{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:23:27Z","timestamp":1792571007643,"version":"4.5.0"},"reference-count":404,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.590369","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:58:42Z","timestamp":1602741522000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Shaza","family":"Asif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadya M.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Mulvihill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.2337\/db17-1539","article-title":"Increased Hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes.","volume":"67","author":"Abderrahmani","year":"2018","journal-title":"Diabetes"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03868-8","article-title":"Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.","volume":"9","author":"Abe","year":"2018","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8052","article-title":"JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI\/SNF association for thermogenesis.","volume":"6","author":"Abe","year":"2015","journal-title":"Nat. Commun."},{"key":"B4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1043-2760(00)00301-5","article-title":"Adipose tissue as an endocrine organ.","volume":"11","author":"Ahima","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","article-title":"DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.","volume":"18","author":"Ahrens","year":"2013","journal-title":"Cell Metab."},{"key":"B6","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.90358.2008","article-title":"Resveratrol alleviates alcoholic fatty liver in mice.","volume":"295","author":"Ajmo","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00059","article-title":"Glucocorticoid metabolism in obesity and following weight loss.","volume":"11","author":"Akalestou","year":"2020","journal-title":"Front. Endocrinol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2020.04.027","article-title":"Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells.","volume":"181","author":"Ang","year":"2020","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6216","DOI":"10.1073\/pnas.1035720100","article-title":"Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake.","volume":"100","author":"Anson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071500","article-title":"The Effects of time restricted feeding on overweight. Older adults: a pilot study.","volume":"11","author":"Anton","year":"2019","journal-title":"Nutrients"},{"key":"B11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/oby.22065","article-title":"Flipping the metabolic switch: understanding and applying the health benefits of fasting.","volume":"26","author":"Anton","year":"2018","journal-title":"Obesity"},{"key":"B12","doi-asserted-by":"crossref","first-page":"E1197","DOI":"10.1152\/ajpendo.00357.2009","article-title":"A very low carbohydrate ketogenic diet improves glucose tolerance in ob\/ob mice independently of weight loss.","volume":"297","author":"Badman","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120159","article-title":"HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.","volume":"3","author":"Bagchi","year":"2018","journal-title":"JCI Insight"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102507","article-title":"Epigenetic mechanisms in hepatic stellate cell activation during liver fibrosis and carcinogenesis.","volume":"20","author":"Barcena-Varela","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002264","article-title":"A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.","volume":"3","author":"Barger","year":"2008","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"crossref","first-page":"E947","DOI":"10.1152\/ajpendo.90378.2008","article-title":"Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction.","volume":"295","author":"Bates","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.bbalip.2015.01.013","article-title":"Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice.","volume":"1851","author":"Baumeier","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet.","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.2337\/db18-0158","article-title":"Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db\/db mice.","volume":"67","author":"Beli","year":"2018","journal-title":"Diabetes"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0569-x","article-title":"An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss.","volume":"16","author":"Benton","year":"2015","journal-title":"Genome Biol."},{"key":"B21","first-page":"101","article-title":"Fatty liver disease in diabetes mellitus.","volume":"4","author":"Bhatt","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"B22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.metabol.2018.08.006","article-title":"TET2 facilitates PPARgamma agonist-mediated gene regulation and insulin sensitization in adipocytes.","volume":"89","author":"Bian","year":"2018","journal-title":"Metabolism"},{"key":"B23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cmet.2013.02.001","article-title":"Identification of a SIRT1 mutation in a family with type 1 diabetes.","volume":"17","author":"Biason-Lauber","year":"2013","journal-title":"Cell Metab."},{"key":"B24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/gerona\/58.3.B212","article-title":"Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction.","volume":"58","author":"Bodkin","year":"2003","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040031","article-title":"Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.","volume":"4","author":"Bordone","year":"2006","journal-title":"PLoS Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1111\/febs.13053","article-title":"Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity.","volume":"282","author":"Bosch-Presegue","year":"2015","journal-title":"FEBS J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3945\/ajcn.2009.28085","article-title":"Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction.","volume":"91","author":"Bouchard","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.molmet.2014.12.008","article-title":"SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function.","volume":"4","author":"Boutant","year":"2015","journal-title":"Mol. Metab."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1016\/j.celrep.2016.02.007","article-title":"SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting.","volume":"14","author":"Boutant","year":"2016","journal-title":"Cell Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1172\/jci66514","article-title":"Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming.","volume":"123","author":"Bramswig","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04361-y","article-title":"The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.","volume":"9","author":"Bricambert","year":"2018","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.molmet.2016.09.011","article-title":"Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.","volume":"5","author":"Bricambert","year":"2016","journal-title":"Mol. Metab."},{"key":"B33","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.1172\/jci41624","article-title":"Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice.","volume":"120","author":"Bricambert","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cmet.2007.12.009","article-title":"Selective versus total insulin resistance: a pathogenic paradox.","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3945\/ajcn.110.007674","article-title":"Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.","volume":"93","author":"Browning","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1093\/hmg\/ddv247","article-title":"Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.","volume":"24","author":"Brun","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B37","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease.","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14384-z","article-title":"Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.","volume":"11","author":"Byun","year":"2020","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0092-8674(78)90305-7","article-title":"Sodium butyrate inhibits histone deacetylation in cultured cells.","volume":"14","author":"Candido","year":"1978","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.2337\/db13-1885","article-title":"Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure.","volume":"63","author":"Carriere","year":"2014","journal-title":"Diabetes"},{"key":"B41","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.atherosclerosis.2014.09.022","article-title":"Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides.","volume":"237","author":"Carter","year":"2014","journal-title":"Atherosclerosis"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215083","article-title":"Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR.","volume":"14","author":"Castellano-Castillo","year":"2019","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.04.015","article-title":"Short-term, intermittent fasting induces long-lasting gut health and tor-independent lifespan extension.","volume":"28","author":"Catterson","year":"2018","journal-title":"Curr. Biol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022","article-title":"Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease.","volume":"7","author":"Chait","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.cmet.2014.11.001","article-title":"Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.","volume":"20","author":"Chaix","year":"2014","journal-title":"Cell Metab."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1194\/jlr.m014647","article-title":"SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL.","volume":"52","author":"Chakrabarti","year":"2011","journal-title":"J. Lipid Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1042\/bst0340802","article-title":"Regulation of insulin secretion by uncoupling protein.","volume":"34","author":"Chan","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000730","article-title":"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.","volume":"5","author":"Chasman","year":"2009","journal-title":"PLoS Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"176","DOI":"10.2337\/db13-1148","article-title":"HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding.","volume":"63","author":"Chatterjee","year":"","journal-title":"Diabetes"},{"key":"B50","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4161\/adip.28814","article-title":"Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease.","volume":"3","author":"Chatterjee","year":"","journal-title":"Adipocyte"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1101\/gad.1650608","article-title":"Tissue-specific regulation of SIRT1 by calorie restriction.","volume":"22","author":"Chen","year":"2008","journal-title":"Genes Dev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1101\/gad.1742509","article-title":"Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a\/Arf expression and regeneration in diabetes mellitus.","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00792","article-title":"Wnt\/beta-catenin signaling and obesity.","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1016\/j.celrep.2017.03.006","article-title":"SIRT6 is essential for adipocyte differentiation by regulating mitotic clonal expansion.","volume":"18","author":"Chen","year":"2017","journal-title":"Cell Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1139\/o10-010","article-title":"Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.","volume":"88","author":"Chen","year":"2010","journal-title":"Biochem. