{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:54:40Z","timestamp":1753890880668,"version":"3.41.2"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>The molecular basis of porcine coping behavior (CB) relies on a sophisticated interplay of genetic and epigenetic features. Deep sequencing technologies allowed the identification of a plethora of new regulatory small non-coding RNA (sncRNA). We characterized mRNA and sncRNA profiles of central parts of the physiological stress response system including amygdala, hippocampus, hypothalamus and adrenal gland using systems biology for integration. Therefore, ten each of high- (HR) and low- (LR) reactive pigs (<jats:italic>n<\/jats:italic> = 20) carrying a CB associated haplotype in a prominent QTL-region on SSC12 were selected for mRNA and sncRNA expression profiling. The molecular markers related to the LR group included <jats:italic>ATP1B2<\/jats:italic>, <jats:italic>MPDU1<\/jats:italic>, miR-19b-5p, let-7g-5p, and 5\u2032-tiRNA<jats:sup><jats:italic>Leu<\/jats:italic><\/jats:sup> in the adrenal gland, miR-194a-5p, miR-125a-5p, miR-7-1-5p, and miR-107-5p in the hippocampus and <jats:italic>CBL<\/jats:italic> and <jats:italic>PVRL1<\/jats:italic> in the hypothalamus. Interestingly, amygdalae of the LR group showed 5\u2032-tiRNA and 5\u2032-tRF (5\u2032-tRF<jats:sup><jats:italic>Lys<\/jats:italic><\/jats:sup>, 5\u2032-tiRNA<jats:sup><jats:italic>Lys<\/jats:italic><\/jats:sup>, 5\u2032-tiRNA<jats:sup><jats:italic>Cys<\/jats:italic><\/jats:sup>, and 5\u2032-tiRNA<jats:sup><jats:italic>Gln<\/jats:italic><\/jats:sup>) enrichment. Contrarily, molecular markers associated with the HR group encompassed miR-26b-5p, tRNA<jats:sup><jats:italic>Arg<\/jats:italic><\/jats:sup>, tRNA<jats:sup><jats:italic>GlyiF<\/jats:italic><\/jats:sup> in the adrenal gland, <jats:italic>IGF1<\/jats:italic> and <jats:italic>APOD<\/jats:italic> in the amygdala and <jats:italic>PBX1<\/jats:italic>, <jats:italic>TOB1<\/jats:italic>, and <jats:italic>C18orf1<\/jats:italic> in the hippocampus and miR-24 in the hypothalamus. In addition, hypothalami of the HR group were characterized by 3\u2032-tiRNA enrichment (3\u2032-tiRNAGln, 3\u2032-tiRNA<jats:sup><jats:italic>Asn<\/jats:italic><\/jats:sup>, 3\u2032-tiRNA<jats:sup><jats:italic>Val<\/jats:italic><\/jats:sup>, 3\u2032-tRF<jats:sup><jats:italic>Pro<\/jats:italic><\/jats:sup>, 3\u2032-tiRNA<jats:sup><jats:italic>Cys<\/jats:italic><\/jats:sup>, and 3\u2032-tiRNA<jats:sup><jats:italic>Ala<\/jats:italic><\/jats:sup>) and 3\u2032-tRFs enrichment (3\u2032-tRF<jats:sup><jats:italic>Asn<\/jats:italic><\/jats:sup>, 3\u2032-tRF<jats:sup><jats:italic>Glu<\/jats:italic><\/jats:sup>, and 3\u2032-tRF<jats:sup><jats:italic>Val<\/jats:italic><\/jats:sup>). These evidence suggest that tRNA-derived fragments and their cleavage activity are a specific marker for coping behavior. Data integration revealed new bio-signatures of important molecular interactions on a multi-transcript level in HPA axis and limbic system of pigs carrying a CB-associated haplotype.<\/jats:p>","DOI":"10.3389\/fgene.2021.635794","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T11:14:22Z","timestamp":1629371662000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi-Transcript Level Profiling Revealed Distinct mRNA, miRNA, and tRNA-Derived Fragment Bio-Signatures for Coping Behavior Linked Haplotypes in HPA Axis and Limbic System"],"prefix":"10.3389","volume":"12","author":[{"given":"Kevin","family":"Gley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieder","family":"Hadlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nares","family":"Trakooljul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiete","family":"Haack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Murani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Gimsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1016\/j.febslet.2014.09.001","article-title":"tRNA fragments in human health and disease.","volume":"588","author":"Anderson","year":"2014","journal-title":"FEBS Lett."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-459","article-title":"Structured RNAs and synteny regions in the pig genome.","volume":"15","author":"Anthon","year":"2014","journal-title":"BMC Genomics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s42003-018-0020-z","article-title":"Ad4BP\/SF-1 regulates cholesterol synthesis to boost the production of steroids.","volume":"1","author":"Baba","year":"2018","journal-title":"Commun. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1261\/rna.783108","article-title":"MicroRNA expression in the adult mouse central nervous system.","volume":"14","author":"Bak","year":"2008","journal-title":"RNA (New York, N.Y.)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/cen3.12125","article-title":"The role of antiproliferative gene Tob1 in the immune system.","volume":"5","author":"Baranzini","year":"2014","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.15252\/embj.201489282","article-title":"Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.","volume":"33","author":"Blanco","year":"2014","journal-title":"EMBO J."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0085","article-title":"Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence.","volume":"368","author":"Bosch","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/jnc.12308","article-title":"MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA.","volume":"126","author":"Choi","year":"2013","journal-title":"J. Neurochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/7854_2017_21","article-title":"Oxytocin and social cognition.","volume":"35","author":"Ebert","year":"2018","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00353","article-title":"Regulation of insect behavior via the insulin-signaling pathway.","volume":"4","author":"Erion","year":"2013","journal-title":"Front. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/sj.mp.4001613","article-title":"Reelin glycoprotein: structure, biology and roles in health and disease.","volume":"10","author":"Fatemi","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1038\/npp.2011.169","article-title":"Reelin, a marker of stress resilience in depression and psychosis.","volume":"36","author":"Fatemi","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.","volume":"40","author":"Friedlander","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs.","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jpsychires.2010.05.004","article-title":"Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia.","volume":"45","author":"Fujii","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/260909","article-title":"tRNA-derived fragments target the ribosome and function as regulatory non-coding RNA in Haloferax volcanii.","volume":"2012","author":"Gebetsberger","year":"2012","journal-title":"Archaea"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1022598900246","article-title":"Brain insulin: regulation, mechanisms of action and functions.","volume":"23","author":"Gerozissis","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00064","article-title":"Psychosocial stress and immunity-what can we learn from pig studies?","volume":"12","author":"Gimsa","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112038","article-title":"Haplotypes of coping behavior associated QTL regions reveal distinct transcript profiles in amygdala and hippocampus.","volume":"372","author":"Gley","year":"","journal-title":"Behav. Brain Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49521-2","article-title":"Transcriptome profiles of hypothalamus and adrenal gland linked to haplotype related to coping behavior in pigs.","volume":"9","author":"Gley","year":"","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.cell.2015.02.053","article-title":"Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement.","volume":"161","author":"Goodarzi","year":"2015","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"circlize implements and enhances circular visualization in R.","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1080\/15476286.2019.1657743","article-title":"Deep sequencing of small non-coding RNA highlights brain-specific expression patterns and RNA cleavage.","volume":"16","author":"Haack","year":"2019","journal-title":"RNA Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/nature11923","article-title":"CLP1 links tRNA metabolism to progressive motor-neuron loss.","volume":"495","author":"Hanada","year":"2013","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.95.26.15718","article-title":"A decrease of reelin expression as a putative vulnerability factor in schizophrenia.","volume":"95","author":"Impagnatiello","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.molcel.2011.06.022","article-title":"Angiogenin-induced tRNA fragments inhibit translation initiation.","volume":"43","author":"Ivanov","year":"2011","journal-title":"Mol. Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.neuroscience.2004.10.044","article-title":"The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.","volume":"131","author":"Jin","year":"2005","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1390","article-title":"A sparse PLS for variable selection when integrating omics data.","volume":"7","author":"L\u00ea Cao","year":"2008","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1042\/bj20150224","article-title":"miRNA let-7 expression is regulated by glucose and TNF-\u03b1 by a remote upstream promoter.","volume":"472","author":"Katayama","year":"2015","journal-title":"Biochem. J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.yfrne.2010.04.001","article-title":"Neuroendocrinology of coping styles: towards understanding the biology of individual variation.","volume":"31","author":"Koolhaas","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0149-7634(99)00026-3","article-title":"Coping styles in animals: current status in behavior and stress-physiology.","volume":"23","author":"Koolhaas","year":"1999","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1100\/tsw.2007.201","article-title":"MicroRNA profiling: from dark matter to white matter, or identifying new players in neurobiology.","volume":"7","author":"Krichevsky","year":"2007","journal-title":"Sci. World J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible.","author":"Kr\u00fcger","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0078-0","article-title":"Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets.","volume":"12","author":"Kumar","year":"2014","journal-title":"BMC Biol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems.","volume":"12","author":"L\u00ea Cao","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaa153","article-title":"Salivary microRNAs are potential biomarkers for the accurate and precise identification of inflammatory response after tail docking and castration in piglets.","volume":"98","author":"Lecchi","year":"2020","journal-title":"J. Anim. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/j.pain.0000000000001709","article-title":"MicroRNA-19b predicts widespread pain and posttraumatic stress symptom risk in a sex-dependent manner following trauma exposure.","volume":"161","author":"Linnstaedt","year":"2020","journal-title":"Pain"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103948","article-title":"Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus.","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS one"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/2211536604666141226194231","article-title":"Wet-lab tested microRNA assays for qPCR studies with SYBR\u00ae Green and DNA primers in pig tissues.","volume":"3","author":"Mentzel","year":"2014","journal-title":"Microrna"},{"journal-title":"The Biology of Animal Stress: Basic Principles and Implications for Animal Welfare.","year":"2000","author":"Moberg","key":"B42"},{"key":"B43","doi-asserted-by":"publisher","first-page":"12680","DOI":"10.1074\/jbc.M114.558981","article-title":"C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.","volume":"289","author":"Nakano","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.conb.2009.06.001","article-title":"Semaphorin function in neural plasticity and disease.","volume":"19","author":"Pasterkamp","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"D128","DOI":"10.1093\/nar\/gkw1008","article-title":"RNAcentral: a comprehensive database of non-coding RNA sequences.","volume":"45","author":"Petrov","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1101\/gad.1956510","article-title":"tRNA biology charges to the front.","volume":"24","author":"Phizicky","year":"2010","journal-title":"Genes Dev."