{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:28:38Z","timestamp":1784366918018,"version":"3.55.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Effects of hypertension, type 2 diabetes and obesity on Bell\u2019s palsy risk remains unclear. The aim of the study was to explore whether hypertension and these metabolic disorders promoted Bell\u2019s palsy at the genetic level.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Genetic variants from genome-wide association studies for hypertension, type 2 diabetes, body mass index and several lipid metabolites were adopted as instrumental variables. Two-sample Mendelian randomization including IVW and MR-Egger was used to measure the genetic relationship between the exposures and Bell\u2019s palsy. Sensitivity analyses (i.e., Cochran\u2019s Q test, MR-Egger intercept test, \u201cleave-one-SNP-out\u201d analysis and funnel plot) were carried out to assess heterogeneity and horizontal pleiotropy. All statistical analyses were performed using R software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Hypertension was significantly associated with the increased risk of Bell\u2019s palsy (IVW: OR = 2.291, 95%CI = 1.025\u20135.122, <jats:italic>p<\/jats:italic> = 0.043; MR-Egger: OR = 16.445, 95%CI = 1.377\u2013196.414, <jats:italic>p<\/jats:italic> = 0.029). Increased level of LDL cholesterol might upexpectedly decrease the risk of the disease (IVW: OR = 0.805, 95%CI = 0.649\u20130.998, <jats:italic>p<\/jats:italic> = 0.048; MR-Egger: OR = 0.784, 95%CI = 0.573\u20131.074, <jats:italic>p<\/jats:italic> = 0.132). In addition, type 2 diabetes, body mass index and other lipid metabolites were not related to the risk of Bell\u2019s palsy. No heterogeneity and horizontal pleiotropy had been found.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Hypertension might be a risk factor for Bell\u2019s palsy at the genetic level, and LDL cholesterol might reduce the risk of the disease. These findings (especially for LDL cholesterol) need to be validated by further studies.<\/jats:p>","DOI":"10.3389\/fgene.2023.1077438","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T10:00:34Z","timestamp":1689674434000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic association of hypertension and several other metabolic disorders with Bell\u2019s palsy"],"prefix":"10.3389","volume":"14","author":[{"given":"Huawei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1365-2273.1982.tb01569.x","article-title":"Predisposing factors in Bell's palsy: A clinical study with reference to diabetes mellitus, hypertension, clotting mechanism and lipid disturbance","volume":"7","author":"Abraham-Inpijn","year":"1982","journal-title":"Clin. 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