{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:44:43Z","timestamp":1790372683360,"version":"4.1.0"},"reference-count":164,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>The most distinctive feature of Down syndrome (DS) is moderate to severe cognitive impairment. Genetic, molecular, and neuronal mechanisms of this complex DS phenotype are currently under intensive investigation. It is becoming increasingly clear that the abnormalities arise from a combination of initial changes caused by triplication of genes on human chromosome 21 (HSA21) and later compensatory adaptations affecting multiple brain systems. Consequently, relatively mild initial cognitive deficits become pronounced with age. This pattern of changes suggests that one approach to improving cognitive function in DS is to target the earliest critical changes, the prevention of which can change the \u2018trajectory\u2019 of the brain development and reduce the destructive effects of the secondary alterations. Here, we review the experimental data on the role of <jats:italic>KCNJ6<\/jats:italic> in DS-specific brain abnormalities, focusing on a putative role of this gene in the development of abnormal neural circuits in the hippocampus of genetic mouse models of DS. It is suggested that the prevention of these early abnormalities with pharmacological or genetic means can ameliorate cognitive impairment in DS.<\/jats:p>","DOI":"10.3389\/fgene.2022.1006068","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:14:25Z","timestamp":1662966865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits"],"prefix":"10.3389","volume":"13","author":[{"given":"Alexander M.","family":"Kleschevnikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jchemneu.2012.11.001","article-title":"Differential maturation of GIRK2-expressing neurons in the mouse cerebellum","volume":"47","author":"Aguado","year":"2013","journal-title":"J. Chem. Neuroanat."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/ajmg.a.31721","article-title":"Differential effects of trisomy on brain shape and volume in related aneuploid mouse models","author":"Aldridge","year":"2007","journal-title":"Am. J. Med. Genet. A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.nbd.2012.11.017","article-title":"Normalization of Dyrk1A expression by AAV2\/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome","volume":"52","author":"Altafaj","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nrg.2016.154","article-title":"Down syndrome and the complexity of genome dosage imbalance","volume":"18","author":"Antonarakis","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B6","doi-asserted-by":"publisher","first-page":"770359","DOI":"10.3389\/fgene.2021.770359","article-title":"Structural characterization of the highly restricted down syndrome critical region on 21q22.13: New KCNJ6 and DSCR4 transcript isoforms","volume":"12","author":"Antonaros","year":"2021","journal-title":"Front. Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5962","DOI":"10.1007\/s12035-017-0818-6","article-title":"Down syndrome iPSC-derived astrocytes impair neuronal synaptogenesis and the mTOR pathway in vitro","volume":"55","author":"Araujo","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbagrm.2007.09.005","article-title":"Analysis of the promoter region of human placenta-specific DSCR4 gene","volume":"1779","author":"Asai","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/ajmg.a.32975","article-title":"Keppen-Lubinsky syndrome: Expanding the phenotype","author":"Basel-Vanagaite","year":"2009","journal-title":"Am. J. Med. Genet. A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.nbd.2013.11.010","article-title":"Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome","volume":"63","author":"Begenisic","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"5938","DOI":"10.1523\/JNEUROSCI.1547-09.2009","article-title":"The \"Down syndrome critical region\" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome","volume":"29","author":"Belichenko","year":"","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0134861","DOI":"10.1371\/journal.pone.0134861","article-title":"Down syndrome cognitive phenotypes modeled in mice trisomic for all HSA 21 homologues","volume":"10","author":"Belichenko","year":"2015","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/cne.21895","article-title":"Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome","volume":"512","author":"Belichenko","year":"","journal-title":"J. Comp. Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/cne.21433","article-title":"Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships","volume":"504","author":"Belichenko","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0152471","DOI":"10.1371\/journal.pone.0152471","article-title":"An anti-beta-amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome","volume":"11","author":"Belichenko","year":"2016","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/cne.20337","article-title":"Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome","volume":"480","author":"Belichenko","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nrn920","article-title":"Excitatory actions of gaba during development: The nature of the nurture","volume":"3","author":"Ben-Ari","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1152\/physrev.00017.2006","article-title":"Gaba: A pioneer transmitter that excites immature neurons and generates primitive