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1007\/s11033-012-2412-3","article-title":"SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats.","volume":"40","author":"Chen","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"B57","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cell.2019.07.048","article-title":"Ketone body signaling mediates intestinal stem cell homeostasis and adaptation to diet.","volume":"178","author":"Cheng","year":"2019","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2017.01.040","article-title":"Fasting-Mimicking diet promotes Ngn3-driven beta-cell regeneration to reverse diabetes.","volume":"168","author":"Cheng","year":"2017","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113539","article-title":"Repression of transcriptional activity of Forkhead Box O1 by histone deacetylase inhibitors ameliorates hyperglycemia in type 2 diabetic rats.","volume":"19","author":"Cho","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2009.05.010","article-title":"Histone methylation regulator PTIP is required for PPARgamma and C\/EBPalpha expression and adipogenesis.","volume":"10","author":"Cho","year":"2009","journal-title":"Cell Metab."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders.","volume":"7","author":"Choe","year":"2016","journal-title":"Front. Endocrinol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.molmet.2018.11.001","article-title":"Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model.","volume":"19","author":"Chung","year":"2019","journal-title":"Mol. Metab."},{"key":"B63","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota.","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"B64","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1173635","article-title":"Caloric restriction delays disease onset and mortality in rhesus monkeys.","volume":"325","author":"Colman","year":"2009","journal-title":"Science"},{"key":"B66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.metabol.2005.07.005","article-title":"Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis.","volume":"55","author":"Colombo","year":"2006","journal-title":"Metabolism"},{"key":"B67","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1530\/joe-12-0420","article-title":"Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.","volume":"216","author":"Cordeiro","year":"2013","journal-title":"J. Endocrinol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/jmg.40.4.300","article-title":"Cryptic terminal deletion of chromosome 9q34: a novel cause of syndromic obesity in childhood?","volume":"40","author":"Cormier-Daire","year":"2003","journal-title":"J. Med. Genet."},{"key":"B69","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s11695-009-0052-z","article-title":"SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.","volume":"20","author":"Costa Cdos","year":"2010","journal-title":"Obes. Surg."},{"key":"B70","doi-asserted-by":"publisher","first-page":"5175","DOI":"10.1172\/jci76388","article-title":"Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia.","volume":"124","author":"Cotter","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B71","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/S0021-9258(17)37831-6","article-title":"Different accessibilities in chromatin to histone acetylase.","volume":"254","author":"Cousens","year":"1979","journal-title":"J. Biol. Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","article-title":"Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist.","volume":"21","author":"Cypess","year":"2015","journal-title":"Cell Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/ijo.2015.31","article-title":"The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.","volume":"39","author":"Dahlman","year":"2015","journal-title":"Int. J. Obes."},{"key":"B74","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s00125-016-4113-2","article-title":"HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells.","volume":"60","author":"Daneshpajooh","year":"2017","journal-title":"Diabetologia"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00592-018-1201-4","article-title":"MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues beta-cell dysfunction caused by Hdac7 upregulation.","volume":"55","author":"Daneshpajooh","year":"2018","journal-title":"Acta Diabetol."},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99762","article-title":"Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome.","volume":"3","author":"d\u2019Avignon","year":"2018","journal-title":"JCI Insight"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004160","article-title":"Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.","volume":"10","author":"Dayeh","year":"2014","journal-title":"PLoS Genet."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s00125-012-2815-7","article-title":"Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.","volume":"56","author":"Dayeh","year":"2013","journal-title":"Diabetologia"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1056\/nejmra1905136","article-title":"Effects of intermittent fasting on health, aging, and disease.","volume":"381","author":"de Cabo","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/15592294.2017.1294305","article-title":"Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action.","volume":"12","author":"de Mello","year":"2017","journal-title":"Epigenetics"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00082","article-title":"SIRT2 as a therapeutic target for age-related disorders.","volume":"3","author":"de Oliveira","year":"2012","journal-title":"Front. Pharmacol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ijo.2015.170","article-title":"MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics.","volume":"40","author":"Deiuliis","year":"2016","journal-title":"Int. J. Obes."},{"key":"B83","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cmet.2018.05.021","article-title":"Short-term fasting reveals amino acid metabolism as a major sex-discriminating factor in the liver.","volume":"28","author":"Della Torre","year":"2018","journal-title":"Cell Metab."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1194\/jlr.r036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism.","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00311","article-title":"E2F1, a novel regulator of metabolism.","volume":"8","author":"Denechaud","year":"2017","journal-title":"Front. Endocrinol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00592-009-0159-7","article-title":"Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.","volume":"47","author":"Deng","year":"2010","journal-title":"Acta Diabetol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/j.1478-3231.2007.01497.x","article-title":"The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.","volume":"27","author":"Deng","year":"2007","journal-title":"Liver Int."},{"key":"B88","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.aau2095","article-title":"A time to fast.","volume":"362","author":"Di Francesco","year":"2018","journal-title":"Science"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183541","article-title":"Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats.","volume":"12","author":"Ding","year":"2017","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ijcard.2011.09.039","article-title":"Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population.","volume":"162","author":"Doehner","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ymgme.2011.08.001","article-title":"SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.","volume":"104","author":"Dong","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112601","article-title":"Effects of periodic fasting on fatty liver index-A prospective observational study.","volume":"11","author":"Drinda","year":"2019","journal-title":"Nutrients"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1002\/hep.29085","article-title":"Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis.","volume":"65","author":"Dulai","year":"2017","journal-title":"Hepatology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.physbeh.2016.08.027","article-title":"Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet.","volume":"167","author":"Duncan","year":"2016","journal-title":"Physiol. Behav."},{"key":"B95","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5093","article-title":"LSD1 promotes oxidative metabolism of white adipose tissue.","volume":"5","author":"Duteil","year":"2014","journal-title":"Nat. Commun."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.celrep.2016.09.053","article-title":"Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue.","volume":"17","author":"Duteil","year":"2016","journal-title":"Cell Rep."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063388","article-title":"Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.","volume":"8","author":"Endo","year":"2013","journal-title":"PLoS One"},{"key":"B98","doi-asserted-by":"publisher","first-page":"11288","DOI":"10.1073\/pnas.0812931106","article-title":"SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.","volume":"106","author":"Erion","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B99","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1101\/gad.2019811","article-title":"EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.","volume":"25","author":"Ezhkova","year":"2011","journal-title":"Genes Dev."},{"key":"B100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.08.005","article-title":"Functional gut microbiota remodeling contributes to the caloric restriction-induced metabolic improvements.","volume":"28","author":"Fabbiano","year":"2018","journal-title":"Cell Metab."},{"key":"B101","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s1534-5807(02)00190-9","article-title":"E2Fs regulate adipocyte differentiation.","volume":"3","author":"Fajas","year":"2002","journal-title":"Dev. Cell"},{"key":"B102","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.cmet.2008.08.017","article-title":"Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.","volume":"8","author":"Feige","year":"2008","journal-title":"Cell Metab."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1126\/science.1198125","article-title":"A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.","volume":"331","author":"Feng","year":"2011","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/ijo.2016.191","article-title":"Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.","volume":"41","author":"Ferrari","year":"","journal-title":"Int. J. Obes."},{"key":"B105","article-title":"HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.","volume":"8","author":"Ferrari","year":"","journal-title":"Nat. Commun."},{"key":"B106","article-title":"Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.","volume":"5","author":"Fletcher","year":"2019","journal-title":"JCI Insight"},{"key":"B107","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans.","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"B108","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1161\/circulationaha.