{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:35:41Z","timestamp":1792193741316,"version":"4.4.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770709"],"award-info":[{"award-number":["81770709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010801"],"award-info":[{"award-number":["2021A1515010801"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Fibronectin glomerulopathy (FNG) is a rare inherited kidney disease characterized by extensive deposition of fibronectin in the glomeruli, especially in the mesangial and subendothelial regions. The disease progresses slowly and eventually leads to kidney failure in 15\u201320\u00a0years. Here, we report an interesting case. The patient presented with proteinuria and was diagnosed with immune complex\u2013mediated glomerulonephritis, and lupus nephritis was suspected. This patient progressed to end-stage renal disease after 18\u00a0years and received an allogeneic kidney transplant. However, proteinuria recurred 27\u00a0months after kidney transplantation. The renal biopsy found extensive deposition in glomeruli, and the patient was diagnosed with FNG using mass spectrometry analysis and confirmed by immunohistochemistry in both the native and transplanted kidneys. Gene sequencing revealed that a missense mutation in the fibronectin 1 (FN1) gene caused reduced binding to heparin, endothelial cells, and podocytes and impaired stress fiber formation. The patient had stable renal function but persistent nephrotic proteinuria after 6\u00a0months of follow-up. Given the persistence of abnormal circulating fibronectin levels, FNG can relapse following renal transplantation. The circulating fibronectin deposits on grafts, and renal function progressively deteriorates after recurrence. Therefore, whether renal transplantation is an acceptable treatment for FNG is still debatable.<\/jats:p>","DOI":"10.3389\/fgene.2022.839703","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T07:32:46Z","timestamp":1655191966000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case Report: Recurrent Deposition in Renal Allografts: A Rare Case of Fibronectin Glomerulopathy Overlooked in Native Kidneys"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaona","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongqiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"B1","first-page":"501","article-title":"Newer Glomerular Diseases","volume":"16","author":"Abt","year":"1996","journal-title":"Semin. Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7812","DOI":"10.1016\/s0021-9258(20)89522-2","article-title":"Localization of the Major Heparin-Binding Site in Fibronectin","volume":"266","author":"Barkalow","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1073\/pnas.0707730105","article-title":"Mutations in FN1 Cause Glomerulopathy with Fibronectin Deposits","volume":"105","author":"Castelletti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3760\/cma.j.cn441217-20200412-00035","article-title":"A Case of Fibronectin Glomerulopathy after Treatment with Angiotension \u2161 Receptor Blockers","volume":"37","author":"Fan","year":"2021","journal-title":"Chin. J. Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1093\/ndt\/12.12.2717","article-title":"An Isolated Case with Predominant Glomerular Fibronectin Deposition Associated with Fibril Formation","volume":"12","author":"Fujigaki","year":"1997","journal-title":"Nephrol. Dial. Transplant."},{"key":"B6","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/s0272-6386(96)90247-4","article-title":"Familial Glomerulopathy with Giant Fibrillar (Fibronectin Positive) Deposits: 15-year Follow-Up in a Large Kindred","volume":"28","author":"Gemperle","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s13730-021-00595-w","article-title":"Prednisone-induced Sustained Remission in a Patient with Familial Fibronectin Glomerulopathy (GFND)","volume":"10","author":"Goldman","year":"2021","journal-title":"Cen. Case Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1053\/j.ajkd.2017.09.001","article-title":"AJKD Atlas of Renal Pathology: Fibronectin Glomerulopathy","volume":"70","author":"Lusco","year":"2017","journal-title":"Am. J. Kidney Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1007\/s00467-016-3368-7","article-title":"Identification of Mutations in FN1 Leading to Glomerulopathy with Fibronectin Deposits","volume":"31","author":"Ohtsubo","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1399-0012.2012.01644.x","article-title":"A Recurrent Fibronectin Glomerulopathy in a Renal Transplant Patient: a Case Report","volume":"26","author":"Otsuka","year":"2012","journal-title":"Clin. 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Engl."},{"key":"B14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3389\/fmed.2020.00439","article-title":"Clinicopathologic Features and Outcomes in Fibronectin Glomerulopathy: A Case Series of 19 Patients","volume":"7","author":"Zhang","year":"2020","journal-title":"Front. 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