{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:15:02Z","timestamp":1787026502671,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless, how the reported risk variants confer risk of anxiety remains unknown. To identify genes whose\n                    <jats:italic>cis<\/jats:italic>\n                    -regulated expression levels are associated with risk of anxiety traits, we conducted a transcriptome-wide association study (TWAS) by integrating genome-wide associations from a large-scale GWAS (\n                    <jats:italic>N<\/jats:italic>\n                    = 175,163) (which evaluated anxiety traits based on Generalized Anxiety Disorder 2-item scale (GAD-2) score) and brain expression quantitative trait loci (eQTL) data (from the PsychENCODE and GTEx). We identified 19 and 17 transcriptome-wide significant (TWS) genes in the PsychENCODE and GTEx, respectively. Intriguingly, 10 genes showed significant associations with anxiety in both datasets, strongly suggesting that genetic risk variants may confer risk of anxiety traits by regulating the expression of these genes. Top TWS genes included\n                    <jats:italic>RNF123<\/jats:italic>\n                    ,\n                    <jats:italic>KANSL1-AS1, GLYCTK, CRHR1, DND1P1, MAPT<\/jats:italic>\n                    and\n                    <jats:italic>ARHGAP27.<\/jats:italic>\n                    Of note, 25 TWS genes were not implicated in the original GWAS. Our TWAS identified 26 risk genes whose\n                    <jats:italic>cis<\/jats:italic>\n                    -regulated expression were significantly associated with anxiety, providing important insights into the genetic component of gene expression in anxiety disorders\/traits and new clues for future drug development.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2021.740134","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:15:08Z","timestamp":1632795308000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety"],"prefix":"10.3389","volume":"12","author":[{"given":"Xi","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong-Jian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1001\/jama.283.19.2529","article-title":"Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder","volume":"283","author":"Barlow","year":"2000","journal-title":"Jama"},{"key":"B2","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for Functional Genomics Data Sets-Uupdate","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-3-319-53889-1_8","article-title":"Anxiety and Epigenetics","volume":"978","author":"Bartlett","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic Effects on Gene Expression across Human Tissues","volume":"550","author":"Battle","year":"2017","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1017\/s0033291713003243","article-title":"The Global burden of Anxiety Disorders in 2010","volume":"44","author":"Baxter","year":"2014","journal-title":"Psychol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41588-020-0610-9","article-title":"Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Insights into the Etiology of Parkinson's Disease","volume":"52","author":"Bryois","year":"2020","journal-title":"Nat. Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"17024","DOI":"10.1038\/nrdp.2017.24","article-title":"Anxiety Disorders","volume":"3","author":"Craske","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.biopsych.2020.09.010","article-title":"Delineating the Genetic Component of Gene Expression in Major Depression","volume":"89","author":"Dall'Aglio","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0134865","DOI":"10.1371\/journal.pone.0134865","article-title":"Generalised Anxiety Disorder - A Twin Study of Genetic Architecture, Genome-wide Association and Differential Gene Expression","volume":"10","author":"Davies","year":"2015","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: Generalized Gene-Set Analysis of GWAS Data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"Plos Comput. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1038\/s41467-019-10649-4","article-title":"Improving the Diagnostic Yield of Exome- Sequencing by Predicting Gene-Phenotype Associations Using Large-Scale Gene Expression Analysis","volume":"10","author":"Deelen","year":"2019","journal-title":"Nat. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/ajmg.b.32448","article-title":"Genome-wide Association Study of Generalized Anxiety Symptoms in the Hispanic Community Health Study\/Study of Latinos","volume":"174","author":"Dunn","year":"2017","journal-title":"Am. J. Med. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1469-1809.2009.00560.x","article-title":"Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease","volume":"74","author":"Edwards","year":"2010","journal-title":"Ann. Hum. Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/mp.2010.41","article-title":"TMEM132D, a New Candidate for Anxiety Phenotypes: Evidence from Human and Mouse Studies","volume":"16","author":"Erhardt","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"eaat8127","DOI":"10.1126\/science.aat8127","article-title":"Transcriptome-wide Isoform-Level Dysregulation in ASD, Schizophrenia, and Bipolar Disorder","volume":"362","author":"Gandal","year":"2018","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jclinepi.2015.09.016","article-title":"Million Veteran Program: A Mega-Biobank to Study Genetic Influences on Health and Disease","volume":"70","author":"Gaziano","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990-2017: a Systematic Analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s41593-019-0447-7","article-title":"Genome-wide Association Study of post-traumatic Stress Disorder Reexperiencing Symptoms in >165,000 US Veterans","volume":"22","author":"Gelernter","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41593-020-00748-7","article-title":"Transcriptomic Organization of the Human Brain in post-traumatic Stress Disorder","volume":"24","author":"Girgenti","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.biopsych.2011.08.022","article-title":"High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes","volume":"71","author":"Glahn","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000086378","article-title":"Transcriptomic Analyses Support the Similarity of Gene Expression between Brain and Testis in Human as Well as Mouse","volume":"111","author":"Guo","year":"2005","journal-title":"Cytogenet. Genome Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative Approaches for Large-Scale Transcriptome-wide Association Studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat. Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s2215-0366(18)30511-x","article-title":"Prevalence of Mental Disorders in China: a Cross-Sectional Epidemiological Study","volume":"6","author":"Huang","year":"2019","journal-title":"The Lancet Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4831","DOI":"10.1158\/1078-0432.ccr-17-0146","article-title":"Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-\u039ab Pathway in Melanoma","volume":"23","author":"Iida","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.biopsych.2009.10.008","article-title":"Endophenotypes: Bridging Genomic Complexity and Disorder Heterogeneity","volume":"66","author":"Insel","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1038\/ncb1194","article-title":"Cytoplasmic Ubiquitin Ligase KPC Regulates Proteolysis of p27Kip1 at G1 Phase","volume":"6","author":"Kamura","year":"2004","journal-title":"Nat. Cel Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1001\/archgenpsychiatry.2011.160","article-title":"Prevalence, Persistence, and Sociodemographic Correlates of DSM-IV Disorders in the National Comorbidity Survey Replication Adolescent Supplement","volume":"69","author":"Kessler","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.genhosppsych.2010.03.006","article-title":"The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a Systematic Review","volume":"32","author":"Kroenke","year":"2010","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/s41588-019-0512-x","article-title":"Comparative Genetic Architectures of Schizophrenia in East Asian and European Populations","volume":"51","author":"Lam","year":"2019","journal-title":"Nat. Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1176\/appi.ajp.2019.19030256","article-title":"Reproducible Genetic Risk Loci for Anxiety: Results from \u223c200,000 Participants in the Million Veteran Program","volume":"177","author":"Levey","year":"2020","journal-title":"Am. J. Psychiatry."},{"key":"B31","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/s41467-019-08912-9","article-title":"Prioritizing Parkinson's Disease Genes Using Population-Scale Transcriptomic Data","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1038\/s41467-019-12450-9","article-title":"Transcriptome-wide Association Study of Attention Deficit Hyperactivity Disorder Identifies Associated Genes and Phenotypes","volume":"10","author":"Liao","year":"2019","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/jne.12175","article-title":"The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations","volume":"26","author":"Maccari","year":"2014","journal-title":"J. Neuroendocrinol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the Missing Heritability of Complex Diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1001\/jamapsychiatry.2019.1119","article-title":"Genetic Variants Associated with Anxiety and Stress-Related Disorders","volume":"76","author":"Meier","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"B36","first-page":"14","article-title":"Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders","volume":"38","author":"Nemeroff CB","year":"2004","journal-title":"Psychopharmacol. Bull."},{"key":"B37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/gbb.12095","article-title":"Further Confirmation of the Association between Anxiety andCTNND2: Replication in Humans","volume":"13","author":"Nivard","year":"2014","journal-title":"Genes, Brain Behav."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1038\/mp.2016.11","article-title":"Meta-analysis of Genome-wide Association Studies of Anxiety Disorders","volume":"21","author":"Otowa","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1038\/tp.2012.89","article-title":"Meta-analysis of Genome-wide Association Studies for Panic Disorder in the Japanese Population","volume":"2","author":"Otowa","year":"2012","journal-title":"Transl Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/jhg.2008.17","article-title":"Genome-wide Association Study of Panic Disorder in the Japanese Population","volume":"54","author":"Otowa","year":"2009","journal-title":"J. Hum. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41588-018-0059-2","article-title":"Common Schizophrenia Alleles Are Enriched in Mutation-Intolerant Genes and in Regions under strong Background Selection","volume":"50","author":"Pardi\u00f1as","year":"2018","journal-title":"Nat. Genet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/ng.3285","article-title":"Meta-analysis of the Heritability of Human Traits Based on Fifty Years of Twin Studies","volume":"47","author":"Polderman","year":"2015","journal-title":"Nat. Genet."},{"key":"B43","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.neuron.2019.06.011","article-title":"A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation","volume":"103","author":"Polioudakis","year":"2019","journal-title":"Neuron"},{"key":"B44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.expneurol.2014.09.001","article-title":"The Effects of Early Life Stress on the Epigenome: From the Womb to Adulthood and Even before","volume":"268","author":"Proven\u00e7al","year":"2015","journal-title":"Exp. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a Tool Set for Whole-Genome Association and Population-Based Linkage Analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1038\/s41380-019-0559-1","article-title":"A Major Role for Common Genetic Variation in Anxiety Disorders","volume":"25","author":"Purves","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological Insights from 108 Schizophrenia-Associated Genetic Loci","volume":"511","year":"2014","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/ng.487","article-title":"Genome-wide Association Study Reveals Genetic Risk Underlying Parkinson's Disease","volume":"41","author":"Sim\u00f3n-S\u00e1nchez","year":"2009","journal-title":"Nat. Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.biopsych.2009.12.011","article-title":"An Association Analysis of Circadian Genes in Anxiety Disorders","volume":"67","author":"Sipil\u00e4","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/npp.2015.266","article-title":"The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders","volume":"41","author":"Smoller","year":"2016","journal-title":"Neuropsychopharmacol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","article-title":"Genome-wide Association Study Identifies 30 Loci Associated with Bipolar Disorder","volume":"51","author":"Stahl","year":"2019","journal-title":"Nat. Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41588-020-00767-x","article-title":"Genome-wide Association Analyses of post-traumatic Stress Disorder and its Symptom Subdomains in the Million Veteran Program","volume":"53","author":"Stein","year":"2021","journal-title":"Nat. Genet."},{"key":"B53","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ajmg.b.32520","article-title":"Genetic Risk Variants for Social Anxiety","volume":"174","author":"Stein","year":"2017","journal-title":"Am. J. Med. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.biopsych.2010.11.008","article-title":"A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Is Associated with Increased Risk for Selective Mutism and Social Anxiety-Related Traits","volume":"69","author":"Stein","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1001\/archpsyc.60.12.1187","article-title":"Schizophrenia as a Complex Trait","volume":"60","author":"Sullivan","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic Epidemiology of Major Depression: Review and Meta-Analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Ajp"},{"key":"B57","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.jad.2013.04.010","article-title":"Correlative Gene Expression Pattern Linking RNF123 to Cellular Stress-Senescence Genes in Patients with Depressive Disorder: Implication of DRD1 in the Cerebral Cortex","volume":"151","author":"Teyssier","year":"2013","journal-title":"J. Affective Disord."},{"key":"B58","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41588-019-0385-z","article-title":"Opportunities and Challenges for Transcriptome-wide Association Studies","volume":"51","author":"Wainberg","year":"2019","journal-title":"Nat. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e80326","DOI":"10.1371\/journal.pone.0080326","article-title":"Performance of Polygenic Scores for Predicting Phobic Anxiety","volume":"8","author":"Walter","year":"2013","journal-title":"PLoS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.15252\/embr.201541703","article-title":"RNF 123 Has an E3 Ligase\u2010independent Function in RIG \u2010I\u2010like Receptor\u2010mediated Antiviral Signaling","volume":"17","author":"Wang","year":"2016","journal-title":"EMBO Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.3390\/cancers12051081","article-title":"Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-\u039ab1 Target SerpinE1 in Aggressive Glioblastoma Tumors","volume":"12","author":"Wang","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional Mapping and Annotation of Genetic Associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41398-021-01225-w","article-title":"DNA Methylation Differences Associated with Social Anxiety Disorder and Early Life Adversity","volume":"11","author":"Wiegand","year":"2021","journal-title":"Transl Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.bbi.2014.09.016","article-title":"Blood Gene Expression Profiles Suggest Altered Immune Function Associated with Symptoms of Generalized Anxiety Disorder","volume":"43","author":"Wingo","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide Association Analyses Identify 44 Risk Variants and Refine the Genetic Architecture of Major Depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ana.21157","article-title":"Association Analysis of MAPT H1 Haplotype and Subhaplotypes in Parkinson's Disease","volume":"62","author":"Zabetian","year":"2007","journal-title":"Ann. Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular Architecture of the Mouse Nervous System","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s41398-019-0648-6","article-title":"The DNA Methylome in Panic Disorder: a Case-Control and Longitudinal Psychotherapy-Epigenetic Study","volume":"9","author":"Ziegler","year":"2019","journal-title":"Transl Psychiatry"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.740134\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:15:12Z","timestamp":1632795312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2021.740134\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":68,"alternative-id":["10.3389\/fgene.2021.740134"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2021.740134","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"article-number":"740134"}}