{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:16:46Z","timestamp":1782868606774,"version":"3.54.5"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Osteoclasts, which are multinucleated cells formed by monocyte fusion, play a key role in bone resorption. Hypoxia-inducible factor (HIF)-1\u03b1 is vital for the development of osteoclasts in hypoxic environments and during bone resorption. However, additional research is required to further study the HIF-1\u03b1-dependent regulation of osteoclast differentiation at the genetic level.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In our study, RNA sequencing (RNA-seq) was used to identify the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in conditional HIF-1\u03b1-knockout osteoclasts.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 1,320 mRNAs and 95 lncRNAs were differentially expressed. The expression of lncRNAs MSTRG.7566.12 and MSTRG.31769.2 were strongly negatively correlated with that of Mmp9, Ctsk, etc.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our research provides a basis for further understanding the role of mRNAs and lncRNAs in conditional HIF-1\u03b1-knockout osteoclasts, and many of these molecules may be potential targets for treating bone diseases related to HIF-1\u03b1.<\/jats:p>","DOI":"10.3389\/fgene.2022.909095","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:59:00Z","timestamp":1655787540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["LncRNA-mRNA Expression Profiles of Osteoclast After Conditional Knockout HIF-1\u03b1"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuanye","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyifan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiwu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bone.2017.12.021","article-title":"Metabolic Properties of the Osteoclast","volume":"115","author":"Arnett","year":"2018","journal-title":"Bone"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna6030027","article-title":"Long-Noncoding RNA (lncRNA) in the Regulation of Hypoxia-Inducible Factor (HIF) in Cancer","volume":"6","author":"Barth","year":"2020","journal-title":"Noncoding RNA"},{"key":"B3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1136\/jcp.38.3.241","article-title":"The Pathobiology of the Osteoclast","volume":"38","author":"Chambers","year":"1985","journal-title":"J. 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