{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:18:19Z","timestamp":1787383099444,"version":"build-2736575974"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Thiamine (vitamin B1) is often deficient in oncopatients, particularly those undergoing chemotherapy. However, interaction between the thiamine deficiency and anticancer action of drugs has not been characterized. A major natural thiamine derivative, thiamine diphosphate (ThDP), is a coenzyme of central metabolism, also known to affect transcriptional activity of the master metabolic regulator and genome guardian p53. A direct transcriptional target of p53, p21, regulates cell cycle dynamics and DNA damage response. Our work focuses on dependence of the action of the DNA damaging anticancer drug cisplatin on metabolic regulation through p53\/p21 axes and cellular thiamine status in human lung adenocarcinoma cells A549. These cells are used as a model of a hardly curable cancer, known to develop chemoresistance to platinum drugs, such as cisplatin. Compared to wild type (A549<jats:sup>WT<\/jats:sup>), a stable line with a 60% knockdown of p21 (A549<jats:sup>p21\u2013<\/jats:sup>) is less sensitive to antiproliferative action of cisplatin. In contrast, in the thiamine-deficient medium, cisplatin impairs the viability of A549<jats:sup>p21\u2013<\/jats:sup> cells more than that of A549<jats:sup>WT<\/jats:sup> cells. Analysis of the associated metabolic changes in the cells indicates that (i) p21 knockdown restricts the production of 2-oxoglutarate <jats:italic>via<\/jats:italic> glutamate oxidation, stimulating that within the tricarboxylic acid (TCA) cycle; (ii) cellular cisplatin sensitivity is associated with a 4-fold upregulation of glutamic-oxaloacetic transaminase (GOT2) by cisplatin; (iii) cellular cisplatin resistance is associated with a 2-fold upregulation of p53 by cisplatin. Correlation analysis of the p53 expression and enzymatic activities upon variations in cellular thiamine\/ThDP levels indicates that p21 knockdown substitutes positive correlation of the p53 expression with the activity of 2-oxoglutarate dehydrogenase complex (OGDHC) for that with the activity of glutamate dehydrogenase (GDH). The knockdown also changes correlations of the levels of OGDHC, GDH and GOT2 with those of the malate and isocitrate dehydrogenases. Thus, a p53\/p21-dependent change in partitioning of the glutamate conversion to 2-oxoglutarate through GOT2 or GDH, linked to NAD(P)-dependent metabolism of 2-oxoglutarate in affiliated pathways, adapts A549 cells to thiamine deficiency or cisplatin treatment. Cellular thiamine deficiency may interfere with antiproliferative action of cisplatin due to their common modulation of the p53\/p21-dependent metabolic switch between the glutamate oxidation and transamination.<\/jats:p>","DOI":"10.3389\/fgene.2021.658446","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T05:31:42Z","timestamp":1617255102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Interplay Between Thiamine and p53\/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate\/Glutamate"],"prefix":"10.3389","volume":"12","author":[{"given":"Vasily A.","family":"Aleshin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuba","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria I.","family":"Bunik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157113","article-title":"Impact of chemotherapy on diet and nutritional status of women with breast cancer: a prospective study.","volume":"11","author":"Ahmad","year":"2016","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1134\/s0006297919080017","article-title":"Mechanisms of the non-coenzyme action of thiamin: protein targets and medical significance.","volume":"84","author":"Aleshin","year":"2019","journal-title":"Biochemistry (Mosc)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/jnc.14951","article-title":"Diurnal regulation of the function of the rat brain glutamate dehydrogenase by acetylation and its dependence on thiamine administration.","volume":"153","author":"Aleshin","year":"2020","journal-title":"J. Neurochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.celrep.2016.09.052","article-title":"Differential aspartate usage identifies a subset of cancer cells particularly dependent on OGDH.","volume":"17","author":"Allen","year":"2016","journal-title":"Cell Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s13238-017-0451-1","article-title":"The emerging role and targetability of the TCA cycle in cancer metabolism.","volume":"9","author":"Anderson","year":"2018","journal-title":"Protein Cell"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207613","article-title":"Establishment of acquired cisplatin resistance in ovarian cancer cell lines characterized by enriched metastatic properties with increased twist expression.","volume":"21","author":"Bahar","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.620593","article-title":"Severe spinal cord injury in rats induces chronic changes in the spinal cord and cerebral cortex metabolism, adjusted by thiamine that improves locomotor performance.","volume":"14","author":"Boyko","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3892\/or.2020.7877","article-title":"Osteopontin-c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity.","volume":"45","author":"Brum","year":"2020","journal-title":"Oncol. Rep."