{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:42:50Z","timestamp":1780569770549,"version":"3.54.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Vitiligo is a common immune-related depigmentation condition, and its pathogenesis remains unclear. This study used a combination of bioinformatics methods and expression analysis techniques to explore the relationship between immune cell infiltration and gene expression in vitiligo. Previously reported gene expression microarray data from the skin (GSE53146 and GSE75819) and peripheral blood (GSE80009 and GSE90880) of vitiligo patients and healthy controls was used in the analysis. R software was used to filter the differentially expressed genes (DEGs) in each dataset, and the KOBAS 2.0 server was used to perform functional enrichment analysis. Compared with healthy controls, the upregulated genes in skin lesions and peripheral blood leukocytes of vitiligo patents were highly enriched in immune response pathways and inflammatory response signaling pathways. Immunedeconv software and the EPIC method were used to analyze the expression levels of marker genes to obtain the immune cell population in the samples. In the lesional skin of vitiligo patients, the proportions of macrophages, B cells and NK cells were increased compared with healthy controls. In the peripheral blood of vitiligo patients, CD8+ T cells and macrophages were significantly increased. A coexpression analysis of the cell populations and DEGs showed that differentially expressed immune and inflammation response genes had a strong positive correlation with macrophages. The TLR4 receptor pathway, interferon gamma-mediated signaling pathway and lipopolysaccharide-related pathway were positively correlated with CD4+ T cells. Regarding immune response-related genes, the overexpression of <jats:italic>IFITM2, TNFSF10, GZMA, ADAMDEC1, NCF2, ADAR, SIGLEC16<\/jats:italic>, and <jats:italic>WIPF2<\/jats:italic> were related to macrophage abundance, while the overexpression of <jats:italic>ICOS, GPR183, RGS1, ILF2<\/jats:italic> and <jats:italic>CD28<\/jats:italic> were related to CD4+ T cell abundance. <jats:italic>GZMA<\/jats:italic> and <jats:italic>CXCL10<\/jats:italic> expression were associated with CD8+ T cell abundance. Regarding inflammatory response-related genes, the overexpression of <jats:italic>CEBPB, ADAM8, CXCR3<\/jats:italic>, and <jats:italic>TNIP3<\/jats:italic> promoted macrophage infiltration. Only <jats:italic>ADORA1<\/jats:italic> expression was associated with CD4+ T cell infiltration. <jats:italic>ADAM8<\/jats:italic> and <jats:italic>CXCL10<\/jats:italic> expression were associated with CD8+ T cell abundance. The overexpression of <jats:italic>CCL18, CXCL10, FOS, NLRC4, LY96, HCK, MYD88<\/jats:italic>, and <jats:italic>KLRG1<\/jats:italic>, which are related to inflammation and immune responses, were associated with macrophage abundance. We also found that immune cells infiltration in vitiligo was associated with antigen presentation-related genes expression. The genes and pathways identified in this study may point to new directions for vitiligo treatment.<\/jats:p>","DOI":"10.3389\/fgene.2021.627092","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T01:22:15Z","timestamp":1613870535000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Comprehensive Analysis of Cell Population Dynamics and Related Core Genes During Vitiligo Development"],"prefix":"10.3389","volume":"12","author":[{"given":"Jingzhan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilinuer","family":"Abudoureyimu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglong","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixian","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13000","article-title":"The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo.","volume":"15","author":"Aghamajidi","year":"2020","journal-title":"Scand. J. Immunol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194413","article-title":"Computational study of C-X-C chemokine receptor (CXCR)3 binding with its natural agonists chemokine (C-X-C Motif) ligand (CXCL)9, 10 and 11 and with synthetic antagonists: insights of receptor activation towards drug design for vitiligo.","volume":"25","author":"Aguilera-Dur\u00e1n","year":"2020","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45260-6","article-title":"Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR\/CD3-mediated activation in CD4+ T lymphocytes.","volume":"9","author":"Alibashe-Ahmed","year":"2019","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jaad.2010.11.061","article-title":"Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.","volume":"65","author":"Alikhan","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"B5","first-page":"171","article-title":"Imbalance of peripheral blood T helper type 17 responses in patients with vitiligo.","volume":"17","author":"Behfarjam","year":"2018","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cellimm.2018.06.009","article-title":"The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.","volume":"331","author":"Bock","year":"2018","journal-title":"Cell. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jid.2017.08.038","article-title":"Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3.","volume":"138","author":"Boniface","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1002\/eji.200526122","article-title":"Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.","volume":"35","author":"Bratke","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a expression defines tissue-resident CD8(+) T cells poised for cytotoxic function in human skin.","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.semcdb.2017.08.049","article-title":"Role of BAG3 in cancer progression: a therapeutic opportunity.","volume":"78","author":"De Marco","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3510-3","article-title":"Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets.","volume":"18","author":"Dey-Rao","year":"2017","journal-title":"BMC Genomics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/s0140-6736(14)60763-7","article-title":"Vitiligo.","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1590\/abd1806-4841.20186068","article-title":"Macrophage migration inhibitory factor as an incriminating agent in vitiligo.","volume":"93","author":"Farag","year":"2018","journal-title":"An. Bras. Dermatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: a review.","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1416","article-title":"Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non-segmental vitiligo in patients from western Mexico.","volume":"8","author":"Garcia-Orozco","year":"2020","journal-title":"Mol. Genet. Genomic Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2013analysis of Affymetrix GeneChip data at the probe level.","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1182\/blood-2004-03-0859","article-title":"Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells.","volume":"104","author":"Grossman","year":"2004","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.jaad.2019.07.036","article-title":"Comorbid diseases of vitiligo: a 10-year cross-sectional retrospective study of an urban US population.","volume":"82","author":"Hadi","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.autrev.2015.12.006","article-title":"Vitiligo: pathogenesis, clinical variants and treatment approaches.","volume":"15","author":"Iannella","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08337-4","article-title":"Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression.","volume":"10","author":"Jin","year":"2019","journal-title":"Nat. Commun."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9005.3","article-title":"RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR.","volume":"5","author":"Law","year":"2016","journal-title":"F1000Research"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1028-7","article-title":"Comprehensive analyses of tumor immunity: implications for cancer immunotherapy.","volume":"17","author":"Li","year":"2016","journal-title":"Genome Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jaci.2016.10.013","article-title":"Oxidative stress drives CD8(+) T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes.","volume":"140","author":"Li","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.06.004","article-title":"Cytotoxic KLRG1 expressing lymphocytes invade portal tracts in primary biliary cholangitis.","volume":"103","author":"Li","year":"2019","journal-title":"J. Autoimmun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"840","DOI":"10.4049\/jimmunol.177.2.840","article-title":"Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.","volume":"177","author":"Lim","year":"2006","journal-title":"J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.mehy.2010.10.034","article-title":"Possible roles of B lymphocyte activating factor of the tumour necrosis factor family in vitiligo autoimmunity.","volume":"76","author":"Lin","year":"2011","journal-title":"Med. Hypotheses"},{"key":"B27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00280-018-3594-8","article-title":"Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy.","volume":"82","author":"Litviakov","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.imlet.2004.09.015","article-title":"Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.","volume":"97","author":"Mitchison","year":"2005","journal-title":"Immunol. Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.12998\/wjcc.v3.i3.221","article-title":"Highlights in pathogenesis of vitiligo.","volume":"3","author":"Mohammed","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02810","article-title":"Tissue resident CD8 memory T cell responses in cancer and autoimmunity.","volume":"9","author":"Molodtsov","year":"2018","journal-title":"Front. Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1158\/1078-0432.ccr-12-3666","article-title":"Cyclophosphamide induces a type I interferon-associated sterile inflammatory response signature in cancer patients\u2019 blood cells: implications for cancer chemoimmunotherapy.","volume":"19","author":"Moschella","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1755-148X.2011.00916.x","article-title":"HSP70i is a critical component of the immune response leading to vitiligo.","volume":"25","author":"Mosenson","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/eji.201545875","article-title":"Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme a expression by virus-specific CD8(+) T cells.","volume":"46","author":"Nguyen","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/1346-8138.12263","article-title":"Role of macrophage infiltration in successful repigmentation in a new periphery-spreading vitiligo lesion in a male Japanese patient.","volume":"40","author":"Oiso","year":"2013","journal-title":"J. Dermatol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00031","article-title":"RNA-binding proteins in the control of LPS-induced macrophage response.","volume":"10","author":"Ostareck","year":"2019","journal-title":"Front. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/ng.603","article-title":"Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.","volume":"42","author":"Quan","year":"2010","journal-title":"Nat. Genet."