{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:23:27Z","timestamp":1775147007447,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Individuals of Ashkenazi Jewish ancestry have been identified as having higher prevalence of specific pathogenic variants associated with susceptibility to specific rare and chronic diseases. In Mexico, the prevalence and composition of rare cancer predisposing germline variants in Ashkenazi Jewish individuals has not been evaluated.<\/jats:p><jats:p><jats:bold>Aim and methods:<\/jats:bold> We aimed to evaluate the prevalence of pathogenic variants by massive parallel sequencing in a panel of 143 cancer-predisposing genes in 341 women from the Ashkenazi Jewish community of Mexico, who were contacted and invited to participate in the study through the ALMA Foundation for Cancer Reconstruction. Pre- and posttest genetic counseling was given and a questionnaire on personal, gyneco-obstetric, demographic and lifestyle variables was conducted. From peripheral blood DNA, the complete coding region, and splicing sites of a panel of 143 cancer susceptibility genes, including 21 clinically relevant genes, were sequenced. The Mexican founder mutation <jats:italic>BRCA1 ex9-12del<\/jats:italic> [NC_000017.10(NM_007294):c. (825+1\u2013826-1)_(4,589+1\u20134,590-1)del] was also evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among study participants (mean age \u00b1standard deviation: 47 \u00b1 14) 15% reported a personal history of cancer (50\/341). Fourteen percent of participants (48\/341) were carriers of pathogenic and likely pathogenic variants distributed among seven high-risk genes (<jats:italic>APC, CHEK2, MSH2, BMPR1A, MEN1, MLH1,<\/jats:italic> and <jats:italic>MSH6<\/jats:italic>), whereas 18.2% (62\/341) had variants of uncertain clinical significance in genes associated with breast and ovarian cancer susceptibility (list of genes with VUS). Pathogenic and likely pathogenic variants in 16 susceptibility genes with ambiguous or non-well-established risk association for cancer were detected in 17.6% (60\/341) of participants. Sixty four percent of participants reported current alcohol consumption compared with the 39 percent prevalence of alcohol consumption in Mexican women. None of the participants carried the recurrent Ashkenazi and Mexican founder mutations in <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic>, but 2% (7\/341) had pathogenic Ashkenazi Jewish founder variants in <jats:italic>BLM<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our findings show a diverse pathogenic variant composition among the recruited individuals of Ashkenazi Jewish ancestry in Mexico consistent with being a high-risk population for genetic diseases, which warrants further investigation to adequately assess the burden of hereditary breast cancer in this group and implement appropriate preventative programs.<\/jats:p>","DOI":"10.3389\/fgene.2023.1094260","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T04:45:51Z","timestamp":1676004351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of genetic alterations in hereditary cancer susceptibility genes in the Ashkenazi Jewish women community of Mexico"],"prefix":"10.3389","volume":"14","author":[{"given":"Clara Estela","family":"D\u00edaz-Vel\u00e1squez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Gitler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Antoniano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Kershenovich Sefchovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo Hugo","family":"De La Cruz-Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Mart\u00ednez-Gregorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto Arturo","family":"Rojas-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Cortez Cardoso Penha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Ignacio","family":"Terrazas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia","family":"Wegman-Ostrosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ephrat","family":"Levi-Lahad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovanny","family":"Zabaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Perdomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Vaca-Paniagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/JGO.18.00163","article-title":"Non-BRCA1\/2 variants detected in a high-risk Chilean cohort with a history of breast and\/or ovarian cancer","volume":"5","author":"Adaniel","year":"2019","journal-title":"J. Glob. Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.31819\/9783954872794","volume-title":"Pertenencia y alteridad: Jud\u00edos en\/de Am\u00e9rica latina: Cuarenta a\u00f1os de cambios","author":"Avni","year":"2011"},{"key":"B4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/sj.ejhg.5201156","article-title":"MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population","volume":"12","author":"Behar","year":"2004","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"B5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","article-title":"Colon cancer, version 2.2021, NCCN clinical practice guidelines in oncology","volume":"19","author":"Benson","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1002\/humu.23652","article-title":"BRCA1 and BRCA2 5\u2019 noncoding region variants identified in breast cancer patients alter promoter activity and protein binding","volume":"39","author":"Burke","year":"2018","journal-title":"Hum. Mutat."