual","year":"2016","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.humimm.2010.05.010","article-title":"Study of chromosomal region 5p13.1 in Crohn\u2019s disease, ulcerative colitis, and rheumatoid arthritis.","volume":"71","author":"Perdigones","year":"2010","journal-title":"Hum. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"5499","DOI":"10.1074\/jbc.M113.532143","article-title":"Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.","volume":"289","author":"Purushothaman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/cei.13294","article-title":"Distinct patterns of naive, activated and memory T and B cells in blood of patients with ulcerative colitis or Crohn\u2019s disease.","volume":"197","author":"Rabe","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/humu.23159","article-title":"Understanding the genomic structure of copy-number variation of the low-affinity fcgamma receptor region allows confirmation of the association of FCGR3B deletion with rheumatoid arthritis.","volume":"38","author":"Rahbari","year":"2017","journal-title":"Hum. Mutat."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1136\/annrheumdis-2015-208216","article-title":"Signs of immune activation and local inflammation are present in the bronchial tissue of patients with untreated early rheumatoid arthritis.","volume":"75","author":"Reynisdottir","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies.","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: ulcerative colitis in adults.","volume":"114","author":"Rubin","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","article-title":"Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017.","volume":"78","author":"Safiri","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.abb.2019.05.021","article-title":"Serglycin as part of IL-1beta induced inflammation in human chondrocytes.","volume":"669","author":"Scuruchi","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0728-9","article-title":"Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis.","volume":"17","author":"Simon","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update.","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization.","volume":"27","author":"Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0086-7","article-title":"Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods.","volume":"15","author":"Song","year":"2015","journal-title":"BMC Oral Health"},{"key":"B51","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10787-011-0104-6","article-title":"Targeting leukocyte migration and adhesion in Crohn\u2019s disease and ulcerative colitis.","volume":"20","author":"Thomas","year":"2012","journal-title":"Inflammopharmacology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1093\/rheumatology\/kev433","article-title":"Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.","volume":"55","author":"Tsang-A-Sjoe","year":"2016","journal-title":"Rheumatology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/s0140-6736(16)32126-2","article-title":"Ulcerative colitis.","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1136\/gutjnl-2012-303063","article-title":"Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcgammaR-mediated CD14 macrophage activation.","volume":"62","author":"Uo","year":"2013","journal-title":"Gut"},{"key":"B56","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1536\/ihj.15-319","article-title":"Bioinformatic analysis of genes and MicroRNAs associated with atrioventricular septal defect in down syndrome patients.","volume":"57","author":"Wang","year":"","journal-title":"Int. Heart J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00296-015-3384-0","article-title":"Association study of copy number variants in FCGR3A and FCGR3B gene with risk of ankylosing spondylitis in a Chinese population.","volume":"36","author":"Wang","year":"","journal-title":"Rheumatol. Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12282-017-0816-6","article-title":"Investigating the therapeutic potential and mechanism of curcumin in breast cancer based on RNA sequencing and bioinformatics analysis.","volume":"25","author":"Wang","year":"2018","journal-title":"Breast Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1084\/jem.20072413","article-title":"Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.","volume":"205","author":"Willcocks","year":"2008","journal-title":"J. Exp. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1093\/ecco-jcc\/jjv193","article-title":"Inflammatory bowel disease and the risk of autoimmune diseases.","volume":"10","author":"Wilson","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1080\/17425255.2017.1377180","article-title":"Primary and secondary nonresponse to infliximab: mechanisms and countermeasures.","volume":"13","author":"Wong","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1159\/000492657","article-title":"SRGN promotes colorectal cancer metastasis as a critical downstream target of HIF-1alpha.","volume":"48","author":"Xu","year":"2018","journal-title":"Cell Physiol. Biochem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters.","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B64","doi-asserted-by":"publisher","first-page":"26792","DOI":"10.1074\/jbc.M512889200","article-title":"Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide.","volume":"281","author":"Zernichow","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00797","article-title":"The apoptosis regulator 14-3-3\u03b7 and its potential as a therapeutic target in pituitary oncocytoma.","volume":"10","author":"Zhao","year":"2019","journal-title":"Front. Endocrinol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.3892\/etm.2017.5069","article-title":"Low copy number of FCGR3B is associated with lupus nephritis in a Chinese population.","volume":"14","author":"Zheng","year":"2017","journal-title":"Exp. Ther. Med."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.572194\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T07:01:13Z","timestamp":1605078073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.572194\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":66,"alternative-id":["10.3389\/fgene.2020.572194"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.572194","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"article-number":"572194"}}