{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:27:08Z","timestamp":1792794428951,"version":"4.5.0"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006049","name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in <jats:italic>Bos taurus<\/jats:italic>. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation.<\/jats:p>","DOI":"10.3389\/fgene.2022.864567","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T04:48:34Z","timestamp":1651639714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle"],"prefix":"10.3389","volume":"13","author":[{"given":"Eugenio","family":"Jara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pe\u00f1agaricano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Tardiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gast\u00f3n","family":"Rodons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Iriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000468538","article-title":"Skin Pigmentation Genetics for the Clinic","volume":"233","author":"Ainger","year":"2017","journal-title":"Dermatology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"997PMC7565090","DOI":"10.3390\/genes110909975","article-title":"Exploring the Regulatory Potential of Long Non-coding RNA in Feed Efficiency of Indicine Cattle","volume":"11","author":"Alexandre","year":"2020","journal-title":"GenesGenes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/s0022-2836(05)80360-2","article-title":"Basic Local Alignment Search Tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/jhered\/82.1.21","article-title":"Genetic Study of Eye Cancer in Cattle","volume":"82","author":"Anderson","year":"1991","journal-title":"J. Hered."},{"key":"B5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/bib\/bby032","article-title":"Prediction of lncRNAs and Their Interactions with Nucleic Acids: Benchmarking Bioinformatics Tools","volume":"20","author":"Antonov","year":"2019","journal-title":"Brief. Bioinform"},{"key":"B6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1139\/gen-2015-0141","article-title":"In Silico prediction of Long Intergenic Non-coding RNAs in Sheep","volume":"59","author":"Bakhtiarizadeh","year":"2016","journal-title":"Genome"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1093\/hmg\/ddm177","article-title":"Receptor Function, Dominant Negative Activity and Phenotype Correlations for MC1R Variant Alleles","volume":"16","author":"Beaumont","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: a Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-15-499","article-title":"Identification of Large Intergenic Non-coding RNAs in Bovine Muscle Using Next-Generation Transcriptomic Sequencing","volume":"15","author":"Billerey","year":"2014","journal-title":"BMC Genomics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.jacc.2015.12.051","article-title":"Long Noncoding RNAs","volume":"67","author":"Boon","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1242\/jcs.164400","article-title":"Regulation of Melanosome Number, Shape and Movement in the Zebrafish Retinal Pigment Epithelium by OA1 and PMEL","volume":"128","author":"Burgoyne","year":"2015","journal-title":"J. Cell Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative Annotation of Human Large Intergenic Noncoding RNAs Reveals Global Properties and Specific Subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e30433","DOI":"10.7554\/eLife.30433","article-title":"LAST, a C-Myc-Inducible Long Noncoding RNA, Cooperates with CNBP to Promote CCND1 mRNA Stability in Human Cells","volume":"6","author":"Cao","year":"2017","journal-title":"Elife"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1126\/science.1112014","article-title":"FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome","volume":"309","author":"Carninci","year":"2005","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrg1673","article-title":"Replication and Transcription: Shaping the Landscape of the Genome","volume":"6","author":"Chakalova","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1755-148X.2009.00653.x","article-title":"Fifteen-year Quest for Microphthalmia-Associated Transcription Factor Target Genes","volume":"23","author":"Cheli","year":"2010","journal-title":"Pigment Cell & melanoma Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jaad.2005.06.052","article-title":"Long-term Treatment of Photoaged Human Skin with Topical Retinoic Acid Improves Epidermal Cell Atypia and Thickens the Collagen Band in Papillary Dermis","volume":"53","author":"Cho","year":"2005","journal-title":"J. Am. Acad. Dermatology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin Melanocytes: Biology and Development","volume":"1","author":"Cichorek","year":"2013","journal-title":"pdia"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1073\/pnas.0506940103","article-title":"Retrotransposon Insertion in SILV Is Responsible for Merle Patterning of the Domestic Dog","volume":"103","author":"Clark","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1083\/jcb.132.3.259","article-title":"XIST RNA Paints the Inactive X Chromosome at Interphase: Evidence for a Novel RNA Involved in Nuclear\/chromosome Structure","volume":"132","author":"Clemson","year":"1996","journal-title":"J. Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1038\/s41388-019-0893-4","article-title":"FABP7 Is a Key Metabolic Regulator in HER2+ Breast Cancer Brain Metastasis","volume":"38","author":"Cordero","year":"2019","journal-title":"Oncogene"},{"key":"B22","doi-asserted-by":"publisher","first-page":"a031260","DOI":"10.1101\/cshperspect.a031260","article-title":"Biology of Fibroblast Growth Factor 23: from Physiology to Pathology","volume":"8","author":"Courbebaisse","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1034\/j.1600-0854.2002.30909.x","article-title":"The Melanocytic Protein Melan-A\/mart-1 Has a Subcellular Localization Distinct from Typical Melanosomal Proteins","volume":"3","author":"De Mazi\u00e8re","year":"2002","journal-title":"Traffic"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/toxsci\/kfw203","article-title":"Long Non-coding RNAs: a Novel Paradigm for Toxicology","volume":"155","author":"Dempsey","year":"2017","journal-title":"Toxicol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE V7 Catalog of Human Long Noncoding RNAs: Analysis of Their Gene Structure, Evolution, and Expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/ijms17071144","article-title":"Signaling Pathways in Melanogenesis","volume":"17","author":"D\u2019Mello","year":"2016","journal-title":"Ijms"},{"key":"B27","first-page":"31","article-title":"Detection of Polymorphisms in the PMEL17 Gene in Beef Cattle of Argentina","volume":"33","author":"Enriqu\u00e9 Steinberg","year":"2013","journal-title":"Rev. Argent. Prod. Anim."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-19950-6","article-title":"Transcriptional Profiling of Long Non-coding RNAs in Mantle of Crassostrea gigas and Their Association with Shell Pigmentation","volume":"8","author":"Feng","year":"2018","journal-title":"Sci. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3892\/mmr.2019.10813","article-title":"A Novel GPR143 Mutation in a Chinese Family with X-linked O-cular A-lbinism T-ype 1","volume":"21","author":"Gao","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1476-4598-10-38","article-title":"The Functional Role of Long Non-coding RNA in Human Carcinomas","volume":"10","author":"Gibb","year":"2011","journal-title":"Mol. Cancer"},{"key":"B31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41576-019-0184-5","article-title":"Regulation of Gene Expression by Cis-Acting Long Non-coding RNAs","volume":"21","author":"Gil","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"20160569","DOI":"10.1098\/rspb.2016.0569","article-title":"Genetics of Complex Traits: Prediction of Phenotype, Identification of Causal Polymorphisms and Genetic Architecture","volume":"283","author":"Goddard","year":"2016","journal-title":"Proc. R. Soc. B"},{"key":"B33","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/sj.jid.5700164","article-title":"Kit and Melanocyte Migration","volume":"126","author":"Grichnik","year":"2006","journal-title":"J. Investigative Dermatology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-38141-x","article-title":"Analysis of Long Non-coding RNA and mRNA Expression in Bovine Macrophages Brings up Novel Aspects of Mycobacterium avium Subspecies Paratuberculosis Infections","volume":"9","author":"Gupta","year":"2019","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long Non-coding RNA HOTAIR Reprograms Chromatin State to Promote Cancer Metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/8496165","article-title":"Long Noncoding RNA Identification: Comparing Machine Learning Based Tools for Long Noncoding Transcripts Discrimination","volume":"2016","author":"Han","year":"2016","journal-title":"BioMed Res. Int."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the Reference Human Genome Annotation for the ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"B38","first-page":"21","article-title":"Bovine Ocular Squamous Cell Carcinoma: an Epidemiological Perspective","volume":"49","author":"Heeney","year":"1985","journal-title":"Can. J. Comp. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"14006","DOI":"10.1074\/jbc.M413692200","article-title":"MART-1 Is Required for the Function of the Melanosomal Matrix Protein PMEL17\/GP100 and the Maturation of Melanosomes","volume":"280","author":"Hoashi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1365-2052.2012.02325.x","article-title":"Genome-wide Identification and Initial Characterization of Bovine Long Non-coding RNAs from EST Data","volume":"43","author":"Huang","year":"2012","journal-title":"Anim. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.mce.2014.10.007","article-title":"Regulation of FGF23 Expression in IDG-SW3 Osteocytes and Human Bone by Pro-inflammatory Stimuli","volume":"399","author":"Ito","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"skac110","DOI":"10.1093\/jas\/skac110","article-title":"Revealing the Genetic Basis of Eyelid Pigmentation in Hereford Cattle","author":"Jara","year":"2022","journal-title":"J. Anim. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/age.13004","article-title":"Transcriptomic Analysis of Eyelid Pigmentation in Hereford Cattle","volume":"51","author":"Jara","year":"2020","journal-title":"Anim. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fncel.2015.00063","article-title":"Transcriptome Analyses of Adult Mouse Brain Reveal Enrichment of lncRNAs in Specific Brain Regions and Neuronal Populations","volume":"9","author":"Kadakkuzha","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"W12","DOI":"10.1093\/nar\/gkx428","article-title":"CPC2: a Fast and Accurate Coding Potential Calculator Based on Sequence Intrinsic Features","volume":"45","author":"Kang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1534\/genetics.104.027995","article-title":"The Dominant White, Dun and Smoky Color Variants in Chicken Are Associated with Insertion\/Deletion Polymorphisms in the PMEL17 GeneSequence Data from This Article Have Been Deposited with the EMBL\/GenBank Data Libraries under Accession Nos. AY636124, AY636125, AY636126, AY636127, AY636128, AY636129","volume":"168","author":"Kerje","year":"2004","journal-title":"Genetics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-018-5037-7","article-title":"Genome-wide Identification of Tissue-specific Long Non-coding RNA in Three Farm Animal Species","volume":"19","author":"Kern","year":"2018","journal-title":"BMC Genomics"},{"key":"B48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a Fast Spliced Aligner with Low Memory Requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1741-7007-11-59","article-title":"Gene Regulation by the Act of Long Non-coding RNA Transcription","volume":"11","author":"Kornienko","year":"2013","journal-title":"BMC Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1017\/S1751731120000841","article-title":"Review: Long Non-coding RNA in Livestock","volume":"14","author":"Kosinska-Selbi","year":"2020","journal-title":"animal"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0141225","DOI":"10.1371\/journal.pone.0141225","article-title":"A Catalogue of Novel Bovine Long Noncoding RNA across 18 Tissues","volume":"10","author":"Koufariotis","year":"2015","journal-title":"PloS one"},{"key":"B52","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/j.1755-148X.2008.00514.x","article-title":"Pigmentation PAX-Ways: the Role of Pax3 in Melanogenesis, Melanocyte Stem Cell Maintenance, and Disease","volume":"21","author":"Kubic","year":"2008","journal-title":"Pigment Cell & melanoma Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/nar\/23.1.154","article-title":"Mousesilver.mutation Is Caused by a Single Base Insertion in the Putative Cytoplasmic Domain of Pmel 17","volume":"23","author":"Kwon","year":"1995","journal-title":"Nucl. Acids Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1126\/science.1147417","article-title":"A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals","volume":"318","author":"Lalueza-Fox","year":"2007","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1755-148X.2008.00479.x","article-title":"Regulation of Eumelaninpheomelanin Synthesis and Visible Pigmentation in Melanocytes by Ligands of the Melanocortin 1 Receptor","volume":"21","author":"Le Pape","year":"2008","journal-title":"Pigment Cell & melanoma Res."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.12.198903","article-title":"FADS2-mediated Fatty Acid Desaturation and Cholesterol Esterification Are Signatures of Metabolic Reprogramming during Melanoma Progression","author":"Lee","year":"2020","journal-title":"bioRxiv"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-15-311","article-title":"PLEK: a Tool for Predicting Long Non-coding RNAs and Messenger RNAs Based on an Improved K-Mer Scheme","volume":"15","author":"Li","year":"2014","journal-title":"BMC Bioinforma."