{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:29:02Z","timestamp":1782217742405,"version":"3.54.5"},"reference-count":133,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011710","name":"Shaanxi Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019JM-230"],"award-info":[{"award-number":["2019JM-230"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700784"],"award-info":[{"award-number":["81700784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.584118","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T09:00:23Z","timestamp":1605258023000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Suryaji","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00198-019-04906-x","article-title":"Glucocorticoid-induced osteoporosis: 2019 concise clinical review.","volume":"30","author":"Adami","year":"2019","journal-title":"Osteoporos Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ecl.2012.04.006","article-title":"Pathophysiology of osteoporosis: new mechanistic insights.","volume":"41","author":"Armas","year":"2012","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-1-4939-6380-5_11","article-title":"Analysis RNA-seq and Noncoding RNA.","volume":"1480","author":"Arrigoni","year":"2016","journal-title":"Methods Mole. Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ajhg.2012.02.026","article-title":"Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish.","volume":"90","author":"Asharani","year":"2012","journal-title":"Am. J. Hum. Genet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bone.2014.10.014","article-title":"Characterization of bone marrow-derived mesenchymal stem cells in aging.","volume":"70","author":"Baker","year":"2015","journal-title":"Bone"},{"key":"B6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-981-13-1426-1_7","article-title":"Regulation of Transcription by Circular RNAs.","volume":"1087","author":"Bose","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1177\/0022034513500306","article-title":"Advances in the regulation of osteoclasts and osteoclast functions.","volume":"92","author":"Boyce","year":"2013","journal-title":"J. Dent Res."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13659","article-title":"Reactive oxygen species: from health to disease.","volume":"142","author":"Brieger","year":"2012","journal-title":"Swiss Med. Wkly"},{"key":"B9","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3349\/ymj.2019.60.8.751","article-title":"Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2.","volume":"60","author":"Cai","year":"2019","journal-title":"Yonsei Med. J."},{"key":"B10","first-page":"18","article-title":"LncRNA LINC00707 promotes osteogenic differentiation of hBMSCs through the Wnt\/\u03b2-catenin pathway activated by LINC00707\/miR-145\/LRP5 axis.","volume":"24","author":"Cai","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00774-015-0656-4","article-title":"Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases.","volume":"33","author":"Callaway","year":"2015","journal-title":"J. Bone Miner. Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA biogenesis.","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1080\/15384101.2020.1747776","article-title":"The lncRNA MCF2L-AS1 controls osteogenic differentiation by regulating miR-33a.","volume":"19","author":"Chen","year":"2020","journal-title":"Cell Cycle"},{"key":"B14","first-page":"9199","article-title":"LncRNA Bmncr alleviates the progression of osteoporosis by inhibiting RANML-induced osteoclast differentiation.","volume":"23","author":"Chen","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1080\/15476286.2019.1624470","article-title":"CircRNA_28313\/miR-195a\/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice.","volume":"16","author":"Chen","year":"","journal-title":"RNA Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3892\/etm.2018.7033","article-title":"Long non-coding RNA XIST promotes osteoporosis through inhibiting bone marrow mesenchymal stem cell differentiation.","volume":"17","author":"Chen","year":"","journal-title":"Exp. Ther. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.7150\/thno.29678","article-title":"Circular RNAs in immune responses and immune diseases.","volume":"9","author":"Chen","year":"","journal-title":"Theranostics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091015","article-title":"Long Non-Coding RNA in the Pathogenesis of Cancers.","volume":"8","author":"Chi","year":"2019","journal-title":"Cells"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/srep23117","article-title":"Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1.","volume":"6","author":"Cui","year":"2016","journal-title":"Sci. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/978-981-13-1426-1_23","article-title":"Circular RNAs in Vascular Functions and Diseases.","volume":"1087","author":"Ding","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1089\/ars.2009.2892","article-title":"The syndrome of inherited partial SBP2 deficiency in humans.","volume":"12","author":"Dumitrescu","year":"2010","journal-title":"Ant. Redox. Sign."