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Although anti-VEGF drugs have been used to effectively treat neovascularization, long-term use of anti-angiogenic factors can cause a variety of neurological and developmental side effects. As a result, better drugs to treat ocular neovascularization are urgently required. There is mounting evidence that epigenetic regulation is important in ocular neovascularization. DNA methylation and histone modification, non-coding RNA, and mRNA modification are all examples of epigenetic mechanisms. In order to shed new light on epigenetic therapeutics in ocular neovascularization, this review focuses on recent advances in the epigenetic control of ocular neovascularization as well as discusses these new mechanisms.<\/jats:p>","DOI":"10.3389\/fgene.2022.970224","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T08:11:25Z","timestamp":1662106285000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential epigenetic molecular regulatory networks in ocular neovascularization"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nature06145","article-title":"'UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development","volume":"449","author":"Agger","year":"2007","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.1038\/sj.emboj.7601273","article-title":"'Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation","volume":"25","author":"Aikawa","year":"2006","journal-title":"EMBO J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3109\/02713683.2015.1095933","article-title":"Probable chemical hypoxia effects on progress of CNV through induction of promoter CpG demethylation and overexpression of IL17RC in human RPE cells","volume":"41","author":"Alivand","year":"2016","journal-title":"Curr. 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