{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:58:27Z","timestamp":1790189907144,"version":"4.1.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["1U54HG009790-01"],"award-info":[{"award-number":["1U54HG009790-01"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>The use of whole exome sequencing (WES) in medical research is increasing in South Africa (SA), raising important questions about whether and which individual genetic research results, particularly incidental findings, should be returned to patients. Whilst some commentaries and opinions related to the topic have been published in SA, there is no qualitative data on the views of professional stakeholders on this topic. Seventeen participants including clinicians, genomics researchers, and genetic counsellors (GCs) were recruited from the Western Cape in SA. Semi-structured interviews were conducted, and the transcripts analysed using the framework approach for data analysis. Current roadblocks for the clinical adoption of WES in SA include a lack of standardised guidelines; complexities relating to variant interpretation due to lack of functional studies and underrepresentation of people of African ancestry in the reference genome, population and variant databases; lack of resources and skilled personnel for variant confirmation and follow-up. Suggestions to overcome these barriers include obtaining funding and buy-in from the private and public sectors and medical insurance companies; the generation of a locally relevant reference genome; training of health professionals in the field of genomics and bioinformatics; and multidisciplinary collaboration. Participants emphasised the importance of upscaling the accessibility to and training of GCs, as well as upskilling of clinicians and genetic nurses for return of genetic data in collaboration with GCs and medical geneticists. Future research could focus on exploring the development of stakeholder partnerships for increased access to trained specialists as well as community engagement and education, alongside the development of guidelines for result disclosure.<\/jats:p>","DOI":"10.3389\/fgene.2022.864822","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T17:02:13Z","timestamp":1654707733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Whole Exome Sequencing in South Africa: Stakeholder Views on Return of Individual Research Results and Incidental Findings"],"prefix":"10.3389","volume":"13","author":[{"given":"Nicole","family":"Van Der Merwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Ramesar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jantina","family":"De Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"B1","volume-title":"A Framework for the Implementation of Genomic Medicine for Public Health in Africa","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1101\/gr.183483.114","article-title":"Actionable Exomic Incidental Findings in 6503 Participants: Challenges of Variant Classification","volume":"25","author":"Amendola","year":"2015","journal-title":"Genome Res."},{"key":"B3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/s41436-021-01171-4","article-title":"Recommendations for Reporting of Secondary Findings in Clinical Exome and Genome Sequencing, 2021 Update: a Policy Statement of the American College of Medical Genetics and Genomics (ACMG)","volume":"23","year":"2021","journal-title":"Genet. 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