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1080\/15476286.2016.1271524","article-title":"Insights into circular RNA biology.","volume":"14","author":"Ebbesen","year":"2017","journal-title":"RNA Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-015-3334-4","article-title":"Treatment of osteoporosis after alendronate or risedronate.","volume":"27","author":"Eiken","year":"2016","journal-title":"Osteoporos Int."},{"key":"B24","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease.","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000495159","article-title":"Long Non-Coding RNA MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling.","volume":"51","author":"Fan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B26","first-page":"7757","article-title":"LncRNA GAS5 overexpression alleviates the development of osteoporosis through promoting osteogenic differentiation of MSCs via targeting microRNA-498 to regulate RUNX2.","volume":"23","author":"Feng","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.omtn.2018.03.004","article-title":"Linc-ROR Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Functioning as a Competing Endogenous RNA for miR-138 and miR-145.","volume":"11","author":"Feng","year":"","journal-title":"Mole. Ther. Nucleic Acids"},{"key":"B28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11010-017-3251-2","article-title":"Long non-coding RNA BDNF-AS modulates osteogenic differentiation of bone marrow-derived mesenchymal stem cells.","volume":"445","author":"Feng","year":"","journal-title":"Mol. Cell Biochem."},{"key":"B29","first-page":"526","article-title":"LncRNA TERC alleviates the progression of osteoporosis by absorbing miRNA-217 to upregulate RUNX2.","volume":"24","author":"Gao","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176081","article-title":"The Role of MicroRNAs in Bone Metabolism and Disease.","volume":"21","author":"Gao","year":"","journal-title":"Int. J. Mole. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"6986","DOI":"10.1002\/jcb.26907","article-title":"Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells.","volume":"119","author":"Gao","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109774","article-title":"H19 lncRNA: Roles in tumorigenesis.","volume":"123","author":"Ghafouri-Fard","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0300-9","article-title":"Aging, inflammation, stem cells, and bone healing.","volume":"7","author":"Gibon","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s13018-019-1430-4","article-title":"LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts.","volume":"14","author":"Han","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3389\/fphys.2018.01262","article-title":"Circular RNAs as Therapeutic Agents and Targets.","volume":"9","author":"Holdt","year":"2018","journal-title":"Front. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.bbrc.2019.07.095","article-title":"Dysregulation of cPWWP2A-miR-579 axis mediates dexamethasone-induced cytotoxicity in human osteoblasts.","volume":"517","author":"Hong","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190445","article-title":"LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis.","volume":"39","author":"Huang","year":"","journal-title":"Biosci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"582","DOI":"10.5732\/cjc.013.10170","article-title":"Noncoding RNAs in cancer and cancer stem cells.","volume":"32","author":"Huang","year":"2013","journal-title":"Chin. J. Cancer"},{"key":"B39","first-page":"4776","article-title":"CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p.","volume":"11","author":"Huang","year":"","journal-title":"Am. J. Transl. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"8432","DOI":"10.1111\/jcmm.14726","article-title":"The roles of circRFWD2 and circINO80 during NELL-1-induced osteogenesis.","volume":"23","author":"Huang","year":"","journal-title":"J. Cell Mol. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"21450","DOI":"10.1002\/jcp.28866","article-title":"Prospect of circular RNA in osteogenesis: A novel orchestrator of signaling pathways.","volume":"234","author":"Huang","year":"","journal-title":"J. Cell Physiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1002\/stem.2225","article-title":"Long Noncoding RNA H19 Promotes Osteoblast Differentiation Via TGF-\u03b21\/Smad3\/HDAC Signaling Pathway by Deriving miR-675.","volume":"33","author":"Huang","year":"2015","journal-title":"Stem Cells"},{"key":"B43","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs.","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bone.2018.08.012","article-title":"E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGF\u03b21-induced pSMAD1 in immature osteoblast.","volume":"116","author":"Jeon","year":"2018","journal-title":"Bone"},{"key":"B45","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13287-019-1161-9","article-title":"Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B.","volume":"10","author":"Jia","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"B46","first-page":"5558","article-title":"Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt\/\u03b2-catenin pathway.","volume":"23","author":"Jiang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.lfs.2019.05.002","article-title":"LncRNA SNHG1 modulates p38 MAPK pathway through Nedd4 and thus inhibits osteogenic differentiation of bone marrow mesenchymal stem cells.","volume":"228","author":"Jiang","year":"","journal-title":"Life sci."