{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:29:58Z","timestamp":1788715798559,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"DOI":"10.3389\/fgene.2020.594824","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:49:46Z","timestamp":1604468986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["The Active Constituent From Gynostemma Pentaphyllum Prevents Liver Fibrosis Through Regulation of the TGF-\u03b21\/NDRG2\/MAPK Axis"],"prefix":"10.3389","volume":"11","author":[{"given":"Hui","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.fitote.2004.04.010","article-title":"Chronic toxicity of Gynostemma pentaphyllum.","volume":"75","author":"Attawish","year":"2004","journal-title":"Fitoterapia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/nrc2353","article-title":"Integrins in angiogenesis and lymphangiogenesis.","volume":"8","author":"Avraamides","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-beta signaling in fibrosis.","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2017.05.016","article-title":"Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents.","volume":"121","author":"Bottcher","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.bbrc.2010.04.162","article-title":"NDRG2 is one of novel intrinsic factors for regulation of IL-10 production in human myeloid cell.","volume":"396","author":"Choi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nprot.2009.36","article-title":"A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics.","volume":"4","author":"Cox","year":"2009","journal-title":"Nat. Protoc."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00357","article-title":"Transforming growth factor-beta-induced cell plasticity in liver fibrosis and hepatocarcinogenesis.","volume":"8","author":"Fabregat","year":"2018","journal-title":"Front. Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis.","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1177\/1556264614552799","article-title":"Privacy in confidential administrative micro data: implementing statistical disclosure control in a secure computing environment.","volume":"9","author":"Hochfellner","year":"2014","journal-title":"J. Empir. Res. Hum. Res. Ethics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00441-005-0137-5","article-title":"Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues.","volume":"325","author":"Hu","year":"2006","journal-title":"Cell Tissue Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00441-017-2643-7","article-title":"NDRG2 knockdown promotes fibrosis in renal tubular epithelial cells through TGF-beta1\/Smad3 pathway.","volume":"369","author":"Jin","year":"2017","journal-title":"Cell Tissue Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1093\/bioinformatics\/btn129","article-title":"adegenet: a R package for the multivariate analysis of genetic markers.","volume":"24","author":"Jombart","year":"2008","journal-title":"Bioinformatics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1158\/0008-5472.CAN-07-5040","article-title":"Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis.","volume":"68","author":"Lee","year":"2008","journal-title":"Cancer Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/wrr.12398","article-title":"Transforming growth factor beta (TGF-beta) isoforms in wound healing and fibrosis.","volume":"24","author":"Lichtman","year":"2016","journal-title":"Wound Repair. Regen."},{"key":"B15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.bbalip.2009.09.022","article-title":"NDRG2 induced by oxidized LDL in macrophages antagonizes growth factor productions via selectively inhibiting ERK activation.","volume":"1801","author":"Liu","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B16","doi-asserted-by":"publisher","first-page":"18100","DOI":"10.1074\/jbc.274.25.18100","article-title":"Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action.","volume":"274","author":"Mitchell","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues.","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.bbrc.2006.12.125","article-title":"Loss of TGF-beta dependent growth control during HSC transdifferentiation.","volume":"353","author":"Purps","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1055\/s-2001-17556","article-title":"Matrix as a modulator of hepatic fibrogenesis.","volume":"21","author":"Schuppan","year":"2001","journal-title":"Semin. Liver Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1038\/s41388-017-0118-7","article-title":"NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21\/p27 axis.","volume":"37","author":"Shen","year":"2018","journal-title":"Oncogene"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2013.48","article-title":"Tumor suppressor NDRG2 tips the balance of oncogenic TGF-beta via EMT inhibition in colorectal cancer.","volume":"3","author":"Shen","year":"2014","journal-title":"Oncogenesis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","article-title":"Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies.","volume":"73","author":"Singh","year":"2019","journal-title":"Prog. Lipid Res."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M110.003699","article-title":"Deep and highly sensitive proteome coverage by LC-MS\/MS without prefractionation.","volume":"10","author":"Thakur","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation.","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00461","article-title":"Targeting TGF-beta mediated SMAD signaling for the prevention of fibrosis.","volume":"8","author":"Walton","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ebiom.2019.03.058","article-title":"TGF-beta1\/p65\/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.","volume":"42","author":"Wang","year":"2019","journal-title":"EBioMedicine"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014230","article-title":"Activation of protein serine\/threonine phosphatase PP2C alpha efficiently prevents liver fibrosis.","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1021\/ac500140s","article-title":"Ion coalescence of neutron encoded TMT 10-plex reporter ions.","volume":"86","author":"Werner","year":"2014","journal-title":"Anal. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1021\/pr1002214","article-title":"Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology.","volume":"9","author":"Wisniewski","year":"2010","journal-title":"J. Proteome Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/j.1524-475X.2010.00614.x","article-title":"NDRG2 in rat liver regeneration: role in proliferation and apoptosis.","volume":"18","author":"Yang","year":"2010","journal-title":"Wound Repair Regen."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027710","article-title":"NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-beta1\/Smad pathway and altering the MMP2\/TIMP2 ratio in rats.","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia.","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1002\/hlca.200590083","article-title":"Six new triterpene saponins with a 21,23-lactone skeleton from Gynostemma pentaphyllum.","volume":"88","author":"Yin","year":"2005","journal-title":"Helv. Chim. Acta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters.","volume":"16","author":"Yu","year":"2012","journal-title":"Omics J. Integrat. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1159\/000492686","article-title":"MicroRNA-486 alleviates hypoxia-induced damage in H9c2 cells by targeting NDRG2 to inactivate JNK\/C-Jun and NF-kappaB signaling pathways.","volume":"48","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-Smad pathways in TGF-beta signaling.","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s11655-016-2640-9","article-title":"Anti-fibrotic effects of Salvia miltiorrhiza and Ligustrazine Injection on LX-2 cells involved with increased N-myc downstream-regulated gene 2 expression.","volume":"23","author":"Zheng","year":"2017","journal-title":"Chin. J. Integr. Med."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.594824\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:49:49Z","timestamp":1604468989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.594824\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":37,"alternative-id":["10.3389\/fgene.2020.594824"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2020.594824","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"article-number":"594824"}}