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"},{"key":"B109","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies.","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018950","article-title":"Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.","volume":"6","author":"Funato","year":"2011","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41586-019-0942-8","article-title":"Diabetes relief in mice by glucose-sensing insulin-secreting human alpha-cells.","volume":"567","author":"Furuyama","year":"2019","journal-title":"Nature"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice.","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"B113","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00394-015-0907-0","article-title":"Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice.","volume":"55","author":"Geng","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20082022","article-title":"The impact of caloric restriction on the epigenetic signatures of aging.","volume":"20","author":"Gensous","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B115","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-018-0525-9","article-title":"Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways.","volume":"10","author":"Gerhard","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"B116","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.molmet.2018.09.004","article-title":"Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.","volume":"18","author":"Gerlini","year":"2018","journal-title":"Mol. Metab."},{"key":"B117","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.2337\/db11-0616","article-title":"SirT1 regulates adipose tissue inflammation.","volume":"60","author":"Gillum","year":"2011","journal-title":"Diabetes"},{"key":"B118","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.ccr.2004.08.029","article-title":"Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.","volume":"6","author":"Gius","year":"2004","journal-title":"Cancer Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.tips.2015.08.001","article-title":"Emerging role of Sirtuin 2 in the regulation of mammalian metabolism.","volume":"36","author":"Gomes","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000212538","article-title":"Effects of intermittent feeding upon growth and life span in rats.","volume":"28","author":"Goodrick","year":"1982","journal-title":"Gerontology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1210\/en.2015-1622","article-title":"Intermittent fasting promotes fat loss with lean mass retention, increased hypothalamic norepinephrine content, and increased neuropeptide y gene expression in diet-induced obese male mice.","volume":"157","author":"Gotthardt","year":"2016","journal-title":"Endocrinology"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004067","article-title":"Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster.","volume":"4","author":"Grandison","year":"2009","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1016\/j.celrep.2017.03.001","article-title":"Impact of dietary interventions on noncoding RNA networks and mRNAs encoding chromatin-related factors.","volume":"18","author":"Green","year":"2017","journal-title":"Cell Rep."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1053\/j.gastro.2019.01.041","article-title":"Polycomb repressive complex 2 proteins EZH1 and EZH2 regulate timing of postnatal hepatocyte maturation and fibrosis by repressing genes with euchromatic promoters in mice.","volume":"156","author":"Grindheim","year":"2019","journal-title":"Gastroenterology"},{"key":"B125","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/s0531-5565(02)00203-6","article-title":"Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice.","volume":"38","author":"Hagopian","year":"2003","journal-title":"Exp. Gerontol."},{"key":"B126","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1187-1","article-title":"Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.","volume":"18","author":"Hahn","year":"2017","journal-title":"Genome Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1080\/15548627.2015.1094597","article-title":"Elevated autophagy gene expression in adipose tissue of obese humans: a potential non-cell-cycle-dependent function of E2F1.","volume":"11","author":"Haim","year":"2015","journal-title":"Autophagy"},{"key":"B128","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.2337\/dcS13-2023","article-title":"Obesity paradox does exist.","volume":"36","author":"Hainer","year":"2013","journal-title":"Diabetes Care"},{"key":"B129","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1152\/japplphysiol.00683.2005","article-title":"Effect of intermittent fasting and refeeding on insulin action in healthy men.","volume":"99","author":"Halberg","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-14-76","article-title":"DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.","volume":"14","author":"Hall","year":"2013","journal-title":"BMC Med. Genet."},{"key":"B131","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mce.2017.11.019","article-title":"The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets.","volume":"472","author":"Hall","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-103","article-title":"Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.","volume":"12","author":"Hall","year":"2014","journal-title":"BMC Med."},{"key":"B133","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.05.020","article-title":"Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake.","volume":"30","author":"Hall","year":"2019","journal-title":"Cell Metab."},{"key":"B134","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2217\/epi.11.71","article-title":"Epigenetic diet: impact on the epigenome and cancer.","volume":"3","author":"Hardy","year":"2011","journal-title":"Epigenomics"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat: development, function and therapeutic potential.","volume":"19","author":"Harms","year":"2013","journal-title":"Nat. Med."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094151","article-title":"Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.","volume":"9","author":"Harvey","year":"2014","journal-title":"PLoS One"},{"key":"B137","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/ijo.2010.171","article-title":"The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women.","volume":"35","author":"Harvie","year":"2011","journal-title":"Int. J. Obes."},{"key":"B138","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.cmet.2012.04.019","article-title":"Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.","volume":"15","author":"Hatori","year":"2012","journal-title":"Cell Metab."},{"key":"B139","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cmet.2016.12.007","article-title":"Adipose tissue CLK2 promotes energy expenditure during high-fat diet intermittent fasting.","volume":"25","author":"Hatting","year":"2017","journal-title":"Cell Metab."},{"key":"B140","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s11010-010-0391-z","article-title":"Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice.","volume":"339","author":"Hayashida","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"B141","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1620\/tjem.227.245","article-title":"Calorie restriction from a young age preserves the functions of pancreatic beta cells in aging rats.","volume":"227","author":"He","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"key":"B142","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1055\/s-2006-924320","article-title":"Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome.","volume":"114","author":"Heald","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"B143","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/ajcn\/81.1.69","article-title":"Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.","volume":"81","author":"Heilbronn","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081943","article-title":"The short-chain fatty acid acetate in body weight control and insulin sensitivity.","volume":"11","author":"Hernandez","year":"2019","journal-title":"Nutrients"},{"key":"B145","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1755","article-title":"FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.","volume":"3","author":"Hino","year":"2012","journal-title":"Nat. Commun."},{"key":"B146","doi-asserted-by":"publisher","first-page":"36431","DOI":"10.1074\/jbc.m105200200","article-title":"Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway.","volume":"276","author":"Hirano","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B147","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-017-0340-8","article-title":"36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner.","volume":"9","author":"Hjort","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"B148","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nature07583","article-title":"Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.","volume":"457","author":"Honjoh","year":"2009","journal-title":"Nature"},{"key":"B149","first-page":"377","article-title":"Development of liver fibrosis during aging: effects of caloric restriction.","volume":"27","author":"Horrillo","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"B150","doi-asserted-by":"crossref","first-page":"E320","DOI":"10.1111\/hepr.12992","article-title":"Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression.","volume":"48","author":"Hotta","year":"2018","journal-title":"Hepatol. Res."},{"key":"B151","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-57973-0","article-title":"Long-term metabolic consequences of acute dioxin exposure differ between male and female mice.","volume":"10","author":"Hoyeck","year":"2020","journal-title":"Sci. Rep."},{"key":"B152","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41390-018-0156-z","article-title":"Time-restricted feeding causes irreversible metabolic disorders and gut microbiota shift in pediatric mice.","volume":"85","author":"Hu","year":"2019","journal-title":"Pediatr. Res."},{"key":"B153","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00125-019-05035-0","article-title":"Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure.","volume":"63","author":"Ibrahim","year":"2020","journal-title":"Diabetologia"},{"key":"B154","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.cell.2016.05.044","article-title":"mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction.","volume":"166","author":"Igarashi","year":"2016","journal-title":"Cell"},{"key":"B155","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1365-2443.2009.01326.x","article-title":"Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.","volume":"14","author":"Inagaki","year":"2009","journal-title":"Genes Cells"},{"key":"B156","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2220\/biomedres.30.217","article-title":"Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue.","volume":"30","author":"Iwanaga","year":"2009","journal-title":"Biomed. Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.2337\/db12-1762","article-title":"Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and beta-cell Function in type 2 diabetic patients.","volume":"62","author":"Jackness","year":"2013","journal-title":"Diabetes"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061234","article-title":"Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans.","volume":"11","author":"Jamshed","year":"2019","journal-title":"Nutrients"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168185","article-title":"Histone H3K9 Demethylase JMJD2B Activates Adipogenesis by Regulating H3K9 Methylation on PPARgamma and C\/EBPalpha during Adipogenesis.","volume":"12","author":"Jang","year":"2017","journal-title":"PLoS One"},{"key":"B160","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1007\/s11033-020-05431-5","article-title":"Adipose tissue mRNA expression of HDAC1, HDAC3 and HDAC9 in obese women in relation to obesity indices and insulin resistance.","volume":"47","author":"Jannat Ali Pour","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"B161","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4419-9967-2_1","article-title":"DNA methyltransferases, DNA damage repair, and cancer.","volume":"754","author":"Jin","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"3746","DOI":"10.1128\/mcb.00622-14","article-title":"Gcn5 and PCAF regulate PPARgamma and Prdm16 expression to facilitate brown adipogenesis.","volume":"34","author":"Jin","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/emboj.2010.318","article-title":"Distinct roles of GCN5\/PCAF-mediated H3K9ac and CBP\/p300-mediated H3K18\/27ac in nuclear receptor transactivation.","volume":"30","author":"Jin","year":"2011","journal-title":"EMBO J."},{"key":"B164","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cmet.2007.07.003","article-title":"SIRT2 regulates adipocyte differentiation through FoxO1 acetylation\/deacetylation.","volume":"6","author":"Jing","year":"2007","journal-title":"Cell Metab."},{"key":"B165","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47763-8","article-title":"A randomised controlled trial on the effectiveness and adherence of modified alternate-day calorie restriction in improving activity of non-alcoholic fatty liver disease.","volume":"9","author":"Johari","year":"2019","journal-title":"Sci. Rep."},{"key":"B166","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.freeradbiomed.2006.12.005","article-title":"Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.","volume":"42","author":"Johnson","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.4161\/cc.7.10.5865","article-title":"Control of pancreatic beta-cell fate by insulin signaling: the sweet spot hypothesis.","volume":"7","author":"Johnson","year":"2008","journal-title":"Cell Cycle"},{"key":"B168","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/164_2018_168","article-title":"Brown adipose tissue development and metabolism.","volume":"251","author":"Jung","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/s0140-6736(13)62154-6","article-title":"Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future.","volume":"383","author":"Kahn","year":"2014","journal-title":"Lancet"},{"key":"B170","first-page":"2588","article-title":"Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice.","volume":"25","author":"Kammel","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B171","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jnutbio.2014.10.007","article-title":"Dietary restriction preserves the mass and function of pancreatic beta cells via cell kinetic regulation and suppression of oxidative\/ER stress in diabetic mice.","volume":"26","author":"Kanda","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"B172","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1210\/er.2015-1137","article-title":"Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus.","volume":"37","author":"Kautzky-Willer","year":"2016","journal-title":"Endocr. Rev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.bbrc.2012.01.120","article-title":"Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins.","volume":"418","author":"Kawakami","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B174","article-title":"Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.","volume":"6","author":"Kim","year":"2015","journal-title":"Nat. Commun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.celrep.2016.10.023","article-title":"Critical roles of the histone methyltransferase MLL4\/KMT2D in murine hepatic steatosis directed by ABL1 and PPARgamma2.","volume":"17","author":"Kim","year":"2016","journal-title":"Cell Rep."},{"key":"B176","article-title":"Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARgamma2.","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"B177","article-title":"RORalpha controls hepatic lipid homeostasis via negative regulation of PPARgamma transcriptional network.","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/cr.2017.126","article-title":"Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage.","volume":"27","author":"Kim","year":"2017","journal-title":"Cell Res."},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.3791\/60174","article-title":"Assessment of the metabolic effects of isocaloric 2:1 intermittent fasting in mice.","volume":"153","author":"Kim","year":"2019","journal-title":"J. Vis. Exp."},{"key":"B180","article-title":"Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob\/ob mice.","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"B181","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.molmet.2015.12.004","article-title":"Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.","volume":"5","author":"Kirchner","year":"2016","journal-title":"Mol. Metab."},{"key":"B182","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2005.08.004","article-title":"FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.","volume":"2","author":"Kitamura","year":"2005","journal-title":"Cell Metab."},{"key":"B183","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.metabol.2012.07.002","article-title":"Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet.","volume":"62","author":"Klempel","year":"2013","journal-title":"Metabolism"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/emboj.2008.51","article-title":"Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks.","volume":"27","author":"Knutson","year":"2008","journal-title":"EMBO J."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151511","article-title":"Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction.","volume":"11","author":"Komiya","year":"2016","journal-title":"PLoS One"},{"key":"B186","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1101\/gad.180406.111","article-title":"Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.","volume":"26","author":"Krishnan","year":"2012","journal-title":"Genes Dev."},{"key":"B187","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1177\/1535370213493727","article-title":"Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D, Pdx-1\/Cre mouse model of pancreatic cancer.","volume":"238","author":"Lanza-Jacoby","year":"2013","journal-title":"Exp. Biol. Med."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/oby.2008.201","article-title":"Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.","volume":"16","author":"Larson-Meyer","year":"2008","journal-title":"Obesity"},{"key":"B189","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.1152\/ajpendo.00267.2017","article-title":"Histone deacetylase inhibition ameliorates hypertension and hyperglycemia in a model of Cushing\u2019s syndrome.","volume":"314","author":"Lee","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B190","doi-asserted-by":"publisher","first-page":"19229","DOI":"10.1073\/pnas.0810100105","article-title":"Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B191","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01503","article-title":"H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.","volume":"2","author":"Lee","year":"2013","journal-title":"eLife"},{"key":"B192","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2337\/db07-1795","article-title":"Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway.","volume":"58","author":"Lee","year":"2009","journal-title":"Diabetes"},{"key":"B193","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cell.2006.02.017","article-title":"Ecological and evolutionary forces shaping microbial diversity in the human intestine.","volume":"124","author":"Ley","year":"","journal-title":"Cell"},{"key":"B194","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity.","volume":"444","author":"Ley","year":"","journal-title":"Nature"},{"key":"B195","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1074\/jbc.m115.677930","article-title":"Histone deacetylase 1 (HDAC1) negatively regulates thermogenic program in brown adipocytes via coordinated regulation of histone H3 Lysine 27 (H3K27) deacetylation and methylation.","volume":"291","author":"Li","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B196","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cmet.2017.08.019","article-title":"Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota.","volume":"26","author":"Li","year":"2017","journal-title":"Cell Metab."},{"key":"B197","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/abbs\/gms108","article-title":"SIRT1 and energy metabolism.","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"B198","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nrendo.2009.101","article-title":"SIRT1 and insulin resistance.","volume":"5","author":"Liang","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1210\/en.2018-00257","article-title":"HDAC3-selective inhibition activates brown and beige fat through PRDM16.","volume":"159","author":"Liao","year":"2018","journal-title":"Endocrinology"},{"key":"B200","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1126\/science.289.5487.2126","article-title":"Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.","volume":"289","author":"Lin","year":"2000","journal-title":"Science"},{"key":"B201","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1101\/gad.1164804","article-title":"Calorie restriction extends yeast life span by lowering the level of NADH.","volume":"18","author":"Lin","year":"2004","journal-title":"Genes Dev."},{"key":"B202","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature00829","article-title":"Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.","volume":"418","author":"Lin","year":"2002","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1210\/en.2018-00701","article-title":"Intermittent fasting improves glucose tolerance and promotes adipose tissue remodeling in male mice fed a high-fat diet.","volume":"160","author":"Liu","year":"2019","journal-title":"Endocrinology"},{"key":"B204","doi-asserted-by":"publisher","first-page":"9856","DOI":"10.1074\/jbc.m110.196790","article-title":"NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.","volume":"286","author":"Liu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B205","article-title":"SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"B206","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature07349","article-title":"A fasting inducible switch modulates gluconeogenesis via activator\/coactivator exchange.","volume":"456","author":"Liu","year":"2008","journal-title":"Nature"},{"key":"B207","article-title":"Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1194\/jlr.m063537","article-title":"Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR\/S6K1 pathway in mice.","volume":"57","author":"Liu","year":"2016","journal-title":"J. Lipid Res."