oscillations","volume":"87","author":"Ben-Ari","year":"2007","journal-title":"Physiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1152\/jn.00626.2006","article-title":"Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current","volume":"97","author":"Best","year":"2007","journal-title":"J. Neurophysiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1523\/JNEUROSCI.0534-10.2010","article-title":"Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome","volume":"30","author":"Bianchi","year":"2010","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/nrn2759","article-title":"Mechanisms underlying spontaneous patterned activity in developing neural circuits","volume":"11","author":"Blankenship","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/epi.13034","article-title":"The GIRK2 subunit is involved in IS-like seizures induced by GABA(B) receptor agonists","volume":"56","author":"Blichowski","year":"2015","journal-title":"Epilepsia"},{"key":"B23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/bs.pbr.2019.10.002","article-title":"Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome","volume":"251","author":"Botte","year":"2020","journal-title":"Prog. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1177\/0269881111405366","article-title":"Specific targeting of the GABA-A receptor \u03b15 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice.","volume":"25","author":"Braudeau","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1523\/JNEUROSCI.5169-06.2007","article-title":"Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo","volume":"27","author":"Cancedda","year":"2007","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome","volume":"27","author":"Chakrabarti","year":"2007","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.aac6472","article-title":"A GABAergic projection from the zona incerta to cortex promotes cortical neuron development","volume":"350","author":"Chen","year":"2015","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1523\/JNEUROSCI.5312-04.2005","article-title":"Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons","volume":"25","author":"Chen","year":"2005","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/alz.12185","article-title":"Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model","volume":"17","author":"Chen","year":"2020","journal-title":"Alzheimers Dement."},{"key":"B30","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000082142","article-title":"Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex","volume":"26","author":"Cheng","year":"2004","journal-title":"Dev. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1038\/s41467-018-07630-y","article-title":"Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro","volume":"9","author":"Chiang","year":"2018","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.expneurol.2006.02.005","article-title":"Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome","volume":"200","author":"Clark","year":"2006","journal-title":"Exp. Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice","volume":"17","author":"Contestabile","year":"2007","journal-title":"Hippocampus"},{"key":"B34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fncel.2017.00054","article-title":"The GABAergic hypothesis for cognitive disabilities in down syndrome","volume":"11","author":"Contestabile","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1073\/pnas.1109099109","article-title":"Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice","volume":"109","author":"Cooper","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1203\/PDR.0b013e31819d9076","article-title":"Infantile spasms and down syndrome: A new animal model","volume":"65","author":"Cortez","year":"2009","journal-title":"Pediatr. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"101542","DOI":"10.1155\/2012\/101542","article-title":"From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome","author":"Cramer","year":"2012","journal-title":"Neural Plast."},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/bs.irn.2015.06.001","article-title":"The roles of g\u03b2\u03b3 and g\u03b1 in gating and regulation of GIRK channels.","volume":"123","author":"Dascal","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/s0031-9384(01)00523-6","article-title":"Murine models for Down syndrome","volume":"73","author":"Dierssen","year":"2001","journal-title":"Physiol. Behav."},{"key":"B40","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1152\/physrev.00032.2007","article-title":"Aneuploidy: From a physiological mechanism of variance to down syndrome","volume":"89","author":"Dierssen","year":"2009","journal-title":"Physiol. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1097\/FTD.0000000000000301","article-title":"Genetic predisposition to poor opioid response in preterm infants: Impact of KCNJ6 and COMT polymorphisms on pain relief after endotracheal intubation","volume":"38","author":"Elens","year":"2016","journal-title":"Ther. Drug Monit."},{"key":"B42","doi-asserted-by":"publisher","first-page":"8951614","DOI":"10.1046\/j.1471-4159.2003.01614.x","article-title":"Molecular changes in fetal Down syndrome brain","volume":"84","author":"Engidawork","year":"2003","journal-title":"J. Neurochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.nbd.2011.04.011","article-title":"Comprehensive behavioral phenotyping of Ts65Dn mouse model of down syndrome: Activation of \u03b21-adrenergic receptor by xamoterol as a potential cognitive enhancer.","volume":"43","author":"Faizi","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nn1860","article-title":"Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome","volume":"10","author":"Fernandez","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1111\/j.1460-9568.2011.07886.x","article-title":"Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK\/Kir3) channel subunits in the brain","volume":"34","author":"Fernandez-Alacid","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"NS20200011","DOI":"10.1042\/NS20200011","article-title":"Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome","volume":"5","author":"Freeburn","year":"2021","journal-title":"Neuronal Signal."