{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:56:00Z","timestamp":1753890960150,"version":"3.41.2"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Stanford type A aortic dissection (ATAAD) is a common life-threatening event in the aorta. Recently, immune disorder has been linked to the risk factors that cause ATAAD at the molecular level. However, the specific immune-related gene signature during the progression is unclear.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The GSE52093 and GSE98770 datasets related to ATAAD from the Gene Expression Omnibus (GEO) database were acquired. The immune gene expression levels were analyzed by single sample gene set enrichment analysis (ssGSEA). The correlations between gene networks and immune scores were determined by weighted gene correlation network analysis (WGCNA). The different immune subgroups were finally divided by consensus clustering. The differentially expressed genes (DEGs) were identified and subsequent functional enrichment analyses were conducted. The hub genes were identified by protein\u2013protein interaction (PPI) network and functional similarities analyses. The immune cell infiltration proportion was determined by the CIBERSORT algorithm.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> According to the ssGSEA results, the 13 ATAAD samples from the GEO database were divided into high- and low-immune subgroups according to the ssGSEA, WGCNA, and consensus clustering analysis results. Sixty-eight immune-related DEGs (IRDEGs) between the two subgroups were enriched in inflammatory-immune response biological processes, including leukocyte cell\u2013cell adhesion, mononuclear cell migration, and myeloid leukocyte migration. Among these IRDEGs, 8 genes (<jats:italic>CXCR4<\/jats:italic>, <jats:italic>LYN<\/jats:italic>, <jats:italic>CCL19<\/jats:italic>, <jats:italic>CCL3L3<\/jats:italic>, <jats:italic>SELL<\/jats:italic>, <jats:italic>F11R<\/jats:italic>, <jats:italic>DPP4<\/jats:italic>, and <jats:italic>VAV3<\/jats:italic>) were identified as hub genes that represented immune-related signatures in ATAAD after the PPI and functional similarities analyses. The proportions of infiltrating CD8 T cells and M1 macrophages were significantly higher in ATAAD patients in the immune-high group than the immune-low group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Eight immune-related genes were identified as hub genes representing potential biomarkers and therapeutic targets linked to the immune response in ATAAD patients.<\/jats:p>","DOI":"10.3389\/fgene.2022.911750","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:09:56Z","timestamp":1655737796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Immune-Related Gene Signature in Stanford Type A Aortic Dissection"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhaoshui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nbt.4086","article-title":"IL-7 and CCL19 Expression in CAR-T Cells Improves Immune Cell Infiltration and CAR-T Cell Survival in the Tumor","volume":"36","author":"Adachi","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: Tool for the Unification of Biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.atherosclerosis.2010.05.014","article-title":"Silencing of the F11R Gene Reveals a Role for F11R\/JAM-A in the Migration of Inflamed Vascular Smooth Muscle Cells and in Atherosclerosis","volume":"212","author":"Azari","year":"2010","journal-title":"Atherosclerosis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"D760","DOI":"10.1093\/nar\/gkl887","article-title":"NCBI GEO: Mining Tens of Millions of Expression Profiles-Ddatabase and Tools Update","volume":"35","author":"Barrett","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"180015","DOI":"10.1038\/sdata.2018.15","article-title":"ImmPort, toward Repurposing of Open Access Immunological Assay Data for Translational and Clinical Research","volume":"5","author":"Bhattacharya","year":"2018","journal-title":"Sci. Data"},{"key":"B6","doi-asserted-by":"publisher","first-page":"bqab152","DOI":"10.1210\/endocr\/bqab152","article-title":"The Src-Family Kinase Lyn in Immunoreceptor Signaling","volume":"162","author":"Brian","year":"2021","journal-title":"Endocrinology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.2147\/ijgm.s317405","article-title":"Patterns of Immune Infiltration and the Key Immune-Related Genes in Acute Type A Aortic Dissection in Bioinformatics Analyses","volume":"14","author":"Chen","year":"2021","journal-title":"Ijgm"},{"key":"B8","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: Identifying Hub Objects and Sub-networks from Complex Interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5947","DOI":"10.3390\/cancers13235947","article-title":"The Serine Protease CD26\/DPP4 in Non-transformed and Malignant T Cells","volume":"13","author":"Chitadze","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3109\/07853890.2015.1073346","article-title":"Stanford-A Acute Aortic Dissection, Inflammation, and Metalloproteinases: a Review","volume":"47","author":"Cifani","year":"2015","journal-title":"Ann. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nrcardio.2014.203","article-title":"Management of Acute Aortic Syndrome","volume":"12","author":"Clough","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s0003-4975(10)65594-4","article-title":"Management of Acute Aortic Dissections","volume":"10","author":"Daily","year":"1970","journal-title":"Ann. Thorac. Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a Bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.jvs.2021.01.054","article-title":"Systematic Review and Meta-Analysis of Endovascular Interventions for Stanford Type A Aortic Dissection","volume":"74","author":"De Freitas","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000355253","article-title":"The Multitasking Role of Macrophages in Stanford Type A Acute Aortic Dissection","volume":"127","author":"Del Porto","year":"2014","journal-title":"Cardiology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3109\/07853890.2010.518156","article-title":"Inflammation and Immune Response in Acute Aortic Dissection","volume":"42","author":"del Porto","year":"2010","journal-title":"Ann. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/jbm.a.37090","article-title":"GSVA Score Reveals Molecular Signatures from Transcriptomes for Biomaterials Comparison","volume":"109","author":"Ferreira","year":"2021","journal-title":"J. Biomed. Mater Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40560-018-0287-7","article-title":"Management of Acute Aortic Dissection and Thoracic Aortic Rupture","volume":"6","author":"Fukui","year":"2018","journal-title":"J. Intensive Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"680065","DOI":"10.3389\/fcvm.2021.680065","article-title":"Analysis of Hub Genes and the Mechanism of Immune Infiltration in Stanford Type a Aortic Dissection","volume":"8","author":"Gao","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.jacc.2014.08.025","article-title":"Thoracic Aortic Aneurysm and Dissection","volume":"64","author":"Goldfinger","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD)","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: Gene Set Variation Analysis for Microarray and RNA-Seq Data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"key":"B23","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jtcvs.2005.09.018","article-title":"Characterization of the Inflammatory and Apoptotic Cells in the Aortas of Patients with Ascending Thoracic Aortic Aneurysms and Dissections","volume":"131","author":"He","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.jtcvs.2007.12.063","article-title":"Characterization of the Inflammatory Cells in Ascending Thoracic Aortic Aneurysms in Patients with Marfan Syndrome, Familial Thoracic Aortic Aneurysms, and Sporadic Aneurysms","volume":"136","author":"He","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/s1357-2725(96)00104-5","article-title":"Lyn, a Src-like Tyrosine Kinase","volume":"29","author":"Hibbs","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1016\/j.jacc.2010.02.015","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM Guidelines for the Diagnosis and Management of Patients with Thoracic Aortic Disease. A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology,American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons,and Society for Vascular Medicine","volume":"55","author":"Hiratzka","year":"20102010","journal-title":"J. Am. Coll. Cardiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.jacc.2003.08.054","article-title":"Characterizing the Young Patient with Aortic Dissection: Results from the International Registry of Aortic Dissection (IRAD)","volume":"43","author":"Januzzi","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"bbab108","DOI":"10.1093\/bib\/bbab108","article-title":"Venn Diagrams in Bioinformatics","volume":"22","author":"Jia","year":"2021","journal-title":"Brief. Bioinform"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e8950","DOI":"10.1590\/1414-431X20198950","article-title":"Identification of the Molecular Mechanisms Associated with Acute Type A Aortic Dissection through Bioinformatics Methods","volume":"52","author":"Jiang","year":"2019","journal-title":"Braz J. Med. Biol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.imlet.2014.03.006","article-title":"Macrophages: a Double-Edged Sword in Experimental Autoimmune Encephalomyelitis","volume":"160","author":"Jiang","year":"2014","journal-title":"Immunol. Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jjcc.2020.08.004","article-title":"Immune Cell Infiltration Landscapes in Pediatric Acute Myocarditis Analyzed by CIBERSORT","volume":"77","author":"Kawada","year":"2021","journal-title":"J. Cardiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/ejcts\/ezx095","article-title":"Gene Expression Profiling of Acute Type A Aortic Dissection Combined with In Vitro Assessment\u2020","volume":"52","author":"Kimura","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"6697848","DOI":"10.1155\/2021\/6697848","article-title":"Identification of Molecular Regulatory Features and Markers for Acute Type A Aortic Dissection","volume":"2021","author":"Lian","year":"2021","journal-title":"Comput. Math. Methods Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database Hallmark Gene Set Collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1210\/clinem\/dgab078","article-title":"DPP4 Activity, Hyperinsulinemia, and Atherosclerosis","volume":"106","author":"Love","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/s0735-1097(02)02005-3","article-title":"Acute Type A Aortic Dissection in the Elderly: Clinical Characteristics, Management, and Outcomes in the Current Era","volume":"40","author":"Mehta","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1378\/chest.117.5.1271","article-title":"Epidemiology and Clinicopathology of Aortic Dissection","volume":"117","author":"M\u00e9sz\u00e1ros","year":"2000","journal-title":"Chest"},{"key":"B38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/ni1191","article-title":"T Cell Costimulation by Chemokine Receptors","volume":"6","author":"Molon","year":"2005","journal-title":"Nat. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining Cell Type Abundance and Expression from Bulk Tissues with Digital Cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"16053","DOI":"10.1038\/nrdp.2016.53","article-title":"Aortic Dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B41","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","article-title":"Leukocyte Migration into Inflamed Tissues","volume":"41","author":"Nourshargh","year":"2014","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jacc.2015.05.029","article-title":"Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends from the International Registry of Acute Aortic Dissection","volume":"66","author":"Pape","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"B44","first-page":"764","article-title":"Acute Type A Aortic Dissection: Beyond the Diameter","volume":"25","author":"Pisano","year":"2016","journal-title":"J. Heart Valve Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.imlet.2016.06.006","article-title":"CXCR4 Signaling in Health and Disease","volume":"177","author":"Pozzobon","year":"2016","journal-title":"Immunol. Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma Powers Differential Expression Analyses for RNA-Sequencing and Microarray Studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/jocs.16297","article-title":"Does Systemic Immune-Inflammation Index Predict the Short Outcomes after an Acute Type A Aortic Dissection Repair? Promising Biomarker for Acute Aortic Syndrome","volume":"37","author":"Samanidis","year":"2022","journal-title":"J. Card. Surg."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1161\/01.atv.0000085631.76095.64","article-title":"Aortic Dissection Precedes Formation of Aneurysms and Atherosclerosis in Angiotensin II-Infused, Apolipoprotein E-Deficient Mice","volume":"23","author":"Saraff","year":"2003","journal-title":"Atvb"},{"key":"B49","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/cells10010037","article-title":"CD8+ T Cells in Atherosclerosis","volume":"10","author":"Sch\u00e4fer","year":"2020","journal-title":"Cells"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jmoldx.2019.08.006","article-title":"Using R and Bioconductor in Clinical Genomics and Transcriptomics","volume":"22","author":"Sepulveda","year":"2020","journal-title":"J. Mol. Diagnostics"},{"key":"B51","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage Plasticity, Polarization, and Function in Health and Disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.3390\/ijms18102035","article-title":"A Novel Vav3 Homolog Identified in Lamprey, Lampetra Japonica, with Roles in Lipopolysaccharide-Mediated Immune Response","volume":"18","author":"Shen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte Recruitment during Infection and Inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1136\/heartjnl-2015-308284","article-title":"Aortic Dissection: Medical, Interventional and Surgical Management","volume":"103","author":"Silaschi","year":"2017","journal-title":"Heart"},{"key":"B55","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/s0025-6196(12)60599-0","article-title":"Clinical Features and Differential Diagnosis of Aortic Dissection: Experience with 236 Cases (1980 through 1990)","volume":"68","author":"Spittell","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1161\/01.cir.99.10.1331","article-title":"Intimal Tear without Hematoma","volume":"99","author":"Svensson","year":"1999","journal-title":"Circulation"},{"key":"B57","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING V11: Protein-Protein Association Networks with Increased Coverage, Supporting Functional Discovery in Genome-wide Experimental Datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B58","first-page":"290","article-title":"Aortic Dissection","volume":"73","author":"Tchana-Sato","year":"2018","journal-title":"Rev. Med. Liege"},{"key":"B59","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ejcb.2011.02.007","article-title":"l-Selectin - A Dynamic Regulator of Leukocyte Migration","volume":"91","author":"Wedepohl","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a Class Discovery Tool with Confidence Assessments and Item Tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"B61","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage Biology in Development, Homeostasis and Disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1266\/ggs.20-00053","article-title":"SELL and IFI44 as Potential Biomarkers of Sj\u00f6gren's Syndrome and Their Correlation with Immune Cell Infiltration","volume":"96","author":"Xu","year":"2021","journal-title":"Genes Genet. Syst."},{"key":"B63","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/jocs.16300","article-title":"Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in ATAD Patients Undergoing Surgery","volume":"37","author":"Xu","year":"2022","journal-title":"J. Card. Surg."},{"key":"B64","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","article-title":"Gene Ontology Semantic Similarity Analysis Using GOSemSim","volume":"2117","author":"Yu","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/bpa.12690","article-title":"Distribution and Prognostic Impact of Microglia\/macrophage Subpopulations in Gliomas","volume":"29","author":"Zeiner","year":"2019","journal-title":"Brain Pathol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"7585149","DOI":"10.1155\/2022\/7585149","article-title":"Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis","volume":"2022","author":"Zhang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8+ T Cells: Foot Soldiers of the Immune System","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.jacc.2020.07.061","article-title":"Type A Aortic Dissection-Experience over 5 Decades","volume":"76","author":"Zhu","year":"2020","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.911750\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:10:02Z","timestamp":1655737802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.911750\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,16]]},"references-count":69,"alternative-id":["10.3389\/fgene.2022.911750"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2022.911750","relation":{},"ISSN":["1664-8021"],"issn-type":[{"type":"electronic","value":"1664-8021"}],"subject":[],"published":{"date-parts":[[2022,6,16]]},"article-number":"911750"}}