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113759","article-title":"Activation of mitochondrial 2-oxoglutarate dehydrogenase by cocarboxylase in human lung adenocarcinoma cells A549 Is p53\/p21-dependent and impairs cellular redox state, mimicking the cisplatin action.","volume":"21","author":"Bunik","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B10","author":"Bunik","year":"2017","journal-title":"Vitamin-Dependent Multienzyme Complexes of 2-Oxo Acid Dehydrogenases : Structure, Function, Regulation and Medical Implications."},{"key":"B11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1134\/s0006297920070081","article-title":"Regulation of thiamine (Vitamin B1)-dependent metabolism in mammals by p53.","volume":"85","author":"Bunik","year":"","journal-title":"Biochemistry (Mosc)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"40036","DOI":"10.18632\/oncotarget.5486","article-title":"Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells.","volume":"6","author":"Bunik","year":"2015","journal-title":"Oncotarget"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26400","DOI":"10.18632\/oncotarget.8387","article-title":"Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.","volume":"7","author":"Bunik","year":"2016","journal-title":"Oncotarget"},{"key":"B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.2040-1124.2010.00077.x","article-title":"Preventive effects of benfotiamine in chronic diabetic complications.","volume":"2","author":"Chakrabarti","year":"2011","journal-title":"J. Diabetes Investig."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010355","article-title":"Adaptation to endoplasmic reticulum stress enhances resistance of oral cancer cells to cisplatin by up-regulating polymerase \u03b7 and increasing DNA repair efficiency.","volume":"22","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/nop\/npv036","article-title":"Association between malignancy and non-alcoholic Wernicke\u2019s encephalopathy: a case report and literature review.","volume":"3","author":"Choi","year":"2016","journal-title":"Neurooncol. Pract."},{"key":"B17","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/15569527.2015.1077857","article-title":"The effect of thiamine pyrophosphate on ethambutol-induced ocular toxicity.","volume":"35","author":"Cinici","year":"2015","journal-title":"Cutan. Ocul. Toxicol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3109\/01480545.2013.851688","article-title":"The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats.","volume":"37","author":"Coskun","year":"2013","journal-title":"Drug Chem. Toxicol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2019.03.009","article-title":"Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1alpha in NSCLC which can be overcome by OXPHOS inhibition.","volume":"135","author":"Cruz-Bermudez","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.12659\/msm.915866","article-title":"Next-generation sequencing analysis of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901.","volume":"25","author":"Deng","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1158\/1078-0432.ccr-13-2805","article-title":"Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine\/glutamate exchanger SLC7A11.","volume":"20","author":"Drayton","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7120","article-title":"Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.","volume":"6","author":"Guarecuco","year":"2020","journal-title":"Sci. Adv."},{"key":"B23","first-page":"801","article-title":"Hypoxia exposure induced cisplatin resistance partially via activating p53 and hypoxia inducible facor-1\u03b1 in non-small cell lung cancer A549 cells.","volume":"16","author":"Guo","year":"2018","journal-title":"Oncol. Lett."},{"key":"B24","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/jbt.21501","article-title":"Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats.","volume":"27","author":"Harisa","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/jjco\/hyy013","article-title":"Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma.","volume":"48","author":"Hiyama","year":"2018","journal-title":"Jpn. J. Clin. Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/bdd.1892","article-title":"Choline transporter-like proteins CTLs\/SLC44 family as a novel molecular target for cancer therapy.","volume":"35","author":"Inazu","year":"2014","journal-title":"Biopharm. Drug Dispos."