},{"key":"B47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.nbd.2017.06.010","article-title":"Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes","volume":"106","author":"Garcia-Cerro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/00005072-199409000-00011","article-title":"Development of the superior temporal neocortex is anomalous in trisomy 21","volume":"53","author":"Golden","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.neuron.2006.01.017","article-title":"Spontaneous network activity in the embryonic spinal cord regulates AMPAergic and GABAergic synaptic strength","volume":"49","author":"Gonzalez-Islas","year":"2006","journal-title":"Neuron"},{"key":"B50","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jchemneu.2011.09.002","article-title":"Alterations of brain circuits in Down syndrome murine models","volume":"42","author":"Gotti","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"B51","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3389\/fncel.2017.00255","article-title":"Early correlated network activity in the Hippocampus: Its putative role in shaping neuronal circuits","volume":"11","author":"Griguoli","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/brain\/awt340","article-title":"Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model","volume":"137","author":"Guidi","year":"2014","journal-title":"Brain"},{"key":"B53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2174\/1567205012666150921095505","article-title":"Cognitive impairment, neuroimaging, and alzheimer neuropathology in mouse models of down syndrome","volume":"13","author":"Hamlett","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"10817","DOI":"10.1073\/pnas.0903603106","article-title":"Development regulates a switch between post- and presynaptic strengthening in response to activity deprivation","volume":"106","author":"Han","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10571-006-9066-4","article-title":"Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model","volume":"26","author":"Harashima","year":"","journal-title":"Cell. Mol. Neurobiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/cne.20844","article-title":"Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: A model of down syndrome","volume":"494","author":"Harashima","year":"","journal-title":"J. Comp. Neurol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"877711","DOI":"10.3389\/fcell.2022.877711","article-title":"Developmental neuropathology and neurodegeneration of down syndrome: Current knowledge in humans","volume":"10","author":"Hasina","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"6175","DOI":"10.1523\/jneurosci.16-19-06175.1996","article-title":"Consequences of trisomy 16 for mouse brain development: Corticogenesis in a model of down syndrome","volume":"16","author":"Haydar","year":"1996","journal-title":"J. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.1523\/jneurosci.20-11-04156.2000","article-title":"Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse","volume":"20","author":"Haydar","year":"2000","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tins.2011.11.001","article-title":"Trisomy 21 and early brain development","volume":"35","author":"Haydar","year":"2012","journal-title":"Trends Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"467251","DOI":"10.1155\/2012\/467251","article-title":"Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome","author":"Heinen","year":"2012","journal-title":"Neural Plast."},{"key":"B62","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1152\/physrev.00021.2009","article-title":"Inwardly rectifying potassium channels: Their structure, function, and physiological roles","volume":"90","author":"Hibino","year":"2010","journal-title":"Physiol. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"13333","DOI":"10.1073\/pnas.93.23.13333","article-title":"Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome","volume":"93","author":"Holtzman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1523\/jneurosci.19-03-01006.1999","article-title":"Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra","volume":"19","author":"Inanobe","year":"1999","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"134569","DOI":"10.1016\/j.neulet.2019.134569","article-title":"Neurodevelopmental wiring deficits in the Ts65Dn mouse model of Down syndrome","volume":"714","author":"Jain","year":"2020","journal-title":"Neurosci. Lett."},{"key":"B66","doi-asserted-by":"publisher","first-page":"107808","DOI":"10.1016\/j.pharmthera.2021.107808","article-title":"Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system","volume":"223","author":"Jeremic","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nature12394","article-title":"Translating dosage compensation to trisomy 21","volume":"500","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"6540","DOI":"10.1093\/hmg\/ddv364","article-title":"Genetic dissection of the Down syndrome critical region","volume":"24","author":"Jiang","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B69","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/ana.24749","article-title":"Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel","volume":"80","author":"Joshi","year":"2016","journal-title":"Ann. Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijpsycho.2016.12.007","article-title":"A KCNJ6 gene polymorphism modulates theta oscillations during reward processing","volume":"115","author":"Kamarajan","year":"2017","journal-title":"Int. J. Psychophysiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1006\/mcne.1997.0655","article-title":"Ontogeny of gene expression of Kir channel subunits in the rat","volume":"10","author":"Karschin","year":"1997","journal-title":"Mol. Cell. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/s42003-021-02242-7","article-title":"A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome","volume":"4","author":"Kawatani","year":"2021","journal-title":"Commun. Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1177\/1073858413510044","article-title":"Spontaneous network activity and synaptic development","volume":"20","author":"Kerschensteiner","year":"2014","journal-title":"Neuroscientist"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1152\/jn.00951.2014","article-title":"A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus","volume":"113","author":"Kim","year":"2015","journal-title":"J. Neurophysiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.neuron.2013.10.030","article-title":"A role for correlated spontaneous activity in the assembly of neural circuits","volume":"80","author":"Kirkby","year":"2013","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1523\/JNEUROSCI.1673-12.2012","article-title":"Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists","volume":"32","author":"Kleschevnikov","year":"","journal-title":"J. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.nbd.2011.10.009","article-title":"Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome","volume":"45","author":"Kleschevnikov","year":"","journal-title":"Neurobiol. Dis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/B978-0-444-54299-1.00010-8","article-title":"Discoveries in down syndrome: Moving basic science to clinical care","volume":"197","author":"Kleschevnikov","year":"","journal-title":"Prog. Brain Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"8153","DOI":"10.1523\/JNEUROSCI.1766-04.2004","article-title":"Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome","volume":"24","author":"Kleschevnikov","year":"2004","journal-title":"J. Neurosci."},{"key":"B80","article-title":"Expression of GIRK2 and related proteins after chronic administrations of Prozac in Ts65Dn mice, a genetic model of Down syndrome","volume-title":"Program No. 115.7","author":"Kleschevnikov","year":"2005"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2017.03.009","article-title":"Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome","volume":"103","author":"Kleschevnikov","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B82","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.neuropharm.2008.10.003","article-title":"Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels","volume":"56","author":"Kobayashi","year":"2009","journal-title":"Neuropharmacology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/sj.bjp.0705172","article-title":"Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac)","volume":"138","author":"Kobayashi","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"B84","first-page":"236","article-title":"Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype","volume":"47","author":"Korenberg","year":"1990","journal-title":"Am. J. Hum. Genet."},{"key":"B85","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1523\/JNEUROSCI.4178-05.2006","article-title":"Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells","volume":"26","author":"Kulik","year":"2006","journal-title":"J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/01.j.pain.0000460319.87643.11","article-title":"Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery","volume":"156","author":"Langford","year":"2015","journal-title":"Pain"},{"key":"B87","first-page":"256","article-title":"Mongolism; a chromosomal disease (trisomy)","volume":"143","author":"Lejeune","year":"1959","journal-title":"Bull. Acad. Natl. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1080\/19336950.2016.1238992","article-title":"T-type calcium channels in synaptic plasticity","volume":"11","author":"Leresche","year":"2017","journal-title":"Channels (Austin)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijdevneu.2004.03.004","article-title":"Perinatal exposure to GABA-transaminase inhibitor impaired psychomotor function in the developing and adult mouse","volume":"22","author":"Levav","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.neuropharm.2007.10.012","article-title":"Impaired synaptogenesis and long-term modulation of behavior following postnatal elevation of GABA levels in mice","volume":"54","author":"Levav","year":"2008","journal-title":"Neuropharmacology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/npp.2009.219","article-title":"A sensitive period of mice inhibitory system to neonatal GABA enhancement by vigabatrin is brain region dependent","volume":"35","author":"Levav-Rabkin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.stem.2012.08.004","article-title":"Trisomy correction in Down syndrome induced pluripotent stem cells","volume":"11","author":"Li","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B93","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1159\/000329422","article-title":"Mouse models for down syndrome-associated developmental cognitive disabilities","volume":"33","author":"Liu","year":"2011","journal-title":"Dev. Neurosci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.brainres.2006.05.022","article-title":"Hippocampal hypocellularity in the Ts65Dn mouse originates early in development","volume":"1104","author":"Lorenzi","year":"2006","journal-title":"Brain Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/B978-0-444-54299-1.00006-6","article-title":"Neurological