{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:36:03Z","timestamp":1790444163537,"version":"4.1.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Spinocerebellar ataxia 36 (SCA36) is a type of repeat expansion-related neurodegenerative disorder identified a decade ago. Like other SCAs, the symptoms of SCA36 include the loss of coordination like gait ataxia and eye movement problems, but motor neuron-related symptoms like muscular atrophy are also present in those patients. The disease is caused by a GGCCTG hexanucleotide repeat expansion in the gene <jats:italic>Nop56<\/jats:italic>, and the demographic incidence map showed that this disease was more common among the ethnic groups of Japanese and Spanish descendants. Although the exact mechanisms are still under investigation, the present evidence supports that the expanded repeats may undergo repeat expansion-related non-AUG-initiated translation, and these dipeptide repeat products could be one of the important ways to lead to pathogenesis. Such studies may help develop potential treatments for this disease.<\/jats:p>","DOI":"10.3389\/fgene.2022.837690","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T07:31:58Z","timestamp":1646379118000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Spinocerebellar Ataxia 36: From Mutations Toward Therapies"],"prefix":"10.3389","volume":"13","author":[{"given":"Samuel","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"B1","article-title":"Spinocerebellar Ataxia Type 36 (Nicknamed Asidan)","author":"Abe","year":"2012","journal-title":"Brain and Nerve 64"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1111\/j.1468-1331.2012.03669.x","article-title":"Cognitive and Affective Impairments of a Novel SCA\/MND Crossroad Mutation Asidan","volume":"19","author":"Abe","year":"2012","journal-title":"Eur. 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