},{"key":"B209","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.exger.2016.03.009","article-title":"Calorie restriction in overweight older adults: Do benefits exceed potential risks?","volume":"86","author":"Locher","year":"2016","journal-title":"Exp. Gerontol."},{"key":"B210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology.","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092358","article-title":"Adipose tissue dysfunction as determinant of obesity-associated metabolic complications.","volume":"20","author":"Longo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B212","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: molecular mechanisms and clinical applications.","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metab."},{"key":"B213","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.cmet.2016.06.001","article-title":"Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan.","volume":"23","author":"Longo","year":"2016","journal-title":"Cell Metab."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2009.01514.x","article-title":"Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine.","volume":"294","author":"Louis","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"B215","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1080\/00498254.2018.1490044","article-title":"Liver-specific knockout of histone methyltransferase G9a impairs liver maturation and dysregulates inflammatory, cytoprotective, and drug-processing genes.","volume":"49","author":"Lu","year":"2019","journal-title":"Xenobiotica"},{"key":"B216","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1007\/s00125-013-2946-5","article-title":"The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing.","volume":"56","author":"Luu","year":"2013","journal-title":"Diabetologia"},{"key":"B217","doi-asserted-by":"publisher","first-page":"7347","DOI":"10.1073\/pnas.1922344117","article-title":"Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.","volume":"117","author":"Luukkonen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B218","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-017-0344-4","article-title":"Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals.","volume":"9","author":"Macartney-Coxson","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"B219","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10157-011-0418-0","article-title":"Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.","volume":"15","author":"Maeda","year":"2011","journal-title":"Clin Exp Nephrol"},{"key":"B220","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00607-3","article-title":"Caloric restriction delays age-related methylation drift.","volume":"8","author":"Maegawa","year":"2017","journal-title":"Nat. Commun."},{"key":"B221","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1042\/cs20171616","article-title":"Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet.","volume":"132","author":"Maiztegui","year":"2018","journal-title":"Clin. Sci."},{"key":"B222","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3945\/ajcn.111.023697","article-title":"Very-low-calorie diet: a quick therapeutic tool to improve beta cell function in morbidly obese patients with type 2 diabetes.","volume":"95","author":"Malandrucco","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.002","article-title":"MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.","volume":"138","author":"Mann","year":"2010","journal-title":"Gastroenterology"},{"key":"B224","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death Differ."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1111\/liv.12769","article-title":"Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans.","volume":"35","author":"Mannisto","year":"2015","journal-title":"Liver Int."},{"key":"B226","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s12020-014-0465-x","article-title":"Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.","volume":"49","author":"Mariani","year":"2015","journal-title":"Endocrine"},{"key":"B227","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.nut.2019.02.020","article-title":"Beneficial effects of intermittent fasting on steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet.","volume":"65","author":"Marinho","year":"2019","journal-title":"Nutrition"},{"key":"B228","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14063","article-title":"Caloric restriction improves health and survival of rhesus monkeys.","volume":"8","author":"Mattison","year":"2017","journal-title":"Nat. Commun."},{"key":"B229","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1056\/NEJMra0906948","article-title":"Genomics, type 2 diabetes, and obesity.","volume":"363","author":"McCarthy","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B230","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.2337\/db07-1369","article-title":"Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans.","volume":"57","author":"Meier","year":"2008","journal-title":"Diabetes"},{"key":"B231","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s12603-011-0002-z","article-title":"The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction.","volume":"15","author":"Meydani","year":"2011","journal-title":"J. Nutr. Health Aging"},{"key":"B232","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cell.2011.03.043","article-title":"Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.","volume":"145","author":"Mihaylova","year":"2011","journal-title":"Cell"},{"key":"B233","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cmet.2018.08.011","article-title":"Daily fasting improves health and survival in male mice independent of diet composition and calories.","volume":"29","author":"Mitchell","year":"2019","journal-title":"Cell Metab."},{"key":"B234","doi-asserted-by":"publisher","first-page":"23813","DOI":"10.1073\/pnas.1912573116","article-title":"Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions.","volume":"116","author":"Miyamoto","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B235","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0921-8734(93)90002-k","article-title":"Effects of energy restriction on age-associated changes of DNA methylation in mouse liver.","volume":"295","author":"Miyamura","year":"1993","journal-title":"Mutat. Res."},{"key":"B236","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cmet.2005.07.001","article-title":"Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.","volume":"2","author":"Moynihan","year":"2005","journal-title":"Cell Metab."},{"key":"B237","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/oby.21377","article-title":"Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity.","volume":"24","author":"Muir","year":"2016","journal-title":"Obesity"},{"key":"B238","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1).","volume":"30","author":"Muller","year":"2019","journal-title":"Mol. Metab."},{"key":"B239","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cmet.2014.12.014","article-title":"Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.","volume":"21","author":"Multhaup","year":"2015","journal-title":"Cell Metab."},{"key":"B240","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/sj.ijo.0800412","article-title":"Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone.","volume":"21","author":"Nam","year":"1997","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"B241","doi-asserted-by":"crossref","first-page":"E439","DOI":"10.1002\/oby.20135","article-title":"Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults.","volume":"21","author":"Neeland","year":"2013","journal-title":"Obesity"},{"key":"B242","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1074\/jbc.m501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.","volume":"280","author":"Nemoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B243","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites.","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B244","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"beta-hydroxybutyrate: a signaling metabolite.","volume":"37","author":"Newman","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"B245","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"B246","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1074\/mcp.m117.067553","article-title":"The landscape of histone modifications in a high-fat diet-induced obese (DIO) mouse model.","volume":"16","author":"Nie","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"B247","doi-asserted-by":"crossref","first-page":"E1491","DOI":"10.1210\/jc.2015-3204","article-title":"Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.","volume":"100","author":"Nilsson","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B248","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s001250050267","article-title":"Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence.","volume":"38","author":"Ohneda","year":"1995","journal-title":"Diabetologia"},{"key":"B249","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nature12652","article-title":"EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.","volume":"504","author":"Ohno","year":"2013","journal-title":"Nature"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004886","article-title":"Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.","volume":"10","author":"Olsson","year":"2014","journal-title":"PLoS Genet."},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00472","article-title":"Carbohydrate sensing through the transcription factor ChREBP.","volume":"10","author":"Ortega-Prieto","year":"2019","journal-title":"Front. Genet."},{"key":"B252","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.devcel.2015.11.002","article-title":"Jmjd3-mediated H3K27me3 dynamics orchestrate brown fat development and regulate white fat plasticity.","volume":"35","author":"Pan","year":"2015","journal-title":"Dev. Cell"},{"key":"B253","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/ijo.2016.36","article-title":"Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.","volume":"40","author":"Parrillo","year":"2016","journal-title":"Int. J. Obes."},{"key":"B254","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00125-016-3933-4","article-title":"Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues.","volume":"59","author":"Pellegrinelli","year":"2016","journal-title":"Diabetologia"},{"key":"B255","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41366-019-0436-7","article-title":"Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.","volume":"44","author":"Perrini","year":"2020","journal-title":"Int. J. Obes."