{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:59:18Z","timestamp":1753891158090,"version":"3.41.2"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>The gene <jats:italic>SYF2<\/jats:italic>\u2014an RNA splicing factor\u2014can interact with Cyclin D-type binding protein 1 (GICP) in many biological processes, including splicing regulation, cell cycle regulation, and DNA damage repair. In our previous study we performed genome-wide identification and functional analysis of <jats:italic>SYF2<\/jats:italic> in plant species. The phylogenetic relationships and expression profiles of <jats:italic>SYF2<\/jats:italic> have not been systematically studied in animals, however. To this end, the gene structure, genes, and protein conserved motifs of 102 <jats:italic>SYF2<\/jats:italic> homologous genes from 91 different animal species were systematically analyzed, along with conserved splicing sites in 45 representative vertebrate species. A differential comparative analysis of expression patterns in humans and mice was made. Molecular bioinformatics analysis of <jats:italic>SYF2<\/jats:italic> showed the gene was conserved and functional in different animal species. In addition, expression pattern analysis found that <jats:italic>SYF2<\/jats:italic> was highly expressed in hematopoietic stem cells, T cells, and lymphoid progenitor cells; in ovary, lung, and spleen; and in other cells and organs. This suggests that changes in <jats:italic>SYF2<\/jats:italic> expression may be associated with disease development in these cells, tissues, or organs. In conclusion, our study analyzes the <jats:italic>SYF2<\/jats:italic> disease resistance genes of different animal species through bioinformatics, reveals the relationship between the <jats:italic>SYF2<\/jats:italic> genotype and the occurrence of certain diseases, and provides a theoretical basis for follow-up study of the relationship between the <jats:italic>SYF2<\/jats:italic> gene and animal diseases.<\/jats:p>","DOI":"10.3389\/fgene.2022.873869","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T14:22:41Z","timestamp":1662128561000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-wide comparison and in silico analysis of splicing factor SYF2\/NTC31\/p29 in eukaryotes: Special focus on vertebrates"],"prefix":"10.3389","volume":"13","author":[{"given":"Bao-Xing","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Chang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo-Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1093\/genetics\/156.4.1503","article-title":"Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae","volume":"156","author":"Ben-Yehuda","year":"2000","journal-title":"Genetics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1073\/pnas.74.8.3171","article-title":"Spliced segments at the 5' terminus of adenovirus 2 late mRNA","volume":"74","author":"Berget","year":"1977","journal-title":"Proc. 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