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180878","article-title":"LncRNA NEF inhibits migration and invasion of HPV-negative cervical squamous cell carcinoma by inhibiting TGF-\u03b2 pathway.","volume":"39","author":"Ju","year":"2019","journal-title":"Biosci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"10631","DOI":"10.1093\/nar\/gkw802","article-title":"The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation.","volume":"44","author":"Kalwa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"626","DOI":"10.2174\/1574888X10666151019115724","article-title":"Osteoclasts and Remodeling Based Bone Formation.","volume":"11","author":"Kylmaoja","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00003086-200003000-00016","article-title":"Osteoporosis.","volume":"372","author":"Lane","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"292","DOI":"10.7150\/ijms.28047","article-title":"Circular RNA: a novel biomarker and therapeutic target for human cancers.","volume":"16","author":"Lei","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.injury.2017.05.016","article-title":"Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis.","volume":"48","author":"Leighton","year":"2017","journal-title":"Injury"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5251","DOI":"10.1172\/JCI99044","article-title":"Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging.","volume":"128","author":"Li","year":"","journal-title":"J. Clin. Investigat."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246229","article-title":"Silencing of lncRNA AK045490 Promotes Osteoblast Differentiation and Bone Formation via \u03b2-Catenin\/TCF1\/Runx2 Signaling Axis.","volume":"20","author":"Li","year":"","journal-title":"Int. J. Mole. Sci."},{"key":"B56","first-page":"3342","article-title":"Long noncoding RNA SNHG5 is up-regulated and serves as a potential prognostic biomarker in acute myeloid leukemia.","volume":"22","author":"Li","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030597","article-title":"Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.","volume":"18","author":"Li","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B58","first-page":"5815","article-title":"CRNDE impacts the proliferation of osteoclast by estrogen deficiency in postmenopausal osteoporosis.","volume":"22","author":"Li","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B59","first-page":"4521","article-title":"LncRNA MEG3 promotes proliferation and differentiation of osteoblasts through Wnt\/\u03b2-catenin signaling pathway.","volume":"23","author":"Li","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.18632\/aging.102674","article-title":"Circular RNA HIPK3 downregulation mediates hydrogen peroxide-induced cytotoxicity in human osteoblasts.","volume":"12","author":"Liang","year":"2020","journal-title":"Aging"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/s41388-017-0041-y","article-title":"LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt\/\u03b2-catenin signaling.","volume":"37","author":"Liang","year":"2018","journal-title":"Oncogene"},{"key":"B63","doi-asserted-by":"publisher","first-page":"20121","DOI":"10.1038\/srep20121","article-title":"H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA.","volume":"6","author":"Liang","year":"2016","journal-title":"Scientif. Rep."},{"key":"B64","first-page":"10195","article-title":"Long noncoding RNA MIRG induces osteoclastogenesis and bone resorption in osteoporosis through negative regulation of miR-1897.","volume":"23","author":"Ling","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1111\/jcmm.13137","article-title":"Collagen type XV and the \u2018osteogenic status\u2019.","volume":"21","author":"Lisignoli","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/jcp.27031","article-title":"LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45.","volume":"234","author":"Liu","year":"","journal-title":"J. Cell. Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00418-018-1643-3","article-title":"Inflammation, mesenchymal stem cells and bone regeneration.","volume":"149","author":"Liu","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ijsu.2019.11.004","article-title":"Long non-coding RNA MALAT1 as a valuable biomarker for prognosis in osteosarcoma: A systematic review and meta-analysis.","volume":"72","author":"Liu","year":"","journal-title":"Int. J. Surg."