phenotypes for Down syndrome across the life span","volume":"197","author":"Lott","year":"2012","journal-title":"Prog. Brain Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fncir.2016.00040","article-title":"Spontaneous neuronal activity in developing neocortical networks: From single cells to large-scale interactions","volume":"10","author":"Luhmann","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"B97","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/s0896-6273(00)80381-5","article-title":"G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons","volume":"19","author":"Luscher","year":"1997","journal-title":"Neuron"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e114521","DOI":"10.1371\/journal.pone.0114521","article-title":"Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome","volume":"9","author":"Lysenko","year":"2014","journal-title":"PLoS One"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2018.03.005","article-title":"Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome","volume":"115","author":"Lysenko","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"B100","volume-title":"Spontaneous neuronal activity is reduced during the \u2018vulnerable\u2019 period of nascent neural circuit formation in the hippocampus of Ts65Dn mice, a genetic model of Down syndrome","author":"Madamba","year":"2021"},{"key":"B101","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/cne.901670105","article-title":"Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study","volume":"167","author":"Marin-Padilla","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/s41598-017-01820-2","article-title":"GIRK2 splice variants and neuronal G protein-gated K+ channels: Implications for channel function and behavior","volume":"7","author":"Marron Fernandez de Velasco","year":"2017","journal-title":"Sci. Rep."},{"key":"B103","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.neubiorev.2013.12.008","article-title":"Treating enhanced GABAergic inhibition in down syndrome: Use of GABA \u03b15-selective inverse agonists.","author":"Martinez-Cue","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B104","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1523\/JNEUROSCI.1203-12.2013","article-title":"Reducing GABAA \u03b15 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.","volume":"33","author":"Martinez-Cue","year":"2013","journal-title":"J. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ajhg.2014.12.011","article-title":"Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6","volume":"96","author":"Masotti","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"B106","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/bs.irn.2015.05.016","article-title":"Behavioral and genetic evidence for GIRK channels in the CNS: Role in physiology, pathophysiology, and drug addiction","volume":"123","author":"Mayfield","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0888-7543(89)90065-7","article-title":"Molecular genetic approach to the characterization of the \"Down syndrome region\" of chromosome 21","volume":"5","author":"McCormick","year":"1989","journal-title":"Genomics"},{"key":"B108","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuropharm.2013.12.015","article-title":"Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice","volume":"79","author":"Melamed","year":"2014","journal-title":"Neuropharmacology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.bcp.2012.06.028","article-title":"Cognitive enhancement by pharmacological and behavioral interventions: The murine down syndrome model","volume":"84","author":"Mohler","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1002\/hipo.22664","article-title":"GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App","volume":"26","author":"Mojabi","year":"2016","journal-title":"Hippocampus"},{"key":"B111","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/s0896-6273(01)00500-1","article-title":"Inactivity produces increases in neurotransmitter release and synapse size","volume":"32","author":"Murthy","year":"2001","journal-title":"Neuron"},{"key":"B112","doi-asserted-by":"publisher","first-page":"102771","DOI":"10.1016\/j.scr.2022.102771","article-title":"Generation of integration free hiPSCs clones, NSi001-A, NSi001-B, and NSi001-C from peripheral blood mononuclear cells of an individual with down syndrome having Robertsonian translocation","volume":"61","author":"Nehra","year":"2022","journal-title":"Stem Cell Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1254\/jphs.14189fp","article-title":"Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence","volume":"126","author":"Nishizawa","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.expneurol.2016.02.005","article-title":"Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome","volume":"279","author":"Olmos-Serrano","year":"2016","journal-title":"Exp. Neurol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1046\/j.1460-9568.2002.02111.x","article-title":"Degeneration of pontine mossy fibres during cerebellar development in weaver mutant mice","volume":"16","author":"Ozaki","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/ng1095-126","article-title":"A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation","volume":"11","author":"Patil","year":"1995","journal-title":"Nat. Genet."