},{"key":"B27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.psym.2015.10.001","article-title":"Nonalcoholic thiamine-related encephalopathy (Wernicke-Korsakoff Syndrome) among inpatients with cancer: a series of 18 cases.","volume":"57","author":"Isenberg-Grzeda","year":"2016","journal-title":"Psychosomatics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1002\/pon.4155","article-title":"High rate of thiamine deficiency among inpatients with cancer referred for psychiatric consultation: results of a single site prevalence study.","volume":"26","author":"Isenberg-Grzeda","year":"2017","journal-title":"Psychooncology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nature11776","article-title":"Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.","volume":"493","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"35422","DOI":"10.18632\/oncotarget.26259","article-title":"The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions.","volume":"9","author":"Jonus","year":"2018","journal-title":"Oncotarget"},{"key":"B31","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.dmpk.2015.04.005","article-title":"Methotrexate influx via folate transporters into alveolar epithelial cell line A549.","volume":"30","author":"Kawami","year":"2015","journal-title":"Drug Metab. Pharmacokinet."},{"key":"B32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2005.08.021","article-title":"Regulation of replicative senescence by NADP+-dependent isocitrate dehydrogenase.","volume":"40","author":"Kil","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1007\/s12035-016-0079-9","article-title":"Thiamine deficiency and neurodegeneration: the interplay among oxidative stress, endoplasmic reticulum stress, and autophagy.","volume":"54","author":"Liu","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3727\/096504015x14496932933656","article-title":"HSP27 Knockdown increases cytoplasmic p21 and cisplatin sensitivity in ovarian carcinoma cells.","volume":"23","author":"Lu","year":"2016","journal-title":"Oncol. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"9958","DOI":"10.1128\/mcb.24.22.9958-9967.2004","article-title":"NAD+ modulates p53 DNA binding specificity and function.","volume":"24","author":"McLure","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"B36","doi-asserted-by":"crossref","DOI":"10.1038\/srep12583","article-title":"Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.","volume":"5","author":"Mkrtchyan","year":"2015","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1074\/jbc.m113.528257","article-title":"Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter.","volume":"289","author":"Nabokina","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1111\/cas.14182","article-title":"Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma.","volume":"110","author":"Okazaki","year":"2019","journal-title":"Cancer Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1017\/s1478951518000469","article-title":"Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab.","volume":"17","author":"Onishi","year":"2018","journal-title":"Palliat. Support. Care"},{"key":"B40","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/1074248414552901","article-title":"Examination of the effects of thiamine and thiamine pyrophosphate on doxorubicin-induced experimental cardiotoxicity.","volume":"20","author":"Polat","year":"2015","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"B41","first-page":"1253","article-title":"Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells.","volume":"33","author":"Qu","year":"2013","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"B42","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.canlet.2016.07.035","article-title":"Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer.","volume":"381","author":"Roh","year":"2016","journal-title":"Cancer Lett."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181081","article-title":"Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2\/M cell cycle arrest.","volume":"12","author":"Sarin","year":"2017","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mrd.22489","article-title":"The imageJ ecosystem: an open platform for biomedical image analysis.","volume":"82","author":"Schindelin","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00210-008-0310-y","article-title":"Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients.","volume":"378","author":"Schupp","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081178","article-title":"p21 in cancer research.","volume":"11","author":"Shamloo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1007\/s11095-016-1916-2","article-title":"Development and characterization of the paclitaxel loaded riboflavin and thiamine conjugated carbon nanotubes for cancer treatment.","volume":"33","author":"Singh","year":"2016","journal-title":"Pharm. Res."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.598880","article-title":"Krupple-like factor 5 is a potential therapeutic target and prognostic marker in epithelial ovarian cancer.","volume":"11","author":"Siraj","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4103\/0253-7613.115005","article-title":"Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney.","volume":"45","author":"Suleyman","year":"2013","journal-title":"Indian J. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.2174\/1871520619666190325150624","article-title":"Does the affinity of cisplatin to B-Vitamins impair the therapeutic effect in the case of patients with lung cancer-consuming carrot or beet juice?","volume":"19","author":"Szefler","year":"2019","journal-title":"Anticancer Agents Med. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1089\/omi.2020.0144","article-title":"Insights Into the mechanism of anticancer drug imatinib revealed through multi-omic analyses in yeast.","volume":"24","author":"Taymaz-Nikerel","year":"2020","journal-title":"OMICS"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.18632\/oncotarget.3468","article-title":"Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.","volume":"6","author":"Tiwana","year":"2015","journal-title":"Oncotarget"},{"key":"B53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/0960327113485251","article-title":"An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine.","volume":"33","author":"Turan","year":"","journal-title":"Hum. Exp. Toxicol."},{"key":"B54","article-title":"The effect of thiamine and thiamine pyrophosphate on oxidative liver damage induced in rats with cisplatin.","volume":"2013","author":"Turan","year":"","journal-title":"Biomed. Res. Int."},{"key":"B55","first-page":"406","article-title":"Impact of thiamine supplementation in the reversal of ethanol induced toxicity in rats.","volume":"57","author":"Vidhya","year":"2013","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.celrep.2016.09.022","article-title":"Acetylation is crucial for p53-mediated ferroptosis and tumor suppression.","volume":"17","author":"Wang","year":"2016","journal-title":"Cell Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.neuroscience.2006.10.008","article-title":"Thiamine deficiency induces endoplasmic reticulum stress in neurons.","volume":"144","author":"Wang","year":"2007","journal-title":"Neuroscience"},{"key":"B58","doi-asserted-by":"publisher","first-page":"49275","DOI":"10.18632\/oncotarget.17568","article-title":"Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer.","volume":"8","author":"Wangpaichitr","year":"2017","journal-title":"Oncotarget"},{"key":"B59","doi-asserted-by":"crossref","first-page":"E934","DOI":"10.1002\/hed.24129","article-title":"Down-regulation of malic enzyme 1 and 2: sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence.","volume":"38","author":"Woo","year":"2016","journal-title":"Head Neck"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-399","article-title":"Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer.","volume":"11","author":"Xia","year":"2011","journal-title":"BMC Cancer"},{"key":"B61","first-page":"2921","article-title":"The anthelmintic agent oxfendazole inhibits cell growth in nonsmall cell lung cancer by suppressing cSrc activation.","volume":"19","author":"Xu","year":"","journal-title":"Mol. Med. Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12640-019-00032-y","article-title":"Effects of chronic voluntary alcohol drinking on thiamine concentrations, endoplasmic reticulum stress, and oxidative stress in the brain of crossed high alcohol preferring mice.","volume":"36","author":"Xu","year":"","journal-title":"Neurotox. Res."},{"key":"B63","first-page":"2690","article-title":"MicroRNA-497 regulates cisplatin chemosensitivity of cervical cancer by targeting transketolase.","volume":"6","author":"Yang","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.bbrc.2019.02.089","article-title":"PACT cessation overcomes ovarian cancer cell chemoresistance to cisplatin by enhancing p53-mediated apoptotic pathway.","volume":"511","author":"Yang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41430-020-00735-y","article-title":"Subclinical thiamine deficiency identified by pretreatment evaluation in an esophageal cancer patient.","volume":"75","author":"Yoshioka","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1017\/s1478951520000978","article-title":"Thiamine deficiency in the outpatient psychiatric oncology setting: a case series.","volume":"18","author":"Zhang","year":"2020","journal-title":"Palliat. Support. Care"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1074\/jbc.m007919200","article-title":"Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.","volume":"276","author":"Zhao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.mam.2012.07.006","article-title":"Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.","volume":"34","author":"Zhao","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4443-1","article-title":"Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.","volume":"18","author":"Zhou","year":"2018","journal-title":"BMC Cancer"},{"key":"B70","doi-asserted-by":"publisher","first-page":"9271","DOI":"10.18632\/oncotarget.3375","article-title":"The mitochondrial carrier SLC25A10 regulates cancer cell growth.","volume":"6","author":"Zhou","year":"2015","journal-title":"Oncotarget"},{"key":"B71","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1039\/c8sc04871a","article-title":"Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism.","volume":"10","author":"Zhu","year":"2019","journal-title":"Chem. Sci."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.658446\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T05:31:51Z","timestamp":1617255111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.658446\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":71,"alternative-id":["10.3389\/fgene.2021.658446"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2021.658446","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"article-number":"658446"}}