{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:24:34Z","timestamp":1776756274846,"version":"3.51.2"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>We studied associations of persistent respiratory morbidity (PRM) at 6 and 12\u00a0months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes. Of the 250 enrolled subjects, 155 and 127 were followed at 6 and 12\u00a0months after an ARF episode, respectively. Logistic regression analysis and SNP\u2013SNP interaction models were used. We found that 1) in the multivariate analysis, an increased risk at 6 and 12\u00a0months was associated with rs1124_A and rs4715_A of <jats:italic>SFTPC<\/jats:italic>, respectively; 2) in a single SNP model, increased and decreased risks of PRM at both timepoints were associated with rs1124 of <jats:italic>SFTPC<\/jats:italic> and rs721917 of <jats:italic>SFTPD<\/jats:italic>, respectively; an increased risk at 6\u00a0months was associated with rs1130866 of <jats:italic>SFTPB<\/jats:italic> and rs4715 of <jats:italic>SFTPC<\/jats:italic>, and increased and decreased risks at 12\u00a0months were associated with rs17886395 of <jats:italic>SFTPA2<\/jats:italic> and rs2243639 of <jats:italic>SFTPD<\/jats:italic>, respectively; 3) in a two-SNP model, PRM susceptibility at both timepoints was associated with a number of intergenic interactions between SNPs of the studied SP genes. An increased risk at 12\u00a0months was associated with one intragenic (rs1965708 and rs113645 of <jats:italic>SFTPA2<\/jats:italic>) interaction; 4) in a three-SNP model, decreased and increased risks at 6 and 12\u00a0months, respectively, were associated with an interaction among rs1130866 of <jats:italic>SFTPB<\/jats:italic>, rs721917 of <jats:italic>SFTPD<\/jats:italic>, and rs1059046 of <jats:italic>SFTPA2<\/jats:italic>. A decreased risk at 6\u00a0months was associated with an interaction among the same SNPs of <jats:italic>SFTPB<\/jats:italic> and <jats:italic>SFTPD<\/jats:italic> and the rs1136450 of <jats:italic>SFTPA1<\/jats:italic>. The findings revealed that SNPs of all <jats:italic>SFTP<\/jats:italic>s appear to play a role in long-term outcomes of ARF survivors and may serve as markers for disease susceptibility.<\/jats:p>","DOI":"10.3389\/fgene.2022.815727","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T03:57:22Z","timestamp":1648526242000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["SNP\u2013SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children"],"prefix":"10.3389","volume":"13","author":[{"given":"Chintan K.","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Meixia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Spear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenqi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett","family":"Keim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"Yehya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Floros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"682160","DOI":"10.3389\/fped.2021.682160","article-title":"Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants","volume":"9","author":"Amatya","year":"2021","journal-title":"Front. 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