},{"key":"B69","first-page":"4584","article-title":"LncRNA TUG1 influences osteoblast proliferation and differentiation through the Wnt\/\u03b2-catenin signaling pathway.","volume":"23","author":"Liu","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1800-z","article-title":"A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma.","volume":"17","author":"Liu","year":"","journal-title":"J. Transl. Med."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0090-4","article-title":"Functions of lncRNA HOTAIR in lung cancer.","volume":"7","author":"Loewen","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1161\/CIRCRESAHA.117.311311","article-title":"RNA Therapeutics in Cardiovascular Disease.","volume":"123","author":"Lucas","year":"2018","journal-title":"Circ. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1177\/0300060519847854","article-title":"LncRNA-NEF is downregulated in postmenopausal osteoporosis and is related to course of treatment and recurrence.","volume":"47","author":"Ma","year":"2019","journal-title":"J. Internat. Med. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.tibs.2018.06.004","article-title":"Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models.","volume":"43","author":"Manning","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nrd.2016.117","article-title":"Non-coding RNAs as drug targets.","volume":"16","author":"Matsui","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"B76","doi-asserted-by":"publisher","first-page":"11988","DOI":"10.18632\/aging.102524","article-title":"CircRNA AFF4 promotes osteoblast cells proliferation and inhibits apoptosis via the Mir-7223-5p\/PIK3R1 axis.","volume":"11","author":"Mi","year":"2019","journal-title":"Aging"},{"key":"B77","first-page":"6239","article-title":"Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma.","volume":"22","author":"Nie","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1517\/14740338.2016.1140743","article-title":"Long-term side effects of glucocorticoids.","volume":"15","author":"Oray","year":"2016","journal-title":"Expert. Opin. Drug Saf."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2161-5","article-title":"CircRNA hsa_circ_0074834 promotes the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by acting as a ceRNA for miR-942-5p.","volume":"10","author":"Ouyang","year":"2019","journal-title":"Cell Death Dis."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215491","article-title":"The Development of Functional Non-Viral Vectors for Gene Delivery.","volume":"4","author":"Patil","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev.med.46.1.249","article-title":"Treatment of osteoporosis.","volume":"46","author":"Prestwood","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"38842","DOI":"10.1371\/journal.pone.0038842","article-title":"ZEB2 mediates multiple pathways regulating cell proliferation, migration, invasion, and apoptosis in glioma.","volume":"7","author":"Qi","year":"2012","journal-title":"PLoS One"},{"key":"B83","first-page":"3459","article-title":"CircRNA_0048211 protects postmenopausal osteoporosis through targeting miRNA-93-5p to regulate BMP2.","volume":"24","author":"Qiao","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-94-017-7417-8_7","article-title":"Non-coding RNAs in Mammary Gland Development and Disease.","volume":"886","author":"Sandhu","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1002\/jcp.26424","article-title":"Long non-coding RNA TCONS_00041960 enhances osteogenesis and inhibits adipogenesis of rat bone marrow mesenchymal stem cell by targeting miR-204-5p and miR-125a-3p.","volume":"233","author":"Shang","year":"2018","journal-title":"J. Cell Physiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis.","volume":"4","author":"S\u00f6zen","year":"2017","journal-title":"Eur. J. Rheumatol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.tig.2015.03.007","article-title":"The Landscape of long noncoding RNA classification.","volume":"31","author":"St Laurent","year":"2015","journal-title":"Trends Genet. TIG"},{"key":"B88","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.bbrc.2018.09.142","article-title":"Long non-coding RNA, Bmcob, regulates osteoblastic differentiation of bone marrow mesenchymal stem cells.","volume":"506","author":"Sun","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1186\/s40199-017-0167-z","article-title":"New horizons in treatment of osteoporosis.","volume":"25","author":"Tabatabaei-Malazy","year":"2017","journal-title":"Daru"},{"key":"B90","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/ars.2013.5514","article-title":"Noncoding RNAs in DNA repair and genome integrity.","volume":"20","author":"Wan","year":"2014","journal-title":"Anti. Redox. Sign."},{"key":"B91","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.yexmp.2019.01.012","article-title":"LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214.","volume":"107","author":"Wang","year":"","journal-title":"Exper. Mole. Pathol."