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02707","article-title":"Lymphoid stress surveillance response contributes to vitiligo pathogenesis.","volume":"9","author":"Raam","year":"2018","journal-title":"Front. Immunol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26476","article-title":"Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data.","volume":"6","author":"Racle","year":"2017","journal-title":"Elife"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007811","article-title":"CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo.","volume":"6","author":"Rashighi","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13255","article-title":"Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.","volume":"22","author":"Rchiad","year":"2020","journal-title":"Cell. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.coi.2013.10.010","article-title":"Innate immune mechanisms in vitiligo: danger from within.","volume":"25","author":"Richmond","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4049\/jimmunol.1900027","article-title":"The role of memory CD8(+) T cells in vitiligo.","volume":"203","author":"Riding","year":"2019","journal-title":"J. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ajhg.2019.06.013","article-title":"Family clustering of autoimmune vitiligo results principally from polygenic inheritance of common risk alleles.","volume":"105","author":"Roberts","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2016.10.048","article-title":"New discoveries in the pathogenesis and classification of vitiligo.","volume":"77","author":"Rodrigues","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases.","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1084\/jem.20070081","article-title":"Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.","volume":"204","author":"Sather","year":"2007","journal-title":"J. Exp. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1084\/jem.20061405","article-title":"CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.","volume":"204","author":"Schneider","year":"2007","journal-title":"J. Exp. Med."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00003","article-title":"Genetic susceptibility to vitiligo: GWAS approaches for identifying vitiligo susceptibility genes and loci.","volume":"7","author":"Shen","year":"2016","journal-title":"Front. Genet."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10253-w","article-title":"Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligo.","volume":"7","author":"Singh","year":"2017","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation.","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02168-w","article-title":"Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease.","author":"Srivastava","year":"2021","journal-title":"Arch. Dermatol. Res."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00278","article-title":"Polymorphisms in toll-like receptor genes are associated with vitiligo.","volume":"6","author":"Traks","year":"2015","journal-title":"Front. Genet."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09963-8","article-title":"Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.","volume":"10","author":"Tulic","year":"2019","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.immuni.2016.05.008","article-title":"Inflammasome-dependent induction of adaptive NK cell memory.","volume":"44","author":"van den Boorn","year":"2016","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-14-169","article-title":"RNA-seq analyses of multiple meristems of soybean: novel and alternative transcripts, evolutionary and functional implications.","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Plant Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jdermsci.2016.07.006","article-title":"The changes of gene expression profiling between segmental vitiligo, generalized vitiligo and healthy individual.","volume":"84","author":"Wang","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1111\/bjd.14416","article-title":"Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo.","volume":"174","author":"Wang","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.12659\/msm.914898","article-title":"Perspectives of new advances in the pathogenesis of vitiligo: from oxidative stress to autoimmunity.","volume":"25","author":"Wang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"B60","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/pcmr.12803","article-title":"Skin-resident memory T cells as a potential new therapeutic target in vitiligo and melanoma.","volume":"32","author":"Willemsen","year":"2019","journal-title":"Pigment Cell Melanoma Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2015.05.001","article-title":"Inflammasomes and human autoimmunity: a comprehensive review.","volume":"61","author":"Yang","year":"2015","journal-title":"J. Autoimmun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.humimm.2019.02.011","article-title":"Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.","volume":"80","author":"Yao","year":"2019","journal-title":"Hum. Immunol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1230513","article-title":"Six-gene signature associated with immune cells in the progression of atherosclerosis discovered by comprehensive bioinformatics analyses.","volume":"2020","author":"Zhao","year":"2020","journal-title":"Cardiovasc. Ther."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223955","article-title":"Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages.","volume":"14","author":"Zhu","year":"2019","journal-title":"PLoS One"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.627092\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T08:54:32Z","timestamp":1618563272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.627092\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":64,"alternative-id":["10.3389\/fgene.2021.627092"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2021.627092","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]},"article-number":"627092"}}