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170101","article-title":"Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits.","volume":"7","author":"Ponsuksili","year":"2017","journal-title":"Open Biol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/srep16264","article-title":"Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior.","volume":"5","author":"Ponsuksili","year":"2015","journal-title":"Sci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tvjl.2015.05.024","article-title":"Social stress as a cause of diseases in farm animals: current knowledge and future directions.","volume":"206","author":"Proudfoot","year":"2015","journal-title":"Vet. J."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152342","article-title":"Identification of differentially expressed genes through integrated study of Alzheimer\u2019s disease affected brain regions.","volume":"11","author":"Puthiyedth","year":"2016","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00171","article-title":"tRNAs as regulators of biological processes.","volume":"5","author":"Raina","year":"2014","journal-title":"Front. Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jchemneu.2009.05.004","article-title":"Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: an immunohistochemical analysis.","volume":"38","author":"Rajput","year":"2009","journal-title":"J. Chem. Neuroanat."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for \u2018omics feature selection and multiple data integration.","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1128\/mcb.00136-14","article-title":"Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress.","volume":"34","author":"Saikia","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.","volume":"33","author":"Shi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1093\/bioinformatics\/bty1054","article-title":"DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays.","volume":"35","author":"Singh","year":"2019","journal-title":"Bioinformatics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"553","DOI":"10.4161\/rna.24285","article-title":"Small RNAs derived from the 5\u2032 end of tRNA can inhibit protein translation in human cells.","volume":"10","author":"Sobala","year":"2013","journal-title":"RNA Biol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817391116","article-title":"Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.","volume":"116","author":"Soto","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1038\/npp.2011.153","article-title":"Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.","volume":"36","author":"Teixeira","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"24797","DOI":"10.18632\/oncotarget.4695","article-title":"Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies.","volume":"6","author":"Telonis","year":"2015","journal-title":"Oncotarget"},{"key":"B61","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/sj.mp.4001223","article-title":"Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder.","volume":"8","author":"Thomas","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/circresaha.117.311572","article-title":"RNA-Seq identifies circulating mir-125a-5p, mir-125b-5p, and mir-143-3p as potential biomarkers for acute ischemic stroke.","volume":"121","author":"Tiedt","year":"2017","journal-title":"Circ. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.gene.2015.12.058","article-title":"tRFs: miRNAs in disguise.","volume":"579","author":"Venkatesh","year":"2016","journal-title":"Gene"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.15252\/embj.201593725","article-title":"A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson\u2019s disease.","volume":"35","author":"Villaescusa","year":"2016","journal-title":"EMBO J."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32426-x","article-title":"MicroRNA-194-5p levels decrease during deep hypothermic circulatory arrest.","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00441-018-2866-2","article-title":"The interplay between oxytocin and the CRF system: regulation of the stress response.","volume":"375","author":"Winter","year":"2019","journal-title":"Cell Tissue Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1083\/jcb.200811106","article-title":"Angiogenin cleaves tRNA and promotes stress-induced translational repression.","volume":"185","author":"Yamasaki","year":"2009","journal-title":"J. Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.5713\/ajas.2005.1237","article-title":"Cloning and initial analysis of porcine MPDU1 gene.","volume":"18","author":"Yang","year":"2005","journal-title":"Asian Aust. J. Anim. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.applanim.2017.05.011","article-title":"The backtest in pigs revisited\u2014Inter-situational behaviour and animal classification.","volume":"194","author":"Zebunke","year":"2017","journal-title":"Appl. Anim. Behav. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jocn.2015.01.031","article-title":"MicroRNA-7\/Shank3 axis involved in schizophrenia pathogenesis.","volume":"22","author":"Zhang","year":"2015","journal-title":"J. Clin. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1007\/s11427-018-9308-8","article-title":"The miR-58 microRNA family is regulated by insulin signaling and contributes to lifespan regulation in Caenorhabditis elegans.","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cell.2011.08.033","article-title":"The Lin28\/let-7 axis regulates glucose metabolism.","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.635794\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T11:14:26Z","timestamp":1629371666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.635794\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":72,"alternative-id":["10.3389\/fgene.2021.635794"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2021.635794","relation":{},"ISSN":["1664-8021"],"issn-type":[{"type":"electronic","value":"1664-8021"}],"subject":[],"published":{"date-parts":[[2021,8,19]]},"article-number":"635794"}}