},{"key":"B92","first-page":"2173","article-title":"Effect of lncRNA AK125437 on postmenopausal osteoporosis rats via MAPK pathway.","volume":"24","author":"Wang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B93","first-page":"2181","article-title":"Effect of lncRNA AK023948 on rats with postmenopausal osteoporosis via PI3K\/AKT signaling pathway.","volume":"24","author":"Wang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.biopha.2017.02.090","article-title":"LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p.","volume":"89","author":"Wang","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.3892\/mmr.2019.10497","article-title":"circRNA_0006393 promotes osteogenesis in glucocorticoid-induced osteoporosis by sponging miR-145-5p and upregulating FOXO1.","volume":"20","author":"Wang","year":"","journal-title":"Mol. Med. Rep."},{"key":"B96","doi-asserted-by":"publisher","first-page":"7435","DOI":"10.1002\/jcp.26589","article-title":"Long noncoding RNA H19 mediates LCoR to impact the osteogenic and adipogenic differentiation of mBMSCs in mice through sponging miR-188.","volume":"233","author":"Wang","year":"","journal-title":"J. Cell. Physiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1159\/000491539","article-title":"LncRNA LINC00311 Promotes the Proliferation and Differentiation of Osteoclasts in Osteoporotic Rats Through the Notch Signaling Pathway by Targeting DLL3.","volume":"47","author":"Wang","year":"","journal-title":"Cell. Physiol. Biochem."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2325-3","article-title":"Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo.","volume":"11","author":"Wang","year":"","journal-title":"Cell Death Dis."},{"key":"B99","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cca.2019.10.026","article-title":"Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.","volume":"501","author":"Wang","year":"","journal-title":"Clin. Chim. Acta"},{"key":"B100","first-page":"763","article-title":"High expression of lnc-CRNDE presents as a biomarker for acute myeloid leukemia and promotes the malignant progression in acute myeloid leukemia cell line U937.","volume":"22","author":"Wang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/iub.1681","article-title":"LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2.","volume":"69","author":"Wang","year":"","journal-title":"IUBMB Life"},{"key":"B102","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ecl.2012.04.004","article-title":"Glucocorticoid-induced osteoporosis and osteonecrosis.","volume":"41","author":"Weinstein","year":"2012","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105719","article-title":"Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.","volume":"122","author":"Wen","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.rdc.2015.08.005","article-title":"Glucocorticoid-induced Osteoporosis.","volume":"42","author":"Whittier","year":"2016","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"B105","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bone.2017.03.044","article-title":"LRP5: From bedside to bench to bone.","volume":"102","author":"Williams","year":"2017","journal-title":"Bone"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3892\/mmr.2020.11264","article-title":"Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3-E1 and MDPC23 by targeting COL15A1.","volume":"22","author":"Wu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B107","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bone.2017.12.013","article-title":"Long non-coding RNA H19 mediates mechanical tension-induced osteogenesis of bone marrow mesenchymal stem cells via FAK by sponging miR-138.","volume":"108","author":"Wu","year":"","journal-title":"Bone"},{"key":"B108","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3389\/fendo.2018.00587","article-title":"Long Non-coding RNAs: A New Regulatory Code for Osteoporosis.","volume":"9","author":"Wu","year":"","journal-title":"Front. Endocrinol."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-019-0230-3","article-title":"lncRNA H19 promotes matrix mineralization through up-regulating IGF1 by sponging miR-185-5p in osteoblasts.","volume":"20","author":"Wu","year":"2019","journal-title":"BMC Mol. Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bbrc.2018.09.033","article-title":"DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p.","volume":"505","author":"Wu","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B111","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3109\/10799893.2015.1041647","article-title":"The PI3K\/AKT cell signaling pathway is involved in regulation of osteoporosis.","volume":"35","author":"Xi","year":"2015","journal-title":"J. Recept Sign. Transduct. Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ymthe.2018.11.019","article-title":"The Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate.","volume":"27","author":"Yang","year":"2019","journal-title":"Mole. Ther. J. Am. Soc. Gene Ther."