},{"key":"B256","doi-asserted-by":"publisher","first-page":"9793","DOI":"10.1073\/pnas.0802917105","article-title":"Sirt1 protects against high-fat diet-induced metabolic damage.","volume":"105","author":"Pfluger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B257","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nature02583","article-title":"Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.","volume":"429","author":"Picard","year":"2004","journal-title":"Nature"},{"key":"B258","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/595649","article-title":"Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment.","volume":"2015","author":"Piciucchi","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128012","article-title":"Pancreas-specific Sirt1-deficiency in mice compromises beta-cell function without development of hyperglycemia.","volume":"10","author":"Pinho","year":"2015","journal-title":"PLoS One"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030176","article-title":"Gender differences in response to prolonged every-other-day feeding on the proliferation and apoptosis of hepatocytes in mice.","volume":"8","author":"Piotrowska","year":"2016","journal-title":"Nutrients"},{"key":"B261","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1136\/gutjnl-2012-302962","article-title":"Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease.","volume":"62","author":"Pirola","year":"2013","journal-title":"Gut"},{"key":"B262","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jhep.2009.03.021","article-title":"Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.","volume":"51","author":"Pogribny","year":"2009","journal-title":"J. Hepatol."},{"key":"B263","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1111\/dom.13224","article-title":"Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.","volume":"20","author":"Polidori","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"B264","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1111\/dom.13488","article-title":"Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?","volume":"20","author":"Prattichizzo","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"B265","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics.","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"B266","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cmet.2018.10.015","article-title":"Hepatocyte-macrophage acetoacetate shuttle protects against tissue fibrosis.","volume":"29","author":"Puchalska","year":"2019","journal-title":"Cell Metab."},{"key":"B267","doi-asserted-by":"crossref","first-page":"e767","DOI":"10.1097\/SCS.0000000000003944","article-title":"Conical modification of forearm free flaps for single-stage reconstruction after total orbital exenteration.","volume":"28","author":"Purnell","year":"2017","journal-title":"J. Craniofac. Surg."},{"key":"B268","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab."},{"key":"B269","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.cell.2012.06.027","article-title":"Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma.","volume":"150","author":"Qiang","year":"2012","journal-title":"Cell"},{"key":"B270","doi-asserted-by":"publisher","first-page":"39915","DOI":"10.1074\/jbc.m607215200","article-title":"SIRT1 regulates adiponectin gene expression through Foxo1-C\/enhancer-binding protein alpha transcriptional complex.","volume":"281","author":"Qiao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B271","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing.","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"B272","doi-asserted-by":"crossref","DOI":"10.1038\/srep43526","article-title":"Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.","volume":"7","author":"Raciti","year":"2017","journal-title":"Sci. Rep."},{"key":"B273","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31560-w","article-title":"Class I and II histone deacetylase inhibitors differentially regulate thermogenic gene expression in brown adipocytes.","volume":"8","author":"Rajan","year":"2018","journal-title":"Sci. Rep."},{"key":"B274","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.jhep.2016.11.004","article-title":"Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression.","volume":"66","author":"Ramirez","year":"2017","journal-title":"J. Hepatol."},{"key":"B275","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1474-9726.2007.00355.x","article-title":"Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.","volume":"7","author":"Ramsey","year":"2008","journal-title":"Aging Cell"},{"key":"B276","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.celrep.2019.02.019","article-title":"Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology.","volume":"26","author":"Rangan","year":"2019","journal-title":"Cell Rep."},{"key":"B277","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/oby.22518","article-title":"Early time-restricted feeding reduces appetite and increases fat oxidation but does not affect energy expenditure in humans.","volume":"27","author":"Ravussin","year":"2019","journal-title":"Obesity"},{"key":"B278","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2018.02.019","article-title":"Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging.","volume":"27","author":"Redman","year":"2018","journal-title":"Cell Metab."},{"key":"B279","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","article-title":"Circadian clock control of liver metabolic functions.","volume":"150","author":"Reinke","year":"2016","journal-title":"Gastroenterology"},{"key":"B280","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1101\/gad.259309.115","article-title":"Gender-specific postnatal demethylation and establishment of epigenetic memory.","volume":"29","author":"Reizel","year":"2015","journal-title":"Genes Dev."},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.6","article-title":"Pancreatic regulation of glucose homeostasis.","volume":"48","author":"Roder","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"B282","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"B283","doi-asserted-by":"publisher","first-page":"12861","DOI":"10.1073\/pnas.0702509104","article-title":"Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.","volume":"104","author":"Rodgers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B284","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1258\/ebm.2012.012303","article-title":"Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease.","volume":"238","author":"Ronis","year":"2013","journal-title":"Exp. Biol. Med."},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199479","article-title":"Food restriction promotes damage reduction in rat models of type 2 diabetes mellitus.","volume":"13","author":"Rosa","year":"2018","journal-title":"PLoS One"},{"key":"B286","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/joim.12547","article-title":"Epigenomic and transcriptional control of insulin resistance.","volume":"280","author":"Rosen","year":"2016","journal-title":"J. Intern. Med."},{"key":"B287","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.2337\/db18-0537","article-title":"Epigenetics and epigenomics: implications for diabetes and obesity.","volume":"67","author":"Rosen","year":"2018","journal-title":"Diabetes"},{"key":"B288","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00592-008-0080-5","article-title":"Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.","volume":"46","author":"Ruchat","year":"2009","journal-title":"Acta Diabetol."},{"key":"B289","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver.","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600677","article-title":"Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL\/6J mice.","volume":"61","author":"Rusli","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"B291","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations.","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B292","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.2337\/db12-1430","article-title":"Anatomical locations of human brown adipose tissue: functional relevance and implications in obesity and type 2 diabetes.","volume":"62","author":"Sacks","year":"2013","journal-title":"Diabetes"},{"key":"B293","doi-asserted-by":"crossref","DOI":"10.1007\/s11906-018-0812-z","article-title":"The global epidemic of the metabolic syndrome.","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"B294","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1016\/j.celrep.2016.05.019","article-title":"LSD1 interacts with Zfp516 to promote UCP1 transcription and brown fat program.","volume":"15","author":"Sambeat","year":"2016","journal-title":"Cell Rep."},{"key":"B295","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.3945\/jn.115.210617","article-title":"Six and 12 weeks of caloric restriction increases beta cell function and lowers fasting and postprandial glucose concentrations in people with Type 2 diabetes.","volume":"145","author":"Sathananthan","year":"2015","journal-title":"J. Nutr."},{"key":"B296","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.diabet.2019.01.008","article-title":"Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: a common comorbidity associated with severe complications.","volume":"45","author":"Scheen","year":"2019","journal-title":"Diabetes Metab."},{"key":"B297","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3109\/07853890.2010.547211","article-title":"Sirtuin 1 in lipid metabolism and obesity.","volume":"43","author":"Schug","year":"2011","journal-title":"Ann. Med."},{"key":"B298","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1172\/jci97736","article-title":"Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid beta-oxidation.","volume":"128","author":"Seok","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B299","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3945\/ajcn.112.038695","article-title":"Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.","volume":"96","author":"Sevastianova","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01329","article-title":"The epigenetic connection between the gut microbiome in obesity and diabetes.","volume":"10","author":"Sharma","year":"2019","journal-title":"Front. Genet."},{"key":"B301","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1101\/gr.112680.110","article-title":"DNA methylation profiles of human active and inactive X chromosomes.","volume":"21","author":"Sharp","year":"2011","journal-title":"Genome Res."},{"key":"B302","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6035046","article-title":"Reversibility of beta-cell-specific transcript factors expression by long-term caloric restriction in db\/db mouse.","volume":"2016","author":"Sheng","year":"2016","journal-title":"J. Diabetes Res."},{"key":"B303","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cmet.2010.11.003","article-title":"SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.","volume":"12","author":"Shimazu","year":"2010","journal-title":"Cell Metab."},{"key":"B304","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor.","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"B305","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1172\/jci71643","article-title":"Vascular rarefaction mediates whitening of brown fat in obesity.","volume":"124","author":"Shimizu","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B306","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1093\/hmg\/ddp178","article-title":"Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.","volume":"18","author":"Shu","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B307","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/21623945.2017.1320002","article-title":"Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression.","volume":"6","author":"Sonne","year":"2017","journal-title":"Adipocyte"},{"key":"B308","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1074\/jbc.m800481200","article-title":"GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes.","volume":"283","author":"Sparling","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B309","doi-asserted-by":"publisher","first-page":"11077","DOI":"10.3748\/wjg.v21.i39.11077","article-title":"Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance.","volume":"21","author":"Stal","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"B310","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cmet.2019.07.016","article-title":"Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans.","volume":"30","author":"Stekovic","year":"2019","journal-title":"Cell Metab."