{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:59:59Z","timestamp":1777471199218,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790643 82121003 82070928"],"award-info":[{"award-number":["81790643 82121003 82070928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0369 2021JDGD0036 2021YFS0404 2020YJ0460 2022JDTD0024"],"award-info":[{"award-number":["2021YFS0369 2021JDGD0036 2021YFS0404 2020YJ0460 2022JDTD0024"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009579","name":"Health Department of Sichuan Province","doi-asserted-by":"publisher","award":["19PJ117"],"award-info":[{"award-number":["19PJ117"]}],"id":[{"id":"10.13039\/501100009579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> Age-related macular degeneration (AMD) is a leading cause of vision loss. A Previous study based on the co-localization analysis of the genome-wide association study (GWAS) and eQTL genetic signals have reported that single nucleotide polymorphisms (SNPs), including rs760975, rs11528744, rs3761159, rs7212510, rs6965458, rs7559693, rs56108400, rs28495773, rs9928736, rs11777697, rs4381465 are associated with AMD in Americans. The aim of this study was to investigate the association of these SNPs in a Han Chinese population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> There were 576 patients with wet AMD and 572 healthy controls collected in this study. All SNPs were genotyped by flight mass spectrum. Hardy\u2013Weinberg equilibrium was applied to evaluate allele distributions for both AMD and control groups. The genotype and allele frequencies were evaluated using the \u03c7<jats:sup>2<\/jats:sup> tests. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Three of the 11 SNPs (rs11528744 in <jats:italic>HTRA1,<\/jats:italic> rs9928736 in <jats:italic>BCRA1<\/jats:italic> and rs4381465 in <jats:italic>B3GLCT<\/jats:italic>) were found to be significantly associated with AMD in the allelic model (corrected <jats:italic>p<\/jats:italic> = 0.001, OR = 1.391, 95%CI = 1.179\u20131.640 for rs11528744; corrected <jats:italic>p<\/jats:italic> = 0.004, OR = 0.695, 95%CI = 0.544\u20130.888 for rs9928736; corrected <jats:italic>p<\/jats:italic> = 0.002, OR = 0.614, 95%CI = 0.448\u20130.841 for rs4381465). There were no differences for the remaining eight SNPs between AMD cases and healthy controls.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our results showed that <jats:italic>HTRA1<\/jats:italic> rs11528744, <jats:italic>BCRA1<\/jats:italic> rs9928736, and <jats:italic>B3GLCT<\/jats:italic> rs4381465 were associated with wet AMD, suggesting that <jats:italic>HTRA1, BCRA1<\/jats:italic>, and <jats:italic>B3GLCT<\/jats:italic> genes may be involved in the development of AMD.<\/jats:p>","DOI":"10.3389\/fgene.2022.997840","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T13:54:27Z","timestamp":1664459667000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["HTRA1 rs11528744, BCRA1 rs9928736, and B3GLCT rs4381465 are associated with age-related macular degeneration in a Chinese population"],"prefix":"10.3389","volume":"13","author":[{"given":"Guo","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuntao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/s0002-9394(00)00732-7","article-title":"The age-related eye disease study (AREDS) System for classifying cataracts from photographs: AREDS report No. 4","volume":"131","year":"2001","journal-title":"Am. 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