},{"key":"B7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"B8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10689-017-0004-z","article-title":"A multi-gene panel study in hereditary breast and ovarian cancer in Colombia","volume":"17","author":"Cock-Rada","year":"2018","journal-title":"Fam. Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.6004\/jnccn.2021.0001","article-title":"Genetic\/Familial high-risk assessment: Breast, ovarian, and pancreatic, version 2.2021, NCCN clinical practice guidelines in oncology","volume":"19","author":"Daly","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"B10","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/humu.22981","article-title":"HGVS recommendations for the description of sequence variants: 2016 update","volume":"37","author":"den Dunnen","year":"2016","journal-title":"Hum. Mutat."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1086\/302167","article-title":"The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry","volume":"63","author":"Ellis","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"B12","article-title":"Encuesta nacional de Consumo de Drogas, alcohol y tabaco, ENCODAT 2016-2017","year":"2017","journal-title":"Gob. Mx."},{"key":"B13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ajhg.2018.07.002","article-title":"A dominantly inherited 5\u2019 UTR variant causing methylation-associated silencing of BRCA1 as a cause of breast and ovarian cancer","volume":"103","author":"Evans","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9723","DOI":"10.1158\/0008-5472.CAN-08-2039","article-title":"Genetic ancestry and risk of breast cancer among U.S. Latinas","volume":"68","author":"Fejerman","year":"2008","journal-title":"Cancer Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/s41431-021-00959-x","article-title":"The LOVD3 platform: Efficient genome-wide sharing of genetic variants","volume":"29","author":"Fokkema","year":"2021","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"B16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.tranon.2019.11.003","article-title":"Clinical evaluation of BRCA1\/2 mutation in Mexican ovarian cancer patients","volume":"13","author":"Gallardo-Rinc\u00f3n","year":"2020","journal-title":"Transl. Oncol."},{"key":"B17","first-page":"87","article-title":"Judeo-mexicanos: Gestaci\u00f3n de una identidad","author":"Goldsmit Brindis","year":"2010","journal-title":"Hist. Graf\u00eda"},{"key":"B18","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1200\/PO.19.00178","article-title":"Pathogenic variants in CHEK2 are associated with an adverse prognosis in symptomatic early-onset breast cancer","volume":"4","author":"Greville-Heygate","year":"2020","journal-title":"JCO Precis. Oncol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/molbev\/msr133","article-title":"The architecture of long-range haplotypes shared within and across populations","volume":"29","author":"Gusev","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1093\/hmg\/dds308","article-title":"Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer","volume":"21","author":"Hansmann","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B21","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inf."},{"key":"B22","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inf."},{"key":"B23","volume-title":"Inegi","year":"2020"},{"key":"B24","doi-asserted-by":"publisher","first-page":"D835","DOI":"10.1093\/nar\/gkz972","article-title":"ClinVar: Improvements to accessing data","volume":"48","author":"Landrum","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B25","first-page":"1059","article-title":"Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: Frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families","volume":"60","author":"Levy-Lahad","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinforma. Oxf. Engl."},{"key":"B27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ajhg.2017.01.004","article-title":"InterVar: Clinical interpretation of genetic variants by the 2015 ACMG-AMP guidelines","volume":"100","author":"Li","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/1471-0528.15905","article-title":"Randomised trial of population-based BRCA testing in Ashkenazi Jews: Long-term outcomes","volume":"127","author":"Manchanda","year":"2020","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1093\/jnci\/dju379","article-title":"Population testing for cancer predisposing BRCA1\/BRCA2 mutations in the ashkenazi-jewish community: A randomized controlled trial","volume":"107","author":"Manchanda","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e1008624","DOI":"10.1371\/journal.pgen.1008624","article-title":"What is ancestry?","volume":"16","author":"Mathieson","year":"2020","journal-title":"PLOS Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1200\/JCO.2009.25.0712","article-title":"Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women","volume":"28","author":"Metcalfe","year":"2010","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/s41436-021-01172-3","article-title":"ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of medical genetics and genomics (ACMG)","volume":"23","author":"Miller","year":"2021","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/jmedgenet-2018-105606","article-title":"Screening of BRCA1\/2 deep intronic regions by targeted gene sequencing identifies the first germline BRCA1 variant causing pseudoexon activation in a patient with breast\/ovarian cancer","volume":"56","author":"Montalban","year":"2019","journal-title":"J. Med. Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5278024","DOI":"10.1155\/2016\/5278024","article-title":"Novel mutations in MLH1 and MSH2 genes in Mexican patients with lynch syndrome","volume":"2016","author":"Moreno-Ortiz","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"B35","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.gim.2021.11.019","article-title":"Carrier screening in the Mexican Jewish community using a pan-ethnic expanded carrier screening NGS panel","volume":"24","author":"Morgenstern-Kaplan","year":"2022","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.3389\/fonc.2019.01429","article-title":"Latin American study of hereditary breast and ovarian cancer lacam: A genomic epidemiology approach","volume":"9","author":"Oliver","year":"2019","journal-title":"Front. Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/35098506","article-title":"A genetic profile of contemporary Jewish populations","volume":"2","author":"Ostrer","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.ajhg.2012.08.030","article-title":"Length distributions of identity by descent reveal fine-scale demographic history","volume":"91","author":"Palamara","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"E361","DOI":"10.3390\/cancers10100361","article-title":"Comprehensive analysis of germline variants in Mexican patients with hereditary breast and ovarian cancer susceptibility","volume":"10","author":"Quezada Urban","year":"2018","journal-title":"Cancers"},{"key":"B40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S1470-2045(21)00279-5","article-title":"Global burden of cancer in 2020 attributable to alcohol consumption: A population-based study","volume":"22","author":"Rumgay","year":"2021","journal-title":"Lancet Oncol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0247363","DOI":"10.1371\/journal.pone.0247363","article-title":"Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis","volume":"16","author":"Sandoval","year":"2021","journal-title":"PloS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/carcin\/bgw043","article-title":"High prevalence of luminal B breast cancer intrinsic subtype in Colombian women","volume":"37","author":"Serrano-Gomez","year":"2016","journal-title":"Carcinogenesis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/hmg\/ddi052","article-title":"Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population","volume":"14","author":"Shaag","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.3390\/cancers13112711","article-title":"Study of the genetic variants in BRCA1\/2 and non-BRCA genes in a population-based cohort of 2155 breast\/ovary cancer patients, including 443 triple-negative breast cancer patients, in Argentina","volume":"13","author":"Solano","year":"2021","journal-title":"Cancers"},{"key":"B46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/gepi.20064","article-title":"Estimation of individual admixture: Analytical and study design considerations","volume":"28","author":"Tang","year":"2005","journal-title":"Genet. Epidemiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"7669","DOI":"10.1038\/s41598-020-63466-x","article-title":"Identifying Ashkenazi Jewish BRCA1\/2 founder variants in individuals who do not self-report Jewish ancestry","volume":"10","author":"Tennen","year":"2020","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative genomics viewer (IGV): High-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Brief. Bioinform."},{"key":"B49","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1158\/1055-9965.EPI-13-0980","article-title":"Recurrent BRCA1 and BRCA2 mutations in Mexican women with breast cancer","volume":"24","author":"Torres-Mej\u00eda","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"11.10.1","DOI":"10.1002\/0471250953.bi1110s43","article-title":"From FastQ data to high confidence variant calls: The genome analysis toolkit best practices pipeline","volume":"43","author":"Van der Auwera","year":"2013","journal-title":"Curr. Protoc. Bioinforma."},{"key":"B51","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/cncr.29058","article-title":"Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico","volume":"121","author":"Villarreal-Garza","year":"2015","journal-title":"Cancer"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1001\/jamaoncol.2017.1996","article-title":"Genetic predisposition to breast cancer due to mutations other than BRCA1 and BRCA2 founder alleles among Ashkenazi jewish women","volume":"3","author":"Walsh","year":"2017","journal-title":"JAMA Oncol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"Annovar: Functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1158\/1055-9965.EPI-07-0198","article-title":"Evidence for common ancestral origin of a recurring BRCA1 genomic rearrangement identified in high-risk Hispanic families","volume":"16","author":"Weitzel","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41525-021-00203-x","article-title":"The prevalence, genetic complexity and population-specific founder effects of human autosomal recessive disorders","volume":"6","author":"Xiao","year":"2021","journal-title":"NPJ Genomic Med."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1094260\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T04:45:59Z","timestamp":1676004359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1094260\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":55,"alternative-id":["10.3389\/fgene.2023.1094260"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2023.1094260","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"article-number":"1094260"}}