},{"key":"B311","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","article-title":"Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk.","volume":"23","author":"Stern","year":"2016","journal-title":"Cell Metab."},{"key":"B312","doi-asserted-by":"publisher","first-page":"13833","DOI":"10.1073\/pnas.2335135100","article-title":"Transcription-dependent degradation controls the stability of the SREBP family of transcription factors.","volume":"100","author":"Sundqvist","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B313","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cmet.2018.04.010","article-title":"Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes.","volume":"27","author":"Sutton","year":"2018","journal-title":"Cell Metab."},{"key":"B314","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pharmthera.2017.05.011","article-title":"Targeting nuclear receptors for the treatment of fatty liver disease.","volume":"179","author":"Tanaka","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"B315","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cmet.2012.06.006","article-title":"A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.","volume":"16","author":"Taneera","year":"2012","journal-title":"Cell Metab."},{"key":"B316","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-052110-115718","article-title":"Adipogenesis: from stem cell to adipocyte.","volume":"81","author":"Tang","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"B317","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nature07777","article-title":"Role of Jhdm2a in regulating metabolic gene expression and obesity resistance.","volume":"458","author":"Tateishi","year":"2009","journal-title":"Nature"},{"key":"B318","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids.","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"B319","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.2337\/diabetes.54.9.2557","article-title":"Very slow turnover of beta-cells in aged adult mice.","volume":"54","author":"Teta","year":"2005","journal-title":"Diabetes"},{"key":"B320","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.cell.2014.09.048","article-title":"Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.","volume":"159","author":"Thaiss","year":"2014","journal-title":"Cell"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28791","article-title":"Is liver stiffness equal to liver fibrosis?","volume":"65","author":"Thiele","year":"2017","journal-title":"Hepatology"},{"key":"B322","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.gene.2008.05.022","article-title":"Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A.","volume":"423","author":"Thieringer","year":"2008","journal-title":"Gene"},{"key":"B323","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1177\/0164027503258738","article-title":"Aging, obesity, and mortality: misplaced concern about obese older people?","volume":"26","author":"Thorpe","year":"2004","journal-title":"Res. Aging"},{"key":"B324","doi-asserted-by":"publisher","first-page":"4803","DOI":"10.1158\/0008-5472.can-14-3786","article-title":"Histone deacetylase HDAC8 promotes insulin resistance and beta-catenin activation in NAFLD-associated hepatocellular carcinoma.","volume":"75","author":"Tian","year":"2015","journal-title":"Cancer Res."},{"key":"B325","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0022-2275(20)30468-5","article-title":"PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.","volume":"43","author":"Tordjman","year":"2002","journal-title":"J. Lipid. Res."},{"key":"B326","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","article-title":"Sex differences in metabolic regulation and diabetes susceptibility.","volume":"63","author":"Tramunt","year":"2020","journal-title":"Diabetologia"},{"key":"B327","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation.","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B328","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.celrep.2012.12.018","article-title":"A fasting-responsive signaling pathway that extends life span in C. elegans.","volume":"3","author":"Uno","year":"2013","journal-title":"Cell Rep."},{"key":"B329","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell"},{"key":"B330","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1101\/gad.1412706","article-title":"SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.","volume":"20","author":"Vaquero","year":"2006","journal-title":"Genes Dev."},{"key":"B331","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.3945\/ajcn.2009.28380","article-title":"Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.","volume":"90","author":"Varady","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"B332","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2891-12-146","article-title":"Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial.","volume":"12","author":"Varady","year":"2013","journal-title":"Nutr. J."},{"key":"B333","doi-asserted-by":"publisher","first-page":"24154","DOI":"10.3390\/ijms141224154","article-title":"EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.","volume":"14","author":"Vella","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B334","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.2337\/db14-0815","article-title":"Adaptive thermogenesis in white adipose tissue: is lactate the new brown(ing)?","volume":"63","author":"Vergnes","year":"2014","journal-title":"Diabetes"},{"key":"B335","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1172\/jci118703","article-title":"Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.","volume":"97","author":"Vidal-Puig","year":"1996","journal-title":"J. Clin. Invest."},{"key":"B336","first-page":"236","article-title":"Time-limited eating in pediatric patients with obesity: a case series.","volume":"2","author":"Vidmar","year":"2019","journal-title":"J. Food Sci. Nutr. Res."},{"key":"B337","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10563-9","article-title":"Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.","volume":"10","author":"Villanueva","year":"2019","journal-title":"Nat. Commun."},{"key":"B338","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16017-x","article-title":"LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.","volume":"11","author":"Vinckier","year":"2020","journal-title":"Nat. Commun."},{"key":"B339","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14617-1","article-title":"Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis.","volume":"11","author":"Viscarra","year":"2020","journal-title":"Nat. Commun."},{"key":"B340","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.","volume":"42","author":"Voight","year":"2010","journal-title":"Nat. Genet."},{"key":"B341","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.cmet.2013.01.014","article-title":"Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism.","volume":"17","author":"von Meyenn","year":"2013","journal-title":"Cell Metab."},{"key":"B342","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP.","volume":"24","author":"Walker","year":"2010","journal-title":"Genes Dev."},{"key":"B343","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2011.04.013","article-title":"A hormone-dependent module regulating energy balance.","volume":"145","author":"Wang","year":"2011","journal-title":"Cell"},{"key":"B344","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1474-9726.2007.00304.x","article-title":"SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.","volume":"6","author":"Wang","year":"2007","journal-title":"Aging Cell"},{"key":"B345","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1091\/mbc.e08-06-0647","article-title":"SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1\u2019s repressive interaction with PPARgamma.","volume":"20","author":"Wang","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"B346","doi-asserted-by":"crossref","DOI":"10.1186\/s12986-020-00466-8","article-title":"TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARalpha promoter.","volume":"17","author":"Wang","year":"2020","journal-title":"Nutr. Metab."},{"key":"B347","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1073\/pnas.1000031107","article-title":"Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B348","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/emboj.2012.306","article-title":"Histone H3K9 methyltransferase G9a represses PPARgamma expression and adipogenesis.","volume":"32","author":"Wang","year":"2013","journal-title":"EMBO J."},{"key":"B349","doi-asserted-by":"publisher","first-page":"682","DOI":"10.7150\/ijbs.6.682","article-title":"Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.","volume":"6","author":"Wang","year":"2010","journal-title":"Int. J. Biol. Sci."},{"key":"B350","doi-asserted-by":"publisher","first-page":"934","DOI":"10.7150\/ijbs.7529","article-title":"SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and beta-cell formation.","volume":"9","author":"Wang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"B351","article-title":"Gut microbiota mediates the anti-obesity effect of calorie restriction in mice.","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"B352","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1186-2","article-title":"Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment.","volume":"18","author":"Wang","year":"2017","journal-title":"Genome Biol."},{"key":"B353","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1074\/jbc.m110.157107","article-title":"Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation.","volume":"286","author":"Weems","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040013","article-title":"Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras\/PKA, Tor, and Sch9.","volume":"4","author":"Wei","year":"2008","journal-title":"PLoS Genet."},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108377","article-title":"Depot-specific regulation of NAD(+)\/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction.","volume":"80","author":"Wei","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030283","article-title":"Nutrients and the pancreas: an epigenetic perspective.","volume":"9","author":"Weisbeck","year":"2017","journal-title":"Nutrients"},{"key":"B357","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.2337\/db07-0156","article-title":"Genes involved in fatty acid partitioning and binding, lipolysis, monocyte\/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.","volume":"56","author":"Westerbacka","year":"2007","journal-title":"Diabetes"},{"key":"B358","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/265417","article-title":"Differential effects of calorie restriction and exercise on the adipose transcriptome in diet-induced obese mice.","volume":"2011","author":"Wheatley","year":"2011","journal-title":"J. Obes."