{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:44:03Z","timestamp":1784591043272,"version":"3.55.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To study whether ankylosing spondylitis (AS) has a causal effect on the risk of atrial fibrillation (AF) using two-sample Mendelian randomization (MR) analysis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Single nucleotide polymorphisms (SNPs) were selected as independent instrumental variables (IVs) from a GWAS study of AS. Summary data from a large-scale GWAS meta-analysis of AF was utilized as the outcome dataset. Inverse-variance weighted (IVW) model was used for the primary analysis. Multiple sensitivity and heterogeneity tests were conducted to confirm the robustness of the results.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In total, 18 SNPs were identified as IVs for MR analysis. Five MR methods consistently found that ankylosing spondylitis was not causally associated with atrial fibrillation (IVW: OR = 0.983 (0.894, 1.080), <jats:italic>p<\/jats:italic> = 0.718; MR-Egger: OR = 1.190 (0.973, 1.456), <jats:italic>p<\/jats:italic> = 0.109; Simple mode: OR = 0.888 (0.718, 1.098), <jats:italic>p<\/jats:italic> = 0.287; Weighted mode: OR = 0.989 (0.854, 1.147), <jats:italic>p<\/jats:italic> = 0.890; Weight median: OR = 0.963 (0.852, 1.088), <jats:italic>p<\/jats:italic> = 0.545). Leave-one-out analysis supported the stability of MR results. Both the MR-Egger intercept and MR-PRESSO method revealed the absence of horizontal pleiotropy.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The two-sample MR analysis did not support a causal relationship between AS and the risk of AF.<\/jats:p>","DOI":"10.3389\/fgene.2022.951893","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T04:48:06Z","timestamp":1668574086000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuhong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoshi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1540-8175.2008.00838.x","article-title":"Assessment of atrial electromechanical coupling characteristics in patients with ankylosing spondylitis","volume":"26","author":"Acar","year":"2009","journal-title":"Echocardiography"},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/annrheumdis-2016-209775","article-title":"EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015\/2016 update","volume":"76","author":"Agca","year":"2017","journal-title":"Ann. 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