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.bulcan.2019.08.011","article-title":"Long non-coding RNA H19 and cancer: A competing endogenous RNA.","volume":"106","author":"Ye","year":"2019","journal-title":"Bull. Cancer"},{"key":"B114","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00441-018-2963-2","article-title":"LncRNA MALAT1 sponges miR-30 to promote osteoblast differentiation of adipose-derived mesenchymal stem cells by promotion of Runx2 expression.","volume":"376","author":"Yi","year":"2019","journal-title":"Cell Tissue Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"11524","DOI":"10.1002\/jcp.27815","article-title":"A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.","volume":"234","author":"Yin","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.2147\/CIA.S205796","article-title":"LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-\u03b1.","volume":"14","author":"Yu","year":"2019","journal-title":"Clin. Intervent. Aging"},{"key":"B117","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.bbrc.2019.06.087","article-title":"circRNA_0016624 could sponge miR-98 to regulate BMP2 expression in postmenopausal osteoporosis.","volume":"516","author":"Yu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01625-7","article-title":"DNA methylation of noncoding RNAs: new insights into osteogenesis and common bone diseases.","volume":"11","author":"Yu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5582\/irdr.2018.01013","article-title":"Circular RNAs and hereditary bone diseases.","volume":"7","author":"Zhai","year":"2018","journal-title":"Intractab. Rare Dis. Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1002\/jcp.26776","article-title":"SEMA3B-AS1-inhibited osteogenic differentiation of human mesenchymal stem cells revealed by quantitative proteomics analysis.","volume":"234","author":"Zhang","year":"","journal-title":"J. Cell Physiol."},{"key":"B121","first-page":"8721","article-title":"LncRNA XIXT promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression by targeting miRNA-30a-5p.","volume":"23","author":"Zhang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"6610","DOI":"10.3748\/wjg.v22.i29.6610","article-title":"Noncoding RNAs in gastric cancer: Research progress and prospects.","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.bbrc.2019.09.058","article-title":"LncRNA MSC-AS1 promotes osteogenic differentiation and alleviates osteoporosis through sponging microRNA-140-5p to upregulate BMP2.","volume":"519","author":"Zhang","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B124","first-page":"6774","article-title":"LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression.","volume":"23","author":"Zhang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/j.bbrc.2018.06.146","article-title":"LncRNA EPIC1 protects human osteoblasts from dexamethasone-induced cell death.","volume":"503","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1080\/15476286.2017.1358347","article-title":"The long noncoding RNA Malat1: Its physiological and pathophysiological functions.","volume":"14","author":"Zhang","year":"2017","journal-title":"RNA Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.prp.2018.12.034","article-title":"LncRNA NEAT1\/miR-29b-3p\/BMP1 axis promotes osteogenic differentiation in human bone marrow-derived mesenchymal stem cells.","volume":"215","author":"Zhang","year":"","journal-title":"Pathol. Res. Pract."},{"key":"B128","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1016\/j.bbagen.2014.08.001","article-title":"Selenoproteins and selenium status in bone physiology and pathology.","volume":"1840","author":"Zhang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9578730","article-title":"lncRNA-TINCR Functions as a Competitive Endogenous RNA to Regulate the Migration of Mesenchymal Stem Cells by Sponging miR-761.","volume":"2020","author":"Zheng","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B130","first-page":"4609","article-title":"LncRNA MALAT1 inhibits osteogenic differentiation of mesenchymal stem cells in osteoporosis rats through MAPK signaling pathway.","volume":"23","author":"Zheng","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"63561","DOI":"10.18632\/oncotarget.11538","article-title":"Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells.","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/stem.1989","article-title":"Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription.","volume":"33","author":"Zhuang","year":"2015","journal-title":"Stem Cells"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1134\/S0006297910130055","article-title":"Telomerase: structure, functions, and activity regulation.","volume":"75","author":"Zvereva","year":"2010","journal-title":"Biochemistry"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.584118\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T09:00:36Z","timestamp":1605258036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.584118\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":133,"alternative-id":["10.3389\/fgene.2020.584118"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.584118","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"article-number":"584118"}}