},{"key":"B359","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cmet.2019.11.004","article-title":"Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome.","volume":"31","author":"Wilkinson","year":"2020","journal-title":"Cell Metab."},{"key":"B360","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000335648","article-title":"Update on Kleefstra Syndrome.","volume":"2","author":"Willemsen","year":"2012","journal-title":"Mol. Syndromol."},{"key":"B361","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ajhg.2010.07.011","article-title":"Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems.","volume":"87","author":"Williams","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"B362","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-019-1219-4","article-title":"Mechanisms and evidence for heart failure benefits from SGLT2 inhibitors.","volume":"21","author":"Wojcik","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"B363","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature03047","article-title":"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.","volume":"432","author":"Wolfrum","year":"2004","journal-title":"Nature"},{"key":"B364","doi-asserted-by":"publisher","DOI":"10.1101\/742403","article-title":"Nutrient regulation of the islet epigenome controls adaptive insulin secretion.","author":"Wortham","year":"2019","journal-title":"bioRxiv"},{"key":"B365","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s10620-008-0585-3","article-title":"Adipose tissue: the new endocrine organ? A review article.","volume":"54","author":"Wozniak","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"B366","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/stem.3073","article-title":"SIRT1 activation promotes beta-cell regeneration by activating endocrine progenitor cells via AMPK signaling-mediated fatty acid oxidation.","volume":"37","author":"Wu","year":"2019","journal-title":"Stem Cells"},{"key":"B367","first-page":"410","article-title":"Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.","volume":"44","author":"Wu","year":"2014","journal-title":"Ann. Clin. Lab. Sci."},{"key":"B368","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbrc.2018.04.073","article-title":"GSK126 alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice.","volume":"501","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B369","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064448","article-title":"Dietary restriction depends on nutrient composition to extend chronological lifespan in budding yeast Saccharomyces cerevisiae.","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"key":"B370","doi-asserted-by":"publisher","first-page":"918","DOI":"10.2337\/db10-1433","article-title":"Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans.","volume":"60","author":"Xiao","year":"2011","journal-title":"Diabetes"},{"key":"B371","doi-asserted-by":"publisher","first-page":"36776","DOI":"10.1074\/jbc.m110.168039","article-title":"SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.","volume":"285","author":"Xiao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B372","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.","volume":"62","author":"Xie","year":"2016","journal-title":"Mol. Cell"},{"key":"B373","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1210\/en.2009-1013","article-title":"Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+\/- mice: a role of lipid mobilization and inflammation.","volume":"151","author":"Xu","year":"2010","journal-title":"Endocrinology"},{"key":"B374","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/oby.21393","article-title":"Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice.","volume":"24","author":"Xu","year":"2016","journal-title":"Obesity"},{"key":"B375","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2337\/db06-1033","article-title":"Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.","volume":"56","author":"Xu","year":"2007","journal-title":"Diabetes"},{"key":"B376","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.celrep.2019.12.092","article-title":"A positive feedback loop of TET3 and TGF-beta1 promotes liver fibrosis.","volume":"30","author":"Xu","year":"2020","journal-title":"Cell Rep."},{"key":"B377","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbadis.2017.10.037","article-title":"Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1.","volume":"1864","author":"Xue","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B378","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s00125-010-1967-6","article-title":"Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.","volume":"54","author":"Yang","year":"2011","journal-title":"Diabetologia"},{"key":"B379","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1210\/me.2012-1004","article-title":"Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.","volume":"26","author":"Yang","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"B380","doi-asserted-by":"publisher","first-page":"6674","DOI":"10.1002\/jcb.26853","article-title":"S6K1 controls epigenetic plasticity for the expression of pancreatic alpha\/beta cell marker genes.","volume":"119","author":"Yi","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B381","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.molcel.2016.03.011","article-title":"S6K1 phosphorylation of H2B mediates EZH2 trimethylation of H3: a determinant of early adipogenesis.","volume":"62","author":"Yi","year":"2016","journal-title":"Mol. Cell"},{"key":"B382","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"B383","first-page":"284","article-title":"Dietary restriction and epigenetics: part I.","volume":"2","author":"Yong-Quan Ng","year":"2019","journal-title":"Cond. Med."},{"key":"B384","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1128\/mcb.00705-08","article-title":"SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.","volume":"29","author":"Yoshizaki","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"B385","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1152\/ajpendo.00417.2009","article-title":"SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.","volume":"298","author":"Yoshizaki","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B386","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30766","article-title":"Dnmt3a is an epigenetic mediator of adipose insulin resistance.","volume":"6","author":"You","year":"2017","journal-title":"eLife"},{"key":"B387","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"B388","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3390\/jcm3031050","article-title":"Reducing liver fat by low carbohydrate caloric restriction targets hepatic glucose production in non-diabetic obese adults with non-alcoholic fatty liver disease.","volume":"3","author":"Yu","year":"2014","journal-title":"J. Clin. Med."},{"key":"B389","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1101\/gad.285312.116","article-title":"Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.","volume":"30","author":"Zeng","year":"2016","journal-title":"Genes Dev."},{"key":"B390","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0056-6","article-title":"Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease.","volume":"7","author":"Zeybel","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"B391","doi-asserted-by":"publisher","first-page":"25151","DOI":"10.1074\/jbc.m115.662650","article-title":"The histone demethylase UTX promotes brown adipocyte thermogenic program via coordinated regulation of H3K27 demethylation and acetylation.","volume":"290","author":"Zha","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B392","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ismej.2009.112","article-title":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice.","volume":"4","author":"Zhang","year":"2010","journal-title":"ISME J."},{"key":"B393","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006122","article-title":"A powerful procedure for pathway-based meta-analysis using summary statistics identifies 43 pathways associated with Type II diabetes in European populations.","volume":"12","author":"Zhang","year":"2016","journal-title":"PLoS Genet."},{"key":"B394","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/j.1872-034x.2009.00521.x","article-title":"Protective effects of trichostatin A on liver injury in septic mice.","volume":"39","author":"Zhang","year":"2009","journal-title":"Hepatol. Res."},{"key":"B395","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1210\/en.2015-1852","article-title":"FoxO1 plays an important role in regulating beta-cell compensation for insulin resistance in male mice.","volume":"157","author":"Zhang","year":"2016","journal-title":"Endocrinology"},{"key":"B396","doi-asserted-by":"publisher","first-page":"32869","DOI":"10.1074\/jbc.m110.135509","article-title":"Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice.","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B397","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/s41418-019-0412-8","article-title":"Histone methyltransferase G9a protects against acute liver injury through GSTP1.","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"key":"B398","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1128\/mcb.00070-14","article-title":"Suv39h1 mediates AP-2alpha-dependent inhibition of C\/EBPalpha expression during adipogenesis.","volume":"34","author":"Zhang","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"B399","doi-asserted-by":"publisher","first-page":"16845","DOI":"10.1074\/jbc.275.22.16845","article-title":"Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation.","volume":"275","author":"Zhao","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B400","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0183-1","article-title":"Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression.","volume":"50","author":"Zhou","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"B401","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3748\/wjg.v23.i1.60","article-title":"Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier.","volume":"23","author":"Zhou","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B402","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/hr.2011.133","article-title":"Dietary methyl-consuming compounds and metabolic syndrome.","volume":"34","author":"Zhou","year":"2011","journal-title":"Hypertens. Res."},{"key":"B403","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.exger.2004.03.024","article-title":"Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization.","volume":"39","author":"Zhu","year":"2004","journal-title":"Exp. Gerontol."},{"key":"B404","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04127-6","article-title":"Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.","volume":"9","author":"Zhuang","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.590369\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T10:11:21Z","timestamp":1669198281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fgene.2020.590369\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":404,"alternative-id":["10.3389\/fgene.2020.590369"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.590369","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]},"article-number":"590369"}}