{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:07:52Z","timestamp":1792591672404,"version":"4.5.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010846","name":"Health and Family Planning Commission of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study aims to estimate the maternal age-related risk of Down syndrome in an Asian population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We performed a retrospective data analysis including a total of 206,295 pregnant women who presented for second-trimester maternal serum screening for Down syndrome at Hubei Maternal and Child Health Hospital for the years 2008\u20132017. Cases were assigned to three groups: \u226426\u00a0years of age, 27\u201333\u00a0years of age, and \u226534\u00a0years of age. The incidence of Down Syndrome was calculated for each age group. The differences between groups were tested using the chi-square (\u03c72) test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The incidence of Down syndrome in women \u226426\u00a0years of age, 27\u201333\u00a0years of age, and \u226534\u00a0years of age was 0.67\u2030, 0.29\u2030, and 2.07\u2030 respectively. Statistically significant difference was found between the three age groups (\u03c72 = 79.748, <jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Down syndrome rate was significantly higher in women \u226534\u00a0years of age. Younger women (\u226426\u00a0years of age) had a significantly higher risk for Down\u2019s syndrome, compared to women aged 27\u201333.<\/jats:p>","DOI":"10.3389\/fgene.2022.980627","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T05:07:25Z","timestamp":1661404045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of Down Syndrome by maternal age in Chinese population"],"prefix":"10.3389","volume":"13","author":[{"given":"Yi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Jieping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Tianshu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhijun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Jingxuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1001\/jama.246.7.758","article-title":"Down's syndrome. recent trends in the United States","volume":"246","author":"Adams","year":"1981","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. 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