{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:22:25Z","timestamp":1775690545161,"version":"3.50.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>The current study aims to further delineate the associations between the synaptotagmin-like 3 (<jats:italic>SYTL3<\/jats:italic>) and solute carrier family 22 member 3 (<jats:italic>SLC22A3<\/jats:italic>) single-nucleotide polymorphisms (SNPs) and their haplotypes and gene\u2013gene (G \u00d7 G)\/environment (G \u00d7 E) interactions on the risk of hyperlipidemia (HLP) in the Maonan and Han ethnic groups. Genotype distribution among the <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> SNPs in 2,829 individual patients bearing no relationship to each other (Han, 1,436; Maonan, 1,393) was analyzed utilizing next-generation sequencing techniques. The genotype frequencies of the rs6455600, rs2129209, and rs446809 SNPs were varied between the two ethnic groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05\u20130.001). Various SNPs were correlated with serum levels of triglyceride (TG; rs446809), total cholesterol (TC; rs6455600, rs2129209, and rs539298), and low-density lipoprotein cholesterol (LDL-C; rs446809) among the Han population, whereas various SNPs were also correlated with TC (rs6455600 and rs539298), TG (rs446809), and LDL-C (rs446809) levels in the Maonan ethnic group (<jats:italic>P<\/jats:italic> &amp;lt; 0.008\u20130.001). One part of haplotypes resulted in worsened HLP-related morbidity in the Han (<jats:italic>SYTL3<\/jats:italic> A-C-A-A; <jats:italic>SLC22A3<\/jats:italic> A-A and A-G; and <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> A-C-A-A-A-A and A-C-A-A-A-G) and Maonan (<jats:italic>SYTL3<\/jats:italic> A-C-A-A; <jats:italic>SLC22A3<\/jats:italic> A-A and A-G; and <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> A-C-A-A-A-A, G-T-C-A-A-A, and G-T-C-A-C-A) ethnic groups, whereas another part of haplotypes lowered HLP-related health risks in the Han (<jats:italic>SLC22A3<\/jats:italic> C-A and C-G and <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> A-C-A-A-C-A, A-C-A-A-C-G, and G-T-C-A-C-A) and Maonan (<jats:italic>SLC22A3<\/jats:italic> C-G and <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> A-C-A-A-C-G) ethnic groups. We discovered that the <jats:italic>SYTL3\u2013SLC22A3<\/jats:italic> SNPs and their haplotypes were associated with serum lipid levels and the risk of HLP in our studied populations.<\/jats:p>","DOI":"10.3389\/fgene.2021.679027","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T11:46:45Z","timestamp":1626868005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["SYTL3\u2013SLC22A3 Single-Nucleotide Polymorphisms and Gene\u2013Gene\/Environment Interactions on the Risk of Hyperlipidemia"],"prefix":"10.3389","volume":"12","author":[{"given":"Peng-Fei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Xing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Zong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Xiong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Liu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cbpa.2017.06.002","article-title":"Lipid homeostasis and regulated cell death.","volume":"39","author":"Agmon","year":"2017","journal-title":"Curr. 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