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1093\/hmg\/ddw116","article-title":"Systematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22.13 as critical to the phenotype","volume":"25","author":"Pelleri","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B118","doi-asserted-by":"publisher","first-page":"e797","DOI":"10.1002\/mgg3.797","article-title":"Partial trisomy 21 map: Ten cases further supporting the highly restricted Down syndrome critical region (HR-DSCR) on human chromosome 21","volume":"7","author":"Pelleri","year":"2019","journal-title":"Mol. Genet. Genomic Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1093\/hmg\/3.10.1735","article-title":"A transcript map of the Down syndrome critical region on chromosome 21","volume":"3","author":"Peterson","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"B120","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/ajmg.c.31530","article-title":"Chromosome therapy: Potential strategies for the correction of severe chromosome aberrations","volume":"172","author":"Plona","year":"2016","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"B121","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/01.fbp.0000236268.79923.18","article-title":"The effects of chronic administration of ethosuximide on learning and memory: A behavioral and biochemical study on nonepileptic rats","volume":"17","author":"Ponnusamy","year":"2006","journal-title":"Behav. Pharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1002\/cne.22573","article-title":"Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome","volume":"519","author":"Popov","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/B978-0-12-804766-8.00017-0","article-title":"Down syndrome","volume":"167","author":"Rafii","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"eaau1810","DOI":"10.1126\/science.aau1810","article-title":"In vivo modeling of human neuron dynamics and Down syndrome","volume":"362","author":"Real","year":"2018","journal-title":"Science"},{"key":"B125","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000494231","article-title":"Paving the way for therapy: The second international conference of the trisomy 21 research society","volume":"9","author":"Reeves","year":"2019","journal-title":"Mol. Syndromol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"B127","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.nbd.2017.06.017","article-title":"Neuroanatomical alterations and synaptic plasticity impairment in the perirhinal cortex of the Ts65Dn mouse model of Down syndrome","volume":"106","author":"Roncace","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"584071","DOI":"10.1155\/2012\/584071","article-title":"Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities","volume":"2012","author":"Rueda","year":"2012","journal-title":"Neural Plast."},{"key":"B129","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.conb.2012.05.002","article-title":"Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome","volume":"22","author":"Ruparelia","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1266\/ggs.20-00012","article-title":"Possible roles for the hominoid-specific DSCR4 gene in human cells","volume":"96","author":"Saber","year":"2021","journal-title":"Genes Genet. Syst."},{"key":"B131","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0006-8993(93)90921-9","article-title":"Inhibitory modulation of long-term potentiation via the 5-HT1A receptor in slices of the rat hippocampal dentate gyrus","volume":"613","author":"Sakai","year":"1993","journal-title":"Brain Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuron.2006.05.022","article-title":"Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration","volume":"51","author":"Salehi","year":"2006","journal-title":"Neuron"},{"key":"B133","doi-asserted-by":"publisher","first-page":"7ra17","DOI":"10.1126\/scitranslmed.3000258","article-title":"Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome","volume":"1","author":"Salehi","year":"2009","journal-title":"Sci. Transl. Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.neuroscience.2005.03.043","article-title":"The effect of GIRK2(wv) on neurite growth, protein expression, and viability in the CNS-derived neuronal cell line, CATH.A-differentiated","volume":"134","author":"Schein","year":"2005","journal-title":"Neuroscience"},{"key":"B135","first-page":"181","article-title":"Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months","volume":"9","author":"Schmidt-Sidor","year":"1990","journal-title":"Clin. Neuropathol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/0006-8993(95)00974-u","article-title":"Morphological abnormalities in the hippocampus of the weaver mutant mouse","volume":"696","author":"Sekiguchi","year":"1995","journal-title":"Brain Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"102890","DOI":"10.1016\/j.scr.2022.102890","article-title":"Generation of AAVS1-EGFP reporter cell lines from an isogenic pair of trisomy 21 and euploid human iPSCs","volume":"64","author":"Sharma","year":"2022","journal-title":"Stem Cell Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.nbd.2014.12.005","article-title":"Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice","volume":"74","author":"Stagni","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B139","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/B978-0-444-54299-1.00005-4","article-title":"Pathways to cognitive deficits in Down syndrome","volume":"197","author":"Sturgeon","year":"2012","journal-title":"Prog. Brain Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1365-2788.1983.tb00294.x","article-title":"The hippocampus in Down's syndrome","volume":"27","author":"Sylvester","year":"1983","journal-title":"J. Ment. Defic. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0387-7604(89)80082-8","article-title":"Dendrites, dementia and the Down syndrome","volume":"11","author":"Takashima","year":"1989","journal-title":"Brain Dev."