{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:02:17Z","timestamp":1778864537838,"version":"3.51.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The prevalence of mitral valve prolapse (MVP) in heart valvular diseases is globally increasing. However, the understanding of its etiology and pathogenesis is limited. So far, the relationship between ferroptosis-related genes and long non-coding RNAs (lncRNAs) in MVP remains unexplored. This study investigates the potential pathogenesis of ferroptosis-related genes in MVP and provides a therapeutic target for the disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Blood samples from patients with MVP and healthy volunteers were collected for transcriptomic sequencing to analyze the expression of ferroptosis-related differentially expressed genes (DEGs) and differentially expressed long non-coding RNAs (DElncRNAs Co-expression network of ferroptosis-related DEGs and DElncRNAs. Furthermore, this work conducted GO and KEGG enrichment analyses.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold><jats:italic>CDKN2A<\/jats:italic>, <jats:italic>SLC1A4<\/jats:italic>, <jats:italic>ATF3,<\/jats:italic> and other core genes related to the mitral valve prolapse were screened out. <jats:italic>CDKN2A<\/jats:italic>, <jats:italic>SLC1A4,<\/jats:italic> and <jats:italic>ATF3<\/jats:italic> genes were at the core position of the network, regulated by numerous lncRNAs. Notably, these genes are primarily involved in the extracellular region and p53 signaling pathway.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In summary, <jats:italic>CDKN2A<\/jats:italic>, <jats:italic>SLC1A4<\/jats:italic>, and <jats:italic>ATF3<\/jats:italic> regulate the pathophysiological process of MVP and are potential therapeutic targets.<\/jats:p>","DOI":"10.3389\/fgene.2022.1062212","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:23:14Z","timestamp":1669710194000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional analysis of differently expressed ferroptosis-related genes in patients with mitral valve prolapse"],"prefix":"10.3389","volume":"13","author":[{"given":"Hui","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liushun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quangong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: Cellular address codes in development and disease","volume":"152","author":"Batista","year":"2013","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"659","DOI":"10.5551\/jat.21774","article-title":"The severity of internal carotid artery stenosis is associated with the cyclin-dependent kinase inhibitor 2A gene expression","volume":"21","author":"Bayoglu","year":"2014","journal-title":"J. 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