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e0124003","DOI":"10.1371\/journal.pone.0124003","article-title":"ALDB: a Domestic-Animal Long Noncoding RNA Database","volume":"10","author":"Li","year":"","journal-title":"PloS one"},{"key":"B59","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/bib\/bbu048","article-title":"LncTar: a Tool for Predicting the RNA Targets of Long Noncoding RNAs","volume":"16","author":"Li","year":"","journal-title":"Brief. Bioinform"},{"key":"B60","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5772\/intechopen.81773","article-title":"The Role of Long Noncoding RNAs in Gene Expression Regulation","volume":"1","author":"Li","year":"2019","journal-title":"Gene Expr. Profiling Cancer"},{"key":"B61","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nature05660","article-title":"Melanocyte Biology and Skin Pigmentation","volume":"445","author":"Lin","year":"2007","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0183163","DOI":"10.1371\/journal.pone.0183163","article-title":"Identification and Analysis of Differentially Expressed Long Non-coding RNAs between Multiparous and Uniparous Goat (Capra hircus) Ovaries","volume":"12","author":"Ling","year":"2017","journal-title":"PloS one"},{"key":"B63","doi-asserted-by":"publisher","first-page":"eaao2110","DOI":"10.1126\/sciadv.aao2110","article-title":"How Do lncRNAs Regulate Transcription?","volume":"3","author":"Long","year":"2017","journal-title":"Sci. Adv."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA Package 2.0","volume":"6","author":"Lorenz","year":"2011","journal-title":"Algorithms Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13059-014-0550-8","article-title":"Differential Analysis of Count Data\u2013The DESeq2 Package","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"924","DOI":"10.4161\/rna.24604","article-title":"On the Classification of Long Non-coding RNAs","volume":"10","author":"Ma","year":"2013","journal-title":"RNA Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/jnr.24246","article-title":"Pigmentation and Vision: Is GPR143 in Control?","volume":"97","author":"McKay","year":"2019","journal-title":"J. Neuro Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1242\/dev.106567","article-title":"The Melanocyte Lineage in Development and Disease","volume":"142","author":"Mort","year":"2015","journal-title":"Development"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.72.1.1","article-title":"Systemic Immunoregulatory and Pathogenic Functions of Homeostatic Chemokine Receptors","volume":"72","author":"M\u00fcller","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"B70","first-page":"8506","article-title":"Cutaneous Expression of TREM, Vitamin D Receptor and HMGB1 in Vitamin D Deficiency","volume":"9","author":"Nguyen","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/cts.12308","article-title":"Triggering Receptor Expressed on Myeloid Cells in Cutaneous Melanoma","volume":"8","author":"Nguyen","year":"2015","journal-title":"Clin. Transl. Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1261\/rna.029520.111","article-title":"Computational Analysis of Functional Long Noncoding RNAs Reveals Lack of Peptide-Coding Capacity and Parallels with 3\u2032 UTRs","volume":"18","author":"Niazi","year":"2012","journal-title":"RNA"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tig.2005.10.003","article-title":"Rapid Evolution of Noncoding RNAs: Lack of Conservation Does Not Mean Lack of Function","volume":"22","author":"Pang","year":"2006","journal-title":"Trends Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e36346","DOI":"10.1371\/journal.pone.0036346","article-title":"Identification of QTL for UV-Protective Eye Area Pigmentation in Cattle by Progeny Phenotyping and Genome-wide Association Analysis","volume":"7","author":"Pausch","year":"2012","journal-title":"PloS one"},{"key":"B75","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fendo.2015.00025","article-title":"IGF-binding Protein 2 \u00c2\u20ac\" Oncogene or Tumor Suppressor?","volume":"6","author":"Pickard","year":"2015","journal-title":"Front. Endocrinol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.brainres.2010.03.110","article-title":"Long Non-coding RNAs in Nervous System Function and Disease","volume":"1338","author":"Qureshi","year":"2010","journal-title":"Brain Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-016-2365-3","article-title":"Genome-wide Analysis of Long Non-coding RNAs at Early Stage of Skin Pigmentation in Goats (Capra hircus)","volume":"17","author":"Ren","year":"2016","journal-title":"BMC Genomics"},{"key":"B78","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1365-2052.2012.02361.x","article-title":"Interaction ofMC1RandPMELalleles on Solid Coat Colors in Highland Cattle","volume":"44","author":"Schmutz","year":"2013","journal-title":"Anim. Genet."},{"key":"B79","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.imbio.2008.07.008","article-title":"From Expression to Signaling: Roles of TREM-1 and TREM-2 in Innate Immunity and Bacterial Infection","volume":"213","author":"Sharif","year":"2008","journal-title":"Immunobiology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"498276","DOI":"10.1155\/2014\/498276","article-title":"Melanins: Skin Pigments and Much More\u2014Types, Structural Models, Biological Functions, and Formation Routes","volume":"2014","author":"Solano","year":"2014","journal-title":"New J. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1741-7015-12-97","article-title":"Dark Matter RNA Illuminates the Puzzle of Genome-wide Association Studies","volume":"12","author":"St. Laurent","year":"2014","journal-title":"BMC Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e12698","DOI":"10.1111\/cpr.12698","article-title":"Long Non\u2010coding RNAs in Cutaneous Biology and Proliferative Skin Diseases: Advances and Perspectives","volume":"53","author":"Tang","year":"2020","journal-title":"Cell Prolif."},{"key":"B83","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","article-title":"Retinoids, Retinoic Acid Receptors, and Cancer","volume":"6","author":"Tang","year":"2011","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript Assembly and Quantification by RNA-Seq Reveals Unannotated Transcripts and Isoform Switching during Cell Differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"a015404","DOI":"10.1101\/cshperspect.a015404","article-title":"Long Noncoding RNA: Significance and Potential in Skin Biology","volume":"4","author":"Wan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-020-00573-4","article-title":"Systematic Identification of Long Intergenic Non-coding RNAs Expressed in Bovine Oocytes","volume":"18","author":"Wang","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1093\/nar\/gkt006","article-title":"CPAT: Coding-Potential Assessment Tool Using an Alignment-free Logistic Regression Model","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/pcmr.12067","article-title":"PMEL: a Pigment Cell-specific Model for Functional Amyloid Formation","volume":"26","author":"Watt","year":"2013","journal-title":"Pigment. Cell Melanoma Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1186\/1471-2164-14-789","article-title":"Identification of Novel Transcripts and Noncoding RNAs in Bovine Skin by Deep Next Generation Sequencing","volume":"14","author":"Weikard","year":"2013","journal-title":"BMC Genomics"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1038\/jid.2013.235","article-title":"Wnt\/\u03b2-Catenin and Kit Signaling Sequentially Regulate Melanocyte Stem Cell Differentiation in UVB-Induced Epidermal Pigmentation","volume":"133","author":"Yamada","year":"2013","journal-title":"J. Investigative Dermatology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-019-5625-1","article-title":"Integrated Analysis of lncRNA and mRNA Repertoires in Marek's Disease Infected Spleens Identifies Genes Relevant to Resistance","volume":"20","author":"You","year":"2019","journal-title":"BMC Genomics"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e0156890","DOI":"10.1371\/journal.pone.0156890","article-title":"Integrated Analysis of the Roles of Long Noncoding RNA and Coding RNA Expression in Sheep (Ovis aries) Skin during Initiation of Secondary Hair Follicle","volume":"11","author":"Yue","year":"2016","journal-title":"PLoS One"},{"key":"B93","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s00018-005-5467-7","article-title":"Evidence that miRNAs Are Different from Other RNAs","volume":"63","author":"Zhang","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jid.2016.01.018","article-title":"The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes","volume":"136","author":"Zhao","year":"","journal-title":"J. Investigative Dermatology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"D203","DOI":"10.1093\/nar\/gkv1252","article-title":"NONCODE 2016: an Informative and Valuable Data Source of Long Non-coding RNAs","volume":"44","author":"Zhao","year":"","journal-title":"Nucleic Acids Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fgene.2018.00102","article-title":"Identification and Functional Analysis of Long Intergenic Non-coding RNAs Underlying Intramuscular Fat Content in Pigs","volume":"9","author":"Zou","year":"2018","journal-title":"Front. Genet."},{"key":"B97","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/nar\/9.1.133","article-title":"Optimal Computer Folding of Large RNA Sequences Using Thermodynamics and Auxiliary Information","volume":"9","author":"Zuker","year":"1981","journal-title":"Nucl. Acids Res."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.864567\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T04:48:50Z","timestamp":1651639730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.864567\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":97,"alternative-id":["10.3389\/fgene.2022.864567"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2022.864567","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,4]]},"article-number":"864567"}}