},{"key":"B142","doi-asserted-by":"publisher","first-page":"135763","DOI":"10.1172\/JCI135763","article-title":"DSCAM\/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome","volume":"131","author":"Tang","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B143","doi-asserted-by":"publisher","first-page":"750","DOI":"10.2174\/1871527318666191114092924","article-title":"Pharmacotherapy of down's syndrome: When and which?","volume":"18","author":"Tayebati","year":"2019","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B144","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-3-7091-6721-2_9","article-title":"Chromosome 21 KIR channels in brain development","author":"Thiery","year":"2003","journal-title":"J. Neural Transm. Suppl."},{"key":"B145","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13064-018-0105-x","article-title":"Homeostatic plasticity in neural development","volume":"13","author":"Tien","year":"2018","journal-title":"Neural Dev."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1097\/AOG.0b013e31818c91dc","article-title":"Prevention of developmental delays in a Down syndrome mouse model","volume":"112","author":"Toso","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1101\/gr.153702","article-title":"Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region","volume":"12","author":"Toyoda","year":"2002","journal-title":"Genome Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrn1327","article-title":"Homeostatic plasticity in the developing nervous system","volume":"5","author":"Turrigiano","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"10372","DOI":"10.1523\/jneurosci.19-23-10372.1999","article-title":"The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite","volume":"19","author":"Tyzio","year":"1999","journal-title":"J. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000520925","article-title":"Early appearance of dendritic alterations in neocortical pyramidal neurons of the Ts65Dn model of down syndrome","volume":"44","author":"Uguagliati","year":"2022","journal-title":"Dev. Neurosci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40478-022-01385-w","article-title":"Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome","volume":"10","author":"Utagawa","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"B152","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neuroscience.2012.06.031","article-title":"Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome","volume":"220","author":"Vidal","year":"2012","journal-title":"Neuroscience"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e03671","DOI":"10.7554\/eLife.03671","article-title":"Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system","volume":"3","author":"Wang","year":"2014","journal-title":"Elife"},{"key":"B154","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nm.3117","article-title":"Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.tins.2016.08.004","article-title":"Homeostatic plasticity of subcellular neuronal structures: From inputs to outputs","volume":"39","author":"Wefelmeyer","year":"2016","journal-title":"Trends Neurosci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1006\/geno.1998.5369","article-title":"Characterization of murine Girk2 transcript isoforms: Structure and differential expression","volume":"51","author":"Wei","year":"1998","journal-title":"Genomics"},{"key":"B157","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/978-1-4939-2627-5_15","article-title":"Gene expression studies on human trisomy 21 iPSCs and neurons: Towards mechanisms underlying down's syndrome and early alzheimer's disease-like pathologies","volume":"1303","author":"Weick","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cell.2011.07.046","article-title":"Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium","volume":"147","author":"Whorton","year":"2011","journal-title":"Cell"},{"key":"B159","doi-asserted-by":"publisher","first-page":"166388","DOI":"10.1016\/j.bbadis.2022.166388","article-title":"Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids","volume":"1868","author":"Xu","year":"2022","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"B160","first-page":"723","article-title":"G protein regulation of potassium ion channels","volume":"50","author":"Yamada","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"B161","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainres.2010.09.107","article-title":"Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice","volume":"1366","author":"Yu","year":"2010","journal-title":"Brain Res."},{"key":"B162","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4161\/bbug.3.1.17696","article-title":"Genetic analysis of Down syndrome facilitated by mouse chromosome engineering","volume":"3","author":"Zhang","year":"2012","journal-title":"Bioeng. Bugs"},{"key":"B163","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1093\/hmg\/ddt446","article-title":"Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits","volume":"23","author":"Zhang","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B164","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/ajmg.b.32734","article-title":"KCNJ6 variants modulate reward-related brain processes and impact executive functions in attention-deficit\/hyperactivity disorder","volume":"183","author":"Ziegler","year":"2020","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.1006068\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:14:45Z","timestamp":1662966885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.1006068\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":164,"alternative-id":["10.3389\/fgene.2022.1006068"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2022.1006068","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"article-number":"1006068"}}